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Q6PFX9

- TNKS1_MOUSE

UniProt

Q6PFX9 - TNKS1_MOUSE

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Protein

Tankyrase-1

Gene
Tnks, Tnks1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity By similarity.

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme regulationi

Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1227 – 12271Zinc By similarity
Metal bindingi1230 – 12301Zinc By similarity
Metal bindingi1235 – 12351Zinc By similarity
Metal bindingi1238 – 12381Zinc By similarity

GO - Molecular functioni

  1. NAD+ ADP-ribosyltransferase activity Source: UniProtKB
  2. zinc ion binding Source: Ensembl

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. mRNA transport Source: UniProtKB-KW
  3. negative regulation of DNA binding Source: Ensembl
  4. peptidyl-serine phosphorylation Source: MGI
  5. peptidyl-threonine phosphorylation Source: MGI
  6. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  7. positive regulation of telomere maintenance via telomerase Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. protein auto-ADP-ribosylation Source: UniProtKB
  10. protein localization to chromosome, telomeric region Source: Ensembl
  11. protein poly-ADP-ribosylation Source: Ensembl
  12. protein polyubiquitination Source: UniProtKB
  13. protein transport Source: UniProtKB-KW
  14. spindle assembly Source: InterPro
  15. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
REACT_219129. degradation of AXIN.

Names & Taxonomyi

Protein namesi
Recommended name:
Tankyrase-1 (EC:2.4.2.30)
Short name:
TANK1
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 5
Short name:
ARTD5
TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Short name:
Tankyrase I
Gene namesi
Name:Tnks
Synonyms:Tnks1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1341087. Tnks.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein By similarity. Chromosomecentromere By similarity. Nucleusnuclear pore complex By similarity. Chromosometelomere Reviewed prediction. Cytoplasmcytoskeletonspindle pole By similarity
Note: Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1 By similarity.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-SubCell
  2. cytosol Source: MGI
  3. Golgi apparatus Source: UniProtKB
  4. Golgi membrane Source: UniProtKB-SubCell
  5. nuclear chromosome, telomeric region Source: Ensembl
  6. nuclear pore Source: UniProtKB-SubCell
  7. spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nuclear pore complex, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Tankyrase-1PRO_0000409511Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis By similarity.
Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation By similarity.
ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination By similarity.

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6PFX9.
PRIDEiQ6PFX9.

PTM databases

PhosphoSiteiQ6PFX9.

Expressioni

Gene expression databases

BgeeiQ6PFX9.
GenevestigatoriQ6PFX9.

Interactioni

Subunit structurei

Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. Interacts with AXIN1, AXIN2, BLZF1 and CASC3 By similarity.

Protein-protein interaction databases

BioGridi204263. 2 interactions.
STRINGi10090.ENSMUSP00000033929.

Structurei

Secondary structure

1
1320
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi317 – 33822
Helixi341 – 3477
Turni350 – 3545
Helixi365 – 3717
Helixi375 – 3839
Helixi398 – 4047
Helixi408 – 4169
Helixi431 – 4377
Helixi441 – 4499
Helixi464 – 4674
Helixi471 – 49121
Helixi495 – 5017
Turni502 – 5043
Turni512 – 5143
Helixi518 – 5247
Helixi530 – 53910
Helixi554 – 5607
Helixi564 – 5729
Helixi587 – 5948
Helixi597 – 6059
Helixi620 – 6234
Helixi626 – 6349
Beta strandi1100 – 11034
Helixi1109 – 112012
Turni1126 – 11327
Beta strandi1138 – 114710
Helixi1149 – 116517
Beta strandi1172 – 11776
Helixi1182 – 11887
Helixi1192 – 11943
Beta strandi1203 – 12097
Helixi1211 – 12155
Turni1216 – 12194
Helixi1221 – 12233
Turni1228 – 12303
Beta strandi1236 – 12383
Beta strandi1240 – 12489
Beta strandi1251 – 12566
Beta strandi1269 – 12735
Beta strandi1284 – 12885
Helixi1290 – 12923
Beta strandi1293 – 130311

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UTMX-ray2.00A/B308-655[»]
4N4TX-ray2.32A/B1097-1307[»]
ProteinModelPortaliQ6PFX9.
SMRiQ6PFX9. Positions 316-635, 641-940, 1098-1307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati174 – 20229ANK 1Add
BLAST
Repeati208 – 23730ANK 2Add
BLAST
Repeati241 – 27030ANK 3Add
BLAST
Repeati274 – 30330ANK 4Add
BLAST
Repeati361 – 39030ANK 5Add
BLAST
Repeati394 – 42330ANK 6Add
BLAST
Repeati427 – 45630ANK 7Add
BLAST
Repeati514 – 54633ANK 8Add
BLAST
Repeati550 – 57930ANK 9Add
BLAST
Repeati583 – 61230ANK 10Add
BLAST
Repeati676 – 70530ANK 11Add
BLAST
Repeati709 – 73830ANK 12Add
BLAST
Repeati742 – 77130ANK 13Add
BLAST
Repeati775 – 80329ANK 14Add
BLAST
Repeati829 – 85830ANK 15Add
BLAST
Repeati862 – 89130ANK 16Add
BLAST
Repeati895 – 92430ANK 17Add
BLAST
Repeati928 – 95730ANK 18Add
BLAST
Domaini1019 – 108264SAMAdd
BLAST
Domaini1105 – 1310206PARP catalyticAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 146Poly-His
Compositional biasi20 – 8364Pro-richAdd
BLAST
Compositional biasi112 – 1187Poly-Gly
Compositional biasi121 – 14626Ser-richAdd
BLAST

Sequence similaritiesi

Contains 18 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00750000117662.
HOGENOMiHOG000246964.
HOVERGENiHBG059472.
InParanoidiQ8BX62.
KOiK10799.
OMAiDDKEYQS.
OrthoDBiEOG7N8ZTP.
PhylomeDBiQ6PFX9.
TreeFamiTF326036.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 6 hits.
3.90.228.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR028731. TNKS.
[Graphical view]
PANTHERiPTHR24180:SF3. PTHR24180:SF3. 1 hit.
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 5 hits.
PF00644. PARP. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 17 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 15 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PFX9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGPTPASPTA     50
GGLAPFASPR HGLALPEGDG SRDPPDRPRS PDPVDGAVCT VAAPAAVPAA 100
SAAVGVAPTP AGGGGGGGNN SASSASSPTS SSSSSPSSPG SSLAESPEAA 150
GVGSTATLGA GAAGLGPGVP AVSGALRELL EACRNGDVSR VKRLVDAANV 200
NAKDMAGRKS SPLHFAAGFG RKDVVEHLLQ MGANVHARDD GGLIPLHNAC 250
SFGHAEVVSL LLCQGADPNA RDNWNYTPLH EAAIKGKIDV CIVLLQHGAD 300
PNIRNTDGKS ALDLADPSAK AVLTGEYKKD ELLEAARSGN EEKLMALLTP 350
LNVNCHASDG RKSTPLHLAA GYNRVRIVQL LLQHGADVHA KDKGGLVPLH 400
NACSYGHYEV TELLLKHGAC VNAMDLWQFT PLHEAASKNR VEVCSLLLSH 450
GADPTLVNCH GKSAVDMAPT PELRERLTYE FKGHSLLQAA READLAKVKK 500
TLALEIINFK QPQSHETALH CAVASLHPKR KQVAELLLRK GANVNEKNKD 550
FMTPLHVAAE RAHNDVMEVL HKHGAKMNAL DSLGQTALHR AALAGHLQTC 600
RLLLSYGSDP SIISLQGFTA AQMGNEAVQQ ILSESTPMRT SDVDYRLLEA 650
SKAGDLETVK QLCSPQNVNC RDLEGRHSTP LHFAAGYNRV SVVEYLLHHG 700
ADVHAKDKGG LVPLHNACSY GHYEVAELLV RHGASVNVAD LWKFTPLHEA 750
AAKGKYEICK LLLKHGADPT KKNRDGNTPL DLVKEGDTDI QDLLRGDAAL 800
LDAAKKGCLA RVQKLCTPEN INCRDTQGRN STPLHLAAGY NNLEVAEYLL 850
EHGADVNAQD KGGLIPLHNA ASYGHVDIAA LLIKYNTCVN ATDKWAFTPL 900
HEAAQKGRTQ LCALLLAHGA DPTMKNQEGQ TPLDLATADD IRALLIDAMP 950
PEALPTCFKP QATVVSASLI SPASTPSCLS AASSIDNLTG PLTDLAVGGA 1000
SNAGDGAAGA ERKEGEVAGL DMNISQFLKS LGLEHLRDIF ETEQITLDVL 1050
ADMGHEELKE IGINAYGHRH KLIKGVERLL GGQQGTNPYL TFHCVNQGTI 1100
LLDLAPEDKE YQSVEEEMQS TIREHRDGGN AGGIFNRYNV IRIQKVVNKK 1150
LRERFCHRQK EVSEENHNHH NERMLFHGSP FINAIIHKGF DERHAYIGGM 1200
FGAGIYFAEN SSKSNQYVYG IGGGTGCPTH KDRSCYICHR QMLFCRVTLG 1250
KSFLQFSTMK MAHAPPGHHS VIGRPSVNGL AYAEYVIYRG EQAYPEYLIT 1300
YQIMKPEAPS QTATAAEQKT 1320
Length:1,320
Mass (Da):140,944
Last modified:July 5, 2004 - v1
Checksum:iA90360DC665FFCC0
GO
Isoform 2 (identifier: Q6PFX9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.

Note: No experimental confirmation available.

Show »
Length:976
Mass (Da):106,651
Checksum:i8DE71F21652C3D4A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 344344Missing in isoform 2. VSP_041320Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti969 – 9691L → V in BAC33475. 1 Publication
Sequence conflicti1025 – 10251S → I in BAC33475. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK048860 mRNA. Translation: BAC33475.1.
AC122458 Genomic DNA. No translation available.
BC057370 mRNA. Translation: AAH57370.1.
CCDSiCCDS22242.1. [Q6PFX9-1]
RefSeqiNP_780300.2. NM_175091.3. [Q6PFX9-1]
UniGeneiMm.88364.

Genome annotation databases

EnsembliENSMUST00000033929; ENSMUSP00000033929; ENSMUSG00000031529. [Q6PFX9-1]
GeneIDi21951.
KEGGimmu:21951.
UCSCiuc009lku.1. mouse. [Q6PFX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK048860 mRNA. Translation: BAC33475.1 .
AC122458 Genomic DNA. No translation available.
BC057370 mRNA. Translation: AAH57370.1 .
CCDSi CCDS22242.1. [Q6PFX9-1 ]
RefSeqi NP_780300.2. NM_175091.3. [Q6PFX9-1 ]
UniGenei Mm.88364.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UTM X-ray 2.00 A/B 308-655 [» ]
4N4T X-ray 2.32 A/B 1097-1307 [» ]
ProteinModelPortali Q6PFX9.
SMRi Q6PFX9. Positions 316-635, 641-940, 1098-1307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204263. 2 interactions.
STRINGi 10090.ENSMUSP00000033929.

PTM databases

PhosphoSitei Q6PFX9.

Proteomic databases

PaxDbi Q6PFX9.
PRIDEi Q6PFX9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033929 ; ENSMUSP00000033929 ; ENSMUSG00000031529 . [Q6PFX9-1 ]
GeneIDi 21951.
KEGGi mmu:21951.
UCSCi uc009lku.1. mouse. [Q6PFX9-1 ]

Organism-specific databases

CTDi 8658.
MGIi MGI:1341087. Tnks.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00750000117662.
HOGENOMi HOG000246964.
HOVERGENi HBG059472.
InParanoidi Q8BX62.
KOi K10799.
OMAi DDKEYQS.
OrthoDBi EOG7N8ZTP.
PhylomeDBi Q6PFX9.
TreeFami TF326036.

Enzyme and pathway databases

Reactomei REACT_207044. TCF dependent signaling in response to WNT.
REACT_219129. degradation of AXIN.

Miscellaneous databases

NextBioi 301616.
PROi Q6PFX9.
SOURCEi Search...

Gene expression databases

Bgeei Q6PFX9.
Genevestigatori Q6PFX9.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.20. 6 hits.
3.90.228.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR028731. TNKS.
[Graphical view ]
PANTHERi PTHR24180:SF3. PTHR24180:SF3. 1 hit.
Pfami PF00023. Ank. 3 hits.
PF12796. Ank_2. 5 hits.
PF00644. PARP. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 17 hits.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 4 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 15 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiTNKS1_MOUSE
AccessioniPrimary (citable) accession number: Q6PFX9
Secondary accession number(s): Q8BX62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi