Q6PFQ2 (EIF3C_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 3 subunit C
Short name=eIF3c

Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8

Gene names

Name:	eif3c
Synonyms:	eif3s8

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	926 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03002
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eIF-3 subunit C family. Contains 1 PCI domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translational initiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	eukaryotic translation initiation factor 3 complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 926	926	Eukaryotic translation initiation factor 3 subunit C HAMAP-Rule MF_03002		PRO_0000365377
Regions
	Domain	711 – 845	135	PCI

Sequences

	Sequence		Length	Mass (Da)
	Q6PFQ2 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 199924DE6CB9E545	FASTA	926	106,367
	10 20 30 40 50 60 MSRFFATGSD SESEESSSAD EITPKAAGTT LRQQALLLSD DEEDTKRVVR SAKDKRFEEL 70 80 90 100 110 120 TNLIKTIRNA IKIRGISKCL EEFEQLCRAF VKSKTIVDKE GVPKFYIRLL ADLEDYLNQL 130 140 150 160 170 180 WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFETEIASYK ENPEQSADEE EEKDDIGSGS 190 200 210 220 230 240 SESDDDDDDD ITAKSFMKKK PQEEEKKAPE ASKFLKGAAD EESESDDDED SEDWASDSVG 250 260 270 280 290 300 SDSESEDNDG TAASLAVVFL KKDVGEKASD RKKDDRRRRH KKKERIEEEA EEEGEAEEGG 310 320 330 340 350 360 WEKVKGGVPL VKEKPKMFAK GTEINTGVVV KKLSEILQAR GKKGTDRAAQ IELLHALAGI 370 380 390 400 410 420 AAENNLGEGI LVKIKFNIIA SLYDYNPNLA AFMKADMWKK CLDCIDELLD ILFNNNNIFI 430 440 450 460 470 480 GENIAEDSEN LAISDQPFRV RGCILTLVER MDEEFTKIMQ NTDPHSQEYV DNLKDEGRVC 490 500 510 520 530 540 GIIDRLLQYL ETKGSTEEVC RVYLRRIMHT YYKFDYKAHR RSLGLQGETK SEQDQEESEG 550 560 570 580 590 600 DDSAIIMDRL CKFIYAKDRT DRIRTCAILC HIYHHALHSR WYQARDLMLM SHLQDNIQHA 610 620 630 640 650 660 DPPVQILYNR TMVQLGICAF RQGMIKDAHN ALLDIQSSGR AKELLGQGLL MRNMQERNAE 670 680 690 700 710 720 QEKIEKRRQV PFHMHINLEL LECVYLVSAM LLEIPYMAAH EFDARRRMIS KQFHHQLRVG 730 740 750 760 770 780 ERQPLLGPPE SMREHVVAAS KAMKMGDWRT CHSFIINEKM NSKVWDLFPE AKCVREMLVR 790 800 810 820 830 840 KIQEESLRTY LFTYSSVYDS ISMETLSEMF ELELPTVHSI ISKMIINEEL MASLDQPTQT 850 860 870 880 890 900 VVMHRTEPTS LQNMALQLAE KLGGLVENNE RVFDLKQGVY GGYFNRDQKG GYQQKQGYQR 910 920 GDQKGGYQQK QNYQRGGYRN QNQSSY

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: AB.
[2]	"Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo." Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R. J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC057465 mRNA. Translation: AAH57465.1.
IPI	IPI00494510.
RefSeq	NP_998628.1. NM_213463.1.
UniGene	Dr.75672.
3D structure databases
ProteinModelPortal	Q6PFQ2.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000011344.
Proteomic databases
PRIDE	Q6PFQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	334234.
KEGG	dre:334234.
Organism-specific databases
CTD	8663.
ZFIN	ZDB-GENE-030131-6166. eif3c.
Phylogenomic databases
eggNOG	NOG305883.
HOGENOM	HOG000029414.
HOVERGEN	HBG035174.
InParanoid	Q6PFQ2.
KO	K03252.
OrthoDB	EOG4NVZJQ.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
HAMAP	MF_03002. eIF3c.
InterPro	IPR008905. eIF3c_N. IPR000717. PCI_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF05470. eIF-3c_N. 1 hit. PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20810318.

Entry information

Entry name

EIF3C_DANRE

Accession

Primary (citable) accession number: Q6PFQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program