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Protein

Oligodendrocyte transcription factor 3

Gene

Olig3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA polymerase II transcription corepressor activity Source: MGI

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of gene expression Source: MGI
  • spinal cord motor neuron cell fate specification Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • spinal cord motor neuron migration Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 3
Short name:
Oligo3
Alternative name(s):
Class B basic helix-loop-helix protein 7
Short name:
bHLHb7
Oligodendrocyte-specific bHLH transcription factor 3
Gene namesi
Name:Olig3
Synonyms:Bhlhb7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2149955. Olig3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Oligodendrocyte transcription factor 3PRO_0000127418Add
BLAST

Proteomic databases

MaxQBiQ6PFG8.
PaxDbiQ6PFG8.
PRIDEiQ6PFG8.

PTM databases

PhosphoSiteiQ6PFG8.

Expressioni

Tissue specificityi

Weakly expressed, mainly in non-neural tissues.1 Publication

Developmental stagei

Restricted to the CNS. At 9.25 and 10.5 dpc, specifically expressed in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed continuously from the upper rhombic lip to the tail. From 10.5 to 12.5 dpc, located in the most dorsal aspect of the spinal cord, excluding the roof plate, mainly in proliferating progenitor cells; quickly down-regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression clusters, corresponding to p3, p2 and p0 domains, transiently appear on the lateral margin of the subventricular zone, in addition to dorsal expression. At 14.5 dpc, weakly expressed in cells scattered in the mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc forebrain, expressed in the ventricular zone of the dorsal thalamus. In the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and lower rhombic lip, in the cerebellar neuroepithelium.2 Publications

Gene expression databases

BgeeiQ6PFG8.
CleanExiMM_OLIG3.
GenevisibleiQ6PFG8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057106.

Structurei

3D structure databases

ProteinModelPortaliQ6PFG8.
SMRiQ6PFG8. Positions 86-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 13855bHLHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 9022Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 339Poly-His
Compositional biasi248 – 2514Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015765.
HOVERGENiHBG053370.
InParanoidiQ6PFG8.
KOiK09085.
OMAiVQKMPGE.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ6PFG8.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032659. Olig3.
[Graphical view]
PANTHERiPTHR19290:SF96. PTHR19290:SF96. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PFG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHHQESRLNS VSSTQGDMVQ
60 70 80 90 100
KMPGESLSRA GAKAAGESSK YKIKKQLSEQ DLQQLRLKIN GRERKRMHDL
110 120 130 140 150
NLAMDGLREV MPYAHGPSVR KLSKIATLLL ARNYILMLTS SLEEMKRLVG
160 170 180 190 200
EIYGGHHSAF HCGTVGHSAG HPAHAANAVH PVHPILGGAL SSGNASSPLS
210 220 230 240 250
ATSLPTIGTI RPPHSLLKAP STPPALQLGS GFQHWAGLPC PCTICQMPPP
260 270
PHLSALSTAN MARLSAESKD LLK
Length:273
Mass (Da):29,507
Last modified:July 5, 2004 - v1
Checksum:i5795CF3FC23121DD
GO

Sequence cautioni

The sequence BAB18908.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038698 mRNA. Translation: BAB18908.1. Different initiation.
BC057564 mRNA. Translation: AAH57564.1.
CCDSiCCDS35855.1.
RefSeqiNP_443734.2. NM_053008.2.
UniGeneiMm.156946.

Genome annotation databases

EnsembliENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591.
GeneIDi94222.
KEGGimmu:94222.
UCSCiuc007ene.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038698 mRNA. Translation: BAB18908.1. Different initiation.
BC057564 mRNA. Translation: AAH57564.1.
CCDSiCCDS35855.1.
RefSeqiNP_443734.2. NM_053008.2.
UniGeneiMm.156946.

3D structure databases

ProteinModelPortaliQ6PFG8.
SMRiQ6PFG8. Positions 86-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057106.

PTM databases

PhosphoSiteiQ6PFG8.

Proteomic databases

MaxQBiQ6PFG8.
PaxDbiQ6PFG8.
PRIDEiQ6PFG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591.
GeneIDi94222.
KEGGimmu:94222.
UCSCiuc007ene.1. mouse.

Organism-specific databases

CTDi167826.
MGIiMGI:2149955. Olig3.

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015765.
HOVERGENiHBG053370.
InParanoidiQ6PFG8.
KOiK09085.
OMAiVQKMPGE.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ6PFG8.
TreeFamiTF322733.

Miscellaneous databases

NextBioi352215.
PROiQ6PFG8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PFG8.
CleanExiMM_OLIG3.
GenevisibleiQ6PFG8. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032659. Olig3.
[Graphical view]
PANTHERiPTHR19290:SF96. PTHR19290:SF96. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3."
    Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R., Nakafuku M., Nabeshima Y.
    Mech. Dev. 99:143-148(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: Swiss Webster.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube."
    Takebayashi H., Ohtsuki T., Uchida T., Kawamoto S., Okubo K., Ikenaka K., Takeichi M., Chisaka O., Nabeshima Y.
    Mech. Dev. 113:169-174(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  4. "The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord."
    Mueller T., Anlag K., Wildner H., Britsch S., Treier M., Birchmeier C.
    Genes Dev. 19:733-743(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiOLIG3_MOUSE
AccessioniPrimary (citable) accession number: Q6PFG8
Secondary accession number(s): Q9EQW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: January 20, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.