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Q6PGN9

- PSRC1_HUMAN

UniProt

Q6PGN9 - PSRC1_HUMAN

Protein

Proline/serine-rich coiled-coil protein 1

Gene

PSRC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.2 Publications

    GO - Molecular functioni

    1. microtubule binding Source: BHF-UCL
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. microtubule bundle formation Source: BHF-UCL
    2. mitotic metaphase plate congression Source: UniProtKB
    3. negative regulation of cell growth Source: BHF-UCL
    4. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    5. positive regulation of microtubule polymerization Source: BHF-UCL
    6. positive regulation of transcription, DNA-templated Source: BHF-UCL
    7. regulation of mitotic spindle organization Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline/serine-rich coiled-coil protein 1
    Gene namesi
    Name:PSRC1
    Synonyms:DDA3
    ORF Names:FP3214
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24472. PSRC1.

    Subcellular locationi

    Cytoplasm. Cytoplasmcytoskeletonspindle. Cytoplasmcytoskeletonspindle pole
    Note: Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytosol Source: UniProtKB
    3. microtubule cytoskeleton Source: BHF-UCL
    4. midbody Source: BHF-UCL
    5. nucleus Source: HPA
    6. spindle Source: BHF-UCL
    7. spindle pole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671120.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Proline/serine-rich coiled-coil protein 1PRO_0000273728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Phosphoserine2 Publications
    Modified residuei65 – 651Phosphoserine2 Publications
    Modified residuei70 – 701Phosphoserine5 Publications
    Modified residuei98 – 981Phosphoserine2 Publications
    Modified residuei145 – 1451Phosphothreonine2 Publications
    Modified residuei186 – 1861Phosphoserine3 Publications
    Modified residuei190 – 1901Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated during mitosis.6 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PGN9.
    PaxDbiQ6PGN9.
    PRIDEiQ6PGN9.

    PTM databases

    PhosphoSiteiQ6PGN9.

    Expressioni

    Tissue specificityi

    Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ6PGN9.
    BgeeiQ6PGN9.
    CleanExiHS_PSRC1.
    GenevestigatoriQ6PGN9.

    Organism-specific databases

    HPAiHPA049315.
    HPA056561.

    Interactioni

    Subunit structurei

    Interacts with APC2 By similarity. Interacts with KIF2A.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi124224. 9 interactions.
    IntActiQ6PGN9. 1 interaction.
    STRINGi9606.ENSP00000358925.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PGN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati38 – 4141
    Repeati68 – 7142
    Repeati238 – 24143
    Repeati243 – 24644

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni103 – 2461444 X 4 AA repeats of P-X-X-PAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili70 – 9425Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi238 – 361124Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PSRC1 family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG39428.
    HOGENOMiHOG000231348.
    HOVERGENiHBG080237.
    InParanoidiQ6PGN9.
    OMAiSPTCNLF.
    OrthoDBiEOG7T4MKW.
    PhylomeDBiQ6PGN9.
    TreeFamiTF338374.

    Family and domain databases

    InterProiIPR026658. DDA3.
    IPR026657. DDA3/GTSE-1.
    [Graphical view]
    PANTHERiPTHR21584. PTHR21584. 1 hit.
    PTHR21584:SF1. PTHR21584:SF1. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform C (identifier: Q6PGN9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS    50
    DPNAVAPAPQ GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG 100
    EGLGPRRVKP SPRRETFVLK DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS 150
    NDRKGSVRAL RATSGKRPSN MKRESPTCNL FPASKSPASS PLTRSTPPVR 200
    GRAGPSGRAA ASEETRAAKL RVSGSGEFVG LTLKFLHPSP PGPPTPIRSV 250
    LAPQPSTSNS QRLPRPQGAA AKSSSQLPIP SAIPRPASRM PLTSRSVPPG 300
    RGALPPDSLS TRKGLPRPST AGHRVRESGH KVPVSQRLNL PVMGATRSNL 350
    QPPRKVAVPG PTR 363
    Length:363
    Mass (Da):38,796
    Last modified:July 5, 2004 - v1
    Checksum:i4B59C01EB74F3B72
    GO
    Isoform A (identifier: Q6PGN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         213-242: Missing.

    Note: Contains a phosphoserine at position 212. Contains a phosphothreonine at position 215.

    Show »
    Length:333
    Mass (Da):35,632
    Checksum:i75BC7DB6B0705E2E
    GO
    Isoform B (identifier: Q6PGN9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         222-310: VSGSGEFVGL...RGALPPDSLS → ACQPNATHQP...KRSGQQARLQ
         311-363: Missing.

    Show »
    Length:310
    Mass (Da):33,638
    Checksum:i79C03FBF5111CBBA
    GO
    Isoform D (identifier: Q6PGN9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-170: Missing.
         213-242: Missing.

    Note: No experimental confirmation available. Contains a phosphoserine at position 42. Contains a phosphothreonine at position 45.

    Show »
    Length:163
    Mass (Da):16,981
    Checksum:i3B72DF56B3BC730E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti312 – 3121R → Q.
    Corresponds to variant rs34863121 [ dbSNP | Ensembl ].
    VAR_051288

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 170170Missing in isoform D. 1 PublicationVSP_022602Add
    BLAST
    Alternative sequencei213 – 24230Missing in isoform A and isoform D. 2 PublicationsVSP_022591Add
    BLAST
    Alternative sequencei222 – 31089VSGSG…PDSLS → ACQPNATHQPECATWQRCPT SGFSVNSKRASKTKHCRTQS AGKWTQGSCFPATKSSCHGC HSQQSAAPQESGSPRTYQVK RSGQQARLQ in isoform B. 1 PublicationVSP_022592Add
    BLAST
    Alternative sequencei311 – 36353Missing in isoform B. 1 PublicationVSP_022593Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF223000 mRNA. Translation: AAN73431.1.
    AF322891 Genomic DNA. Translation: AAN73434.1.
    AK126567 mRNA. Translation: BAC86599.1.
    AF447874 mRNA. Translation: AAQ04649.1.
    AL390252 Genomic DNA. Translation: CAI13172.1.
    AL390252 Genomic DNA. Translation: CAI13173.1.
    AL390252 Genomic DNA. Translation: CAI13174.2.
    CH471122 Genomic DNA. Translation: EAW56373.1.
    BC056909 mRNA. Translation: AAH56909.1.
    CCDSiCCDS30791.1. [Q6PGN9-3]
    CCDS797.1. [Q6PGN9-2]
    RefSeqiNP_001005290.1. NM_001005290.3. [Q6PGN9-3]
    NP_001027462.1. NM_001032291.2. [Q6PGN9-2]
    NP_116025.1. NM_032636.7. [Q6PGN9-2]
    XP_005271339.1. XM_005271282.1. [Q6PGN9-1]
    XP_005271340.1. XM_005271283.1. [Q6PGN9-2]
    XP_006711045.1. XM_006710982.1. [Q6PGN9-2]
    XP_006711046.1. XM_006710983.1. [Q6PGN9-2]
    XP_006711047.1. XM_006710984.1. [Q6PGN9-2]
    XP_006711048.1. XM_006710985.1. [Q6PGN9-3]
    UniGeneiHs.405925.

    Genome annotation databases

    EnsembliENST00000369903; ENSP00000358919; ENSG00000134222. [Q6PGN9-2]
    ENST00000369904; ENSP00000358920; ENSG00000134222. [Q6PGN9-3]
    ENST00000369907; ENSP00000358923; ENSG00000134222. [Q6PGN9-2]
    ENST00000369909; ENSP00000358925; ENSG00000134222. [Q6PGN9-2]
    ENST00000409138; ENSP00000474667; ENSG00000134222. [Q6PGN9-1]
    ENST00000409267; ENSP00000386323; ENSG00000134222. [Q6PGN9-2]
    GeneIDi84722.
    KEGGihsa:84722.
    UCSCiuc001dxb.3. human. [Q6PGN9-4]
    uc001dxc.3. human. [Q6PGN9-2]
    uc001dxf.3. human. [Q6PGN9-3]
    uc001dxj.3. human. [Q6PGN9-1]

    Polymorphism databases

    DMDMi74737651.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF223000 mRNA. Translation: AAN73431.1 .
    AF322891 Genomic DNA. Translation: AAN73434.1 .
    AK126567 mRNA. Translation: BAC86599.1 .
    AF447874 mRNA. Translation: AAQ04649.1 .
    AL390252 Genomic DNA. Translation: CAI13172.1 .
    AL390252 Genomic DNA. Translation: CAI13173.1 .
    AL390252 Genomic DNA. Translation: CAI13174.2 .
    CH471122 Genomic DNA. Translation: EAW56373.1 .
    BC056909 mRNA. Translation: AAH56909.1 .
    CCDSi CCDS30791.1. [Q6PGN9-3 ]
    CCDS797.1. [Q6PGN9-2 ]
    RefSeqi NP_001005290.1. NM_001005290.3. [Q6PGN9-3 ]
    NP_001027462.1. NM_001032291.2. [Q6PGN9-2 ]
    NP_116025.1. NM_032636.7. [Q6PGN9-2 ]
    XP_005271339.1. XM_005271282.1. [Q6PGN9-1 ]
    XP_005271340.1. XM_005271283.1. [Q6PGN9-2 ]
    XP_006711045.1. XM_006710982.1. [Q6PGN9-2 ]
    XP_006711046.1. XM_006710983.1. [Q6PGN9-2 ]
    XP_006711047.1. XM_006710984.1. [Q6PGN9-2 ]
    XP_006711048.1. XM_006710985.1. [Q6PGN9-3 ]
    UniGenei Hs.405925.

    3D structure databases

    ProteinModelPortali Q6PGN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124224. 9 interactions.
    IntActi Q6PGN9. 1 interaction.
    STRINGi 9606.ENSP00000358925.

    PTM databases

    PhosphoSitei Q6PGN9.

    Polymorphism databases

    DMDMi 74737651.

    Proteomic databases

    MaxQBi Q6PGN9.
    PaxDbi Q6PGN9.
    PRIDEi Q6PGN9.

    Protocols and materials databases

    DNASUi 84722.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369903 ; ENSP00000358919 ; ENSG00000134222 . [Q6PGN9-2 ]
    ENST00000369904 ; ENSP00000358920 ; ENSG00000134222 . [Q6PGN9-3 ]
    ENST00000369907 ; ENSP00000358923 ; ENSG00000134222 . [Q6PGN9-2 ]
    ENST00000369909 ; ENSP00000358925 ; ENSG00000134222 . [Q6PGN9-2 ]
    ENST00000409138 ; ENSP00000474667 ; ENSG00000134222 . [Q6PGN9-1 ]
    ENST00000409267 ; ENSP00000386323 ; ENSG00000134222 . [Q6PGN9-2 ]
    GeneIDi 84722.
    KEGGi hsa:84722.
    UCSCi uc001dxb.3. human. [Q6PGN9-4 ]
    uc001dxc.3. human. [Q6PGN9-2 ]
    uc001dxf.3. human. [Q6PGN9-3 ]
    uc001dxj.3. human. [Q6PGN9-1 ]

    Organism-specific databases

    CTDi 84722.
    GeneCardsi GC01M109822.
    HGNCi HGNC:24472. PSRC1.
    HPAi HPA049315.
    HPA056561.
    MIMi 613126. gene.
    neXtProti NX_Q6PGN9.
    PharmGKBi PA142671120.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39428.
    HOGENOMi HOG000231348.
    HOVERGENi HBG080237.
    InParanoidi Q6PGN9.
    OMAi SPTCNLF.
    OrthoDBi EOG7T4MKW.
    PhylomeDBi Q6PGN9.
    TreeFami TF338374.

    Miscellaneous databases

    ChiTaRSi PSRC1. human.
    GeneWikii PSRC1.
    GenomeRNAii 84722.
    NextBioi 74828.
    PROi Q6PGN9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PGN9.
    Bgeei Q6PGN9.
    CleanExi HS_PSRC1.
    Genevestigatori Q6PGN9.

    Family and domain databases

    InterProi IPR026658. DDA3.
    IPR026657. DDA3/GTSE-1.
    [Graphical view ]
    PANTHERi PTHR21584. PTHR21584. 1 hit.
    PTHR21584:SF1. PTHR21584:SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human and mouse DDA3 genes."
      Lo P.-K., Wang F.-F.
      Biochim. Biophys. Acta 1579:214-218(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM A), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Tissue: Cerebellum.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS A AND B).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
      Tissue: Skin.
    7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND THR-215 (ISOFORM A), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-45 (ISOFORM D), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement."
      Jang C.Y., Wong J., Coppinger J.A., Seki A., Yates J.R. III, Fang G.
      J. Cell Biol. 181:255-267(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH KIF2A, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-145; SER-186 AND SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3."
      Jang C.Y., Fang G.
      Cell Cycle 8:3165-3171(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-70; SER-98 AND SER-186, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND THR-215 (ISOFORM A), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND THR-45 (ISOFORM D), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPSRC1_HUMAN
    AccessioniPrimary (citable) accession number: Q6PGN9
    Secondary accession number(s): Q5T2Z3
    , Q6ZTI8, Q71MG3, Q9BV77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3