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Protein

Probable global transcription activator SNF2L1

Gene

Smarca1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-transducing component of the NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes, which facilitate the perturbation of chromatin structure in an ATP-dependent manner.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 219ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: MGI
  • brain development Source: MGI
  • chromatin remodeling Source: HGNC
  • covalent chromatin modification Source: UniProtKB-KW
  • neuron differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: HGNC
  • regulation of neural precursor cell proliferation Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: HGNC

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable global transcription activator SNF2L1 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase SMARCA1
DNA-dependent ATPase SNF2L
Nucleosome-remodeling factor subunit SNF2L
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
Gene namesi
Name:Smarca1
Synonyms:Snf2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1935127. Smarca1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002492461 – 1046Probable global transcription activator SNF2L1Add BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki720Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki742Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei946PhosphotyrosineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PGB8.
PaxDbiQ6PGB8.
PRIDEiQ6PGB8.

PTM databases

iPTMnetiQ6PGB8.
PhosphoSitePlusiQ6PGB8.

Expressioni

Tissue specificityi

Predominantly expressed in cortex, cerebellum, ovaries, testes, uterus and placenta.2 Publications

Developmental stagei

Expressed throughout the embryo at E9.5-E15.5. Brain expression increases during the first two weeks of postnatal development.1 Publication

Inductioni

By ovulation in ovaries (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000031099.
ExpressionAtlasiQ6PGB8. baseline and differential.
GenevisibleiQ6PGB8. MM.

Interactioni

Subunit structurei

Part of the nucleosome-remodeling factor complex (NURF) which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Part of the CECR2-containing-remodeling factor (CERF) complex which contains CECR2 and SMARCA1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220299. 3 interactors.
STRINGi10090.ENSMUSP00000076769.

Structurei

3D structure databases

ProteinModelPortaliQ6PGB8.
SMRiQ6PGB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 364Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini494 – 645Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152
Domaini847 – 899SANT 1PROSITE-ProRule annotationAdd BLAST53
Domaini950 – 1014SANT 2PROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1003 – 1037Sequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi315 – 318DEAH box4

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0385. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00860000133761.
HOGENOMiHOG000192862.
HOVERGENiHBG056329.
InParanoidiQ6PGB8.
KOiK11727.
OMAiLEDYCHW.
OrthoDBiEOG091G01GJ.
PhylomeDBiQ6PGB8.
TreeFamiTF300674.

Family and domain databases

InterProiView protein in InterPro
IPR020838. DBINO.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR009057. Homeobox-like.
IPR029915. ISWI.
IPR015194. ISWI_HAND-dom.
IPR027417. P-loop_NTPase.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR015195. SLIDE.
IPR000330. SNF2_N.
PANTHERiPTHR10799:SF902. PTHR10799:SF902. 1 hit.
PfamiView protein in Pfam
PF13892. DBINO. 1 hit.
PF09110. HAND. 1 hit.
PF00271. Helicase_C. 1 hit.
PF09111. SLIDE. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00717. SANT. 2 hits.
SUPFAMiSSF101224. SSF101224. 1 hit.
SSF46689. SSF46689. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51293. SANT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPDTATEAA TVAVSDARAT VVVVEDEQPG PSTFKEEGAA AAATEGTTAT
60 70 80 90 100
EKGEKKEKIT SPFQLKLAAK ASKSEKEMDP EYEEKMVNMP LKADRAKRFE
110 120 130 140 150
FLLKQTELFA HFIQPSAQKS PTSPLNMKLA RPRVKKDDKQ SLISVGDYRH
160 170 180 190 200
RRTEQEEDEE LLSESRKTSN VCVRFEVSPS YVKGGPLRDY QIRGLNWLIS
210 220 230 240 250
LYENGVNGIL ADEMGLGKTL QTIALLGYLK HYRNIPGPHM VLVPKSTLHN
260 270 280 290 300
WMNEFKRWVP SLRVICFVGD KDVRAAFIRD EMMPGEWDVC VTSYEMVIKE
310 320 330 340 350
KSVFKKFHWR YLVIDEAHRI KNEKSKLSEI VREFKSTNRL LLTGTPLQNN
360 370 380 390 400
LHELWALLNF LLPDVFNSAD DFDSWFDTKN CLGDQKLVER LHAVLKPFLL
410 420 430 440 450
RRIKTDVEKS LPPKKEIKIY LGLSKMQREW YTKILMKDID VLNSSGKMDK
460 470 480 490 500
MRLLNILMQL RKCCNHPYLF DGAEPGPPYT TDEHIVGNSG KMVALDKLLA
510 520 530 540 550
RIKEQGSRVL IFSQMTRLLD ILEDYCMWRG YEYSRLDGQT PHEEREEAID
560 570 580 590 600
AFNAPNSSKF IFMLSTRAGG LGINLASADV VILYDSDWNP QVDLQAMDRA
610 620 630 640 650
HRIGQKKPVR VFRLITDNTV EERIVERAEI KLRLDSIVIQ QGRLIDQQSN
660 670 680 690 700
KLAKEEMLQM IRHGATHVFA CKESELTDED IVTILERGEK KTAEMNERMQ
710 720 730 740 750
KMGESSLRNF RMDLEQSLYK FEGEDYREKQ KLGTVEWIEP PKRERKANYA
760 770 780 790 800
VDAYFREALR VSEPKIPKAP RPPKQPNVQD FQFFPPRLFE LLEKEILYYR
810 820 830 840 850
KTIGYKVPRN PEIPNPAIAQ REEQKKIDGA EPLTPQETEE KDKLLTQGFT
860 870 880 890 900
NWTKRDFNQF IKANEKYGRD DIDNIAREVE GKSPEEVMEY SAVFWERCNE
910 920 930 940 950
LQDIEKIMAQ IERGEARIQR RISIKKALDA KIARYKAPFH QLRIQYGTSK
960 970 980 990 1000
GKNYTEEEDR FLICMLHKMG FDRENVYEEL RQCVRNAPQF RFDWFIKSRT
1010 1020 1030 1040
AMEFQRRCNT LISLIEKENM EIEERERAEK KKRATKTPMV KFSAFS
Length:1,046
Mass (Da):121,715
Last modified:July 5, 2004 - v1
Checksum:i11D60F70FE466FC5
GO
Isoform 2 (identifier: Q6PGB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1046: VKFSAFS → SQKRKAESATESSGRKDVKKVKS

Show »
Length:1,062
Mass (Da):123,465
Checksum:iD8C2D0F878AED9D2
GO

Sequence cautioni

The sequence AAK52453 differs from that shown. Reason: Frameshift at positions 60, 68, 71, 845, 852 and 853.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53G → A in AAK52453 (PubMed:11359880).Curated1
Sequence conflicti53G → A in BAC27109 (PubMed:16141072).Curated1
Sequence conflicti94D → A in AAK52453 (PubMed:11359880).Curated1
Sequence conflicti459Q → H in BAC27109 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0203781040 – 1046VKFSAFS → SQKRKAESATESSGRKDVKK VKS in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325920 mRNA. Translation: AAK52453.1. Frameshift.
AK030741 mRNA. Translation: BAC27109.1.
AL671903 Genomic DNA. Translation: CAM19307.1.
AL671903 Genomic DNA. Translation: CAM19308.1.
BC057115 mRNA. Translation: AAH57115.1.
CCDSiCCDS30104.1. [Q6PGB8-1]
CCDS72374.1. [Q6PGB8-2]
RefSeqiNP_001277637.1. NM_001290708.1. [Q6PGB8-2]
NP_444353.3. NM_053123.4. [Q6PGB8-1]
UniGeneiMm.229151.

Genome annotation databases

EnsembliENSMUST00000077569; ENSMUSP00000076769; ENSMUSG00000031099. [Q6PGB8-1]
ENSMUST00000088973; ENSMUSP00000086366; ENSMUSG00000031099. [Q6PGB8-1]
ENSMUST00000101616; ENSMUSP00000099138; ENSMUSG00000031099. [Q6PGB8-2]
GeneIDi93761.
KEGGimmu:93761.
UCSCiuc009tbl.2. mouse. [Q6PGB8-1]
uc009tbm.2. mouse. [Q6PGB8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMCA1_MOUSE
AccessioniPrimary (citable) accession number: Q6PGB8
Secondary accession number(s): B1AUP6
, B1AUP7, Q8BSS1, Q91Y58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families