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Protein

REST corepressor 3

Gene

Rcor3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 3
Gene namesi
Name:Rcor3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2441920 Rcor3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267821 – 451REST corepressor 3Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei212PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei401Asymmetric dimethylarginineCombined sources1
Modified residuei413Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6PGA0
PRIDEiQ6PGA0

PTM databases

iPTMnetiQ6PGA0
PhosphoSitePlusiQ6PGA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000037395
CleanExiMM_RCOR3
ExpressionAtlasiQ6PGA0 baseline and differential
GenevisibleiQ6PGA0 MM

Interactioni

GO - Molecular functioni

  • enzyme binding Source: MGI
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi229560, 1 interactor
IntActiQ6PGA0, 1 interactor
STRINGi10090.ENSMUSP00000073004

Structurei

3D structure databases

ProteinModelPortaliQ6PGA0
SMRiQ6PGA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 139ELM2PROSITE-ProRule annotationAdd BLAST85
Domaini140 – 191SANTPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili293 – 329Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 437Pro-richAdd BLAST103

Sequence similaritiesi

Belongs to the CoREST family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1194 Eukaryota
ENOG410XSIS LUCA
GeneTreeiENSGT00840000129748
HOGENOMiHOG000065784
HOVERGENiHBG079800
InParanoidiQ6PGA0
PhylomeDBiQ6PGA0
TreeFamiTF106450

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGMMEKGPE LLGKSRSANG GAKSPAGGGG SSANGGLHFS EPESGCSSDD
60 70 80 90 100
EHGDVGMRVG AEYQARIPEF DPGATKYTDK DNGGMLVWSP YHSIPDAKLD
110 120 130 140 150
EYIAIAKEKH GYNVEQALGM LFWHKHNIEK SLADLPNFTP FPDEWTVEDK
160 170 180 190 200
VLFEQAFSFH GKSFHRIQQM LPDKTIASLV KYYYSWKKTR SRTSLMDRQA
210 220 230 240 250
RKLANRHNQG DSDDDVEEAH PMDGNDSDYD PKKEAKREGN ADQPVQTSKI
260 270 280 290 300
GLGRREYQSL QHRHHSQRSK CRPPKGMYLT QEDVVAVSCS PNAANTILRQ
310 320 330 340 350
LDMELISLKR QVQNAKQVNS ALKQKMEGGI EEFKPPEAQT PQAPRTLGPS
360 370 380 390 400
PPAPSSTPTP TVPIATLNQP PPLLRPTLPA APALHRQPPP LQQQARFIQP
410 420 430 440 450
RPTLNQPPPP LIRPANSMPP RLNPRPVLTT VGGQQPPSLI GIQTDSQPSL

H
Length:451
Mass (Da):49,779
Last modified:March 7, 2006 - v2
Checksum:iFE0A068325A06C82
GO
Isoform 2 (identifier: Q6PGA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-434: AQTPQAPRTL...RPVLTTVGGQ → SNQKINARWT...SASSTSHSPC
     435-451: Missing.

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):47,471
Checksum:i2BEDF63F73A3829F
GO

Sequence cautioni

The sequence AAH57141 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK135612 differs from that shown. Reason: Frameshift at positions 28 and 419.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017463338 – 434AQTPQ…TVGGQ → SNQKINARWTTEEQLLAVQG TDPTGSSDSGSITSCPIIHS NTNSPHCHSEPASTTSSSNT ACRPCSSPTTSSTPAAGSVH PAPANSQSASSTSHSPC in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_017464435 – 451Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135612 mRNA No translation available.
BC057141 mRNA Translation: AAH57141.2 Different initiation.
CCDSiCCDS69995.1 [Q6PGA0-1]
CCDS69996.1 [Q6PGA0-2]
RefSeqiNP_001277207.1, NM_001290278.1 [Q6PGA0-2]
NP_659063.3, NM_144814.3 [Q6PGA0-1]
UniGeneiMm.207457

Genome annotation databases

EnsembliENSMUST00000073279; ENSMUSP00000073004; ENSMUSG00000037395 [Q6PGA0-1]
ENSMUST00000110849; ENSMUSP00000106473; ENSMUSG00000037395 [Q6PGA0-2]
ENSMUST00000213864; ENSMUSP00000149465; ENSMUSG00000111452 [Q6PGA0-2]
ENSMUST00000217048; ENSMUSP00000149587; ENSMUSG00000111452 [Q6PGA0-1]
GeneIDi214742
KEGGimmu:214742
UCSCiuc007edh.2 mouse [Q6PGA0-1]
uc007edi.2 mouse [Q6PGA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRCOR3_MOUSE
AccessioniPrimary (citable) accession number: Q6PGA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health