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Protein

Sodium-dependent proline transporter

Gene

Slc6a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.By similarity

GO - Molecular functioni

GO - Biological processi

  • proline transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent proline transporter
Alternative name(s):
Solute carrier family 6 member 7
Gene namesi
Name:Slc6a7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147363. Slc6a7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 214ExtracellularSequence analysisAdd BLAST77
Transmembranei215 – 233Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei242 – 259Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei295 – 312Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei324 – 345Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei378 – 397Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei425 – 443Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei459 – 479Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei500 – 519Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei538 – 556Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini557 – 637CytoplasmicSequence analysisAdd BLAST81

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147711 – 637Sodium-dependent proline transporterAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphothreonineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Modified residuei573PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Modified residuei588PhosphothreonineBy similarity1
Modified residuei591PhosphotyrosineBy similarity1
Modified residuei598PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6PGE7.
PeptideAtlasiQ6PGE7.
PRIDEiQ6PGE7.

PTM databases

iPTMnetiQ6PGE7.
PhosphoSitePlusiQ6PGE7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052026.
GenevisibleiQ6PGE7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025520.

Structurei

3D structure databases

ProteinModelPortaliQ6PGE7.
SMRiQ6PGE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ6PGE7.
KOiK05038.
OMAiTPQFDHL.
OrthoDBiEOG091G08PX.
PhylomeDBiQ6PGE7.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PGE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLQEAHLR KPITPDLLMT PSDQGDVDLD VDFAADRGNW TGKLDFLLSC
60 70 80 90 100
IGYCVGLGNV WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF
110 120 130 140 150
SSLGPLAVWK ISPLFKGAGA AMLLIVGLVA IYYNMIIAYV LFYLFASLTS
160 170 180 190 200
NLPWEHCGNW WNTELCLEHR GPKSGNGVLP LNLSSTVSPS EEYWSRYVLH
210 220 230 240 250
IQGSQGIGRP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG KVVYFTATFP
260 270 280 290 300
YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG
310 320 330 340 350
VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ
360 370 380 390 400
ELGVPVDQVA KAGPGLAFVV YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ
410 420 430 440 450
FAFLETIVTA VTDEFPYYLR PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL
460 470 480 490 500
VLLDDYSASF GLMVVVITTC LAVTRVYGIQ RFCRDIHMML GFKPGLYFRA
510 520 530 540 550
CWLFLSPATL LALLVYSIVK YQPSEYGSYR FPAWAELLGI LMGLLSCLMI
560 570 580 590 600
PAGMLVAVLR EEGSLWERLQ QASRPAMDWG PSLEENRTGM YVATLAGSQS
610 620 630
PKPLMVHMRK YGGITSFENT AIEVDREIAE EEEESMM
Length:637
Mass (Da):71,066
Last modified:July 5, 2004 - v1
Checksum:iA122D5A6ED074680
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21P → S in AAH50103 (PubMed:15489334).Curated1
Sequence conflicti202Q → R in AAH50103 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050103 mRNA. Translation: AAH50103.1.
BC057070 mRNA. Translation: AAH57070.1.
CCDSiCCDS29278.1.
RefSeqiNP_958741.1. NM_201353.1.
UniGeneiMm.39846.

Genome annotation databases

EnsembliENSMUST00000025520; ENSMUSP00000025520; ENSMUSG00000052026.
GeneIDi240332.
KEGGimmu:240332.
UCSCiuc008fbi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050103 mRNA. Translation: AAH50103.1.
BC057070 mRNA. Translation: AAH57070.1.
CCDSiCCDS29278.1.
RefSeqiNP_958741.1. NM_201353.1.
UniGeneiMm.39846.

3D structure databases

ProteinModelPortaliQ6PGE7.
SMRiQ6PGE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025520.

PTM databases

iPTMnetiQ6PGE7.
PhosphoSitePlusiQ6PGE7.

Proteomic databases

PaxDbiQ6PGE7.
PeptideAtlasiQ6PGE7.
PRIDEiQ6PGE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025520; ENSMUSP00000025520; ENSMUSG00000052026.
GeneIDi240332.
KEGGimmu:240332.
UCSCiuc008fbi.1. mouse.

Organism-specific databases

CTDi6534.
MGIiMGI:2147363. Slc6a7.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ6PGE7.
KOiK05038.
OMAiTPQFDHL.
OrthoDBiEOG091G08PX.
PhylomeDBiQ6PGE7.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiQ6PGE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052026.
GenevisibleiQ6PGE7. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A7_MOUSE
AccessioniPrimary (citable) accession number: Q6PGE7
Secondary accession number(s): Q80UM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.