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Protein

Tankyrase-1

Gene

Tnks

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Enzyme regulationi

Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1227 – 12271ZincBy similarity
Metal bindingi1230 – 12301ZincBy similarity
Metal bindingi1235 – 12351ZincBy similarity
Metal bindingi1238 – 12381ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiREACT_275732. degradation of AXIN.
REACT_335672. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Recommended name:
Tankyrase-1 (EC:2.4.2.30)
Short name:
TANK1
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 5
Short name:
ARTD5
TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Short name:
Tankyrase I
Gene namesi
Name:Tnks
Synonyms:Tnks1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1341087. Tnks.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nuclear pore complex, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Tankyrase-1PRO_0000409511Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis (By similarity).By similarity
Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.By similarity
ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination (By similarity).By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6PFX9.
PaxDbiQ6PFX9.
PRIDEiQ6PFX9.

PTM databases

PhosphoSiteiQ6PFX9.

Expressioni

Gene expression databases

BgeeiQ6PFX9.
GenevisibleiQ6PFX9. MM.

Interactioni

Subunit structurei

Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. Interacts with AXIN1, AXIN2, BLZF1 and CASC3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204263. 2 interactions.
STRINGi10090.ENSMUSP00000033929.

Structurei

Secondary structure

1
1320
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi317 – 33822Combined sources
Helixi341 – 3477Combined sources
Turni350 – 3545Combined sources
Helixi365 – 3717Combined sources
Helixi375 – 3839Combined sources
Helixi398 – 4047Combined sources
Helixi408 – 4169Combined sources
Helixi431 – 4377Combined sources
Helixi441 – 4499Combined sources
Helixi464 – 4674Combined sources
Helixi471 – 49121Combined sources
Helixi495 – 5017Combined sources
Turni502 – 5043Combined sources
Turni512 – 5143Combined sources
Helixi518 – 5247Combined sources
Helixi530 – 53910Combined sources
Helixi554 – 5607Combined sources
Helixi564 – 5729Combined sources
Helixi587 – 5948Combined sources
Helixi597 – 6059Combined sources
Helixi620 – 6234Combined sources
Helixi626 – 6349Combined sources
Beta strandi1100 – 11034Combined sources
Helixi1109 – 112012Combined sources
Turni1126 – 11327Combined sources
Beta strandi1138 – 114710Combined sources
Helixi1149 – 116517Combined sources
Beta strandi1172 – 11776Combined sources
Helixi1182 – 11887Combined sources
Helixi1192 – 11943Combined sources
Beta strandi1203 – 12097Combined sources
Helixi1211 – 12155Combined sources
Turni1216 – 12194Combined sources
Helixi1221 – 12233Combined sources
Turni1228 – 12303Combined sources
Beta strandi1236 – 12383Combined sources
Beta strandi1240 – 12489Combined sources
Beta strandi1251 – 12566Combined sources
Beta strandi1269 – 12735Combined sources
Beta strandi1284 – 12885Combined sources
Helixi1290 – 12923Combined sources
Beta strandi1293 – 130311Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UTMX-ray2.00A/B308-655[»]
4N4TX-ray2.32A/B1097-1307[»]
ProteinModelPortaliQ6PFX9.
SMRiQ6PFX9. Positions 316-635, 641-940, 1098-1307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati174 – 20229ANK 1Add
BLAST
Repeati208 – 23730ANK 2Add
BLAST
Repeati241 – 27030ANK 3Add
BLAST
Repeati274 – 30330ANK 4Add
BLAST
Repeati361 – 39030ANK 5Add
BLAST
Repeati394 – 42330ANK 6Add
BLAST
Repeati427 – 45630ANK 7Add
BLAST
Repeati514 – 54633ANK 8Add
BLAST
Repeati550 – 57930ANK 9Add
BLAST
Repeati583 – 61230ANK 10Add
BLAST
Repeati676 – 70530ANK 11Add
BLAST
Repeati709 – 73830ANK 12Add
BLAST
Repeati742 – 77130ANK 13Add
BLAST
Repeati775 – 80329ANK 14Add
BLAST
Repeati829 – 85830ANK 15Add
BLAST
Repeati862 – 89130ANK 16Add
BLAST
Repeati895 – 92430ANK 17Add
BLAST
Repeati928 – 95730ANK 18Add
BLAST
Domaini1019 – 108264SAMPROSITE-ProRule annotationAdd
BLAST
Domaini1105 – 1310206PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 146Poly-His
Compositional biasi20 – 8364Pro-richAdd
BLAST
Compositional biasi112 – 1187Poly-Gly
Compositional biasi121 – 14626Ser-richAdd
BLAST

Sequence similaritiesi

Contains 18 ANK repeats.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118950.
HOGENOMiHOG000246964.
HOVERGENiHBG059472.
InParanoidiQ6PFX9.
KOiK10799.
OMAiDDKEYQS.
OrthoDBiEOG7N8ZTP.
PhylomeDBiQ6PFX9.
TreeFamiTF326036.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 6 hits.
3.90.228.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR028731. TNKS.
[Graphical view]
PANTHERiPTHR24180:SF3. PTHR24180:SF3. 1 hit.
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 5 hits.
PF00644. PARP. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 17 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 15 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PFX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGPTPASPTA
60 70 80 90 100
GGLAPFASPR HGLALPEGDG SRDPPDRPRS PDPVDGAVCT VAAPAAVPAA
110 120 130 140 150
SAAVGVAPTP AGGGGGGGNN SASSASSPTS SSSSSPSSPG SSLAESPEAA
160 170 180 190 200
GVGSTATLGA GAAGLGPGVP AVSGALRELL EACRNGDVSR VKRLVDAANV
210 220 230 240 250
NAKDMAGRKS SPLHFAAGFG RKDVVEHLLQ MGANVHARDD GGLIPLHNAC
260 270 280 290 300
SFGHAEVVSL LLCQGADPNA RDNWNYTPLH EAAIKGKIDV CIVLLQHGAD
310 320 330 340 350
PNIRNTDGKS ALDLADPSAK AVLTGEYKKD ELLEAARSGN EEKLMALLTP
360 370 380 390 400
LNVNCHASDG RKSTPLHLAA GYNRVRIVQL LLQHGADVHA KDKGGLVPLH
410 420 430 440 450
NACSYGHYEV TELLLKHGAC VNAMDLWQFT PLHEAASKNR VEVCSLLLSH
460 470 480 490 500
GADPTLVNCH GKSAVDMAPT PELRERLTYE FKGHSLLQAA READLAKVKK
510 520 530 540 550
TLALEIINFK QPQSHETALH CAVASLHPKR KQVAELLLRK GANVNEKNKD
560 570 580 590 600
FMTPLHVAAE RAHNDVMEVL HKHGAKMNAL DSLGQTALHR AALAGHLQTC
610 620 630 640 650
RLLLSYGSDP SIISLQGFTA AQMGNEAVQQ ILSESTPMRT SDVDYRLLEA
660 670 680 690 700
SKAGDLETVK QLCSPQNVNC RDLEGRHSTP LHFAAGYNRV SVVEYLLHHG
710 720 730 740 750
ADVHAKDKGG LVPLHNACSY GHYEVAELLV RHGASVNVAD LWKFTPLHEA
760 770 780 790 800
AAKGKYEICK LLLKHGADPT KKNRDGNTPL DLVKEGDTDI QDLLRGDAAL
810 820 830 840 850
LDAAKKGCLA RVQKLCTPEN INCRDTQGRN STPLHLAAGY NNLEVAEYLL
860 870 880 890 900
EHGADVNAQD KGGLIPLHNA ASYGHVDIAA LLIKYNTCVN ATDKWAFTPL
910 920 930 940 950
HEAAQKGRTQ LCALLLAHGA DPTMKNQEGQ TPLDLATADD IRALLIDAMP
960 970 980 990 1000
PEALPTCFKP QATVVSASLI SPASTPSCLS AASSIDNLTG PLTDLAVGGA
1010 1020 1030 1040 1050
SNAGDGAAGA ERKEGEVAGL DMNISQFLKS LGLEHLRDIF ETEQITLDVL
1060 1070 1080 1090 1100
ADMGHEELKE IGINAYGHRH KLIKGVERLL GGQQGTNPYL TFHCVNQGTI
1110 1120 1130 1140 1150
LLDLAPEDKE YQSVEEEMQS TIREHRDGGN AGGIFNRYNV IRIQKVVNKK
1160 1170 1180 1190 1200
LRERFCHRQK EVSEENHNHH NERMLFHGSP FINAIIHKGF DERHAYIGGM
1210 1220 1230 1240 1250
FGAGIYFAEN SSKSNQYVYG IGGGTGCPTH KDRSCYICHR QMLFCRVTLG
1260 1270 1280 1290 1300
KSFLQFSTMK MAHAPPGHHS VIGRPSVNGL AYAEYVIYRG EQAYPEYLIT
1310 1320
YQIMKPEAPS QTATAAEQKT
Length:1,320
Mass (Da):140,944
Last modified:July 5, 2004 - v1
Checksum:iA90360DC665FFCC0
GO
Isoform 2 (identifier: Q6PFX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.

Note: No experimental confirmation available.
Show »
Length:976
Mass (Da):106,651
Checksum:i8DE71F21652C3D4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti969 – 9691L → V in BAC33475 (PubMed:16141072).Curated
Sequence conflicti1025 – 10251S → I in BAC33475 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 344344Missing in isoform 2. 1 PublicationVSP_041320Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048860 mRNA. Translation: BAC33475.1.
AC122458 Genomic DNA. No translation available.
BC057370 mRNA. Translation: AAH57370.1.
CCDSiCCDS22242.1. [Q6PFX9-1]
RefSeqiNP_780300.2. NM_175091.3. [Q6PFX9-1]
UniGeneiMm.88364.

Genome annotation databases

EnsembliENSMUST00000033929; ENSMUSP00000033929; ENSMUSG00000031529. [Q6PFX9-1]
GeneIDi21951.
KEGGimmu:21951.
UCSCiuc009lku.1. mouse. [Q6PFX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048860 mRNA. Translation: BAC33475.1.
AC122458 Genomic DNA. No translation available.
BC057370 mRNA. Translation: AAH57370.1.
CCDSiCCDS22242.1. [Q6PFX9-1]
RefSeqiNP_780300.2. NM_175091.3. [Q6PFX9-1]
UniGeneiMm.88364.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UTMX-ray2.00A/B308-655[»]
4N4TX-ray2.32A/B1097-1307[»]
ProteinModelPortaliQ6PFX9.
SMRiQ6PFX9. Positions 316-635, 641-940, 1098-1307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204263. 2 interactions.
STRINGi10090.ENSMUSP00000033929.

Chemistry

BindingDBiQ6PFX9.
ChEMBLiCHEMBL3232702.

PTM databases

PhosphoSiteiQ6PFX9.

Proteomic databases

MaxQBiQ6PFX9.
PaxDbiQ6PFX9.
PRIDEiQ6PFX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033929; ENSMUSP00000033929; ENSMUSG00000031529. [Q6PFX9-1]
GeneIDi21951.
KEGGimmu:21951.
UCSCiuc009lku.1. mouse. [Q6PFX9-1]

Organism-specific databases

CTDi8658.
MGIiMGI:1341087. Tnks.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118950.
HOGENOMiHOG000246964.
HOVERGENiHBG059472.
InParanoidiQ6PFX9.
KOiK10799.
OMAiDDKEYQS.
OrthoDBiEOG7N8ZTP.
PhylomeDBiQ6PFX9.
TreeFamiTF326036.

Enzyme and pathway databases

ReactomeiREACT_275732. degradation of AXIN.
REACT_335672. TCF dependent signaling in response to WNT.

Miscellaneous databases

NextBioi301616.
PROiQ6PFX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PFX9.
GenevisibleiQ6PFX9. MM.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.20. 6 hits.
3.90.228.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR028731. TNKS.
[Graphical view]
PANTHERiPTHR24180:SF3. PTHR24180:SF3. 1 hit.
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 5 hits.
PF00644. PARP. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 17 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 15 hits.
PS51059. PARP_CATALYTIC. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiTNKS1_MOUSE
AccessioniPrimary (citable) accession number: Q6PFX9
Secondary accession number(s): Q8BX62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.