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Protein
Submitted name:

MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

Gene

mlh1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • chiasma assembly Source: ZFIN
  • chromosome segregation Source: ZFIN
  • male meiosis I Source: ZFIN
  • meiotic metaphase I plate congression Source: ZFIN
  • mismatch repair Source: InterPro
  • spermatogenesis Source: ZFIN

Names & Taxonomyi

Protein namesi
Submitted name:
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)Imported
Gene namesi
Name:mlh1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-1600 mlh1

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliQ6PFL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini213 – 332DNA_mis_repairInterPro annotationAdd BLAST120

Phylogenomic databases

eggNOGiKOG1979 Eukaryota
COG0323 LUCA
HOVERGENiHBG006374
KOiK08734
PhylomeDBiQ6PFL1

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR011186 DNA_mismatch_repair_MLH1
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR032189 Mlh1_C
IPR038973 MutL/Mlh/Pms
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PTHR10073:SF40 PTHR10073:SF40, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF16413 Mlh1_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PFL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVIRRLDE TVVNRIAAGE IIQRPANAIK EMMENCLDAK STNIQITVKE
60 70 80 90 100
GGLKLILIQD NGTGIRKDDM EIVCERFTTS KLKSFDDLSS IATYGFRGEA
110 120 130 140 150
LASISHVAHV TITTKTADAK CAYRANYCDG KLKSPPKPCA GNQGTLISVE
160 170 180 190 200
DLFYNVSTRR KALKSPSEEY SRIVEVVSRY AIHNSGKSFS VKKQGEMVAD
210 220 230 240 250
VKTLPNASVL DNIRVVFGVA VSRELIEVEC EDQKFAFKVK GYISNANYSV
260 270 280 290 300
KKCILILFIN HRLVESSALK KAIETVYTAY LPKNTHPFLY LSLEIAPQNI
310 320 330 340 350
DVNVHPTKHE VHFLHEDSII ESIQKHIENK LLGSNSSRTY FTQTLLPGLS
360 370 380 390 400
ASASVAKASS SSADPQERVY AHQMVRTDSK AQKLDAFLQP SASSSSSAAQ
410 420 430 440 450
RKTEKTSSTS TAVQDSVELD DAELLTAADV EPCGGEDPQT DAQPPGDEAP
460 470 480 490 500
PRKRPHVEEV KEDLTAASLP RRRIVKLTSI KGLRDQIELQ THKGLQELLQ
510 520 530 540 550
NHSFVGSVSP QWTLVQHQTK LYLLNTTKLS QELFYQILIY DFGNFGVLRL
560 570 580 590 600
SNPAPLYDLA MLALDSEESG WTEEDGPKEG LAQYIVDFLK QKAEMLEEYF
610 620 630 640 650
SLEIDAEGNL TGLPMLLDNY TPAMEGLPMF ILRLATEVNW DKEKECFREF
660 670 680 690 700
SVECSHFYSI RKSYTLEADA DEPQDAEMSW QWKVEHVLFK ALRSLFSPAK
710 720
HLSEDGSVLQ IASLPDLYKV FERC
Length:724
Mass (Da):80,812
Last modified:July 5, 2004 - v1
Checksum:iD4A169EC62B9F66F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057507 mRNA Translation: AAH57507.1
RefSeqiNP_956953.1, NM_200659.1
UniGeneiDr.77529

Genome annotation databases

GeneIDi393632
KEGGidre:393632

Similar proteinsi

Entry informationi

Entry nameiQ6PFL1_DANRE
AccessioniPrimary (citable) accession number: Q6PFL1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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