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Protein

N-alpha-acetyltransferase 50

Gene

Naa50

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity.By similarity

GO - Molecular functioni

GO - Biological processi

  • mitotic sister chromatid cohesion, centromeric Source: UniProtKB
  • N-terminal protein amino acid acetylation Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 50 (EC:2.3.1.-)
Alternative name(s):
N-acetyltransferase NAT13
NatE catalytic subunit
Gene namesi
Name:Naa50
Synonyms:Mak3, Nat13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1919367. Naa50.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • extracellular exosome Source: MGI
  • NatA complex Source: Ensembl
  • protein acetyltransferase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849031 – 169N-alpha-acetyltransferase 50Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineBy similarity1
Modified residuei34N6-acetyllysineCombined sources1
Modified residuei37N6-acetyllysineCombined sources1
Modified residuei110PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6PGB6.
PaxDbiQ6PGB6.
PeptideAtlasiQ6PGB6.
PRIDEiQ6PGB6.

PTM databases

iPTMnetiQ6PGB6.
PhosphoSitePlusiQ6PGB6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022698.
CleanExiMM_NAT13.
GenevisibleiQ6PGB6. MM.

Interactioni

Subunit structurei

Interacts with NAA15 and NAA11 (By similarity). Interacts with NAA35.By similarity1 Publication

Protein-protein interaction databases

BioGridi215162. 31 interactors.
IntActiQ6PGB6. 32 interactors.
MINTiMINT-1857014.
STRINGi10090.ENSMUSP00000070140.

Structurei

3D structure databases

ProteinModelPortaliQ6PGB6.
SMRiQ6PGB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155N-acetyltransferasePROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 90Coenzyme A bindingBy similarityAdd BLAST12

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3138. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009110.
HOGENOMiHOG000238056.
HOVERGENiHBG060820.
InParanoidiQ6PGB6.
KOiK20793.
OMAiPIKYSEK.
OrthoDBiEOG091G0PAG.
PhylomeDBiQ6PGB6.
TreeFamiTF314841.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLAY
60 70 80 90 100
FNDIAVGAVC CRVDHSQNQK RLYIMTLGCL APYRRLGIGT KMLNHVLNIC
110 120 130 140 150
EKDGTFDNIY LHVQISNESA IDFYRKFGFE IIETKKNYYK RIEPADAHVL
160
QKNLKVPSGQ NAETQKTDN
Length:169
Mass (Da):19,414
Last modified:July 5, 2004 - v1
Checksum:i153A8021B745347C
GO
Isoform 2 (identifier: Q6PGB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: Missing.

Show »
Length:168
Mass (Da):19,327
Checksum:i3E0CE8B79B6DF970
GO
Isoform 3 (identifier: Q6PGB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-88: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,902
Checksum:iD36C0EE34082F3D8
GO
Isoform 4 (identifier: Q6PGB6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MKG → MPGTVGHEH

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):20,044
Checksum:i49203461C605930C
GO
Isoform 5 (identifier: Q6PGB6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-4: Missing.
     101-169: EKDGTFDNIY...QNAETQKTDN → GWMDGWMDGW...RALAKRRGHK

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,594
Checksum:iF8741E3E3447FB73
GO

Sequence cautioni

The sequence BAE40319 differs from that shown. Reason: Erroneous termination at position 170. Translated as stop.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0247481 – 3MKG → MPGTVGHEH in isoform 4. 1 Publication3
Alternative sequenceiVSP_0247494Missing in isoform 2 and isoform 5. 2 Publications1
Alternative sequenceiVSP_02475049 – 88Missing in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_024751101 – 169EKDGT…QKTDN → GWMDGWMDGWMDGRASEIVE IPCLFLGYQFPKQSKSKLRS LVLSTFTLMDKLQRALAKRR GHK in isoform 5. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011160 mRNA. Translation: BAB27439.1.
AK135658 mRNA. Translation: BAE22602.1.
AK145345 mRNA. Translation: BAE26378.1.
AK156791 mRNA. Translation: BAE33858.1.
AK167141 mRNA. Translation: BAE39286.1.
AK168394 mRNA. Translation: BAE40319.1. Sequence problems.
BC046283 mRNA. Translation: AAH46283.1.
BC055846 mRNA. Translation: AAH55846.1.
BC057117 mRNA. Translation: AAH57117.1.
CCDSiCCDS28183.1. [Q6PGB6-2]
RefSeqiNP_082384.1. NM_028108.3. [Q6PGB6-2]
XP_006522652.1. XM_006522589.2. [Q6PGB6-1]
UniGeneiMm.278726.

Genome annotation databases

EnsembliENSMUST00000063520; ENSMUSP00000070140; ENSMUSG00000022698. [Q6PGB6-2]
ENSMUST00000063542; ENSMUSP00000067361; ENSMUSG00000022698. [Q6PGB6-3]
ENSMUST00000159514; ENSMUSP00000125517; ENSMUSG00000022698. [Q6PGB6-4]
ENSMUST00000161326; ENSMUSP00000124291; ENSMUSG00000022698. [Q6PGB6-1]
GeneIDi72117.
KEGGimmu:72117.
UCSCiuc007zgy.1. mouse. [Q6PGB6-2]
uc007zgz.1. mouse. [Q6PGB6-4]
uc007zha.1. mouse. [Q6PGB6-1]
uc012afx.1. mouse. [Q6PGB6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011160 mRNA. Translation: BAB27439.1.
AK135658 mRNA. Translation: BAE22602.1.
AK145345 mRNA. Translation: BAE26378.1.
AK156791 mRNA. Translation: BAE33858.1.
AK167141 mRNA. Translation: BAE39286.1.
AK168394 mRNA. Translation: BAE40319.1. Sequence problems.
BC046283 mRNA. Translation: AAH46283.1.
BC055846 mRNA. Translation: AAH55846.1.
BC057117 mRNA. Translation: AAH57117.1.
CCDSiCCDS28183.1. [Q6PGB6-2]
RefSeqiNP_082384.1. NM_028108.3. [Q6PGB6-2]
XP_006522652.1. XM_006522589.2. [Q6PGB6-1]
UniGeneiMm.278726.

3D structure databases

ProteinModelPortaliQ6PGB6.
SMRiQ6PGB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215162. 31 interactors.
IntActiQ6PGB6. 32 interactors.
MINTiMINT-1857014.
STRINGi10090.ENSMUSP00000070140.

PTM databases

iPTMnetiQ6PGB6.
PhosphoSitePlusiQ6PGB6.

Proteomic databases

EPDiQ6PGB6.
PaxDbiQ6PGB6.
PeptideAtlasiQ6PGB6.
PRIDEiQ6PGB6.

Protocols and materials databases

DNASUi72117.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063520; ENSMUSP00000070140; ENSMUSG00000022698. [Q6PGB6-2]
ENSMUST00000063542; ENSMUSP00000067361; ENSMUSG00000022698. [Q6PGB6-3]
ENSMUST00000159514; ENSMUSP00000125517; ENSMUSG00000022698. [Q6PGB6-4]
ENSMUST00000161326; ENSMUSP00000124291; ENSMUSG00000022698. [Q6PGB6-1]
GeneIDi72117.
KEGGimmu:72117.
UCSCiuc007zgy.1. mouse. [Q6PGB6-2]
uc007zgz.1. mouse. [Q6PGB6-4]
uc007zha.1. mouse. [Q6PGB6-1]
uc012afx.1. mouse. [Q6PGB6-3]

Organism-specific databases

CTDi80218.
MGIiMGI:1919367. Naa50.

Phylogenomic databases

eggNOGiKOG3138. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009110.
HOGENOMiHOG000238056.
HOVERGENiHBG060820.
InParanoidiQ6PGB6.
KOiK20793.
OMAiPIKYSEK.
OrthoDBiEOG091G0PAG.
PhylomeDBiQ6PGB6.
TreeFamiTF314841.

Miscellaneous databases

ChiTaRSiNaa50. mouse.
PROiQ6PGB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022698.
CleanExiMM_NAT13.
GenevisibleiQ6PGB6. MM.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAA50_MOUSE
AccessioniPrimary (citable) accession number: Q6PGB6
Secondary accession number(s): Q3TH79
, Q3TK59, Q7TML2, Q80VE3, Q9D0Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.