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Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Gene

PPIP5K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.3 Publications

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

Kineticsi

The catalytic efficiency is 80 folds higher for 5-PP-InsP5 (InsP7) compared to InsP6.

  1. KM=0.12 µM for InsP63 Publications
  2. KM=0.10 µM for InsP73 Publications
  1. Vmax=0.03 nmol/min/mg enzyme with InsP6 as substrate3 Publications
  2. Vmax=0.13 nmol/min/mg enzyme with InsP7 as substrate3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei145ATPBy similarity1
Binding sitei198ATPBy similarity1
Binding sitei205ATPBy similarity1
Binding sitei224ATPBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei273SubstrateBy similarity1
Binding sitei275ATPBy similarity1
Binding sitei320ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 251ATPBy similarity4
Nucleotide bindingi257 – 259ATPBy similarity3
Nucleotide bindingi332 – 334ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS09822-MONOMER.
ZFISH:HS09822-MONOMER.
BRENDAi2.7.4.24. 2681.
ReactomeiR-HSA-1855167. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC:2.7.4.21, EC:2.7.4.24)
Alternative name(s):
Diphosphoinositol pentakisphosphate kinase 1
Histidine acid phosphatase domain-containing protein 2A
IP6 kinase
Inositol pyrophosphate synthase 1
InsP6 and PP-IP5 kinase 1
VIP1 homolog
Short name:
hsVIP1
Gene namesi
Name:PPIP5K1
Synonyms:HISPPD2A, IP6K, IPS1, KIAA0377, VIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29023. PPIP5K1.

Subcellular locationi

  • Cytoplasmcytosol 3 Publications
  • Cell membrane 1 Publication

  • Note: Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.1 Publication

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi399R → A: Decreases 8-fold the affinity for PtdIns(3,4,5)P3. 1 Publication1
Mutagenesisi417R → A: Decreases 16-fold the affinity for PtdIns(3,4,5)P3. 1 Publication1

Organism-specific databases

DisGeNETi9677.
OpenTargetsiENSG00000168781.
PharmGKBiPA165479401.

Chemistry databases

ChEMBLiCHEMBL5046.

Polymorphism and mutation databases

BioMutaiPPIP5K1.
DMDMi74758334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156881 – 1433Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1Add BLAST1433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei944PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Modified residuei1037PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PFW1.
MaxQBiQ6PFW1.
PaxDbiQ6PFW1.
PeptideAtlasiQ6PFW1.
PRIDEiQ6PFW1.

PTM databases

iPTMnetiQ6PFW1.
PhosphoSitePlusiQ6PFW1.

Expressioni

Tissue specificityi

Widely expressed, with a higher expression in skeletal muscle, heart and brain.1 Publication

Gene expression databases

BgeeiENSG00000168781.
ExpressionAtlasiQ6PFW1. baseline and differential.
GenevisibleiQ6PFW1. HS.

Organism-specific databases

HPAiHPA039380.

Interactioni

Protein-protein interaction databases

BioGridi115031. 10 interactors.
STRINGi9606.ENSP00000380129.

Structurei

3D structure databases

ProteinModelPortaliQ6PFW1.
SMRiQ6PFW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 65Substrate bindingBy similarity2
Regioni224 – 225Substrate bindingBy similarity2
Regioni337 – 340Substrate bindingBy similarity4
Regioni382 – 453Polyphosphoinositide-binding domain1 PublicationAdd BLAST72

Domaini

The C-terminal acid phosphatase-like domain binds PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the phosphatase domain of histidine acid phosphatases, it has no phosphatase activity.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1057. Eukaryota.
ENOG410XNSN. LUCA.
GeneTreeiENSGT00390000009048.
HOVERGENiHBG108657.
InParanoidiQ6PFW1.
KOiK13024.
OMAiMHSNQAS.
OrthoDBiEOG091G00ZU.
PhylomeDBiQ6PFW1.
TreeFamiTF313594.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 4 hits.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
IPR030138. PPIP5K1.
[Graphical view]
PANTHERiPTHR12750:SF11. PTHR12750:SF11. 1 hit.
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 3 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PFW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSLTASEGE STTAHFFLGA GDEGLGTRGI GMRPEESDSE LLEDEEDEVP
60 70 80 90 100
PEPQIIVGIC AMTKKSKSKP MTQILERLCR FDYLTVVILG EDVILNEPVE
110 120 130 140 150
NWPSCHCLIS FHSKGFPLDK AVAYSKLRNP FLINDLAMQY YIQDRREVYR
160 170 180 190 200
ILQEEGIDLP RYAVLNRDPA RPEECNLIEG EDQVEVNGAV FPKPFVEKPV
210 220 230 240 250
SAEDHNVYIY YPSSAGGGSQ RLFRKIGSRS SVYSPESSVR KTGSYIYEEF
260 270 280 290 300
MPTDGTDVKV YTVGPDYAHA EARKSPALDG KVERDSEGKE IRYPVMLTAM
310 320 330 340 350
EKLVARKVCV AFKQTVCGFD LLRANGHSFV CDVNGFSFVK NSMKYYDDCA
360 370 380 390 400
KILGNTIMRE LAPQFQIPWS IPTEAEDIPI VPTTSGTMME LRCVIAIIRH
410 420 430 440 450
GDRTPKQKMK MEVKHPRFFA LFEKHGGYKT GKLKLKRPEQ LQEVLDITRL
460 470 480 490 500
LLAELEKEPG GEIEEKTGKL EQLKSVLEMY GHFSGINRKV QLTYYPHGVK
510 520 530 540 550
ASNEGQDPQR ETLAPSLLLV LKWGGELTPA GRVQAEELGR AFRCMYPGGQ
560 570 580 590 600
GDYAGFPGCG LLRLHSTFRH DLKIYASDEG RVQMTAAAFA KGLLALEGEL
610 620 630 640 650
TPILVQMVKS ANMNGLLDSD GDSLSSCQHR VKARLHHILQ QDAPFGPEDY
660 670 680 690 700
DQLAPTRSTS LLNSMTIIQN PVKVCDQVFA LIENLTHQIR ERMQDPRSVD
710 720 730 740 750
LQLYHSETLE LMLQRWSKLE RDFRQKSGRY DISKIPDIYD CVKYDVQHNG
760 770 780 790 800
SLGLQGTAEL LRLSKALADV VIPQEYGISR EEKLEIAVGF CLPLLRKILL
810 820 830 840 850
DLQRTHEDES VNKLHPLCYL RYSRGVLSPG RHVRTRLYFT SESHVHSLLS
860 870 880 890 900
VFRYGGLLDE TQDAQWQRAL DYLSAISELN YMTQIVIMLY EDNTQDPLSE
910 920 930 940 950
ERFHVELHFS PGVKGVEEEG SAPAGCGFRP ASSENEEMKT NQGSMENLCP
960 970 980 990 1000
GKASDEPDRA LQTSPQPPEG PGLPRRSPLI RNRKAGSMEV LSETSSSRPG
1010 1020 1030 1040 1050
GYRLFSSSRP PTEMKQSGLG SQCTGLFSTT VLGGSSSAPN LQDYARSHGK
1060 1070 1080 1090 1100
KLPPASLKHR DELLFVPAVK RFSVSFAKHP TNGFEGCSMV PTIYPLETLH
1110 1120 1130 1140 1150
NALSLRQVSE FLSRVCQRHT DAQAQASAAL FDSMHSSQAS DNPFSPPRTL
1160 1170 1180 1190 1200
HSPPLQLQQR SEKPPWYSSG PSSTVSSAGP SSPTTVDGNS QFGFSDQPSL
1210 1220 1230 1240 1250
NSHVAEEHQG LGLLQETPGS GAQELSIEGE QELFEPNQSP QVPPMETSQP
1260 1270 1280 1290 1300
YEEVSQPCQE VPDISQPCQD ISEALSQPCQ KVPDISQQCQ ENHDNGNHTC
1310 1320 1330 1340 1350
QEVPHISQPC QKSSQLCQKV SEEVCQLCLE NSEEVSQPCQ GVSVEVGKLV
1360 1370 1380 1390 1400
HKFHVGVGSL VQETLVEVGS PAEEIPEEVI QPYQEFSVEV GRLAQETSAI
1410 1420 1430
NLLSQGIPEI DKPSQEFPEE IDLQAQEVPE EIN
Length:1,433
Mass (Da):159,521
Last modified:July 5, 2004 - v1
Checksum:iBA0DEFB2A71B1467
GO
Isoform 2 (identifier: Q6PFW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1082-1082: N → NG

Show »
Length:1,430
Mass (Da):159,042
Checksum:i11E6EC888FB5703C
GO
Isoform 3 (identifier: Q6PFW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1062-1082: Missing.

Show »
Length:1,408
Mass (Da):156,616
Checksum:iE88E96597599F5BA
GO
Isoform 4 (identifier: Q6PFW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     653-653: Missing.
     818-821: Missing.
     1062-1082: Missing.

Show »
Length:1,407
Mass (Da):156,502
Checksum:i1DC5FCBF5A726F14
GO
Isoform 5 (identifier: Q6PFW1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-821: Missing.
     865-957: Missing.
     1107-1240: Missing.

Show »
Length:1,194
Mass (Da):133,447
Checksum:iF29D866BFAD98841
GO
Isoform 6 (identifier: Q6PFW1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-1433: Missing.

Note: No experimental confirmation available.
Show »
Length:817
Mass (Da):92,061
Checksum:i4DBCE9B366905530
GO
Isoform 7 (identifier: Q6PFW1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     818-821: Missing.
     1020-1082: Missing.
     1167-1167: Y → LETRFCHVGQAGLELLTSSDLPASASQSAGITGVSHRTQPD

Note: No experimental confirmation available.
Show »
Length:1,406
Mass (Da):156,320
Checksum:i77C01F2E2AC7446D
GO

Sequence cautioni

The sequence BAA20831 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44D → G in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti304V → M in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti374E → V in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti423E → Q in AAP30843 (PubMed:12825070).Curated1
Sequence conflicti423E → Q in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti423E → Q in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti473L → P in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti483F → S in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti483F → S in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti490V → E in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti548G → V in CAD97968 (PubMed:17974005).Curated1
Sequence conflicti738I → L in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti738I → L in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti788V → A in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti788V → A in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti936E → G in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti985A → V in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti985A → V in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1020G → A in AAP30843 (PubMed:12825070).Curated1
Sequence conflicti1041L → P in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1041L → P in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1066V → L in AAP30842 (PubMed:12825070).Curated1
Sequence conflicti1126A → T in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1134M → V in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1198P → R in CAI46011 (PubMed:17974005).Curated1
Sequence conflicti1293H → M in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1293H → M in AAN40768 (PubMed:12825070).Curated1
Sequence conflicti1294D → T in AAP30845 (PubMed:12825070).Curated1
Sequence conflicti1294D → T in AAN40768 (PubMed:12825070).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030615653Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_030616810 – 821Missing in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030617818 – 1433Missing in isoform 6. 1 PublicationAdd BLAST616
Alternative sequenceiVSP_030618818 – 821Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 3 Publications4
Alternative sequenceiVSP_030619865 – 957Missing in isoform 5. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0306201020 – 1082Missing in isoform 7. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_0306211062 – 1082Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0306221082N → NG in isoform 2. 1 Publication1
Alternative sequenceiVSP_0306231107 – 1240Missing in isoform 5. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_0306241167Y → LETRFCHVGQAGLELLTSSD LPASASQSAGITGVSHRTQP D in isoform 7. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502586 mRNA. Translation: AAP30842.1.
AF502587 mRNA. Translation: AAP30843.1.
AF502588 mRNA. Translation: AAP30844.1.
AF502589 mRNA. Translation: AAP30845.1.
AF543190 mRNA. Translation: AAN40768.1.
AB002375 mRNA. Translation: BAA20831.2. Different initiation.
BX538022 mRNA. Translation: CAD97968.1.
BX647814 mRNA. Translation: CAI46011.1.
BC050263 mRNA. Translation: AAH50263.1.
BC057395 mRNA. Translation: AAH57395.1.
CCDSiCCDS32215.1. [Q6PFW1-3]
CCDS45252.1. [Q6PFW1-1]
CCDS53937.1. [Q6PFW1-7]
RefSeqiNP_001124330.1. NM_001130858.2. [Q6PFW1-1]
NP_001124331.1. NM_001130859.2. [Q6PFW1-3]
NP_001177143.1. NM_001190214.1. [Q6PFW1-7]
NP_055474.3. NM_014659.5. [Q6PFW1-3]
XP_005254861.1. XM_005254804.1. [Q6PFW1-3]
XP_016878237.1. XM_017022748.1. [Q6PFW1-3]
XP_016878238.1. XM_017022749.1. [Q6PFW1-3]
XP_016878239.1. XM_017022750.1. [Q6PFW1-3]
XP_016878240.1. XM_017022751.1. [Q6PFW1-3]
XP_016878248.1. XM_017022759.1. [Q6PFW1-6]
UniGeneiHs.156814.
Hs.679105.
Hs.679911.

Genome annotation databases

EnsembliENST00000334933; ENSP00000334779; ENSG00000168781. [Q6PFW1-3]
ENST00000348806; ENSP00000308773; ENSG00000168781. [Q6PFW1-7]
ENST00000360135; ENSP00000353253; ENSG00000168781. [Q6PFW1-7]
ENST00000360301; ENSP00000353446; ENSG00000168781. [Q6PFW1-3]
ENST00000396923; ENSP00000380129; ENSG00000168781. [Q6PFW1-1]
ENST00000420765; ENSP00000400887; ENSG00000168781. [Q6PFW1-1]
GeneIDi9677.
KEGGihsa:9677.
UCSCiuc001zrw.3. human. [Q6PFW1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502586 mRNA. Translation: AAP30842.1.
AF502587 mRNA. Translation: AAP30843.1.
AF502588 mRNA. Translation: AAP30844.1.
AF502589 mRNA. Translation: AAP30845.1.
AF543190 mRNA. Translation: AAN40768.1.
AB002375 mRNA. Translation: BAA20831.2. Different initiation.
BX538022 mRNA. Translation: CAD97968.1.
BX647814 mRNA. Translation: CAI46011.1.
BC050263 mRNA. Translation: AAH50263.1.
BC057395 mRNA. Translation: AAH57395.1.
CCDSiCCDS32215.1. [Q6PFW1-3]
CCDS45252.1. [Q6PFW1-1]
CCDS53937.1. [Q6PFW1-7]
RefSeqiNP_001124330.1. NM_001130858.2. [Q6PFW1-1]
NP_001124331.1. NM_001130859.2. [Q6PFW1-3]
NP_001177143.1. NM_001190214.1. [Q6PFW1-7]
NP_055474.3. NM_014659.5. [Q6PFW1-3]
XP_005254861.1. XM_005254804.1. [Q6PFW1-3]
XP_016878237.1. XM_017022748.1. [Q6PFW1-3]
XP_016878238.1. XM_017022749.1. [Q6PFW1-3]
XP_016878239.1. XM_017022750.1. [Q6PFW1-3]
XP_016878240.1. XM_017022751.1. [Q6PFW1-3]
XP_016878248.1. XM_017022759.1. [Q6PFW1-6]
UniGeneiHs.156814.
Hs.679105.
Hs.679911.

3D structure databases

ProteinModelPortaliQ6PFW1.
SMRiQ6PFW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115031. 10 interactors.
STRINGi9606.ENSP00000380129.

Chemistry databases

ChEMBLiCHEMBL5046.

PTM databases

iPTMnetiQ6PFW1.
PhosphoSitePlusiQ6PFW1.

Polymorphism and mutation databases

BioMutaiPPIP5K1.
DMDMi74758334.

Proteomic databases

EPDiQ6PFW1.
MaxQBiQ6PFW1.
PaxDbiQ6PFW1.
PeptideAtlasiQ6PFW1.
PRIDEiQ6PFW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334933; ENSP00000334779; ENSG00000168781. [Q6PFW1-3]
ENST00000348806; ENSP00000308773; ENSG00000168781. [Q6PFW1-7]
ENST00000360135; ENSP00000353253; ENSG00000168781. [Q6PFW1-7]
ENST00000360301; ENSP00000353446; ENSG00000168781. [Q6PFW1-3]
ENST00000396923; ENSP00000380129; ENSG00000168781. [Q6PFW1-1]
ENST00000420765; ENSP00000400887; ENSG00000168781. [Q6PFW1-1]
GeneIDi9677.
KEGGihsa:9677.
UCSCiuc001zrw.3. human. [Q6PFW1-1]

Organism-specific databases

CTDi9677.
DisGeNETi9677.
GeneCardsiPPIP5K1.
H-InvDBHIX0012186.
HGNCiHGNC:29023. PPIP5K1.
HPAiHPA039380.
MIMi610979. gene.
neXtProtiNX_Q6PFW1.
OpenTargetsiENSG00000168781.
PharmGKBiPA165479401.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1057. Eukaryota.
ENOG410XNSN. LUCA.
GeneTreeiENSGT00390000009048.
HOVERGENiHBG108657.
InParanoidiQ6PFW1.
KOiK13024.
OMAiMHSNQAS.
OrthoDBiEOG091G00ZU.
PhylomeDBiQ6PFW1.
TreeFamiTF313594.

Enzyme and pathway databases

BioCyciMetaCyc:HS09822-MONOMER.
ZFISH:HS09822-MONOMER.
BRENDAi2.7.4.24. 2681.
ReactomeiR-HSA-1855167. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

GenomeRNAii9677.
PROiQ6PFW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168781.
ExpressionAtlasiQ6PFW1. baseline and differential.
GenevisibleiQ6PFW1. HS.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 4 hits.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
IPR030138. PPIP5K1.
[Graphical view]
PANTHERiPTHR12750:SF11. PTHR12750:SF11. 1 hit.
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 3 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIP1_HUMAN
AccessioniPrimary (citable) accession number: Q6PFW1
Secondary accession number(s): O15082
, Q5HYF8, Q7Z3A7, Q86TE7, Q86UV3, Q86UV4, Q86XW8, Q8IZN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.