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Q6PFX9

- TNKS1_MOUSE

UniProt

Q6PFX9 - TNKS1_MOUSE

Protein

Tankyrase-1

Gene

Tnks

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity By similarity.By similarity

    Catalytic activityi

    NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

    Enzyme regulationi

    Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1227 – 12271ZincBy similarity
    Metal bindingi1230 – 12301ZincBy similarity
    Metal bindingi1235 – 12351ZincBy similarity
    Metal bindingi1238 – 12381ZincBy similarity

    GO - Molecular functioni

    1. NAD+ ADP-ribosyltransferase activity Source: UniProtKB
    2. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. mRNA transport Source: UniProtKB-KW
    3. negative regulation of DNA binding Source: Ensembl
    4. peptidyl-serine phosphorylation Source: MGI
    5. peptidyl-threonine phosphorylation Source: MGI
    6. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    7. positive regulation of telomere maintenance via telomerase Source: Ensembl
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. protein auto-ADP-ribosylation Source: UniProtKB
    10. protein localization to chromosome, telomeric region Source: Ensembl
    11. protein poly-ADP-ribosylation Source: Ensembl
    12. protein polyubiquitination Source: UniProtKB
    13. protein transport Source: UniProtKB-KW
    14. spindle assembly Source: InterPro
    15. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
    REACT_219129. degradation of AXIN.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tankyrase-1 (EC:2.4.2.30)
    Short name:
    TANK1
    Alternative name(s):
    ADP-ribosyltransferase diphtheria toxin-like 5
    Short name:
    ARTD5
    TRF1-interacting ankyrin-related ADP-ribose polymerase 1
    Short name:
    Tankyrase I
    Gene namesi
    Name:Tnks
    Synonyms:Tnks1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1341087. Tnks.

    Subcellular locationi

    Cytoplasm By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity. Chromosomecentromere By similarity. Nucleusnuclear pore complex By similarity. Chromosometelomere Curated. Cytoplasmcytoskeletonspindle pole By similarity
    Note: Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1 By similarity.By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. cytosol Source: MGI
    3. Golgi apparatus Source: UniProtKB
    4. Golgi membrane Source: UniProtKB-SubCell
    5. nuclear chromosome, telomeric region Source: Ensembl
    6. nuclear pore Source: UniProtKB-SubCell
    7. spindle pole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nuclear pore complex, Nucleus, Telomere

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13201320Tankyrase-1PRO_0000409511Add
    BLAST

    Post-translational modificationi

    Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis By similarity.By similarity
    Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.By similarity
    ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination By similarity.By similarity

    Keywords - PTMi

    ADP-ribosylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ6PFX9.
    PRIDEiQ6PFX9.

    PTM databases

    PhosphoSiteiQ6PFX9.

    Expressioni

    Gene expression databases

    BgeeiQ6PFX9.
    GenevestigatoriQ6PFX9.

    Interactioni

    Subunit structurei

    Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. Interacts with AXIN1, AXIN2, BLZF1 and CASC3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204263. 2 interactions.
    STRINGi10090.ENSMUSP00000033929.

    Structurei

    Secondary structure

    1
    1320
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi317 – 33822
    Helixi341 – 3477
    Turni350 – 3545
    Helixi365 – 3717
    Helixi375 – 3839
    Helixi398 – 4047
    Helixi408 – 4169
    Helixi431 – 4377
    Helixi441 – 4499
    Helixi464 – 4674
    Helixi471 – 49121
    Helixi495 – 5017
    Turni502 – 5043
    Turni512 – 5143
    Helixi518 – 5247
    Helixi530 – 53910
    Helixi554 – 5607
    Helixi564 – 5729
    Helixi587 – 5948
    Helixi597 – 6059
    Helixi620 – 6234
    Helixi626 – 6349
    Beta strandi1100 – 11034
    Helixi1109 – 112012
    Turni1126 – 11327
    Beta strandi1138 – 114710
    Helixi1149 – 116517
    Beta strandi1172 – 11776
    Helixi1182 – 11887
    Helixi1192 – 11943
    Beta strandi1203 – 12097
    Helixi1211 – 12155
    Turni1216 – 12194
    Helixi1221 – 12233
    Turni1228 – 12303
    Beta strandi1236 – 12383
    Beta strandi1240 – 12489
    Beta strandi1251 – 12566
    Beta strandi1269 – 12735
    Beta strandi1284 – 12885
    Helixi1290 – 12923
    Beta strandi1293 – 130311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UTMX-ray2.00A/B308-655[»]
    4N4TX-ray2.32A/B1097-1307[»]
    ProteinModelPortaliQ6PFX9.
    SMRiQ6PFX9. Positions 316-635, 641-940, 1098-1307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati174 – 20229ANK 1Add
    BLAST
    Repeati208 – 23730ANK 2Add
    BLAST
    Repeati241 – 27030ANK 3Add
    BLAST
    Repeati274 – 30330ANK 4Add
    BLAST
    Repeati361 – 39030ANK 5Add
    BLAST
    Repeati394 – 42330ANK 6Add
    BLAST
    Repeati427 – 45630ANK 7Add
    BLAST
    Repeati514 – 54633ANK 8Add
    BLAST
    Repeati550 – 57930ANK 9Add
    BLAST
    Repeati583 – 61230ANK 10Add
    BLAST
    Repeati676 – 70530ANK 11Add
    BLAST
    Repeati709 – 73830ANK 12Add
    BLAST
    Repeati742 – 77130ANK 13Add
    BLAST
    Repeati775 – 80329ANK 14Add
    BLAST
    Repeati829 – 85830ANK 15Add
    BLAST
    Repeati862 – 89130ANK 16Add
    BLAST
    Repeati895 – 92430ANK 17Add
    BLAST
    Repeati928 – 95730ANK 18Add
    BLAST
    Domaini1019 – 108264SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini1105 – 1310206PARP catalyticPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 146Poly-His
    Compositional biasi20 – 8364Pro-richAdd
    BLAST
    Compositional biasi112 – 1187Poly-Gly
    Compositional biasi121 – 14626Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 18 ANK repeats.PROSITE-ProRule annotation
    Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00750000117662.
    HOGENOMiHOG000246964.
    HOVERGENiHBG059472.
    InParanoidiQ8BX62.
    KOiK10799.
    OMAiDDKEYQS.
    OrthoDBiEOG7N8ZTP.
    PhylomeDBiQ6PFX9.
    TreeFamiTF326036.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.25.40.20. 6 hits.
    3.90.228.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR028731. TNKS.
    [Graphical view]
    PANTHERiPTHR24180:SF3. PTHR24180:SF3. 1 hit.
    PfamiPF00023. Ank. 3 hits.
    PF12796. Ank_2. 5 hits.
    PF00644. PARP. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 17 hits.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 4 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 15 hits.
    PS51059. PARP_CATALYTIC. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PFX9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGPTPASPTA     50
    GGLAPFASPR HGLALPEGDG SRDPPDRPRS PDPVDGAVCT VAAPAAVPAA 100
    SAAVGVAPTP AGGGGGGGNN SASSASSPTS SSSSSPSSPG SSLAESPEAA 150
    GVGSTATLGA GAAGLGPGVP AVSGALRELL EACRNGDVSR VKRLVDAANV 200
    NAKDMAGRKS SPLHFAAGFG RKDVVEHLLQ MGANVHARDD GGLIPLHNAC 250
    SFGHAEVVSL LLCQGADPNA RDNWNYTPLH EAAIKGKIDV CIVLLQHGAD 300
    PNIRNTDGKS ALDLADPSAK AVLTGEYKKD ELLEAARSGN EEKLMALLTP 350
    LNVNCHASDG RKSTPLHLAA GYNRVRIVQL LLQHGADVHA KDKGGLVPLH 400
    NACSYGHYEV TELLLKHGAC VNAMDLWQFT PLHEAASKNR VEVCSLLLSH 450
    GADPTLVNCH GKSAVDMAPT PELRERLTYE FKGHSLLQAA READLAKVKK 500
    TLALEIINFK QPQSHETALH CAVASLHPKR KQVAELLLRK GANVNEKNKD 550
    FMTPLHVAAE RAHNDVMEVL HKHGAKMNAL DSLGQTALHR AALAGHLQTC 600
    RLLLSYGSDP SIISLQGFTA AQMGNEAVQQ ILSESTPMRT SDVDYRLLEA 650
    SKAGDLETVK QLCSPQNVNC RDLEGRHSTP LHFAAGYNRV SVVEYLLHHG 700
    ADVHAKDKGG LVPLHNACSY GHYEVAELLV RHGASVNVAD LWKFTPLHEA 750
    AAKGKYEICK LLLKHGADPT KKNRDGNTPL DLVKEGDTDI QDLLRGDAAL 800
    LDAAKKGCLA RVQKLCTPEN INCRDTQGRN STPLHLAAGY NNLEVAEYLL 850
    EHGADVNAQD KGGLIPLHNA ASYGHVDIAA LLIKYNTCVN ATDKWAFTPL 900
    HEAAQKGRTQ LCALLLAHGA DPTMKNQEGQ TPLDLATADD IRALLIDAMP 950
    PEALPTCFKP QATVVSASLI SPASTPSCLS AASSIDNLTG PLTDLAVGGA 1000
    SNAGDGAAGA ERKEGEVAGL DMNISQFLKS LGLEHLRDIF ETEQITLDVL 1050
    ADMGHEELKE IGINAYGHRH KLIKGVERLL GGQQGTNPYL TFHCVNQGTI 1100
    LLDLAPEDKE YQSVEEEMQS TIREHRDGGN AGGIFNRYNV IRIQKVVNKK 1150
    LRERFCHRQK EVSEENHNHH NERMLFHGSP FINAIIHKGF DERHAYIGGM 1200
    FGAGIYFAEN SSKSNQYVYG IGGGTGCPTH KDRSCYICHR QMLFCRVTLG 1250
    KSFLQFSTMK MAHAPPGHHS VIGRPSVNGL AYAEYVIYRG EQAYPEYLIT 1300
    YQIMKPEAPS QTATAAEQKT 1320
    Length:1,320
    Mass (Da):140,944
    Last modified:July 5, 2004 - v1
    Checksum:iA90360DC665FFCC0
    GO
    Isoform 2 (identifier: Q6PFX9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-344: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:976
    Mass (Da):106,651
    Checksum:i8DE71F21652C3D4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti969 – 9691L → V in BAC33475. (PubMed:16141072)Curated
    Sequence conflicti1025 – 10251S → I in BAC33475. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 344344Missing in isoform 2. 1 PublicationVSP_041320Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048860 mRNA. Translation: BAC33475.1.
    AC122458 Genomic DNA. No translation available.
    BC057370 mRNA. Translation: AAH57370.1.
    CCDSiCCDS22242.1. [Q6PFX9-1]
    RefSeqiNP_780300.2. NM_175091.3. [Q6PFX9-1]
    UniGeneiMm.88364.

    Genome annotation databases

    EnsembliENSMUST00000033929; ENSMUSP00000033929; ENSMUSG00000031529. [Q6PFX9-1]
    GeneIDi21951.
    KEGGimmu:21951.
    UCSCiuc009lku.1. mouse. [Q6PFX9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048860 mRNA. Translation: BAC33475.1 .
    AC122458 Genomic DNA. No translation available.
    BC057370 mRNA. Translation: AAH57370.1 .
    CCDSi CCDS22242.1. [Q6PFX9-1 ]
    RefSeqi NP_780300.2. NM_175091.3. [Q6PFX9-1 ]
    UniGenei Mm.88364.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UTM X-ray 2.00 A/B 308-655 [» ]
    4N4T X-ray 2.32 A/B 1097-1307 [» ]
    ProteinModelPortali Q6PFX9.
    SMRi Q6PFX9. Positions 316-635, 641-940, 1098-1307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204263. 2 interactions.
    STRINGi 10090.ENSMUSP00000033929.

    PTM databases

    PhosphoSitei Q6PFX9.

    Proteomic databases

    PaxDbi Q6PFX9.
    PRIDEi Q6PFX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033929 ; ENSMUSP00000033929 ; ENSMUSG00000031529 . [Q6PFX9-1 ]
    GeneIDi 21951.
    KEGGi mmu:21951.
    UCSCi uc009lku.1. mouse. [Q6PFX9-1 ]

    Organism-specific databases

    CTDi 8658.
    MGIi MGI:1341087. Tnks.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00750000117662.
    HOGENOMi HOG000246964.
    HOVERGENi HBG059472.
    InParanoidi Q8BX62.
    KOi K10799.
    OMAi DDKEYQS.
    OrthoDBi EOG7N8ZTP.
    PhylomeDBi Q6PFX9.
    TreeFami TF326036.

    Enzyme and pathway databases

    Reactomei REACT_207044. TCF dependent signaling in response to WNT.
    REACT_219129. degradation of AXIN.

    Miscellaneous databases

    NextBioi 301616.
    PROi Q6PFX9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PFX9.
    Genevestigatori Q6PFX9.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.25.40.20. 6 hits.
    3.90.228.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR028731. TNKS.
    [Graphical view ]
    PANTHERi PTHR24180:SF3. PTHR24180:SF3. 1 hit.
    Pfami PF00023. Ank. 3 hits.
    PF12796. Ank_2. 5 hits.
    PF00644. PARP. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 17 hits.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 4 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 15 hits.
    PS51059. PARP_CATALYTIC. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiTNKS1_MOUSE
    AccessioniPrimary (citable) accession number: Q6PFX9
    Secondary accession number(s): Q8BX62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3