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Q6PFQ2

- EIF3C_DANRE

UniProt

Q6PFQ2 - EIF3C_DANRE

Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

eif3c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    2. regulation of translational initiation Source: UniProtKB-HAMAP
    3. translational initiation Source: UniProtKB

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit CUniRule annotation
    Short name:
    eIF3cUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
    Gene namesi
    Name:eif3c
    Synonyms:eif3s8
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-030131-6166. eif3c.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 926926Eukaryotic translation initiation factor 3 subunit CPRO_0000365377Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ6PFQ2.

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.UniRule annotation

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000011344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PFQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini711 – 845135PCIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit C family.UniRule annotation
    Contains 1 PCI domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG305883.
    HOGENOMiHOG000029414.
    HOVERGENiHBG035174.
    InParanoidiQ6PFQ2.
    KOiK03252.
    PhylomeDBiQ6PFQ2.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_03002. eIF3c.
    InterProiIPR016024. ARM-type_fold.
    IPR027516. EIF3C.
    IPR008905. EIF3C_N_dom.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05470. eIF-3c_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view]
    SMARTiSM00088. PINT. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6PFQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRFFATGSD SESEESSSAD EITPKAAGTT LRQQALLLSD DEEDTKRVVR    50
    SAKDKRFEEL TNLIKTIRNA IKIRGISKCL EEFEQLCRAF VKSKTIVDKE 100
    GVPKFYIRLL ADLEDYLNQL WEDKEGKKKM NKNNAKALST LRQKIRKYNR 150
    DFETEIASYK ENPEQSADEE EEKDDIGSGS SESDDDDDDD ITAKSFMKKK 200
    PQEEEKKAPE ASKFLKGAAD EESESDDDED SEDWASDSVG SDSESEDNDG 250
    TAASLAVVFL KKDVGEKASD RKKDDRRRRH KKKERIEEEA EEEGEAEEGG 300
    WEKVKGGVPL VKEKPKMFAK GTEINTGVVV KKLSEILQAR GKKGTDRAAQ 350
    IELLHALAGI AAENNLGEGI LVKIKFNIIA SLYDYNPNLA AFMKADMWKK 400
    CLDCIDELLD ILFNNNNIFI GENIAEDSEN LAISDQPFRV RGCILTLVER 450
    MDEEFTKIMQ NTDPHSQEYV DNLKDEGRVC GIIDRLLQYL ETKGSTEEVC 500
    RVYLRRIMHT YYKFDYKAHR RSLGLQGETK SEQDQEESEG DDSAIIMDRL 550
    CKFIYAKDRT DRIRTCAILC HIYHHALHSR WYQARDLMLM SHLQDNIQHA 600
    DPPVQILYNR TMVQLGICAF RQGMIKDAHN ALLDIQSSGR AKELLGQGLL 650
    MRNMQERNAE QEKIEKRRQV PFHMHINLEL LECVYLVSAM LLEIPYMAAH 700
    EFDARRRMIS KQFHHQLRVG ERQPLLGPPE SMREHVVAAS KAMKMGDWRT 750
    CHSFIINEKM NSKVWDLFPE AKCVREMLVR KIQEESLRTY LFTYSSVYDS 800
    ISMETLSEMF ELELPTVHSI ISKMIINEEL MASLDQPTQT VVMHRTEPTS 850
    LQNMALQLAE KLGGLVENNE RVFDLKQGVY GGYFNRDQKG GYQQKQGYQR 900
    GDQKGGYQQK QNYQRGGYRN QNQSSY 926
    Length:926
    Mass (Da):106,367
    Last modified:July 5, 2004 - v1
    Checksum:i199924DE6CB9E545
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057465 mRNA. Translation: AAH57465.1.
    RefSeqiNP_998628.1. NM_213463.1.
    UniGeneiDr.75672.

    Genome annotation databases

    GeneIDi334234.
    KEGGidre:334234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057465 mRNA. Translation: AAH57465.1 .
    RefSeqi NP_998628.1. NM_213463.1.
    UniGenei Dr.75672.

    3D structure databases

    ProteinModelPortali Q6PFQ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000011344.

    Proteomic databases

    PRIDEi Q6PFQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 334234.
    KEGGi dre:334234.

    Organism-specific databases

    CTDi 8663.
    ZFINi ZDB-GENE-030131-6166. eif3c.

    Phylogenomic databases

    eggNOGi NOG305883.
    HOGENOMi HOG000029414.
    HOVERGENi HBG035174.
    InParanoidi Q6PFQ2.
    KOi K03252.
    PhylomeDBi Q6PFQ2.

    Miscellaneous databases

    NextBioi 20810318.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_03002. eIF3c.
    InterProi IPR016024. ARM-type_fold.
    IPR027516. EIF3C.
    IPR008905. EIF3C_N_dom.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05470. eIF-3c_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view ]
    SMARTi SM00088. PINT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.
    2. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
      Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
      J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiEIF3C_DANRE
    AccessioniPrimary (citable) accession number: Q6PFQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3