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Q6PFE3

- RA54B_MOUSE

UniProt

Q6PFE3 - RA54B_MOUSE

Protein

DNA repair and recombination protein RAD54B

Gene

Rad54b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi304 – 3118ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. DNA translocase activity Source: Ensembl
    4. helicase activity Source: UniProtKB-KW

    GO - Biological processi

    1. double-strand break repair via homologous recombination Source: Ensembl

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA repair and recombination protein RAD54B (EC:3.6.4.-)
    Alternative name(s):
    RAD54 homolog B
    Gene namesi
    Name:Rad54b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:3605986. Rad54b.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886DNA repair and recombination protein RAD54BPRO_0000074341Add
    BLAST

    Proteomic databases

    PRIDEiQ6PFE3.

    PTM databases

    PhosphoSiteiQ6PFE3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PFE3.
    BgeeiQ6PFE3.
    GenevestigatoriQ6PFE3.

    Interactioni

    Subunit structurei

    Interacts with RAD51 through the NH2-terminal domain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PFE3.
    SMRiQ6PFE3. Positions 300-813.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini291 – 458168Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini627 – 788162Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi409 – 4124DEGH box

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0553.
    GeneTreeiENSGT00550000074619.
    HOGENOMiHOG000204521.
    HOVERGENiHBG058654.
    InParanoidiA2AIV0.
    KOiK10877.
    OMAiVYHLRPH.
    OrthoDBiEOG7DJSKN.
    PhylomeDBiQ6PFE3.
    TreeFamiTF101223.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PFE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRSAAPSQV QGKSFKKTRF IPPGRSNADV SKEITKMSPD PKLFQGAEQS    50
    QNDPGVCSSN PCPSEGIPRE VGDGTRVDPL PPVHSASKEI TESKAQEEEA 100
    SSLLKYFSVV WCKASKKKHK KWEGDAILIV RGRSFTLKDL EGKDIGRGIG 150
    YKFKDLENVE EGQTLIIGGK EIEILGTISS DDFNSGKCFQ HGSGSPAVPS 200
    SQAARKCFSN PFKSVCQSTQ AQGKRWNDCR PRHNPCTPNA LVMPRPDENH 250
    QRMFNRHCSP IVDVVIDPHL VHHLRPHQKD GIIFLYECVM GMRAVGKCGA 300
    ILADEMGLGK TLQCISLIWT LQCQGPYGGK PVIKKTLIVT PGSLVNNWRK 350
    EFQKWLGSER IKIFTVDQDH KVEEFINSTF HSVLIISYEM LLRSLDQIKT 400
    IPFGLLICDE GHRLKNSSIK TTTALSSLSC EKTVILTGTP VQNDLQEFFA 450
    LVDFVNPGIL GSLSSYRKIY EEPIIISREP SSSKEERELG ERRATELTRL 500
    TGRFILRRTQ EVINKYLPPK IENVVFCRPG ALQIELYRKL LRSQSVRFCL 550
    QGLLENSAHL ICIGALKKLC NHPCLLFSSV KGKEFSSSCE ENEERNLCQG 600
    LLSVFPAGYN PLQFSEEESG KLQVLVKLLA VIHELRPTEK VILVSNYRQT 650
    LNVLEEVCKR HGYACARLDG QTPVSQRQHI VDSFNSKYST DFIFLLSSKA 700
    GGVGLNLIGG SHLILYDIDW NPATDIQAMS RVWRDGQKHP VHIYRLLTTG 750
    TIEEKIYQRQ ISKQGLSGAV VDLTRSSEHI QFSVEELKNL FTLHESSHCV 800
    THDLLDCECT GEKGHTEDAS EGPVASRQCQ FGPQKSDALR PLSMSQLKQW 850
    KHFSGDHLNL PDPFLERIRE NVSFFFQNIT NQAPAV 886
    Length:886
    Mass (Da):99,338
    Last modified:July 5, 2004 - v1
    Checksum:iA723501E5D5723A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL732538 Genomic DNA. Translation: CAM18403.1.
    BC057604 mRNA. Translation: AAH57604.1.
    CCDSiCCDS17970.1.
    RefSeqiNP_001034645.1. NM_001039556.3.
    UniGeneiMm.491200.

    Genome annotation databases

    EnsembliENSMUST00000070755; ENSMUSP00000066977; ENSMUSG00000078773.
    GeneIDi623474.
    KEGGimmu:623474.
    UCSCiuc008rzs.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL732538 Genomic DNA. Translation: CAM18403.1 .
    BC057604 mRNA. Translation: AAH57604.1 .
    CCDSi CCDS17970.1.
    RefSeqi NP_001034645.1. NM_001039556.3.
    UniGenei Mm.491200.

    3D structure databases

    ProteinModelPortali Q6PFE3.
    SMRi Q6PFE3. Positions 300-813.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PFE3.

    Proteomic databases

    PRIDEi Q6PFE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070755 ; ENSMUSP00000066977 ; ENSMUSG00000078773 .
    GeneIDi 623474.
    KEGGi mmu:623474.
    UCSCi uc008rzs.2. mouse.

    Organism-specific databases

    CTDi 25788.
    MGIi MGI:3605986. Rad54b.

    Phylogenomic databases

    eggNOGi COG0553.
    GeneTreei ENSGT00550000074619.
    HOGENOMi HOG000204521.
    HOVERGENi HBG058654.
    InParanoidi A2AIV0.
    KOi K10877.
    OMAi VYHLRPH.
    OrthoDBi EOG7DJSKN.
    PhylomeDBi Q6PFE3.
    TreeFami TF101223.

    Miscellaneous databases

    NextBioi 417142.
    PROi Q6PFE3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PFE3.
    Bgeei Q6PFE3.
    Genevestigatori Q6PFE3.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Embryonic brain.
    3. "Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination."
      Bross L., Wesoly J., Buerstedde J.-M., Kanaar R., Jacobs H.
      Eur. J. Immunol. 33:352-357(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRA54B_MOUSE
    AccessioniPrimary (citable) accession number: Q6PFE3
    Secondary accession number(s): A2AIV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3