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Protein

NADPH-dependent diflavin oxidoreductase 1

Gene

ndor1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of ciapin1.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotation
  • FMNUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321FMNUniRule annotation
Binding sitei348 – 3481FADUniRule annotation
Binding sitei458 – 4581NADPUniRule annotation
Binding sitei594 – 5941FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176FMNUniRule annotation
Nucleotide bindingi59 – 624FMNUniRule annotation
Nucleotide bindingi97 – 10610FMNUniRule annotation
Nucleotide bindingi380 – 3834FADUniRule annotation
Nucleotide bindingi414 – 4174FADUniRule annotation
Nucleotide bindingi513 – 5142NADPUniRule annotation
Nucleotide bindingi519 – 5235NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent diflavin oxidoreductase 1UniRule annotation (EC:1.18.1.-UniRule annotation)
Alternative name(s):
NADPH-dependent FMN and FAD-containing oxidoreductaseUniRule annotation
Gene namesi
Name:ndor1UniRule annotation
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1555. ndor1.

Subcellular locationi

  • Cytoplasmperinuclear region UniRule annotation

  • Note: Concentrated in perinuclear structure.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595NADPH-dependent diflavin oxidoreductase 1PRO_0000319541Add
BLAST

Proteomic databases

PaxDbiQ6PFP6.
PRIDEiQ6PFP6.

Interactioni

Subunit structurei

Interacts with ciapin1. Interacts with dcps.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000031709.

Structurei

3D structure databases

ProteinModelPortaliQ6PFP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 150145Flavodoxin-likeUniRule annotationAdd
BLAST
Domaini204 – 444241FAD-binding FR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
Contains 1 FAD-binding FR-type domain.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1159. Eukaryota.
COG0369. LUCA.
HOGENOMiHOG000173033.
HOVERGENiHBG104950.
InParanoidiQ6PFP6.
PhylomeDBiQ6PFP6.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
HAMAPiMF_03178. NDOR1.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_dom.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR028879. NDOR1.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PFP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGHTVLVLY GSQTGTAQDT AERIGRQAQR RRLRVKVEAL DTYNVVNLIS
60 70 80 90 100
ESLVVFVCAT TGQGDPPDNM KKFWRFLFRK SLPADSLSRL DCAVLGLGDS
110 120 130 140 150
SYPKFNFVAK KLHKRLLQLG ANMLLPVGLA DDQHDLGPDG VIDPWLLSFW
160 170 180 190 200
QKTLSLYPPP AGLAPLREED KLPPRYIFHF LSEVPNKLTE HLQTVDNKSS
210 220 230 240 250
PTPLRPFPAP LVFNQRVTHT AHFQDVRHIE FDITGSNIEF SAGDTVMMRP
260 270 280 290 300
CNTSEDVEQL CQLLKLDPES YFTLTPTDSS TEVPARLPQP CSIRFLLEHF
310 320 330 340 350
LDISAVPRRS FFELLATFAT DELEQEKLLE FSSAAGQDTL HSYCNRPRRT
360 370 380 390 400
ALEVLTDFPH TTAELSIGRL LDLFPEIQPR SFSIASSLLE HPNRIQILLA
410 420 430 440 450
VVKYKTMLVK PRKGLCSSWL ASLDPSKGDV YVPLWVKKGS LKFPQDPESP
460 470 480 490 500
VIMVGPGTGV APFRSAIQER VAQGKMANVL FFGCRSESKD FYCGSEWQEK
510 520 530 540 550
VQAGQMILVT AFSRDQEDKV YVQHRVKEQG KLLWDLIAKK NAFFYIAGNA
560 570 580 590
KQMPTSVCDA LKAVFQKEGG MSENQAQEML DGMEKNGRFQ SETWS
Length:595
Mass (Da):66,890
Last modified:July 5, 2004 - v1
Checksum:i106DEEB1D47EB28D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461V → A in AAH49440 (Ref. 1) Curated
Sequence conflicti203 – 2031P → S in AAH49440 (Ref. 1) Curated
Sequence conflicti245 – 2451T → I in AAH49440 (Ref. 1) Curated
Sequence conflicti369 – 3691R → C in AAH49440 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049440 mRNA. Translation: AAH49440.1.
BC057471 mRNA. Translation: AAH57471.1.
RefSeqiNP_956942.1. NM_200648.1.
UniGeneiDr.32954.

Genome annotation databases

GeneIDi393621.
KEGGidre:393621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049440 mRNA. Translation: AAH49440.1.
BC057471 mRNA. Translation: AAH57471.1.
RefSeqiNP_956942.1. NM_200648.1.
UniGeneiDr.32954.

3D structure databases

ProteinModelPortaliQ6PFP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000031709.

Proteomic databases

PaxDbiQ6PFP6.
PRIDEiQ6PFP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393621.
KEGGidre:393621.

Organism-specific databases

CTDi27158.
ZFINiZDB-GENE-040426-1555. ndor1.

Phylogenomic databases

eggNOGiKOG1159. Eukaryota.
COG0369. LUCA.
HOGENOMiHOG000173033.
HOVERGENiHBG104950.
InParanoidiQ6PFP6.
PhylomeDBiQ6PFP6.

Miscellaneous databases

PROiQ6PFP6.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
HAMAPiMF_03178. NDOR1.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin-like.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like_dom.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR028879. NDOR1.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNDOR1_DANRE
AccessioniPrimary (citable) accession number: Q6PFP6
Secondary accession number(s): Q5RL12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.