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Protein

Transformer-2 protein homolog alpha

Gene

Tra2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transformer-2 protein homolog alpha
Short name:
TRA-2 alpha
Short name:
TRA2-alpha
Alternative name(s):
Transformer-2 protein homolog A
Gene namesi
Name:Tra2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1933972. Tra2a.

Subcellular locationi

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 281280Transformer-2 protein homolog alphaPRO_0000081982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei24 – 241PhosphothreonineBy similarity
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei80 – 801PhosphoserineBy similarity
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei86 – 861PhosphothreonineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineBy similarity
Modified residuei98 – 981PhosphoserineBy similarity
Modified residuei200 – 2001PhosphothreonineBy similarity
Modified residuei202 – 2021PhosphothreonineBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei256 – 2561Dimethylated arginineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ6PFR5.
MaxQBiQ6PFR5.
PaxDbiQ6PFR5.
PeptideAtlasiQ6PFR5.
PRIDEiQ6PFR5.

PTM databases

iPTMnetiQ6PFR5.
PhosphoSiteiQ6PFR5.

Expressioni

Gene expression databases

CleanExiMM_TRA2A.

Interactioni

Subunit structurei

Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-913075,EBI-913075
Nol3Q9D1X04EBI-913075,EBI-913097
Srsf7Q8BL974EBI-913075,EBI-913123

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiQ6PFR5. 4 interactions.
MINTiMINT-4138392.
STRINGi10090.ENSMUSP00000031841.

Structurei

3D structure databases

ProteinModelPortaliQ6PFR5.
SMRiQ6PFR5. Positions 108-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 19579RRMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 22328LinkerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 11081Arg/Ser-rich (RS1 domain)Add
BLAST
Compositional biasi224 – 28158Arg/Ser-rich (RS2 domain)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQWZ. Eukaryota.
ENOG4111HSX. LUCA.
HOGENOMiHOG000276232.
HOVERGENiHBG102125.
InParanoidiQ6PFR5.
PhylomeDBiQ6PFR5.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PFR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVEENNFE GRESRSQSKS PTGTPARVKS ESRSGSRSPS RVSKHSESHS
60 70 80 90 100
RSRSKSRSRS RRHSHRRYTR SRSHSHRRRS RSRSYTPEYR RRRSRSHSPM
110 120 130 140 150
SNRRRHTGSR ANPDPNTCLG VFGLSLYTTE RDLREVFSRY GPLSGVNVVY
160 170 180 190 200
DQRTGRSRGF AFVYFERIDD SKEAMERANG MELDGRRIRV DYSITKRAHT
210 220 230 240 250
PTPGIYMGRP THSGGGGGGG GGGGGGGGGG GGRRRDSYYD RGYDRGYDRY
260 270 280
EDYDYRRRSP SPYYSRYRSR SRSRSYSPRR Y
Length:281
Mass (Da):32,316
Last modified:July 5, 2004 - v1
Checksum:i8074C89D4494D7F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057448 mRNA. Translation: AAH57448.1.
UniGeneiMm.196598.

Genome annotation databases

UCSCiuc009bwm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057448 mRNA. Translation: AAH57448.1.
UniGeneiMm.196598.

3D structure databases

ProteinModelPortaliQ6PFR5.
SMRiQ6PFR5. Positions 108-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PFR5. 4 interactions.
MINTiMINT-4138392.
STRINGi10090.ENSMUSP00000031841.

PTM databases

iPTMnetiQ6PFR5.
PhosphoSiteiQ6PFR5.

Proteomic databases

EPDiQ6PFR5.
MaxQBiQ6PFR5.
PaxDbiQ6PFR5.
PeptideAtlasiQ6PFR5.
PRIDEiQ6PFR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009bwm.1. mouse.

Organism-specific databases

MGIiMGI:1933972. Tra2a.

Phylogenomic databases

eggNOGiENOG410IQWZ. Eukaryota.
ENOG4111HSX. LUCA.
HOGENOMiHOG000276232.
HOVERGENiHBG102125.
InParanoidiQ6PFR5.
PhylomeDBiQ6PFR5.

Miscellaneous databases

ChiTaRSiTra2a. mouse.
PROiQ6PFR5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRA2A.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiTRA2A_MOUSE
AccessioniPrimary (citable) accession number: Q6PFR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.