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Protein

ATP-dependent RNA helicase DHX29

Gene

Dhx29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi594 – 601ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, Initiation factor
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DHX29UniRule annotation (EC:3.6.4.13UniRule annotation)
Alternative name(s):
DEAH box protein 29UniRule annotation
Gene namesi
Name:Dhx29UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145374 Dhx29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455361 – 1365ATP-dependent RNA helicase DHX29Add BLAST1365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei198PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PGC1
MaxQBiQ6PGC1
PaxDbiQ6PGC1
PeptideAtlasiQ6PGC1
PRIDEiQ6PGC1

PTM databases

iPTMnetiQ6PGC1
PhosphoSitePlusiQ6PGC1

Expressioni

Gene expression databases

BgeeiENSMUSG00000042426
CleanExiMM_DHX29
ExpressionAtlasiQ6PGC1 baseline and differential
GenevisibleiQ6PGC1 MM

Interactioni

Subunit structurei

Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6PGC1, 1 interactor
MINTiQ6PGC1
STRINGi10090.ENSMUSP00000035244

Structurei

3D structure databases

ProteinModelPortaliQ6PGC1
SMRiQ6PGC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini581 – 754Helicase ATP-bindingUniRule annotationAdd BLAST174
Domaini848 – 1025Helicase C-terminalUniRule annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili281 – 308UniRule annotationAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi701 – 704DEAH boxUniRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 53Ala-richAdd BLAST44
Compositional biasi499 – 507Poly-Gln9
Compositional biasi788 – 792Poly-Glu5

Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00760000119189
HOGENOMiHOG000247063
HOVERGENiHBG081436
InParanoidiQ6PGC1
KOiK18995
OMAiCGYQIRM
OrthoDBiEOG091G01I0
PhylomeDBiQ6PGC1
TreeFamiTF324744

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_03068 DHX29, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR034730 DHX29
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PGC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGKNKKHKA PGAAAMRAAV SASRARSAEA GAVGEAQSKK PVARPAPAVP
60 70 80 90 100
TGAREPRVKQ GPKIYSFNSA NDSGGSANLD KSILKVVINN KLEQRIIGVI
110 120 130 140 150
NEHKKQNSDR GAISGRLSAK KLQDLYMALQ AFSFKTKDIE DAMTNTLLHG
160 170 180 190 200
GDLHSALDWL CLNLSDDALP EGFSQEFEEQ QPKSRPKFQS VQIQATLSPP
210 220 230 240 250
QQTKTKRQEE DPKIKPKKEE TTVEVNMKEW ILRYAEQQDE EEKGEGSKGL
260 270 280 290 300
EEEEKFDPNQ RYLNLAARLL DAKEQAAAFK LEKNKQGQKE AQEKIRKFQR
310 320 330 340 350
EMETLEDHPI FNPAIKISHQ QNEKKKPAPA TEAESALNLN LFEKSAAATE
360 370 380 390 400
EEKGKKKEPH DVRNFDYTAR SWTGKSPKQF LIDWVRKNLP KSPNPSFEKV
410 420 430 440 450
AVGRYWKCRV RVVRSEDDVL VVCPTILTED GMQAQHLGAT LALYRLVKGQ
460 470 480 490 500
SVHQLLPPTY RDVWLEWSDE EKKREELNKM ETNKPRDLFI AKLLNKLKQQ
510 520 530 540 550
QQQQQQQRPE SEKGGSEDPE ESWENLVSDE DLAALSLEPT SAEDLAPVRS
560 570 580 590 600
LFRRLQSTPK YQRLLKERQQ LPVFKHRDSI VETLKRHRVV VVAGETGSGK
610 620 630 640 650
STQVPHFLLE DLLLDECGAR KCNIVCTQPR RISAVSLATR VCEELGCESG
660 670 680 690 700
PGGRNSLCGY QIRMESRASE STRLLYCTTG VLLRKLQEDG LLADVSHVIV
710 720 730 740 750
DEVHERSVQS DFLLVILKEI LQKRSDLHLI LMSATVDSDK FSTYFTHCPI
760 770 780 790 800
LRISGRSYPV EVFHLEDIVE ETGFVLEKDS EYCQKFLEEE EEITINVTSK
810 820 830 840 850
AGGVKKYQEY IPVQSGASPE LNPFYQKYSS RTQHAILYMN PHKINLDLIL
860 870 880 890 900
ELLVYLDKSP QFRNIEGAVL IFLPGLAHIQ QLYDLLSSDR RFYSERYQVI
910 920 930 940 950
ALHSVLSTQD QAAAFMFPPP GVRKIVLATN IAETGITIPD VVFVIDTGRT
960 970 980 990 1000
KENKYHESSQ MSSLVETFVS KASALQRQGR AGRVRDGFCF RLYTRERFEG
1010 1020 1030 1040 1050
FLDYSVPEIL RVPLEELCLH IMKCDLGSPE DFLSKALDPP QLQVISNAMN
1060 1070 1080 1090 1100
LLRKIGACEP NEPKLTPLGQ HLAALPVNVK IGKMLIFGAI FGCLEPVATL
1110 1120 1130 1140 1150
AAVMTEKSPF ITPIGRKDEA DLAKSSLAVA DSDHLTIYNA YLGWKKAQQE
1160 1170 1180 1190 1200
GGFRSEISYC QRNFLNRTSL LTLEDVKQEL MKLVKAAGFS SSPSWEGRKG
1210 1220 1230 1240 1250
PQTLSFQDIA LLKAVLAAGL YDSVGKIMCT KSVDVTEKLA CMVETAQGKA
1260 1270 1280 1290 1300
QVHPSSVNRD LQTYGWLLYQ EKVRYTRVYL RETTLITPFP VLLFGGDIEV
1310 1320 1330 1340 1350
QHRERLLSVD GWIYFQAPVK IAVIFKQLRV LIDSVLRKKL ENPKMSLEND
1360
KILQIITELI KTENN
Length:1,365
Mass (Da):153,975
Last modified:July 5, 2004 - v1
Checksum:i4143A705CB092280
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057112 mRNA Translation: AAH57112.1
BC082319 mRNA Translation: AAH82319.1
AK028342 mRNA Translation: BAC25894.1
AK042066 mRNA Translation: BAC31148.2
AK042497 mRNA Translation: BAC31274.2
AK049530 mRNA Translation: BAC33796.1
CCDSiCCDS26779.1
RefSeqiNP_766182.2, NM_172594.2
UniGeneiMm.35094
Mm.471395

Genome annotation databases

EnsembliENSMUST00000038574; ENSMUSP00000035244; ENSMUSG00000042426
GeneIDi218629
KEGGimmu:218629
UCSCiuc007rwx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDHX29_MOUSE
AccessioniPrimary (citable) accession number: Q6PGC1
Secondary accession number(s): Q8BQJ4
, Q8BT01, Q8C9B7, Q8C9H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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