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Protein

Tomoregulin-1

Gene

Tmeff1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May inhibit NODAL and BMP signaling during neural patterning.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Protein family/group databases

MEROPSiI01.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Tomoregulin-1
Short name:
TR-1
Alternative name(s):
M7365
Transmembrane protein with EGF-like and one follistatin-like domain
Gene namesi
Name:Tmeff1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1926810. Tmeff1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 322ExtracellularSequence analysisAdd BLAST287
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 372CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000028605736 – 372Tomoregulin-1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi267 ↔ 280By similarity
Disulfide bondi275 ↔ 291By similarity
Disulfide bondi293 ↔ 302By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6PFE7.
PeptideAtlasiQ6PFE7.
PRIDEiQ6PFE7.

PTM databases

iPTMnetiQ6PFE7.
PhosphoSitePlusiQ6PFE7.

Expressioni

Tissue specificityi

Expressed in brain, neurointermediate lobe, pars distalis, pancreas, ovary and testis.2 Publications

Developmental stagei

At E8.5, highly expressed in the first branchial arch, somites, splanchnic mesoderm and ventral foregut epithelium. At E9.5, highly expressed in motor neurons and superficial neurons from the neural tube, and in the dorsal part of diencephalon and mesencephalon. At E11.5 and E12.5, expressed in limbs. At E15.5, highly expressed in brain and spinal cord.2 Publications

Gene expression databases

BgeeiENSMUSG00000028347.
ExpressionAtlasiQ6PFE7. baseline and differential.
GenevisibleiQ6PFE7. MM.

Interactioni

Subunit structurei

May interact with ST14.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030032.

Structurei

3D structure databases

ProteinModelPortaliQ6PFE7.
SMRiQ6PFE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 137Kazal-like 1PROSITE-ProRule annotationAdd BLAST53
Domaini176 – 229Kazal-like 2PROSITE-ProRule annotationAdd BLAST54
Domaini263 – 303EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 45Poly-Gly4

Sequence similaritiesi

Belongs to the tomoregulin family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Kazal-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCWX. Eukaryota.
ENOG410XQG4. LUCA.
GeneTreeiENSGT00730000110884.
HOGENOMiHOG000154541.
HOVERGENiHBG053816.
InParanoidiQ6PFE7.
OMAiNIDCSGH.
OrthoDBiEOG091G0AKU.
PhylomeDBiQ6PFE7.
TreeFamiTF330868.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS51465. KAZAL_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PFE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAQAPLRLP AAPPLAVCGY TSVLLLFAFC LPGSRASNQP AGGGGDCPGG
60 70 80 90 100
RGKSNCSELN LRESDIRVCD ESSCKYGGVC KEDGDGLKCA CQFQCHTNYI
110 120 130 140 150
PVCGSNGDTY QNECFLRRAA CKHQKDITVV ARGPCYSDNG SGSGEGEEEG
160 170 180 190 200
SGAGAHRKHS KCGPCKYKAE CDEDAENVGC VCNIDCSGYS FNPVCASDGS
210 220 230 240 250
SYNNPCFVRE ASCIKQEQID IRHLGHCTDT DDVSLLGKKD DGLQYRPDVK
260 270 280 290 300
DAGDEREDVY IGSHMPCPEN LNGYCIHGKC EFIYSTQKAS CRCESGYTGQ
310 320 330 340 350
HCEKTDFSIL YVVPSRQKLT HVLIAAIIGA VQIAIIVAIV MCITRKCPKN
360 370
NRGRRQKQNL GHFTSDTSSR MV
Length:372
Mass (Da):40,114
Last modified:July 5, 2004 - v1
Checksum:iBB3DA6710B78A530
GO
Isoform 2 (identifier: Q6PFE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-146: G → GA

Show »
Length:373
Mass (Da):40,185
Checksum:iA61A462F91A87887
GO
Isoform 3 (identifier: Q6PFE7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-146: G → GA
     251-252: Missing.

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):39,999
Checksum:i85A373FD5D933E05
GO

Sequence cautioni

The sequence CAB90827 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235L → S in CAB90827 (PubMed:16141072).Curated1
Sequence conflicti241D → P in CAB90827 (PubMed:16141072).Curated1
Sequence conflicti244Q → L in CAB90827 (PubMed:16141072).Curated1
Sequence conflicti370R → K in CAB90827 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024960146G → GA in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_024961251 – 252Missing in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807771, AL772151 Genomic DNA. Translation: CAM15043.1.
AL807771, AL772151 Genomic DNA. Translation: CAM15044.1.
AL772151, AL807771 Genomic DNA. Translation: CAM20710.1.
AL772151, AL807771 Genomic DNA. Translation: CAM20711.1.
BC057598 mRNA. Translation: AAH57598.1.
AJ400622 mRNA. Translation: CAB90827.1. Different initiation.
AK043792 mRNA. Translation: BAC31655.1.
AK079633 mRNA. Translation: BAC37709.1.
CCDSiCCDS18168.1. [Q6PFE7-1]
RefSeqiNP_067411.1. NM_021436.2. [Q6PFE7-1]
XP_006537899.1. XM_006537836.1. [Q6PFE7-2]
XP_006537900.1. XM_006537837.1. [Q6PFE7-3]
UniGeneiMm.422686.

Genome annotation databases

EnsembliENSMUST00000030032; ENSMUSP00000030032; ENSMUSG00000028347. [Q6PFE7-1]
ENSMUST00000123476; ENSMUSP00000115841; ENSMUSG00000028347. [Q6PFE7-1]
GeneIDi230157.
KEGGimmu:230157.
UCSCiuc008svk.1. mouse. [Q6PFE7-1]
uc008svl.1. mouse. [Q6PFE7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807771, AL772151 Genomic DNA. Translation: CAM15043.1.
AL807771, AL772151 Genomic DNA. Translation: CAM15044.1.
AL772151, AL807771 Genomic DNA. Translation: CAM20710.1.
AL772151, AL807771 Genomic DNA. Translation: CAM20711.1.
BC057598 mRNA. Translation: AAH57598.1.
AJ400622 mRNA. Translation: CAB90827.1. Different initiation.
AK043792 mRNA. Translation: BAC31655.1.
AK079633 mRNA. Translation: BAC37709.1.
CCDSiCCDS18168.1. [Q6PFE7-1]
RefSeqiNP_067411.1. NM_021436.2. [Q6PFE7-1]
XP_006537899.1. XM_006537836.1. [Q6PFE7-2]
XP_006537900.1. XM_006537837.1. [Q6PFE7-3]
UniGeneiMm.422686.

3D structure databases

ProteinModelPortaliQ6PFE7.
SMRiQ6PFE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030032.

Protein family/group databases

MEROPSiI01.974.

PTM databases

iPTMnetiQ6PFE7.
PhosphoSitePlusiQ6PFE7.

Proteomic databases

PaxDbiQ6PFE7.
PeptideAtlasiQ6PFE7.
PRIDEiQ6PFE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030032; ENSMUSP00000030032; ENSMUSG00000028347. [Q6PFE7-1]
ENSMUST00000123476; ENSMUSP00000115841; ENSMUSG00000028347. [Q6PFE7-1]
GeneIDi230157.
KEGGimmu:230157.
UCSCiuc008svk.1. mouse. [Q6PFE7-1]
uc008svl.1. mouse. [Q6PFE7-2]

Organism-specific databases

CTDi8577.
MGIiMGI:1926810. Tmeff1.

Phylogenomic databases

eggNOGiENOG410KCWX. Eukaryota.
ENOG410XQG4. LUCA.
GeneTreeiENSGT00730000110884.
HOGENOMiHOG000154541.
HOVERGENiHBG053816.
InParanoidiQ6PFE7.
OMAiNIDCSGH.
OrthoDBiEOG091G0AKU.
PhylomeDBiQ6PFE7.
TreeFamiTF330868.

Miscellaneous databases

PROiQ6PFE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028347.
ExpressionAtlasiQ6PFE7. baseline and differential.
GenevisibleiQ6PFE7. MM.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF07648. Kazal_2. 2 hits.
[Graphical view]
SMARTiSM00280. KAZAL. 2 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS51465. KAZAL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEFF1_MOUSE
AccessioniPrimary (citable) accession number: Q6PFE7
Secondary accession number(s): A2AJN3
, Q8BRP7, Q8C536, Q9JJS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.