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Protein
Submitted name:

MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

Gene

mlh1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • chiasma assembly Source: ZFIN
  • chromosome segregation Source: ZFIN
  • male meiosis I Source: ZFIN
  • meiotic metaphase I plate congression Source: ZFIN
  • mismatch repair Source: InterPro
  • spermatogenesis Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)Imported
Gene namesi
Name:mlh1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-1600. mlh1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ6PFL1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113460.

Structurei

3D structure databases

ProteinModelPortaliQ6PFL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini213 – 332120DNA_mis_repairInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1979. Eukaryota.
COG0323. LUCA.
HOVERGENiHBG006374.
KOiK08734.
PhylomeDBiQ6PFL1.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR003594. HATPase_C.
IPR032189. Mlh1_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF16413. Mlh1_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PFL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVIRRLDE TVVNRIAAGE IIQRPANAIK EMMENCLDAK STNIQITVKE
60 70 80 90 100
GGLKLILIQD NGTGIRKDDM EIVCERFTTS KLKSFDDLSS IATYGFRGEA
110 120 130 140 150
LASISHVAHV TITTKTADAK CAYRANYCDG KLKSPPKPCA GNQGTLISVE
160 170 180 190 200
DLFYNVSTRR KALKSPSEEY SRIVEVVSRY AIHNSGKSFS VKKQGEMVAD
210 220 230 240 250
VKTLPNASVL DNIRVVFGVA VSRELIEVEC EDQKFAFKVK GYISNANYSV
260 270 280 290 300
KKCILILFIN HRLVESSALK KAIETVYTAY LPKNTHPFLY LSLEIAPQNI
310 320 330 340 350
DVNVHPTKHE VHFLHEDSII ESIQKHIENK LLGSNSSRTY FTQTLLPGLS
360 370 380 390 400
ASASVAKASS SSADPQERVY AHQMVRTDSK AQKLDAFLQP SASSSSSAAQ
410 420 430 440 450
RKTEKTSSTS TAVQDSVELD DAELLTAADV EPCGGEDPQT DAQPPGDEAP
460 470 480 490 500
PRKRPHVEEV KEDLTAASLP RRRIVKLTSI KGLRDQIELQ THKGLQELLQ
510 520 530 540 550
NHSFVGSVSP QWTLVQHQTK LYLLNTTKLS QELFYQILIY DFGNFGVLRL
560 570 580 590 600
SNPAPLYDLA MLALDSEESG WTEEDGPKEG LAQYIVDFLK QKAEMLEEYF
610 620 630 640 650
SLEIDAEGNL TGLPMLLDNY TPAMEGLPMF ILRLATEVNW DKEKECFREF
660 670 680 690 700
SVECSHFYSI RKSYTLEADA DEPQDAEMSW QWKVEHVLFK ALRSLFSPAK
710 720
HLSEDGSVLQ IASLPDLYKV FERC
Length:724
Mass (Da):80,812
Last modified:July 5, 2004 - v1
Checksum:iD4A169EC62B9F66F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057507 mRNA. Translation: AAH57507.1.
RefSeqiNP_956953.1. NM_200659.1.
UniGeneiDr.77529.

Genome annotation databases

GeneIDi393632.
KEGGidre:393632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057507 mRNA. Translation: AAH57507.1.
RefSeqiNP_956953.1. NM_200659.1.
UniGeneiDr.77529.

3D structure databases

ProteinModelPortaliQ6PFL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113460.

Proteomic databases

PaxDbiQ6PFL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393632.
KEGGidre:393632.

Organism-specific databases

CTDi4292.
ZFINiZDB-GENE-040426-1600. mlh1.

Phylogenomic databases

eggNOGiKOG1979. Eukaryota.
COG0323. LUCA.
HOVERGENiHBG006374.
KOiK08734.
PhylomeDBiQ6PFL1.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR003594. HATPase_C.
IPR032189. Mlh1_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF16413. Mlh1_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6PFL1_DANRE
AccessioniPrimary (citable) accession number: Q6PFL1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.