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Protein

Aspartate-rich protein 1

Gene

DRICH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-rich protein 1
Gene namesi
Name:DRICH1
Synonyms:C22orf43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28031. DRICH1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189269.
PharmGKBiPA164717092.

Polymorphism and mutation databases

BioMutaiC22orf43.
DMDMi74737656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003195921 – 229Aspartate-rich protein 1Add BLAST229

Proteomic databases

PaxDbiQ6PGQ1.
PRIDEiQ6PGQ1.

PTM databases

iPTMnetiQ6PGQ1.
PhosphoSitePlusiQ6PGQ1.

Expressioni

Gene expression databases

BgeeiENSG00000189269.
GenevisibleiQ6PGQ1. HS.

Organism-specific databases

HPAiHPA020446.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYOZ2Q9NPC63EBI-10253641,EBI-746712
RYDENQ9NUL53EBI-10253641,EBI-10313866

Protein-protein interaction databases

BioGridi119396. 8 interactors.
IntActiQ6PGQ1. 3 interactors.
MINTiMINT-4724802.

Structurei

3D structure databases

ProteinModelPortaliQ6PGQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 205Asp-richAdd BLAST90

Phylogenomic databases

eggNOGiENOG410IUXS. Eukaryota.
ENOG4110PSK. LUCA.
GeneTreeiENSGT00520000056310.
HOGENOMiHOG000112089.
InParanoidiQ6PGQ1.
OMAiGQDLQHI.
OrthoDBiEOG091G0N83.
PhylomeDBiQ6PGQ1.
TreeFamiTF340710.

Sequencei

Sequence statusi: Complete.

Q6PGQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILTCCIN SHCGWPRGKD APCYESDTDI YETVAAATSE STTVEPGKLD
60 70 80 90 100
VGATEGQDLQ HISNQKMPTG PPEDRLSLKF LPSSEEDNDD AKILPSPVQG
110 120 130 140 150
SSEDNLSLVC LPRSEDDDCD DDDDDDAQIL PSRVQGGCYR FDSSSCSSED
160 170 180 190 200
NLSLVCLPRS EDDDCDDDDD DAQILPSPVQ ACSEDSLFLR CSLRHKDEEE
210 220
EDDDDIHITA RIESDLTLES LSDEEIHPG
Length:229
Mass (Da):25,064
Last modified:July 5, 2004 - v1
Checksum:iBB7B6F201690A1F2
GO

Sequence cautioni

The sequence CAB75693 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120Missing in CAG30256 (PubMed:15461802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0390144I → T.Corresponds to variant rs3827318dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456370 mRNA. Translation: CAG30256.1.
AL080197 mRNA. Translation: CAB75693.1. Sequence problems.
AP000346 Genomic DNA. No translation available.
BC056888 mRNA. Translation: AAH56888.1.
CCDSiCCDS42985.1.
RefSeqiNP_057533.2. NM_016449.3.
UniGeneiHs.517466.

Genome annotation databases

EnsembliENST00000317749; ENSP00000316137; ENSG00000189269.
ENST00000614553; ENSP00000483208; ENSG00000189269.
GeneIDi51233.
KEGGihsa:51233.
UCSCiuc002zxf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456370 mRNA. Translation: CAG30256.1.
AL080197 mRNA. Translation: CAB75693.1. Sequence problems.
AP000346 Genomic DNA. No translation available.
BC056888 mRNA. Translation: AAH56888.1.
CCDSiCCDS42985.1.
RefSeqiNP_057533.2. NM_016449.3.
UniGeneiHs.517466.

3D structure databases

ProteinModelPortaliQ6PGQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119396. 8 interactors.
IntActiQ6PGQ1. 3 interactors.
MINTiMINT-4724802.

PTM databases

iPTMnetiQ6PGQ1.
PhosphoSitePlusiQ6PGQ1.

Polymorphism and mutation databases

BioMutaiC22orf43.
DMDMi74737656.

Proteomic databases

PaxDbiQ6PGQ1.
PRIDEiQ6PGQ1.

Protocols and materials databases

DNASUi51233.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317749; ENSP00000316137; ENSG00000189269.
ENST00000614553; ENSP00000483208; ENSG00000189269.
GeneIDi51233.
KEGGihsa:51233.
UCSCiuc002zxf.3. human.

Organism-specific databases

CTDi51233.
GeneCardsiDRICH1.
H-InvDBHIX0213270.
HGNCiHGNC:28031. DRICH1.
HPAiHPA020446.
neXtProtiNX_Q6PGQ1.
OpenTargetsiENSG00000189269.
PharmGKBiPA164717092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUXS. Eukaryota.
ENOG4110PSK. LUCA.
GeneTreeiENSGT00520000056310.
HOGENOMiHOG000112089.
InParanoidiQ6PGQ1.
OMAiGQDLQHI.
OrthoDBiEOG091G0N83.
PhylomeDBiQ6PGQ1.
TreeFamiTF340710.

Enzyme and pathway databases

BioCyciZFISH:G66-31011-MONOMER.

Miscellaneous databases

GenomeRNAii51233.
PROiQ6PGQ1.

Gene expression databases

BgeeiENSG00000189269.
GenevisibleiQ6PGQ1. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiDRIC1_HUMAN
AccessioniPrimary (citable) accession number: Q6PGQ1
Secondary accession number(s): Q6ICJ8, Q6P4I3, Q9NU31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.