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Protein

Proline/serine-rich coiled-coil protein 1

Gene

PSRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.3 Publications

GO - Molecular functioni

  • microtubule binding Source: BHF-UCL

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule bundle formation Source: BHF-UCL
  • mitotic metaphase plate congression Source: UniProtKB
  • negative regulation of cell growth Source: BHF-UCL
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
  • positive regulation of microtubule polymerization Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of mitotic spindle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Proline/serine-rich coiled-coil protein 1
Gene namesi
Name:PSRC1
Synonyms:DDA3
ORF Names:FP3214
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24472. PSRC1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytosol Source: UniProtKB
  • microtubule cytoskeleton Source: BHF-UCL
  • midbody Source: BHF-UCL
  • spindle Source: BHF-UCL
  • spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi84722.
OpenTargetsiENSG00000134222.
PharmGKBiPA142671120.

Polymorphism and mutation databases

BioMutaiPSRC1.
DMDMi74737651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002737281 – 363Proline/serine-rich coiled-coil protein 1Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei145PhosphothreonineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Isoform D (identifier: Q6PGN9-4)
Modified residuei42PhosphoserineCombined sources1
Modified residuei45PhosphothreonineCombined sources1
Isoform A (identifier: Q6PGN9-2)
Modified residuei212PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGN9.
MaxQBiQ6PGN9.
PeptideAtlasiQ6PGN9.
PRIDEiQ6PGN9.

PTM databases

iPTMnetiQ6PGN9.
PhosphoSitePlusiQ6PGN9.

Expressioni

Tissue specificityi

Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000134222.
CleanExiHS_PSRC1.
ExpressionAtlasiQ6PGN9. baseline and differential.
GenevisibleiQ6PGN9. HS.

Organism-specific databases

HPAiHPA049315.

Interactioni

Subunit structurei

Interacts with APC2 (By similarity). Interacts with KIF2A (PubMed:18411309). Interacts with ANKRD53; recruits ANKRD53 to the spindle during mitosis (PubMed:26820536).By similarity2 Publications

GO - Molecular functioni

  • microtubule binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi124224. 21 interactors.
IntActiQ6PGN9. 11 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6PGN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 4114
Repeati68 – 7124
Repeati238 – 24134
Repeati243 – 24644

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 2464 X 4 AA repeats of P-X-X-PAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 94Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 361Pro/Ser-richAdd BLAST124

Sequence similaritiesi

Belongs to the PSRC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00510000048604.
HOGENOMiHOG000231348.
HOVERGENiHBG080237.
InParanoidiQ6PGN9.
OMAiSPTCNLF.
OrthoDBiEOG091G12JI.
PhylomeDBiQ6PGN9.
TreeFamiTF338374.

Family and domain databases

InterProiIPR026658. DDA3.
IPR026657. DDA3/GTSE-1.
IPR032768. GTSE1_N.
[Graphical view]
PANTHERiPTHR21584. PTHR21584. 2 hits.
PTHR21584:SF1. PTHR21584:SF1. 2 hits.
PfamiPF15259. GTSE1_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: Q6PGN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDLEEDVRF IVDETLDFGG LSPSDSREEE DITVLVTPEK PLRRGLSHRS
60 70 80 90 100
DPNAVAPAPQ GVRLSLGPLS PEKLEEILDE ANRLAAQLEQ CALQDRESAG
110 120 130 140 150
EGLGPRRVKP SPRRETFVLK DSPVRDLLPT VNSLTRSTPS PSSLTPRLRS
160 170 180 190 200
NDRKGSVRAL RATSGKRPSN MKRESPTCNL FPASKSPASS PLTRSTPPVR
210 220 230 240 250
GRAGPSGRAA ASEETRAAKL RVSGSGEFVG LTLKFLHPSP PGPPTPIRSV
260 270 280 290 300
LAPQPSTSNS QRLPRPQGAA AKSSSQLPIP SAIPRPASRM PLTSRSVPPG
310 320 330 340 350
RGALPPDSLS TRKGLPRPST AGHRVRESGH KVPVSQRLNL PVMGATRSNL
360
QPPRKVAVPG PTR
Length:363
Mass (Da):38,796
Last modified:July 5, 2004 - v1
Checksum:i4B59C01EB74F3B72
GO
Isoform A (identifier: Q6PGN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-242: Missing.

Show »
Length:333
Mass (Da):35,632
Checksum:i75BC7DB6B0705E2E
GO
Isoform B (identifier: Q6PGN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-310: VSGSGEFVGL...RGALPPDSLS → ACQPNATHQP...KRSGQQARLQ
     311-363: Missing.

Show »
Length:310
Mass (Da):33,638
Checksum:i79C03FBF5111CBBA
GO
Isoform D (identifier: Q6PGN9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     213-242: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:163
Mass (Da):16,981
Checksum:i3B72DF56B3BC730E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051288312R → Q.Corresponds to variant rs34863121dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226021 – 170Missing in isoform D. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_022591213 – 242Missing in isoform A and isoform D. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_022592222 – 310VSGSG…PDSLS → ACQPNATHQPECATWQRCPT SGFSVNSKRASKTKHCRTQS AGKWTQGSCFPATKSSCHGC HSQQSAAPQESGSPRTYQVK RSGQQARLQ in isoform B. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_022593311 – 363Missing in isoform B. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223000 mRNA. Translation: AAN73431.1.
AF322891 Genomic DNA. Translation: AAN73434.1.
AK126567 mRNA. Translation: BAC86599.1.
AF447874 mRNA. Translation: AAQ04649.1.
AL390252 Genomic DNA. Translation: CAI13172.1.
AL390252 Genomic DNA. Translation: CAI13173.1.
AL390252 Genomic DNA. Translation: CAI13174.2.
CH471122 Genomic DNA. Translation: EAW56373.1.
BC056909 mRNA. Translation: AAH56909.1.
CCDSiCCDS30791.1. [Q6PGN9-3]
CCDS797.1. [Q6PGN9-2]
RefSeqiNP_001005290.1. NM_001005290.3. [Q6PGN9-3]
NP_001027462.1. NM_001032291.2. [Q6PGN9-2]
NP_116025.1. NM_032636.7. [Q6PGN9-2]
XP_005271340.1. XM_005271283.2. [Q6PGN9-2]
XP_016858049.1. XM_017002560.1. [Q6PGN9-1]
XP_016858050.1. XM_017002561.1. [Q6PGN9-1]
XP_016858051.1. XM_017002562.1. [Q6PGN9-1]
XP_016858052.1. XM_017002563.1. [Q6PGN9-1]
XP_016858053.1. XM_017002564.1. [Q6PGN9-1]
XP_016858054.1. XM_017002565.1. [Q6PGN9-1]
XP_016858055.1. XM_017002566.1. [Q6PGN9-1]
XP_016858056.1. XM_017002567.1. [Q6PGN9-1]
XP_016858057.1. XM_017002568.1. [Q6PGN9-2]
XP_016858058.1. XM_017002569.1. [Q6PGN9-2]
XP_016858059.1. XM_017002570.1. [Q6PGN9-2]
XP_016858065.1. XM_017002576.1. [Q6PGN9-3]
XP_016858066.1. XM_017002577.1. [Q6PGN9-3]
UniGeneiHs.405925.

Genome annotation databases

EnsembliENST00000369903; ENSP00000358919; ENSG00000134222. [Q6PGN9-2]
ENST00000369904; ENSP00000358920; ENSG00000134222. [Q6PGN9-3]
ENST00000369907; ENSP00000358923; ENSG00000134222. [Q6PGN9-2]
ENST00000369909; ENSP00000358925; ENSG00000134222. [Q6PGN9-2]
ENST00000409138; ENSP00000474667; ENSG00000134222. [Q6PGN9-1]
ENST00000409267; ENSP00000386323; ENSG00000134222. [Q6PGN9-2]
GeneIDi84722.
KEGGihsa:84722.
UCSCiuc001dxc.4. human. [Q6PGN9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223000 mRNA. Translation: AAN73431.1.
AF322891 Genomic DNA. Translation: AAN73434.1.
AK126567 mRNA. Translation: BAC86599.1.
AF447874 mRNA. Translation: AAQ04649.1.
AL390252 Genomic DNA. Translation: CAI13172.1.
AL390252 Genomic DNA. Translation: CAI13173.1.
AL390252 Genomic DNA. Translation: CAI13174.2.
CH471122 Genomic DNA. Translation: EAW56373.1.
BC056909 mRNA. Translation: AAH56909.1.
CCDSiCCDS30791.1. [Q6PGN9-3]
CCDS797.1. [Q6PGN9-2]
RefSeqiNP_001005290.1. NM_001005290.3. [Q6PGN9-3]
NP_001027462.1. NM_001032291.2. [Q6PGN9-2]
NP_116025.1. NM_032636.7. [Q6PGN9-2]
XP_005271340.1. XM_005271283.2. [Q6PGN9-2]
XP_016858049.1. XM_017002560.1. [Q6PGN9-1]
XP_016858050.1. XM_017002561.1. [Q6PGN9-1]
XP_016858051.1. XM_017002562.1. [Q6PGN9-1]
XP_016858052.1. XM_017002563.1. [Q6PGN9-1]
XP_016858053.1. XM_017002564.1. [Q6PGN9-1]
XP_016858054.1. XM_017002565.1. [Q6PGN9-1]
XP_016858055.1. XM_017002566.1. [Q6PGN9-1]
XP_016858056.1. XM_017002567.1. [Q6PGN9-1]
XP_016858057.1. XM_017002568.1. [Q6PGN9-2]
XP_016858058.1. XM_017002569.1. [Q6PGN9-2]
XP_016858059.1. XM_017002570.1. [Q6PGN9-2]
XP_016858065.1. XM_017002576.1. [Q6PGN9-3]
XP_016858066.1. XM_017002577.1. [Q6PGN9-3]
UniGeneiHs.405925.

3D structure databases

ProteinModelPortaliQ6PGN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124224. 21 interactors.
IntActiQ6PGN9. 11 interactors.

PTM databases

iPTMnetiQ6PGN9.
PhosphoSitePlusiQ6PGN9.

Polymorphism and mutation databases

BioMutaiPSRC1.
DMDMi74737651.

Proteomic databases

EPDiQ6PGN9.
MaxQBiQ6PGN9.
PeptideAtlasiQ6PGN9.
PRIDEiQ6PGN9.

Protocols and materials databases

DNASUi84722.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369903; ENSP00000358919; ENSG00000134222. [Q6PGN9-2]
ENST00000369904; ENSP00000358920; ENSG00000134222. [Q6PGN9-3]
ENST00000369907; ENSP00000358923; ENSG00000134222. [Q6PGN9-2]
ENST00000369909; ENSP00000358925; ENSG00000134222. [Q6PGN9-2]
ENST00000409138; ENSP00000474667; ENSG00000134222. [Q6PGN9-1]
ENST00000409267; ENSP00000386323; ENSG00000134222. [Q6PGN9-2]
GeneIDi84722.
KEGGihsa:84722.
UCSCiuc001dxc.4. human. [Q6PGN9-1]

Organism-specific databases

CTDi84722.
DisGeNETi84722.
GeneCardsiPSRC1.
HGNCiHGNC:24472. PSRC1.
HPAiHPA049315.
MIMi613126. gene.
neXtProtiNX_Q6PGN9.
OpenTargetsiENSG00000134222.
PharmGKBiPA142671120.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000048604.
HOGENOMiHOG000231348.
HOVERGENiHBG080237.
InParanoidiQ6PGN9.
OMAiSPTCNLF.
OrthoDBiEOG091G12JI.
PhylomeDBiQ6PGN9.
TreeFamiTF338374.

Miscellaneous databases

ChiTaRSiPSRC1. human.
GeneWikiiPSRC1.
GenomeRNAii84722.
PROiQ6PGN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134222.
CleanExiHS_PSRC1.
ExpressionAtlasiQ6PGN9. baseline and differential.
GenevisibleiQ6PGN9. HS.

Family and domain databases

InterProiIPR026658. DDA3.
IPR026657. DDA3/GTSE-1.
IPR032768. GTSE1_N.
[Graphical view]
PANTHERiPTHR21584. PTHR21584. 2 hits.
PTHR21584:SF1. PTHR21584:SF1. 2 hits.
PfamiPF15259. GTSE1_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSRC1_HUMAN
AccessioniPrimary (citable) accession number: Q6PGN9
Secondary accession number(s): Q5T2Z3
, Q6ZTI8, Q71MG3, Q9BV77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.