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Protein

Guanine nucleotide-binding protein-like 3-like protein

Gene

Gnl3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 169GTPSequence analysis4
Nucleotide bindingi253 – 260GTPSequence analysis8
Nucleotide bindingi297 – 300GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein-like 3-like protein
Gene namesi
Name:Gnl3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2448557 Gnl3l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi166N → I: No effect on TERF1-binding. Loss of ability to stabilize TERF1 protein. 1 Publication1
Mutagenesisi253G → V: Mislocalized to the nucleoplasm. No effect on the reduction of MDM2 ubiquitination. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843821 – 577Guanine nucleotide-binding protein-like 3-like proteinAdd BLAST577

Proteomic databases

EPDiQ6PGG6
MaxQBiQ6PGG6
PaxDbiQ6PGG6
PeptideAtlasiQ6PGG6
PRIDEiQ6PGG6

PTM databases

iPTMnetiQ6PGG6
PhosphoSitePlusiQ6PGG6

Expressioni

Gene expression databases

BgeeiENSMUSG00000025266
ExpressionAtlasiQ6PGG6 baseline and differential
GenevisibleiQ6PGG6 MM

Interactioni

Subunit structurei

Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT.2 Publications

Protein-protein interaction databases

BioGridi231842, 2 interactors
IntActiQ6PGG6, 1 interactor
MINTiQ6PGG6
STRINGi10090.ENSMUSP00000026297

Structurei

3D structure databases

ProteinModelPortaliQ6PGG6
SMRiQ6PGG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 304CP-type GPROSITE-ProRule annotationAdd BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 28Required for nucleolar localizationBy similarityAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 103Sequence analysisAdd BLAST61

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2484 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00810000125472
HOGENOMiHOG000207716
HOVERGENiHBG051747
InParanoidiQ6PGG6
KOiK14538
OMAiHQMGWAK
OrthoDBiEOG091G08IZ
PhylomeDBiQ6PGG6
TreeFamiTF313085

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PGG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKIRHKNKK PGKGSKGCKK PARQNGKKVT SRPSSAPQIV HGNDHASREA
60 70 80 90 100
ELKKKRVEEM REKQQVAREQ ERQRHRTMES YCQDVLKRQQ EFEQKEEVLQ
110 120 130 140 150
ELNMFPQLDD EATRKAYYKE FRKVVEYSDV ILEVLDARDP LGCRCFQMEE
160 170 180 190 200
TVLRAEGNKK LVLVLNKIDL VPKEIVEKWL EYLLNELPTV AFKASTQHHQ
210 220 230 240 250
VKNLTRCKVP VDQASESLLK SRACFGAENL MRVLGNYCRL GEVRGHIRVG
260 270 280 290 300
VVGLPNVGKS SLINSLKRSR ACSVGAVPGV TKFMQEVYLD KFIRLLDAPG
310 320 330 340 350
IVPGPNSEVG TILRNCIHVQ KLADPVTPVE TILQRCNLEE ISSYYGVSGF
360 370 380 390 400
QTTEHFLTAV AHRLGKKKKG GVYSQEQAAK AVLADWVSGK ISFYTLPPPT
410 420 430 440 450
HTLPTHLSAE IVKEMTEVFD IEDTEHANED TMECLAVGES DELLGDMDPQ
460 470 480 490 500
EMEVRWLHSP LVKIADAIEN RSTVYKIGNL TGYCTKPNRN QMGWPKRNVD
510 520 530 540 550
HHCPQNNRVV EVSSVDRRPM LQRILETDPL QQGQALASAL KNKKKLQKRS
560 570
DKIATKLSDS MMSMLDLSGN SDDCAGD
Length:577
Mass (Da):65,195
Last modified:July 5, 2004 - v1
Checksum:iC2F6E1FE5EED9815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805937 Genomic DNA No translation available.
BC057033 mRNA Translation: AAH57033.1
BC079653 mRNA Translation: AAH79653.1
CCDSiCCDS41174.1
RefSeqiNP_001162071.1, NM_001168600.1
NP_932778.1, NM_198110.2
XP_006528868.1, XM_006528805.3
UniGeneiMm.45987

Genome annotation databases

EnsembliENSMUST00000026297; ENSMUSP00000026297; ENSMUSG00000025266
ENSMUST00000112691; ENSMUSP00000108311; ENSMUSG00000025266
GeneIDi237107
KEGGimmu:237107
UCSCiuc009uou.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGNL3L_MOUSE
AccessioniPrimary (citable) accession number: Q6PGG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health