Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exocyst complex component 8

Gene

Exoc8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 8
Alternative name(s):
Exocyst complex 84 kDa subunit
Gene namesi
Name:Exoc8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142527 Exoc8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275511 – 716Exocyst complex component 8Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei313PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGF7
MaxQBiQ6PGF7
PaxDbiQ6PGF7
PeptideAtlasiQ6PGF7
PRIDEiQ6PGF7

PTM databases

iPTMnetiQ6PGF7
PhosphoSitePlusiQ6PGF7

Expressioni

Gene expression databases

BgeeiENSMUSG00000074030
CleanExiMM_EXOC8
GenevisibleiQ6PGF7 MM

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts (via PH domain) with GTP-bound RALA and RALB (By similarity). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6PGF7, 3 interactors
STRINGi10090.ENSMUSP00000095915

Structurei

3D structure databases

ProteinModelPortaliQ6PGF7
SMRiQ6PGF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 273PHPROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Belongs to the EXO84 family.Curated

Phylogenomic databases

eggNOGiKOG2215 Eukaryota
ENOG410XT7U LUCA
GeneTreeiENSGT00390000015936
HOGENOMiHOG000006737
HOVERGENiHBG081489
InParanoidiQ6PGF7
KOiK19986
OMAiHAFLMND
OrthoDBiEOG091G0349
PhylomeDBiQ6PGF7
TreeFamiTF105819

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR033961 Exo84
IPR032403 Exo84_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR21426 PTHR21426, 1 hit
PfamiView protein in Pfam
PF16528 Exo84_C, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PGF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSGASRLR RQLESGGFEA RLYVKQLSQQ SDGDRDLQEH RQRVQALAEE
60 70 80 90 100
TAQNLKRNVY QNYRQFIETA REISYLESEM YQLSHLLTEQ KSSLESIPLA
110 120 130 140 150
LLPAAAAGAS AGEDTAGAGP RERGAVQAGF LPGPAGVPRE GSGTGEEGKQ
160 170 180 190 200
RTLTTLLEKV EGCRDLLETP GQYLVYNGDL VEYDADHMAQ LQRVHGFLMN
210 220 230 240 250
DCLLVATWLP QRRGMYRYNA LYPLDRLAVV NVKDNPPMKD MFKLLMFPES
260 270 280 290 300
RIFQAENAKI KREWLEVLEE TKRALSDKRR REQEEAAAPR APPPVTSKGS
310 320 330 340 350
NPFEDEDDEE LATPEAEEEK VDLSMEWIQE LPEDLDVCIA QRDFEGAVDL
360 370 380 390 400
LDKLNHYLED KPSPPPVKEL RAKVDERVRQ LTEVLVFELS PDRSLRGGPK
410 420 430 440 450
ATRRAVSQLI RLGQCTKACE LFLRNRAAAV HTAIRQLRIE GATLLYIHKL
460 470 480 490 500
CHVFFTSLLE TAREFETDFA GTDSGCYSAF VVWARSAMGM FVDAFSKQVF
510 520 530 540 550
DSKESLSTAA ECVKVAKEHC QQLGEIGLDL TFIIHALLVK DIQGALHSYK
560 570 580 590 600
EIIIEATKHR NSEEMWRRMN LMTPEALGKL KEEMKSCGVS NFEQYTGDDC
610 620 630 640 650
WVNLSYTVVA FTKQTMGFLE EALKLYFPEL HMVLLESLVE IILVAVQHVD
660 670 680 690 700
YSLRCEQDPE KKAFIRQNAS FLYETVLPVV ERRFEEGVGK PAKQLQDLRN
710
ASRLLRVNPE STTSVV
Length:716
Mass (Da):81,035
Last modified:July 5, 2004 - v1
Checksum:iE512707F1DEF36E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057052 mRNA Translation: AAH57052.1
CCDSiCCDS22777.1
RefSeqiNP_932771.1, NM_198103.2
UniGeneiMm.347360
Mm.392449

Genome annotation databases

EnsembliENSMUST00000098312; ENSMUSP00000095915; ENSMUSG00000074030
GeneIDi102058
KEGGimmu:102058
UCSCiuc009nxw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEXOC8_MOUSE
AccessioniPrimary (citable) accession number: Q6PGF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health