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Protein

Serine/threonine-protein kinase DCLK2

Gene

Dclk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase with a significantly reduced Ca2++/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei422 – 4221ATPPROSITE-ProRule annotation
Active sitei514 – 5141Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi399 – 4079ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • hippocampus development Source: MGI
  • intracellular signal transduction Source: InterPro
  • microtubule cytoskeleton organization Source: MGI
  • negative regulation of protein localization to nucleus Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • pyramidal neuron development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase DCLK2 (EC:2.7.11.1)
Alternative name(s):
CaMK-like CREB regulatory kinase 2
Short name:
CL2
Short name:
CLICK-II
Short name:
CLICK2
Doublecortin-like and CAM kinase-like 2
Doublecortin-like kinase 2
Gene namesi
Name:Dclk2
Synonyms:Dcamkl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1918012. Dclk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi422 – 4221K → A: Loss of kinase activity. No effect on colocalization with microtubules. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756Serine/threonine-protein kinase DCLK2PRO_0000085923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei646 – 6461PhosphoserineBy similarity
Modified residuei665 – 6651PhosphothreonineBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PGN3.
PaxDbiQ6PGN3.
PRIDEiQ6PGN3.

PTM databases

iPTMnetiQ6PGN3.
PhosphoSiteiQ6PGN3.

Expressioni

Tissue specificityi

Expressed in the central and peripheral nervous system including the brain, spinal cord, cranial and dorsal root ganglia and in the parasympathetic ganglia. Present in neurons, but not in glial cells, in most forebrain areas. Strong expression in the hippocampal CA1 pyramidal cell layer. Expressed in the photoreceptor sensory cilium complex and in eyes. Also detected in individual cells of the olfactory epithelium.4 Publications

Developmental stagei

At 17.5 dpc, predominantly expressed in the central nervous system, throughout the forebrain, midbrain, hindbrain, and the spinal cord. Expressed in the developing neocortex and at low levels in the ventricular zone, especially in the outer neuroblastic layer. In the developing retina, strongly expressed in the postmitotic inner neuroblastic layer. Also found in the developing ovary and, to a lower extent, throughout the kidney.3 Publications

Gene expression databases

BgeeiQ6PGN3.
CleanExiMM_DCLK2.
ExpressionAtlasiQ6PGN3. baseline and differential.
GenevisibleiQ6PGN3. MM.

Interactioni

Subunit structurei

Binds to and stabilizes microtubules (By similarity). Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.By similarity1 Publication

Protein-protein interaction databases

BioGridi214240. 2 interactions.
STRINGi10090.ENSMUSP00000029719.

Structurei

3D structure databases

ProteinModelPortaliQ6PGN3.
SMRiQ6PGN3. Positions 69-169, 391-700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 15887Doublecortin 1PROSITE-ProRule annotationAdd
BLAST
Domaini196 – 27984Doublecortin 2PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 650258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 36170Ser-richAdd
BLAST
Compositional biasi719 – 74022Pro-richAdd
BLAST

Domaini

The doublecortin domains are involved in the colocalization with microtubules.

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG3757. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOVERGENiHBG003790.
InParanoidiQ6PGN3.
KOiK08805.
OMAiECIDRST.
OrthoDBiEOG7M98FQ.
PhylomeDBiQ6PGN3.
TreeFamiTF318770.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSISGPK GNGLIPSPAH
60 70 80 90 100
SAHCSFYRTR TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISNDRFRSFD
110 120 130 140 150
ALLIELTRSL SDNVNLPQGV RTIYTIDGSR KVTSLDELLE GESYVCASNE
160 170 180 190 200
PFRKVDYTKN VNPNWSVNIK GGTTRTLAVA SAKSEVKESK DFIKPKLVTV
210 220 230 240 250
IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TEAIKLDSGV VKRLCTLDGK
260 270 280 290 300
QVTCLQDFFG DDDVFIACGP EKYRYAQDDF VLDHSECRVL KSSYSRASAA
310 320 330 340 350
KYSGSRSPGF SRRSKSPASV NGTPSSQLST PKSTKSSSSS PTSPGSFRGL
360 370 380 390 400
KQISAQGRSS SNVNGGPELD RCLSPEGVNG NRCSESFPLL EKYRIGKVIG
410 420 430 440 450
DGNFAVVKEC VDRYTGKEFA LKIIDKAKCC GKEHLIENEV SILRRVKHPN
460 470 480 490 500
IIMLVEEMET ATDLFLVMEL VKGGDLFDAI TSSTKYTERD GSAMVYNLAN
510 520 530 540 550
ALRYLHSLSI VHRDIKPENL LVCEYPDGTK SLKLGDFGLA TVVEGPLYTV
560 570 580 590 600
CGTPTYVAPE IIAETGYGLK VDVWAAGVIT YILLCGFPPF RSENNLQEDL
610 620 630 640 650
FDQILAGKLE FPAPYWDNIT DSAKELISQM LQVNVEARCT AGEILSHPWV
660 670 680 690 700
SDDASQENNM QAEVTGKLKQ HFNNALPKQN STTTGVSVIM NTALDKEGQI
710 720 730 740 750
FCSKLCQDSS RPSREQTSPV PPSAQEAPPP LESPRPPGPP ATSGCDLAGT

WRRHRD
Length:756
Mass (Da):82,979
Last modified:July 5, 2004 - v1
Checksum:iC658F0999547B779
GO
Isoform 2 (identifier: Q6PGN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-352: Missing.

Show »
Length:755
Mass (Da):82,851
Checksum:iC62712085A7B4EFD
GO
Isoform 3 (identifier: Q6PGN3-3) [UniParc]FASTAAdd to basket

Also known as: alpha

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: V → VKRAGHSSAYSTAKSPV
     352-352: Missing.

Show »
Length:771
Mass (Da):84,480
Checksum:iEA80C01F97CEAE34
GO
Isoform 4 (identifier: Q6PGN3-4) [UniParc]FASTAAdd to basket

Also known as: beta1

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: V → VKRAGHSSAYSTAKSPV
     691-699: NTALDKEGQ → VQGHEHGSR
     700-756: Missing.

Note: No experimental confirmation available.
Show »
Length:715
Mass (Da):78,504
Checksum:i249329B4D057C7B7
GO
Isoform 5 (identifier: Q6PGN3-5) [UniParc]FASTAAdd to basket

Also known as: beta2

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: V → VKRAGHSSAYSTAKSPV
     352-352: Missing.
     691-699: NTALDKEGQ → VQGHEHGSR
     700-756: Missing.

Note: No experimental confirmation available.
Show »
Length:714
Mass (Da):78,376
Checksum:i69C254CB69E7D103
GO
Isoform 6 (identifier: Q6PGN3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-651: Missing.
     691-756: NTALDKEGQI...LAGTWRRHRD → VSGTQSSASE...SCLHGGLPGM

Note: No experimental confirmation available.
Show »
Length:708
Mass (Da):77,474
Checksum:iCA65DF114E4345A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331G → D in AAY40245 (PubMed:16684769).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei320 – 3201V → VKRAGHSSAYSTAKSPV in isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_038892
Alternative sequencei352 – 3521Missing in isoform 2, isoform 3 and isoform 5. 3 PublicationsVSP_012797
Alternative sequencei625 – 65127Missing in isoform 6. 1 PublicationVSP_038893Add
BLAST
Alternative sequencei691 – 75666NTALD…RRHRD → VSGTQSSASESRGWPSWSCC LDSQGSAHGSWCLPCSCLHG GLPGM in isoform 6. 1 PublicationVSP_038894Add
BLAST
Alternative sequencei691 – 6999NTALDKEGQ → VQGHEHGSR in isoform 4 and isoform 5. 1 PublicationVSP_038895
Alternative sequencei700 – 75657Missing in isoform 4 and isoform 5. 1 PublicationVSP_038896Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY968049 mRNA. Translation: AAY40243.1.
AY968050 mRNA. Translation: AAY40244.1.
AY968051 mRNA. Translation: AAY40245.1.
AB198721 mRNA. Translation: BAE06836.1.
AK049179 mRNA. Translation: BAC33590.1.
AK082633 mRNA. Translation: BAC38555.1.
BC056921 mRNA. Translation: AAH56921.1.
CCDSiCCDS17448.1. [Q6PGN3-1]
CCDS79936.1. [Q6PGN3-2]
RefSeqiNP_001182425.1. NM_001195496.1. [Q6PGN3-3]
NP_001182426.1. NM_001195497.1. [Q6PGN3-2]
NP_001182427.1. NM_001195498.1. [Q6PGN3-4]
NP_001182428.1. NM_001195499.1. [Q6PGN3-5]
NP_081815.3. NM_027539.5. [Q6PGN3-1]
UniGeneiMm.44490.

Genome annotation databases

EnsembliENSMUST00000029719; ENSMUSP00000029719; ENSMUSG00000028078. [Q6PGN3-1]
ENSMUST00000191752; ENSMUSP00000141707; ENSMUSG00000028078. [Q6PGN3-6]
ENSMUST00000195561; ENSMUSP00000142267; ENSMUSG00000028078. [Q6PGN3-2]
GeneIDi70762.
KEGGimmu:70762.
UCSCiuc008prl.3. mouse. [Q6PGN3-1]
uc008prm.3. mouse. [Q6PGN3-5]
uc008prn.3. mouse. [Q6PGN3-4]
uc008pro.3. mouse. [Q6PGN3-3]
uc008prp.3. mouse. [Q6PGN3-2]
uc008prq.3. mouse. [Q6PGN3-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY968049 mRNA. Translation: AAY40243.1.
AY968050 mRNA. Translation: AAY40244.1.
AY968051 mRNA. Translation: AAY40245.1.
AB198721 mRNA. Translation: BAE06836.1.
AK049179 mRNA. Translation: BAC33590.1.
AK082633 mRNA. Translation: BAC38555.1.
BC056921 mRNA. Translation: AAH56921.1.
CCDSiCCDS17448.1. [Q6PGN3-1]
CCDS79936.1. [Q6PGN3-2]
RefSeqiNP_001182425.1. NM_001195496.1. [Q6PGN3-3]
NP_001182426.1. NM_001195497.1. [Q6PGN3-2]
NP_001182427.1. NM_001195498.1. [Q6PGN3-4]
NP_001182428.1. NM_001195499.1. [Q6PGN3-5]
NP_081815.3. NM_027539.5. [Q6PGN3-1]
UniGeneiMm.44490.

3D structure databases

ProteinModelPortaliQ6PGN3.
SMRiQ6PGN3. Positions 69-169, 391-700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214240. 2 interactions.
STRINGi10090.ENSMUSP00000029719.

PTM databases

iPTMnetiQ6PGN3.
PhosphoSiteiQ6PGN3.

Proteomic databases

MaxQBiQ6PGN3.
PaxDbiQ6PGN3.
PRIDEiQ6PGN3.

Protocols and materials databases

DNASUi70762.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029719; ENSMUSP00000029719; ENSMUSG00000028078. [Q6PGN3-1]
ENSMUST00000191752; ENSMUSP00000141707; ENSMUSG00000028078. [Q6PGN3-6]
ENSMUST00000195561; ENSMUSP00000142267; ENSMUSG00000028078. [Q6PGN3-2]
GeneIDi70762.
KEGGimmu:70762.
UCSCiuc008prl.3. mouse. [Q6PGN3-1]
uc008prm.3. mouse. [Q6PGN3-5]
uc008prn.3. mouse. [Q6PGN3-4]
uc008pro.3. mouse. [Q6PGN3-3]
uc008prp.3. mouse. [Q6PGN3-2]
uc008prq.3. mouse. [Q6PGN3-6]

Organism-specific databases

CTDi166614.
MGIiMGI:1918012. Dclk2.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG3757. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00840000129744.
HOVERGENiHBG003790.
InParanoidiQ6PGN3.
KOiK08805.
OMAiECIDRST.
OrthoDBiEOG7M98FQ.
PhylomeDBiQ6PGN3.
TreeFamiTF318770.

Miscellaneous databases

PROiQ6PGN3.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PGN3.
CleanExiMM_DCLK2.
ExpressionAtlasiQ6PGN3. baseline and differential.
GenevisibleiQ6PGN3. MM.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533. Doublecortin_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF03607. DCX. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00537. DCX. 2 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50309. DC. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV."
    Ohmae S., Takemoto-Kimura S., Okamura M., Adachi-Morishima A., Nonaka M., Fuse T., Kida S., Tanji M., Furuyashiki T., Arakawa Y., Narumiya S., Okuno H., Bito H.
    J. Biol. Chem. 281:20427-20439(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, MUTAGENESIS OF LYS-422.
    Strain: ICR.
    Tissue: Brain.
  2. "Molecular cloning and expression of mouse doublecortin like protein kinase."
    Shimomura S., Nagamine T., Sueyoshi N., Kameshita I.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryonic stem cell.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, GENE FAMILY.
  6. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MAPK8IP1; MAPK8IP2; MAPK9; PPP1R9B AND ACTIN.
  7. "Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice."
    Tuy F.P.D., Saillour Y., Kappeler C., Chelly J., Francis F.
    Dev. Neurosci. 30:171-186(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures."
    Kerjan G., Koizumi H., Han E.B., Dube C.M., Djakovic S.N., Patrick G.N., Baram T.Z., Heinemann S.F., Gleeson J.G.
    Proc. Natl. Acad. Sci. U.S.A. 106:6766-6771(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  10. Cited for: REVIEW, GENE FAMILY.

Entry informationi

Entry nameiDCLK2_MOUSE
AccessioniPrimary (citable) accession number: Q6PGN3
Secondary accession number(s): Q1EDG7
, Q1EDG8, Q4H483, Q4W8V1, Q8BUU0, Q8BX25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.