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Protein

Cadherin-24

Gene

Cdh24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-24
Gene namesi
Name:Cdh24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1928330. Cdh24.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 603ExtracellularSequence analysisAdd BLAST559
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 781CytoplasmicSequence analysisAdd BLAST157

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000032010023 – 44Sequence analysisAdd BLAST22
ChainiPRO_000032010145 – 781Cadherin-24Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi446N-linked (GlcNAc...)Sequence analysis1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi525N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ6PFX6.
PRIDEiQ6PFX6.

PTM databases

PhosphoSitePlusiQ6PFX6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059674.
CleanExiMM_CDH24.

Interactioni

Subunit structurei

Associates with alpha-, beta- and delta-catenins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066005.

Structurei

3D structure databases

ProteinModelPortaliQ6PFX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 150Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini151 – 259Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini260 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini375 – 479Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini479 – 592Cadherin 5PROSITE-ProRule annotationAdd BLAST114

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ6PFX6.
KOiK06814.
OMAiRVWHNLT.
OrthoDBiEOG091G02RV.
PhylomeDBiQ6PFX6.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PFX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGLVRLLLA WLGGWGCMGR LAAPVPAWAG SRGHSGPTLL RTRRSWVWNQ
60 70 80 90 100
FFVIEEYSGP EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN
110 120 130 140 150
IHVTKSLDRE EKAQYVLLAQ AVDRASNRPL EPPSEFIIKV QDINDNPPVF
160 170 180 190 200
PLGPYHATVP EMSNVGTSVI QVTAHDADDP SYGNSAKLVY TVLDGLPFFS
210 220 230 240 250
VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS GSTTVTVTLS
260 270 280 290 300
DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LKAQDPDLGD NALVAYSILN
310 320 330 340 350
GEGSEVFSIS TDSQGQDGLL TVRKPLDFET RRSYTFRVEA TNTLIDPAYL
360 370 380 390 400
RRGPFKDVAS VRVTVQDAPE PPAFTQATYH LAVPENKAPG TLVGQISASD
410 420 430 440 450
LDSPASPIRY SILPHSDPER CFSIEPEDGT IRTAVRLDRE ARVWHNLTIL
460 470 480 490 500
ATELDSSAQS SRVQVAIQTL DENDNAPQLA EPYDIFVCDS AAPGQLIKVI
510 520 530 540 550
RALDRDEVGN SSQVSLQGPV GPDANFTVRD NRDGSASLLL PSRPAPPRQA
560 570 580 590 600
PYLIPIELWD WGQPALSSTA TVTVSVCRCR PDGSMASCWP EAQLSPTGLS
610 620 630 640 650
TGALLAIVTC MGTLLALVVL FVALRRQKQE ALMVLEEEDV RENIITYDDE
660 670 680 690 700
GGGEEDTEAF DITALQNPDG AAPPAAGPPV RRDVLPRTRA PRQPRPPGPA
710 720 730 740 750
DVVQLLALRL READEDPSVP PYDSVQVYGY EGRGSSCGSL SSLGSGSEAG
760 770 780
GVPGPAEPLD DWGPLFRTLA ELYGAKEPPA P
Length:781
Mass (Da):84,104
Last modified:July 5, 2004 - v1
Checksum:i15996D6E6C9835AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057373 mRNA. Translation: AAH57373.1.
CCDSiCCDS36923.1.
RefSeqiNP_955764.1. NM_199470.2.
UniGeneiMm.386871.

Genome annotation databases

EnsembliENSMUST00000067784; ENSMUSP00000066005; ENSMUSG00000059674.
GeneIDi239096.
KEGGimmu:239096.
UCSCiuc011zlc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057373 mRNA. Translation: AAH57373.1.
CCDSiCCDS36923.1.
RefSeqiNP_955764.1. NM_199470.2.
UniGeneiMm.386871.

3D structure databases

ProteinModelPortaliQ6PFX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066005.

PTM databases

PhosphoSitePlusiQ6PFX6.

Proteomic databases

PaxDbiQ6PFX6.
PRIDEiQ6PFX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067784; ENSMUSP00000066005; ENSMUSG00000059674.
GeneIDi239096.
KEGGimmu:239096.
UCSCiuc011zlc.1. mouse.

Organism-specific databases

CTDi64403.
MGIiMGI:1928330. Cdh24.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ6PFX6.
KOiK06814.
OMAiRVWHNLT.
OrthoDBiEOG091G02RV.
PhylomeDBiQ6PFX6.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PROiQ6PFX6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059674.
CleanExiMM_CDH24.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD24_MOUSE
AccessioniPrimary (citable) accession number: Q6PFX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.