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Protein

Sodium-dependent proline transporter

Gene

Slc6a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.By similarity

GO - Molecular functioni

GO - Biological processi

  • proline transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent proline transporter
Alternative name(s):
Solute carrier family 6 member 7
Gene namesi
Name:Slc6a7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147363. Slc6a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence analysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9320Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 21477ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23319Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei242 – 25918Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei295 – 31218Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei324 – 34522Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei378 – 39720Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei425 – 44319Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei459 – 47921Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei500 – 51920Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei538 – 55619Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini557 – 63781CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Sodium-dependent proline transporterPRO_0000214771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphothreonineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Modified residuei573 – 5731PhosphoserineBy similarity
Modified residuei582 – 5821PhosphoserineBy similarity
Modified residuei588 – 5881PhosphothreonineBy similarity
Modified residuei591 – 5911PhosphotyrosineBy similarity
Modified residuei598 – 5981PhosphoserineCombined sources
Modified residuei600 – 6001PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6PGE7.
PaxDbiQ6PGE7.
PeptideAtlasiQ6PGE7.
PRIDEiQ6PGE7.

PTM databases

iPTMnetiQ6PGE7.
PhosphoSiteiQ6PGE7.

Expressioni

Gene expression databases

BgeeiQ6PGE7.
GenevisibleiQ6PGE7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025520.

Structurei

3D structure databases

ProteinModelPortaliQ6PGE7.
SMRiQ6PGE7. Positions 36-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ6PGE7.
KOiK05038.
OMAiTPQFDHL.
OrthoDBiEOG793B71.
PhylomeDBiQ6PGE7.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PGE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLQEAHLR KPITPDLLMT PSDQGDVDLD VDFAADRGNW TGKLDFLLSC
60 70 80 90 100
IGYCVGLGNV WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF
110 120 130 140 150
SSLGPLAVWK ISPLFKGAGA AMLLIVGLVA IYYNMIIAYV LFYLFASLTS
160 170 180 190 200
NLPWEHCGNW WNTELCLEHR GPKSGNGVLP LNLSSTVSPS EEYWSRYVLH
210 220 230 240 250
IQGSQGIGRP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG KVVYFTATFP
260 270 280 290 300
YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG
310 320 330 340 350
VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ
360 370 380 390 400
ELGVPVDQVA KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ
410 420 430 440 450
FAFLETIVTA VTDEFPYYLR PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL
460 470 480 490 500
VLLDDYSASF GLMVVVITTC LAVTRVYGIQ RFCRDIHMML GFKPGLYFRA
510 520 530 540 550
CWLFLSPATL LALLVYSIVK YQPSEYGSYR FPAWAELLGI LMGLLSCLMI
560 570 580 590 600
PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS
610 620 630
PKPLMVHMRK YGGITSFENT AIEVDREIAE EEEESMM
Length:637
Mass (Da):71,066
Last modified:July 5, 2004 - v1
Checksum:iA122D5A6ED074680
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211P → S in AAH50103 (PubMed:15489334).Curated
Sequence conflicti202 – 2021Q → R in AAH50103 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050103 mRNA. Translation: AAH50103.1.
BC057070 mRNA. Translation: AAH57070.1.
CCDSiCCDS29278.1.
RefSeqiNP_958741.1. NM_201353.1.
UniGeneiMm.39846.

Genome annotation databases

EnsembliENSMUST00000025520; ENSMUSP00000025520; ENSMUSG00000052026.
GeneIDi240332.
KEGGimmu:240332.
UCSCiuc008fbi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050103 mRNA. Translation: AAH50103.1.
BC057070 mRNA. Translation: AAH57070.1.
CCDSiCCDS29278.1.
RefSeqiNP_958741.1. NM_201353.1.
UniGeneiMm.39846.

3D structure databases

ProteinModelPortaliQ6PGE7.
SMRiQ6PGE7. Positions 36-578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025520.

PTM databases

iPTMnetiQ6PGE7.
PhosphoSiteiQ6PGE7.

Proteomic databases

MaxQBiQ6PGE7.
PaxDbiQ6PGE7.
PeptideAtlasiQ6PGE7.
PRIDEiQ6PGE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025520; ENSMUSP00000025520; ENSMUSG00000052026.
GeneIDi240332.
KEGGimmu:240332.
UCSCiuc008fbi.1. mouse.

Organism-specific databases

CTDi6534.
MGIiMGI:2147363. Slc6a7.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ6PGE7.
KOiK05038.
OMAiTPQFDHL.
OrthoDBiEOG793B71.
PhylomeDBiQ6PGE7.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiQ6PGE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PGE7.
GenevisibleiQ6PGE7. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and ICRImported.
    Tissue: BrainImported and Trophoblast stem cell.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-22; SER-598 AND SER-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSC6A7_MOUSE
AccessioniPrimary (citable) accession number: Q6PGE7
Secondary accession number(s): Q80UM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.