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Protein

Tomoregulin-1

Gene

Tmeff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May inhibit NODAL and BMP signaling during neural patterning.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Protein family/group databases

MEROPSiI01.974

Names & Taxonomyi

Protein namesi
Recommended name:
Tomoregulin-1
Short name:
TR-1
Alternative name(s):
M7365
Transmembrane protein with EGF-like and one follistatin-like domain
Gene namesi
Name:Tmeff1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1926810 Tmeff1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 322ExtracellularSequence analysisAdd BLAST287
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 372CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000028605736 – 372Tomoregulin-1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 121PROSITE-ProRule annotation
Disulfide bondi95 ↔ 114PROSITE-ProRule annotation
Disulfide bondi103 ↔ 135PROSITE-ProRule annotation
Disulfide bondi182 ↔ 213PROSITE-ProRule annotation
Disulfide bondi186 ↔ 206PROSITE-ProRule annotation
Disulfide bondi195 ↔ 227PROSITE-ProRule annotation
Disulfide bondi267 ↔ 280By similarity
Disulfide bondi275 ↔ 291By similarity
Disulfide bondi293 ↔ 302By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6PFE7
PeptideAtlasiQ6PFE7
PRIDEiQ6PFE7

PTM databases

iPTMnetiQ6PFE7
PhosphoSitePlusiQ6PFE7

Expressioni

Tissue specificityi

Expressed in brain, neurointermediate lobe, pars distalis, pancreas, ovary and testis.2 Publications

Developmental stagei

At E8.5, highly expressed in the first branchial arch, somites, splanchnic mesoderm and ventral foregut epithelium. At E9.5, highly expressed in motor neurons and superficial neurons from the neural tube, and in the dorsal part of diencephalon and mesencephalon. At E11.5 and E12.5, expressed in limbs. At E15.5, highly expressed in brain and spinal cord.2 Publications

Gene expression databases

BgeeiENSMUSG00000028347
ExpressionAtlasiQ6PFE7 baseline and differential
GenevisibleiQ6PFE7 MM

Interactioni

Subunit structurei

May interact with ST14.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6PFE7
SMRiQ6PFE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 137Kazal-like 1PROSITE-ProRule annotationAdd BLAST53
Domaini176 – 229Kazal-like 2PROSITE-ProRule annotationAdd BLAST54
Domaini263 – 303EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 45Poly-Gly4

Sequence similaritiesi

Belongs to the tomoregulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCWX Eukaryota
ENOG410XQG4 LUCA
GeneTreeiENSGT00730000110884
HOGENOMiHOG000154541
HOVERGENiHBG053816
InParanoidiQ6PFE7
OMAiCFVREAS
OrthoDBiEOG091G0AKU
PhylomeDBiQ6PFE7
TreeFamiTF330868

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS51465 KAZAL_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PFE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAQAPLRLP AAPPLAVCGY TSVLLLFAFC LPGSRASNQP AGGGGDCPGG
60 70 80 90 100
RGKSNCSELN LRESDIRVCD ESSCKYGGVC KEDGDGLKCA CQFQCHTNYI
110 120 130 140 150
PVCGSNGDTY QNECFLRRAA CKHQKDITVV ARGPCYSDNG SGSGEGEEEG
160 170 180 190 200
SGAGAHRKHS KCGPCKYKAE CDEDAENVGC VCNIDCSGYS FNPVCASDGS
210 220 230 240 250
SYNNPCFVRE ASCIKQEQID IRHLGHCTDT DDVSLLGKKD DGLQYRPDVK
260 270 280 290 300
DAGDEREDVY IGSHMPCPEN LNGYCIHGKC EFIYSTQKAS CRCESGYTGQ
310 320 330 340 350
HCEKTDFSIL YVVPSRQKLT HVLIAAIIGA VQIAIIVAIV MCITRKCPKN
360 370
NRGRRQKQNL GHFTSDTSSR MV
Length:372
Mass (Da):40,114
Last modified:July 5, 2004 - v1
Checksum:iBB3DA6710B78A530
GO
Isoform 2 (identifier: Q6PFE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-146: G → GA

Show »
Length:373
Mass (Da):40,185
Checksum:iA61A462F91A87887
GO
Isoform 3 (identifier: Q6PFE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-146: G → GA
     251-252: Missing.

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):39,999
Checksum:i85A373FD5D933E05
GO

Sequence cautioni

The sequence CAB90827 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235L → S in CAB90827 (PubMed:16141072).Curated1
Sequence conflicti241D → P in CAB90827 (PubMed:16141072).Curated1
Sequence conflicti244Q → L in CAB90827 (PubMed:16141072).Curated1
Sequence conflicti370R → K in CAB90827 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024960146G → GA in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_024961251 – 252Missing in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807771, AL772151 Genomic DNA Translation: CAM15043.1
AL807771, AL772151 Genomic DNA Translation: CAM15044.1
AL772151, AL807771 Genomic DNA Translation: CAM20710.1
AL772151, AL807771 Genomic DNA Translation: CAM20711.1
BC057598 mRNA Translation: AAH57598.1
AJ400622 mRNA Translation: CAB90827.1 Different initiation.
AK043792 mRNA Translation: BAC31655.1
AK079633 mRNA Translation: BAC37709.1
CCDSiCCDS18168.1 [Q6PFE7-1]
RefSeqiNP_067411.1, NM_021436.2 [Q6PFE7-1]
XP_006537899.1, XM_006537836.1
XP_006537900.1, XM_006537837.1 [Q6PFE7-3]
UniGeneiMm.422686

Genome annotation databases

EnsembliENSMUST00000030032; ENSMUSP00000030032; ENSMUSG00000028347 [Q6PFE7-1]
ENSMUST00000123476; ENSMUSP00000115841; ENSMUSG00000028347 [Q6PFE7-1]
GeneIDi230157
KEGGimmu:230157
UCSCiuc008svk.1 mouse [Q6PFE7-1]
uc008svl.1 mouse [Q6PFE7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTEFF1_MOUSE
AccessioniPrimary (citable) accession number: Q6PFE7
Secondary accession number(s): A2AJN3
, Q8BRP7, Q8C536, Q9JJS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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