UniProtKB - Q6PGB8 (SMCA1_MOUSE)
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Protein
Probable global transcription activator SNF2L1
Gene
Smarca1
Organism
Mus musculus (Mouse)
Status
Functioni
Energy-transducing component of the NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes, which facilitate the perturbation of chromatin structure in an ATP-dependent manner.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 212 – 219 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- annealing helicase activity Source: UniProtKB
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- helicase activity Source: UniProtKB-KW
- nucleosome binding Source: InterPro
- transcription factor binding Source: MGI
GO - Biological processi
- ATP-dependent chromatin remodeling Source: MGI
- brain development Source: MGI
- chromatin remodeling Source: HGNC
- covalent chromatin modification Source: UniProtKB-KW
- neuron differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: HGNC
- regulation of neural precursor cell proliferation Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- transcription, DNA-templated Source: HGNC
Keywordsi
Molecular function | Activator, Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.17. 3474. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable global transcription activator SNF2L1 (EC:3.6.4.-)Alternative name(s): ATP-dependent helicase SMARCA1 DNA-dependent ATPase SNF2L Nucleosome-remodeling factor subunit SNF2L SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 |
Gene namesi | Name:Smarca1 Synonyms:Snf2l |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1935127. Smarca1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249246 | 1 – 1046 | Probable global transcription activator SNF2L1Add BLAST | 1046 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 120 | PhosphoserineBy similarity | 1 | |
Modified residuei | 123 | PhosphoserineBy similarity | 1 | |
Cross-linki | 654 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 720 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 742 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 946 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6PGB8. |
PaxDbi | Q6PGB8. |
PRIDEi | Q6PGB8. |
PTM databases
iPTMneti | Q6PGB8. |
PhosphoSitePlusi | Q6PGB8. |
Expressioni
Tissue specificityi
Predominantly expressed in cortex, cerebellum, ovaries, testes, uterus and placenta.2 Publications
Developmental stagei
Expressed throughout the embryo at E9.5-E15.5. Brain expression increases during the first two weeks of postnatal development.1 Publication
Inductioni
By ovulation in ovaries (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031099. |
ExpressionAtlasi | Q6PGB8. baseline and differential. |
Genevisiblei | Q6PGB8. MM. |
Interactioni
Subunit structurei
Part of the nucleosome-remodeling factor complex (NURF) which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Part of the CECR2-containing-remodeling factor (CERF) complex which contains CECR2 and SMARCA1 (By similarity).By similarity
GO - Molecular functioni
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGridi | 220299. 4 interactors. |
STRINGi | 10090.ENSMUSP00000076769. |
Structurei
3D structure databases
ProteinModelPortali | Q6PGB8. |
SMRi | Q6PGB8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 199 – 364 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 166 | |
Domaini | 494 – 645 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 152 | |
Domaini | 847 – 899 | SANT 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 950 – 1014 | SANT 2PROSITE-ProRule annotationAdd BLAST | 65 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1003 – 1037 | Sequence analysisAdd BLAST | 35 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 315 – 318 | DEAH box | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0385. Eukaryota. COG0553. LUCA. |
GeneTreei | ENSGT00900000140963. |
HOGENOMi | HOG000192862. |
HOVERGENi | HBG056329. |
InParanoidi | Q6PGB8. |
KOi | K11727. |
OMAi | LEDYCHW. |
OrthoDBi | EOG091G01GJ. |
PhylomeDBi | Q6PGB8. |
TreeFami | TF300674. |
Family and domain databases
CDDi | cd00079. HELICc. 1 hit. cd00167. SANT. 1 hit. |
Gene3Di | 1.10.1040.30. 1 hit. |
InterProi | View protein in InterPro IPR020838. DBINO. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR009057. Homeobox-like_sf. IPR029915. ISWI. IPR015194. ISWI_HAND-dom. IPR036306. ISWI_HAND-dom_sf. IPR027417. P-loop_NTPase. IPR001005. SANT/Myb. IPR017884. SANT_dom. IPR015195. SLIDE. IPR000330. SNF2_N. |
PANTHERi | PTHR10799:SF819. PTHR10799:SF819. 1 hit. |
Pfami | View protein in Pfam PF13892. DBINO. 1 hit. PF09110. HAND. 1 hit. PF00271. Helicase_C. 1 hit. PF09111. SLIDE. 1 hit. PF00176. SNF2_N. 1 hit. |
SMARTi | View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00717. SANT. 2 hits. |
SUPFAMi | SSF101224. SSF101224. 1 hit. SSF46689. SSF46689. 2 hits. SSF52540. SSF52540. 2 hits. |
PROSITEi | View protein in PROSITE PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51293. SANT. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6PGB8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEPDTATEAA TVAVSDARAT VVVVEDEQPG PSTFKEEGAA AAATEGTTAT
60 70 80 90 100
EKGEKKEKIT SPFQLKLAAK ASKSEKEMDP EYEEKMVNMP LKADRAKRFE
110 120 130 140 150
FLLKQTELFA HFIQPSAQKS PTSPLNMKLA RPRVKKDDKQ SLISVGDYRH
160 170 180 190 200
RRTEQEEDEE LLSESRKTSN VCVRFEVSPS YVKGGPLRDY QIRGLNWLIS
210 220 230 240 250
LYENGVNGIL ADEMGLGKTL QTIALLGYLK HYRNIPGPHM VLVPKSTLHN
260 270 280 290 300
WMNEFKRWVP SLRVICFVGD KDVRAAFIRD EMMPGEWDVC VTSYEMVIKE
310 320 330 340 350
KSVFKKFHWR YLVIDEAHRI KNEKSKLSEI VREFKSTNRL LLTGTPLQNN
360 370 380 390 400
LHELWALLNF LLPDVFNSAD DFDSWFDTKN CLGDQKLVER LHAVLKPFLL
410 420 430 440 450
RRIKTDVEKS LPPKKEIKIY LGLSKMQREW YTKILMKDID VLNSSGKMDK
460 470 480 490 500
MRLLNILMQL RKCCNHPYLF DGAEPGPPYT TDEHIVGNSG KMVALDKLLA
510 520 530 540 550
RIKEQGSRVL IFSQMTRLLD ILEDYCMWRG YEYSRLDGQT PHEEREEAID
560 570 580 590 600
AFNAPNSSKF IFMLSTRAGG LGINLASADV VILYDSDWNP QVDLQAMDRA
610 620 630 640 650
HRIGQKKPVR VFRLITDNTV EERIVERAEI KLRLDSIVIQ QGRLIDQQSN
660 670 680 690 700
KLAKEEMLQM IRHGATHVFA CKESELTDED IVTILERGEK KTAEMNERMQ
710 720 730 740 750
KMGESSLRNF RMDLEQSLYK FEGEDYREKQ KLGTVEWIEP PKRERKANYA
760 770 780 790 800
VDAYFREALR VSEPKIPKAP RPPKQPNVQD FQFFPPRLFE LLEKEILYYR
810 820 830 840 850
KTIGYKVPRN PEIPNPAIAQ REEQKKIDGA EPLTPQETEE KDKLLTQGFT
860 870 880 890 900
NWTKRDFNQF IKANEKYGRD DIDNIAREVE GKSPEEVMEY SAVFWERCNE
910 920 930 940 950
LQDIEKIMAQ IERGEARIQR RISIKKALDA KIARYKAPFH QLRIQYGTSK
960 970 980 990 1000
GKNYTEEEDR FLICMLHKMG FDRENVYEEL RQCVRNAPQF RFDWFIKSRT
1010 1020 1030 1040
AMEFQRRCNT LISLIEKENM EIEERERAEK KKRATKTPMV KFSAFS
Sequence cautioni
The sequence AAK52453 differs from that shown. Reason: Frameshift at positions 60, 68, 71, 845, 852 and 853.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 53 | G → A in AAK52453 (PubMed:11359880).Curated | 1 | |
Sequence conflicti | 53 | G → A in BAC27109 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 94 | D → A in AAK52453 (PubMed:11359880).Curated | 1 | |
Sequence conflicti | 459 | Q → H in BAC27109 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020378 | 1040 – 1046 | VKFSAFS → SQKRKAESATESSGRKDVKK VKS in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF325920 mRNA. Translation: AAK52453.1. Frameshift. AK030741 mRNA. Translation: BAC27109.1. AL671903 Genomic DNA. No translation available. BC057115 mRNA. Translation: AAH57115.1. |
CCDSi | CCDS30104.1. [Q6PGB8-1] CCDS72374.1. [Q6PGB8-2] |
RefSeqi | NP_001277637.1. NM_001290708.1. [Q6PGB8-2] NP_444353.3. NM_053123.4. [Q6PGB8-1] |
UniGenei | Mm.229151. |
Genome annotation databases
Ensembli | ENSMUST00000077569; ENSMUSP00000076769; ENSMUSG00000031099. [Q6PGB8-1] ENSMUST00000088973; ENSMUSP00000086366; ENSMUSG00000031099. [Q6PGB8-1] ENSMUST00000101616; ENSMUSP00000099138; ENSMUSG00000031099. [Q6PGB8-2] |
GeneIDi | 93761. |
KEGGi | mmu:93761. |
UCSCi | uc009tbl.2. mouse. [Q6PGB8-1] uc009tbm.2. mouse. [Q6PGB8-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | SMCA1_MOUSE | |
Accessioni | Q6PGB8Primary (citable) accession number: Q6PGB8 Secondary accession number(s): B1AUP6 Q91Y58 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | March 28, 2018 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |