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Protein

Cadherin-24

Gene

Cdh24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-24
Gene namesi
Name:Cdh24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1928330 Cdh24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 603ExtracellularSequence analysisAdd BLAST559
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 781CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000032010023 – 44Sequence analysisAdd BLAST22
ChainiPRO_000032010145 – 781Cadherin-24Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ6PFX6
PRIDEiQ6PFX6

PTM databases

PhosphoSitePlusiQ6PFX6

Expressioni

Gene expression databases

BgeeiENSMUSG00000059674
CleanExiMM_CDH24

Interactioni

Subunit structurei

Associates with alpha-, beta- and delta-catenins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066005

Structurei

3D structure databases

ProteinModelPortaliQ6PFX6
SMRiQ6PFX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 150Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini151 – 259Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini260 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini375 – 479Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini479 – 592Cadherin 5PROSITE-ProRule annotationAdd BLAST114

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ6PFX6
KOiK06814
OMAiRVWHNLT
OrthoDBiEOG091G02RV
PhylomeDBiQ6PFX6
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.101 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PFX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGLVRLLLA WLGGWGCMGR LAAPVPAWAG SRGHSGPTLL RTRRSWVWNQ
60 70 80 90 100
FFVIEEYSGP EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN
110 120 130 140 150
IHVTKSLDRE EKAQYVLLAQ AVDRASNRPL EPPSEFIIKV QDINDNPPVF
160 170 180 190 200
PLGPYHATVP EMSNVGTSVI QVTAHDADDP SYGNSAKLVY TVLDGLPFFS
210 220 230 240 250
VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS GSTTVTVTLS
260 270 280 290 300
DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LKAQDPDLGD NALVAYSILN
310 320 330 340 350
GEGSEVFSIS TDSQGQDGLL TVRKPLDFET RRSYTFRVEA TNTLIDPAYL
360 370 380 390 400
RRGPFKDVAS VRVTVQDAPE PPAFTQATYH LAVPENKAPG TLVGQISASD
410 420 430 440 450
LDSPASPIRY SILPHSDPER CFSIEPEDGT IRTAVRLDRE ARVWHNLTIL
460 470 480 490 500
ATELDSSAQS SRVQVAIQTL DENDNAPQLA EPYDIFVCDS AAPGQLIKVI
510 520 530 540 550
RALDRDEVGN SSQVSLQGPV GPDANFTVRD NRDGSASLLL PSRPAPPRQA
560 570 580 590 600
PYLIPIELWD WGQPALSSTA TVTVSVCRCR PDGSMASCWP EAQLSPTGLS
610 620 630 640 650
TGALLAIVTC MGTLLALVVL FVALRRQKQE ALMVLEEEDV RENIITYDDE
660 670 680 690 700
GGGEEDTEAF DITALQNPDG AAPPAAGPPV RRDVLPRTRA PRQPRPPGPA
710 720 730 740 750
DVVQLLALRL READEDPSVP PYDSVQVYGY EGRGSSCGSL SSLGSGSEAG
760 770 780
GVPGPAEPLD DWGPLFRTLA ELYGAKEPPA P
Length:781
Mass (Da):84,104
Last modified:July 5, 2004 - v1
Checksum:i15996D6E6C9835AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057373 mRNA Translation: AAH57373.1
CCDSiCCDS36923.1
RefSeqiNP_955764.1, NM_199470.2
UniGeneiMm.386871

Genome annotation databases

EnsembliENSMUST00000067784; ENSMUSP00000066005; ENSMUSG00000059674
GeneIDi239096
KEGGimmu:239096
UCSCiuc011zlc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCAD24_MOUSE
AccessioniPrimary (citable) accession number: Q6PFX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome