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Protein

Exocyst complex component 8

Gene

Exoc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 8
Alternative name(s):
Exocyst complex 84 kDa subunit
Gene namesi
Name:Exoc8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142527. Exoc8.

Subcellular locationi

  • Cytoplasm
  • Cell projectiongrowth cone By similarity

  • Note: Redistributes to growing neurites and growth cones during cell differentiation. Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Exocyst complex component 8PRO_0000227551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei313 – 3131PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGF7.
MaxQBiQ6PGF7.
PaxDbiQ6PGF7.
PeptideAtlasiQ6PGF7.
PRIDEiQ6PGF7.

PTM databases

iPTMnetiQ6PGF7.
PhosphoSiteiQ6PGF7.

Expressioni

Gene expression databases

BgeeiQ6PGF7.
CleanExiMM_EXOC8.
GenevisibleiQ6PGF7. MM.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with the GTP-bound forms of RALA and RALB via its PH domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6PGF7. 3 interactions.
STRINGi10090.ENSMUSP00000095915.

Structurei

3D structure databases

ProteinModelPortaliQ6PGF7.
SMRiQ6PGF7. Positions 171-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 273101PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EXO84 family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2215. Eukaryota.
ENOG410XT7U. LUCA.
GeneTreeiENSGT00390000015936.
HOGENOMiHOG000006737.
HOVERGENiHBG081489.
InParanoidiQ6PGF7.
KOiK19986.
OMAiRNFEQYT.
OrthoDBiEOG7NSB1Q.
PhylomeDBiQ6PGF7.
TreeFamiTF105819.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016159. Cullin_repeat-like_dom.
IPR032403. Exo84_C.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF16528. Exo84_C. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF74788. SSF74788. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PGF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSGASRLR RQLESGGFEA RLYVKQLSQQ SDGDRDLQEH RQRVQALAEE
60 70 80 90 100
TAQNLKRNVY QNYRQFIETA REISYLESEM YQLSHLLTEQ KSSLESIPLA
110 120 130 140 150
LLPAAAAGAS AGEDTAGAGP RERGAVQAGF LPGPAGVPRE GSGTGEEGKQ
160 170 180 190 200
RTLTTLLEKV EGCRDLLETP GQYLVYNGDL VEYDADHMAQ LQRVHGFLMN
210 220 230 240 250
DCLLVATWLP QRRGMYRYNA LYPLDRLAVV NVKDNPPMKD MFKLLMFPES
260 270 280 290 300
RIFQAENAKI KREWLEVLEE TKRALSDKRR REQEEAAAPR APPPVTSKGS
310 320 330 340 350
NPFEDEDDEE LATPEAEEEK VDLSMEWIQE LPEDLDVCIA QRDFEGAVDL
360 370 380 390 400
LDKLNHYLED KPSPPPVKEL RAKVDERVRQ LTEVLVFELS PDRSLRGGPK
410 420 430 440 450
ATRRAVSQLI RLGQCTKACE LFLRNRAAAV HTAIRQLRIE GATLLYIHKL
460 470 480 490 500
CHVFFTSLLE TAREFETDFA GTDSGCYSAF VVWARSAMGM FVDAFSKQVF
510 520 530 540 550
DSKESLSTAA ECVKVAKEHC QQLGEIGLDL TFIIHALLVK DIQGALHSYK
560 570 580 590 600
EIIIEATKHR NSEEMWRRMN LMTPEALGKL KEEMKSCGVS NFEQYTGDDC
610 620 630 640 650
WVNLSYTVVA FTKQTMGFLE EALKLYFPEL HMVLLESLVE IILVAVQHVD
660 670 680 690 700
YSLRCEQDPE KKAFIRQNAS FLYETVLPVV ERRFEEGVGK PAKQLQDLRN
710
ASRLLRVNPE STTSVV
Length:716
Mass (Da):81,035
Last modified:July 5, 2004 - v1
Checksum:iE512707F1DEF36E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057052 mRNA. Translation: AAH57052.1.
CCDSiCCDS22777.1.
RefSeqiNP_932771.1. NM_198103.2.
UniGeneiMm.347360.
Mm.392449.

Genome annotation databases

EnsembliENSMUST00000098312; ENSMUSP00000095915; ENSMUSG00000074030.
GeneIDi102058.
KEGGimmu:102058.
UCSCiuc009nxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057052 mRNA. Translation: AAH57052.1.
CCDSiCCDS22777.1.
RefSeqiNP_932771.1. NM_198103.2.
UniGeneiMm.347360.
Mm.392449.

3D structure databases

ProteinModelPortaliQ6PGF7.
SMRiQ6PGF7. Positions 171-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PGF7. 3 interactions.
STRINGi10090.ENSMUSP00000095915.

PTM databases

iPTMnetiQ6PGF7.
PhosphoSiteiQ6PGF7.

Proteomic databases

EPDiQ6PGF7.
MaxQBiQ6PGF7.
PaxDbiQ6PGF7.
PeptideAtlasiQ6PGF7.
PRIDEiQ6PGF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098312; ENSMUSP00000095915; ENSMUSG00000074030.
GeneIDi102058.
KEGGimmu:102058.
UCSCiuc009nxw.1. mouse.

Organism-specific databases

CTDi149371.
MGIiMGI:2142527. Exoc8.

Phylogenomic databases

eggNOGiKOG2215. Eukaryota.
ENOG410XT7U. LUCA.
GeneTreeiENSGT00390000015936.
HOGENOMiHOG000006737.
HOVERGENiHBG081489.
InParanoidiQ6PGF7.
KOiK19986.
OMAiRNFEQYT.
OrthoDBiEOG7NSB1Q.
PhylomeDBiQ6PGF7.
TreeFamiTF105819.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiExoc8. mouse.
PROiQ6PGF7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PGF7.
CleanExiMM_EXOC8.
GenevisibleiQ6PGF7. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016159. Cullin_repeat-like_dom.
IPR032403. Exo84_C.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF16528. Exo84_C. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF74788. SSF74788. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiEXOC8_MOUSE
AccessioniPrimary (citable) accession number: Q6PGF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.