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Protein

GEM-interacting protein

Gene

Gmip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates, in vitro and in vivo, the GTPase activity of RhoA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri492 – 53645Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
GEM-interacting protein
Short name:
GMIP
Gene namesi
Name:Gmip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1926066. Gmip.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 971971GEM-interacting proteinPRO_0000056726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei235 – 2351PhosphoserineBy similarity
Modified residuei238 – 2381PhosphoserineBy similarity
Modified residuei247 – 2471PhosphoserineBy similarity
Modified residuei436 – 4361PhosphoserineCombined sources
Modified residuei440 – 4401PhosphoserineCombined sources
Modified residuei659 – 6591PhosphothreonineBy similarity
Modified residuei884 – 8841PhosphoserineBy similarity
Modified residuei908 – 9081PhosphoserineBy similarity
Modified residuei924 – 9241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGG2.
MaxQBiQ6PGG2.
PaxDbiQ6PGG2.
PeptideAtlasiQ6PGG2.
PRIDEiQ6PGG2.

PTM databases

iPTMnetiQ6PGG2.
PhosphoSiteiQ6PGG2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036246.
CleanExiMM_GMIP.
ExpressionAtlasiQ6PGG2. baseline and differential.
GenevisibleiQ6PGG2. MM.

Interactioni

Subunit structurei

Interacts with GEM through its N-terminal.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045676.

Structurei

3D structure databases

ProteinModelPortaliQ6PGG2.
SMRiQ6PGG2. Positions 85-356, 494-756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 348264F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini553 – 756204Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi256 – 2616Poly-Arg
Compositional biasi361 – 3666Poly-Pro

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri492 – 53645Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPS0. Eukaryota.
ENOG410XPZ9. LUCA.
GeneTreeiENSGT00840000129703.
HOGENOMiHOG000112746.
HOVERGENiHBG052839.
InParanoidiQ6PGG2.
OMAiFEPGQRY.
OrthoDBiEOG091G01V3.
PhylomeDBiQ6PGG2.
TreeFamiTF351450.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSAETELTP APEGRKRYSD IFQSLDNLEI SLGNVTFDPL AGDPVRREDL
60 70 80 90 100
EPDKADTATV VTEENSEASS WRDLSPEGPA PLTEEELDLR LIRTKGGVDA
110 120 130 140 150
ALEYAKAWSR YAKELLAWTD KRANYELEFA KSIMKLAEAG KVSILQQSQM
160 170 180 190 200
PLQYIYTLFL EHDLSLGALA LETVAQQKRD YYQPLAAKRM EIEKWRKEFK
210 220 230 240 250
EQWLKEQKRM NEAVQALRRS ELQYIQRRED LRARSQGSPE DPPSQASPGS
260 270 280 290 300
NKQQERRRRS REEAQAKAHE AEALYQACVR EANSRQQDLE TTKRRIVSHV
310 320 330 340 350
RKLVLQGDEV LRRVTLGLFE LRGAQAERGP RSFSALAECC VPFEPGQRYQ
360 370 380 390 400
EFVRTLQPGA PPPPSPAFCF QEFTAVVHSF PQDTKKKFSG PLPPRLEEEG
410 420 430 440 450
SPEPGPWEVA SLGSQGIPGS DVDSVGGGSE SRSLDSPTSS PGAGARRLVK
460 470 480 490 500
ASSTGTESSD DFEERDPDLG DGIENGVGSP FRKWTLSTAA QTHRLRRLRG
510 520 530 540 550
PAKCRECEAF MVSGTECEEC FLTCHKRCLE TLLILCGHRR LPARMSLFGV
560 570 580 590 600
DFLQLPRDFP EEVPFVITRC TAEIEHRALG LQGIYRVSGS RVRVERLCQA
610 620 630 640 650
FENGRALVEL SGNSPHDITS VLKRFLQELT DPVVPFHLYD AFISLAKTLH
660 670 680 690 700
ADPGDDPGTP NPSPEIIRSL KTLLVQLPDS NYSTLRHLVA HLFRVAARFE
710 720 730 740 750
ENKMSANNLG IVFGPTLLRP PDGPRATGAS PVACLLDSGH QAQLVEFLIV
760 770 780 790 800
HYEQIFGMDE LPLASEPLTQ DPGLAPACLE SSPQHPASLL AQDTQPLTIA
810 820 830 840 850
LDSSPDPKHH SALEKCPEVT PPELATLQRD QREEEVEDTR DGAGDGSSHC
860 870 880 890 900
PEDLALGAQS RGHFSRQPVK YSRGGVRPVT HQLSSLALVA SKLCEETPVT
910 920 930 940 950
VSAVHRGSLR VRGLGPAAAC PEGSPLRRNP LPKHFEITQE TARLLSKLNS
960 970
DAVSRTTCCA DPEPEESEEH L
Length:971
Mass (Da):107,545
Last modified:July 5, 2004 - v1
Checksum:i0ACA8B6048BD97F2
GO
Isoform 2 (identifier: Q6PGG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     824-839: LATLQRDQREEEVEDT → VGISLPCRCGEGPVCV
     840-971: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):93,130
Checksum:i336749F754D7305D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei824 – 83916LATLQ…EVEDT → VGISLPCRCGEGPVCV in isoform 2. 1 PublicationVSP_013190Add
BLAST
Alternative sequencei840 – 971132Missing in isoform 2. 1 PublicationVSP_013191Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057037 mRNA. Translation: AAH57037.1.
BC060628 mRNA. Translation: AAH60628.1.
CCDSiCCDS22350.1. [Q6PGG2-1]
RefSeqiNP_932769.1. NM_198101.1. [Q6PGG2-1]
UniGeneiMm.324305.

Genome annotation databases

EnsembliENSMUST00000036074; ENSMUSP00000045676; ENSMUSG00000036246. [Q6PGG2-1]
ENSMUST00000123453; ENSMUSP00000116542; ENSMUSG00000036246. [Q6PGG2-2]
GeneIDi78816.
KEGGimmu:78816.
UCSCiuc009lxs.1. mouse. [Q6PGG2-2]
uc009lxt.1. mouse. [Q6PGG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057037 mRNA. Translation: AAH57037.1.
BC060628 mRNA. Translation: AAH60628.1.
CCDSiCCDS22350.1. [Q6PGG2-1]
RefSeqiNP_932769.1. NM_198101.1. [Q6PGG2-1]
UniGeneiMm.324305.

3D structure databases

ProteinModelPortaliQ6PGG2.
SMRiQ6PGG2. Positions 85-356, 494-756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045676.

PTM databases

iPTMnetiQ6PGG2.
PhosphoSiteiQ6PGG2.

Proteomic databases

EPDiQ6PGG2.
MaxQBiQ6PGG2.
PaxDbiQ6PGG2.
PeptideAtlasiQ6PGG2.
PRIDEiQ6PGG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036074; ENSMUSP00000045676; ENSMUSG00000036246. [Q6PGG2-1]
ENSMUST00000123453; ENSMUSP00000116542; ENSMUSG00000036246. [Q6PGG2-2]
GeneIDi78816.
KEGGimmu:78816.
UCSCiuc009lxs.1. mouse. [Q6PGG2-2]
uc009lxt.1. mouse. [Q6PGG2-1]

Organism-specific databases

CTDi51291.
MGIiMGI:1926066. Gmip.

Phylogenomic databases

eggNOGiENOG410IPS0. Eukaryota.
ENOG410XPZ9. LUCA.
GeneTreeiENSGT00840000129703.
HOGENOMiHOG000112746.
HOVERGENiHBG052839.
InParanoidiQ6PGG2.
OMAiFEPGQRY.
OrthoDBiEOG091G01V3.
PhylomeDBiQ6PGG2.
TreeFamiTF351450.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ6PGG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036246.
CleanExiMM_GMIP.
ExpressionAtlasiQ6PGG2. baseline and differential.
GenevisibleiQ6PGG2. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR031160. F_BAR.
IPR002219. PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMIP_MOUSE
AccessioniPrimary (citable) accession number: Q6PGG2
Secondary accession number(s): Q6P9S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.