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Q6PFQ2

- EIF3C_DANRE

UniProt

Q6PFQ2 - EIF3C_DANRE

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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene
eif3c, eif3s8
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
  3. translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit C
Short name:
eIF3c
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8
Gene namesi
Name:eif3c
Synonyms:eif3s8
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-6166. eif3c.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Eukaryotic translation initiation factor 3 subunit CUniRule annotationPRO_0000365377Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6PFQ2.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m By similarity.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011344.

Structurei

3D structure databases

ProteinModelPortaliQ6PFQ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini711 – 845135PCIAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.
Contains 1 PCI domain.

Phylogenomic databases

eggNOGiNOG305883.
HOGENOMiHOG000029414.
HOVERGENiHBG035174.
InParanoidiQ6PFQ2.
KOiK03252.
PhylomeDBiQ6PFQ2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c.
InterProiIPR016024. ARM-type_fold.
IPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6PFQ2-1 [UniParc]FASTAAdd to Basket

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MSRFFATGSD SESEESSSAD EITPKAAGTT LRQQALLLSD DEEDTKRVVR    50
SAKDKRFEEL TNLIKTIRNA IKIRGISKCL EEFEQLCRAF VKSKTIVDKE 100
GVPKFYIRLL ADLEDYLNQL WEDKEGKKKM NKNNAKALST LRQKIRKYNR 150
DFETEIASYK ENPEQSADEE EEKDDIGSGS SESDDDDDDD ITAKSFMKKK 200
PQEEEKKAPE ASKFLKGAAD EESESDDDED SEDWASDSVG SDSESEDNDG 250
TAASLAVVFL KKDVGEKASD RKKDDRRRRH KKKERIEEEA EEEGEAEEGG 300
WEKVKGGVPL VKEKPKMFAK GTEINTGVVV KKLSEILQAR GKKGTDRAAQ 350
IELLHALAGI AAENNLGEGI LVKIKFNIIA SLYDYNPNLA AFMKADMWKK 400
CLDCIDELLD ILFNNNNIFI GENIAEDSEN LAISDQPFRV RGCILTLVER 450
MDEEFTKIMQ NTDPHSQEYV DNLKDEGRVC GIIDRLLQYL ETKGSTEEVC 500
RVYLRRIMHT YYKFDYKAHR RSLGLQGETK SEQDQEESEG DDSAIIMDRL 550
CKFIYAKDRT DRIRTCAILC HIYHHALHSR WYQARDLMLM SHLQDNIQHA 600
DPPVQILYNR TMVQLGICAF RQGMIKDAHN ALLDIQSSGR AKELLGQGLL 650
MRNMQERNAE QEKIEKRRQV PFHMHINLEL LECVYLVSAM LLEIPYMAAH 700
EFDARRRMIS KQFHHQLRVG ERQPLLGPPE SMREHVVAAS KAMKMGDWRT 750
CHSFIINEKM NSKVWDLFPE AKCVREMLVR KIQEESLRTY LFTYSSVYDS 800
ISMETLSEMF ELELPTVHSI ISKMIINEEL MASLDQPTQT VVMHRTEPTS 850
LQNMALQLAE KLGGLVENNE RVFDLKQGVY GGYFNRDQKG GYQQKQGYQR 900
GDQKGGYQQK QNYQRGGYRN QNQSSY 926
Length:926
Mass (Da):106,367
Last modified:July 5, 2004 - v1
Checksum:i199924DE6CB9E545
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057465 mRNA. Translation: AAH57465.1.
RefSeqiNP_998628.1. NM_213463.1.
UniGeneiDr.75672.

Genome annotation databases

GeneIDi334234.
KEGGidre:334234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057465 mRNA. Translation: AAH57465.1 .
RefSeqi NP_998628.1. NM_213463.1.
UniGenei Dr.75672.

3D structure databases

ProteinModelPortali Q6PFQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000011344.

Proteomic databases

PRIDEi Q6PFQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 334234.
KEGGi dre:334234.

Organism-specific databases

CTDi 8663.
ZFINi ZDB-GENE-030131-6166. eif3c.

Phylogenomic databases

eggNOGi NOG305883.
HOGENOMi HOG000029414.
HOVERGENi HBG035174.
InParanoidi Q6PFQ2.
KOi K03252.
PhylomeDBi Q6PFQ2.

Miscellaneous databases

NextBioi 20810318.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03002. eIF3c.
InterProi IPR016024. ARM-type_fold.
IPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
  2. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
    Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
    J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiEIF3C_DANRE
AccessioniPrimary (citable) accession number: Q6PFQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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