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Protein

REST corepressor 3

Gene

Rcor3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 3
Gene namesi
Name:Rcor3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2441920. Rcor3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267821 – 451REST corepressor 3Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei212PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei401Asymmetric dimethylarginineCombined sources1
Modified residuei413Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6PGA0.
PRIDEiQ6PGA0.

PTM databases

iPTMnetiQ6PGA0.
PhosphoSitePlusiQ6PGA0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037395.
CleanExiMM_RCOR3.
ExpressionAtlasiQ6PGA0. baseline and differential.
GenevisibleiQ6PGA0. MM.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: MGI
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi229560. 1 interactor.
IntActiQ6PGA0. 1 interactor.
STRINGi10090.ENSMUSP00000073004.

Structurei

3D structure databases

ProteinModelPortaliQ6PGA0.
SMRiQ6PGA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 139ELM2PROSITE-ProRule annotationAdd BLAST85
Domaini140 – 191SANTPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili293 – 329Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 437Pro-richAdd BLAST103

Sequence similaritiesi

Belongs to the CoREST family.Curated
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ6PGA0.
PhylomeDBiQ6PGA0.
TreeFamiTF106450.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PGA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGMMEKGPE LLGKSRSANG GAKSPAGGGG SSANGGLHFS EPESGCSSDD
60 70 80 90 100
EHGDVGMRVG AEYQARIPEF DPGATKYTDK DNGGMLVWSP YHSIPDAKLD
110 120 130 140 150
EYIAIAKEKH GYNVEQALGM LFWHKHNIEK SLADLPNFTP FPDEWTVEDK
160 170 180 190 200
VLFEQAFSFH GKSFHRIQQM LPDKTIASLV KYYYSWKKTR SRTSLMDRQA
210 220 230 240 250
RKLANRHNQG DSDDDVEEAH PMDGNDSDYD PKKEAKREGN ADQPVQTSKI
260 270 280 290 300
GLGRREYQSL QHRHHSQRSK CRPPKGMYLT QEDVVAVSCS PNAANTILRQ
310 320 330 340 350
LDMELISLKR QVQNAKQVNS ALKQKMEGGI EEFKPPEAQT PQAPRTLGPS
360 370 380 390 400
PPAPSSTPTP TVPIATLNQP PPLLRPTLPA APALHRQPPP LQQQARFIQP
410 420 430 440 450
RPTLNQPPPP LIRPANSMPP RLNPRPVLTT VGGQQPPSLI GIQTDSQPSL

H
Length:451
Mass (Da):49,779
Last modified:March 7, 2006 - v2
Checksum:iFE0A068325A06C82
GO
Isoform 2 (identifier: Q6PGA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-434: AQTPQAPRTL...RPVLTTVGGQ → SNQKINARWT...SASSTSHSPC
     435-451: Missing.

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):47,471
Checksum:i2BEDF63F73A3829F
GO

Sequence cautioni

The sequence AAH57141 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK135612 differs from that shown. Reason: Frameshift at positions 28 and 419.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017463338 – 434AQTPQ…TVGGQ → SNQKINARWTTEEQLLAVQG TDPTGSSDSGSITSCPIIHS NTNSPHCHSEPASTTSSSNT ACRPCSSPTTSSTPAAGSVH PAPANSQSASSTSHSPC in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_017464435 – 451Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135612 mRNA. No translation available.
BC057141 mRNA. Translation: AAH57141.2. Different initiation.
CCDSiCCDS69995.1. [Q6PGA0-1]
CCDS69996.1. [Q6PGA0-2]
RefSeqiNP_001277207.1. NM_001290278.1. [Q6PGA0-2]
NP_659063.3. NM_144814.3. [Q6PGA0-1]
UniGeneiMm.207457.

Genome annotation databases

EnsembliENSMUST00000073279; ENSMUSP00000073004; ENSMUSG00000037395. [Q6PGA0-1]
ENSMUST00000110849; ENSMUSP00000106473; ENSMUSG00000037395. [Q6PGA0-2]
GeneIDi214742.
KEGGimmu:214742.
UCSCiuc007edh.2. mouse. [Q6PGA0-1]
uc007edi.2. mouse. [Q6PGA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135612 mRNA. No translation available.
BC057141 mRNA. Translation: AAH57141.2. Different initiation.
CCDSiCCDS69995.1. [Q6PGA0-1]
CCDS69996.1. [Q6PGA0-2]
RefSeqiNP_001277207.1. NM_001290278.1. [Q6PGA0-2]
NP_659063.3. NM_144814.3. [Q6PGA0-1]
UniGeneiMm.207457.

3D structure databases

ProteinModelPortaliQ6PGA0.
SMRiQ6PGA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229560. 1 interactor.
IntActiQ6PGA0. 1 interactor.
STRINGi10090.ENSMUSP00000073004.

PTM databases

iPTMnetiQ6PGA0.
PhosphoSitePlusiQ6PGA0.

Proteomic databases

PaxDbiQ6PGA0.
PRIDEiQ6PGA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073279; ENSMUSP00000073004; ENSMUSG00000037395. [Q6PGA0-1]
ENSMUST00000110849; ENSMUSP00000106473; ENSMUSG00000037395. [Q6PGA0-2]
GeneIDi214742.
KEGGimmu:214742.
UCSCiuc007edh.2. mouse. [Q6PGA0-1]
uc007edi.2. mouse. [Q6PGA0-2]

Organism-specific databases

CTDi55758.
MGIiMGI:2441920. Rcor3.

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ6PGA0.
PhylomeDBiQ6PGA0.
TreeFamiTF106450.

Miscellaneous databases

ChiTaRSiRcor3. mouse.
PROiQ6PGA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037395.
CleanExiMM_RCOR3.
ExpressionAtlasiQ6PGA0. baseline and differential.
GenevisibleiQ6PGA0. MM.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCOR3_MOUSE
AccessioniPrimary (citable) accession number: Q6PGA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.