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Protein

Zinc finger protein 790

Gene

ZNF790

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 220C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri226 – 248C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32496-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 790
Gene namesi
Name:ZNF790
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33114. ZNF790.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197863.
PharmGKBiPA162410507.

Polymorphism and mutation databases

BioMutaiZNF790.
DMDMi296453059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002613361 – 636Zinc finger protein 790Add BLAST636

Proteomic databases

MaxQBiQ6PG37.
PaxDbiQ6PG37.
PeptideAtlasiQ6PG37.
PRIDEiQ6PG37.

PTM databases

iPTMnetiQ6PG37.
PhosphoSitePlusiQ6PG37.

Expressioni

Gene expression databases

BgeeiENSG00000197863.
CleanExiHS_ZNF790.
ExpressionAtlasiQ6PG37. baseline and differential.

Organism-specific databases

HPAiHPA056134.
HPA060288.

Interactioni

Protein-protein interaction databases

BioGridi132730. 4 interactors.
IntActiQ6PG37. 4 interactors.
STRINGi9606.ENSP00000349161.

Structurei

3D structure databases

ProteinModelPortaliQ6PG37.
SMRiQ6PG37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 76KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 220C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri226 – 248C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PG37.
KOiK09228.
OMAiCFRGDWE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6PG37.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PG37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLMMFRDV AVDFSQEEWE CLDLEQRDLY RDVMLENYSN MVSLGFCIYQ
60 70 80 90 100
PEAFSLLEKG KEPWKILRDE TRGPCPDMQS RCQTKKLLPK NGIFEREIAQ
110 120 130 140 150
LEIMRICKNH SLDCLCFRGD WEGNTQFQTL QDNQEECFKQ VIRTCEKRPT
160 170 180 190 200
FNQHTVFNLH QRLNTGDKLN EFKELGKAFI SGSDHTQHQL IHTSEKFCGD
210 220 230 240 250
KECGNTFLPD SEVIQYQTVH TVKKTYECKE CGKSFSLRSS LTGHKRIHTG
260 270 280 290 300
EKPFKCKDCG KAFRFHSQLS VHKRIHTGEK SYECKECGKA FSCGSDLTRH
310 320 330 340 350
QRIHTGEKPY ECNECRKAFS QRSHLIKHQR IHTGEKPYEC KECGKAFTRG
360 370 380 390 400
SHLTQHQRIH TGEKSHECKE CGKAFIRGSN LAQHQNVHVG RKPYKCEKCG
410 420 430 440 450
KAYIWSSHLA RHQRIHTGRK PYECKQCGKT FTWASYLAQH EKIHNERKSY
460 470 480 490 500
ECKECGKTFL HGSEFNRHQK IHTGERNYEC KECGKTFFRG SELNRHQKIH
510 520 530 540 550
TGKRPYECEE CGKAFLWGSQ LTRHQRMHTG EEPYVCKECG KSFIWGSQLT
560 570 580 590 600
RHKKIHTDAE PYGCKKSSHI FSHHSYFTEQ KIHNSANLCE WTDYGNTFSH
610 620 630
ESNFAQHQNI YTFEKSYEFK DFEKAFSSSS HFISLL
Length:636
Mass (Da):74,571
Last modified:May 18, 2010 - v2
Checksum:iE4B6D8DA68E4A051
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060434301Q → R.1 PublicationCorresponds to variant rs3745775dbSNPEnsembl.1
Natural variantiVAR_057453486T → S.Corresponds to variant rs4369791dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020928 Genomic DNA. No translation available.
BC057245 mRNA. Translation: AAH57245.1.
CCDSiCCDS12496.1.
RefSeqiNP_001229729.1. NM_001242800.1.
NP_001229730.1. NM_001242801.1.
NP_001229731.1. NM_001242802.1.
NP_996777.2. NM_206894.3.
XP_005258960.1. XM_005258903.4.
XP_011525252.1. XM_011526950.2.
UniGeneiHs.282067.
Hs.734830.

Genome annotation databases

EnsembliENST00000356725; ENSP00000349161; ENSG00000197863.
ENST00000613249; ENSP00000480764; ENSG00000197863.
ENST00000614179; ENSP00000480834; ENSG00000197863.
ENST00000615484; ENSP00000478852; ENSG00000197863.
GeneIDi388536.
KEGGihsa:388536.
UCSCiuc002oew.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020928 Genomic DNA. No translation available.
BC057245 mRNA. Translation: AAH57245.1.
CCDSiCCDS12496.1.
RefSeqiNP_001229729.1. NM_001242800.1.
NP_001229730.1. NM_001242801.1.
NP_001229731.1. NM_001242802.1.
NP_996777.2. NM_206894.3.
XP_005258960.1. XM_005258903.4.
XP_011525252.1. XM_011526950.2.
UniGeneiHs.282067.
Hs.734830.

3D structure databases

ProteinModelPortaliQ6PG37.
SMRiQ6PG37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132730. 4 interactors.
IntActiQ6PG37. 4 interactors.
STRINGi9606.ENSP00000349161.

PTM databases

iPTMnetiQ6PG37.
PhosphoSitePlusiQ6PG37.

Polymorphism and mutation databases

BioMutaiZNF790.
DMDMi296453059.

Proteomic databases

MaxQBiQ6PG37.
PaxDbiQ6PG37.
PeptideAtlasiQ6PG37.
PRIDEiQ6PG37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356725; ENSP00000349161; ENSG00000197863.
ENST00000613249; ENSP00000480764; ENSG00000197863.
ENST00000614179; ENSP00000480834; ENSG00000197863.
ENST00000615484; ENSP00000478852; ENSG00000197863.
GeneIDi388536.
KEGGihsa:388536.
UCSCiuc002oew.4. human.

Organism-specific databases

CTDi388536.
GeneCardsiZNF790.
HGNCiHGNC:33114. ZNF790.
HPAiHPA056134.
HPA060288.
neXtProtiNX_Q6PG37.
OpenTargetsiENSG00000197863.
PharmGKBiPA162410507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PG37.
KOiK09228.
OMAiCFRGDWE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6PG37.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:G66-32496-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii388536.
PROiQ6PG37.

Gene expression databases

BgeeiENSG00000197863.
CleanExiHS_ZNF790.
ExpressionAtlasiQ6PG37. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN790_HUMAN
AccessioniPrimary (citable) accession number: Q6PG37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.