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Q6PFQ2 (EIF3C_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 3 subunit C

Short name=eIF3c
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8
Gene names
Name:eif3c
Synonyms:eif3s8
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03002

Subunit structure

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03002.

Sequence similarities

Belongs to the eIF-3 subunit C family.

Contains 1 PCI domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 926926Eukaryotic translation initiation factor 3 subunit C HAMAP-Rule MF_03002
PRO_0000365377

Regions

Domain711 – 845135PCI

Sequences

Sequence LengthMass (Da)Tools
Q6PFQ2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 199924DE6CB9E545

FASTA926106,367
        10         20         30         40         50         60 
MSRFFATGSD SESEESSSAD EITPKAAGTT LRQQALLLSD DEEDTKRVVR SAKDKRFEEL 

        70         80         90        100        110        120 
TNLIKTIRNA IKIRGISKCL EEFEQLCRAF VKSKTIVDKE GVPKFYIRLL ADLEDYLNQL 

       130        140        150        160        170        180 
WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFETEIASYK ENPEQSADEE EEKDDIGSGS 

       190        200        210        220        230        240 
SESDDDDDDD ITAKSFMKKK PQEEEKKAPE ASKFLKGAAD EESESDDDED SEDWASDSVG 

       250        260        270        280        290        300 
SDSESEDNDG TAASLAVVFL KKDVGEKASD RKKDDRRRRH KKKERIEEEA EEEGEAEEGG 

       310        320        330        340        350        360 
WEKVKGGVPL VKEKPKMFAK GTEINTGVVV KKLSEILQAR GKKGTDRAAQ IELLHALAGI 

       370        380        390        400        410        420 
AAENNLGEGI LVKIKFNIIA SLYDYNPNLA AFMKADMWKK CLDCIDELLD ILFNNNNIFI 

       430        440        450        460        470        480 
GENIAEDSEN LAISDQPFRV RGCILTLVER MDEEFTKIMQ NTDPHSQEYV DNLKDEGRVC 

       490        500        510        520        530        540 
GIIDRLLQYL ETKGSTEEVC RVYLRRIMHT YYKFDYKAHR RSLGLQGETK SEQDQEESEG 

       550        560        570        580        590        600 
DDSAIIMDRL CKFIYAKDRT DRIRTCAILC HIYHHALHSR WYQARDLMLM SHLQDNIQHA 

       610        620        630        640        650        660 
DPPVQILYNR TMVQLGICAF RQGMIKDAHN ALLDIQSSGR AKELLGQGLL MRNMQERNAE 

       670        680        690        700        710        720 
QEKIEKRRQV PFHMHINLEL LECVYLVSAM LLEIPYMAAH EFDARRRMIS KQFHHQLRVG 

       730        740        750        760        770        780 
ERQPLLGPPE SMREHVVAAS KAMKMGDWRT CHSFIINEKM NSKVWDLFPE AKCVREMLVR 

       790        800        810        820        830        840 
KIQEESLRTY LFTYSSVYDS ISMETLSEMF ELELPTVHSI ISKMIINEEL MASLDQPTQT 

       850        860        870        880        890        900 
VVMHRTEPTS LQNMALQLAE KLGGLVENNE RVFDLKQGVY GGYFNRDQKG GYQQKQGYQR 

       910        920 
GDQKGGYQQK QNYQRGGYRN QNQSSY 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.
[2]"Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC057465 mRNA. Translation: AAH57465.1.
RefSeqNP_998628.1. NM_213463.1.
UniGeneDr.75672.

3D structure databases

ProteinModelPortalQ6PFQ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000011344.

Proteomic databases

PRIDEQ6PFQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID334234.
KEGGdre:334234.

Organism-specific databases

CTD8663.
ZFINZDB-GENE-030131-6166. eif3c.

Phylogenomic databases

eggNOGNOG305883.
HOGENOMHOG000029414.
HOVERGENHBG035174.
InParanoidQ6PFQ2.
KOK03252.
PhylomeDBQ6PFQ2.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_03002. eIF3c.
InterProIPR016024. ARM-type_fold.
IPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
ProtoNetSearch...

Other

NextBio20810318.

Entry information

Entry nameEIF3C_DANRE
AccessionPrimary (citable) accession number: Q6PFQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries