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Protein

DNA repair and recombination protein RAD54B

Gene

Rad54b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi304 – 311ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: MGI
  • determination of adult lifespan Source: MGI
  • double-strand break repair via homologous recombination Source: MGI
  • response to drug Source: MGI
  • response to ionizing radiation Source: MGI

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RAD54B (EC:3.6.4.-)
Alternative name(s):
RAD54 homolog B
Gene namesi
Name:Rad54b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3605986 Rad54b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743411 – 886DNA repair and recombination protein RAD54BAdd BLAST886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PFE3
MaxQBiQ6PFE3
PaxDbiQ6PFE3
PRIDEiQ6PFE3

PTM databases

iPTMnetiQ6PFE3
PhosphoSitePlusiQ6PFE3

Expressioni

Gene expression databases

BgeeiENSMUSG00000078773
ExpressionAtlasiQ6PFE3 baseline and differential
GenevisibleiQ6PFE3 MM

Interactioni

Subunit structurei

Interacts with RAD51 through the NH2-terminal domain.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066977

Structurei

3D structure databases

ProteinModelPortaliQ6PFE3
SMRiQ6PFE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini291 – 458Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini627 – 788Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi409 – 412DEGH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

eggNOGiKOG0390 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00910000144164
HOGENOMiHOG000204521
HOVERGENiHBG058654
InParanoidiQ6PFE3
KOiK10877
OMAiIFLYECV
OrthoDBiEOG091G01Z3
PhylomeDBiQ6PFE3
TreeFamiTF101223

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PFE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSAAPSQV QGKSFKKTRF IPPGRSNADV SKEITKMSPD PKLFQGAEQS
60 70 80 90 100
QNDPGVCSSN PCPSEGIPRE VGDGTRVDPL PPVHSASKEI TESKAQEEEA
110 120 130 140 150
SSLLKYFSVV WCKASKKKHK KWEGDAILIV RGRSFTLKDL EGKDIGRGIG
160 170 180 190 200
YKFKDLENVE EGQTLIIGGK EIEILGTISS DDFNSGKCFQ HGSGSPAVPS
210 220 230 240 250
SQAARKCFSN PFKSVCQSTQ AQGKRWNDCR PRHNPCTPNA LVMPRPDENH
260 270 280 290 300
QRMFNRHCSP IVDVVIDPHL VHHLRPHQKD GIIFLYECVM GMRAVGKCGA
310 320 330 340 350
ILADEMGLGK TLQCISLIWT LQCQGPYGGK PVIKKTLIVT PGSLVNNWRK
360 370 380 390 400
EFQKWLGSER IKIFTVDQDH KVEEFINSTF HSVLIISYEM LLRSLDQIKT
410 420 430 440 450
IPFGLLICDE GHRLKNSSIK TTTALSSLSC EKTVILTGTP VQNDLQEFFA
460 470 480 490 500
LVDFVNPGIL GSLSSYRKIY EEPIIISREP SSSKEERELG ERRATELTRL
510 520 530 540 550
TGRFILRRTQ EVINKYLPPK IENVVFCRPG ALQIELYRKL LRSQSVRFCL
560 570 580 590 600
QGLLENSAHL ICIGALKKLC NHPCLLFSSV KGKEFSSSCE ENEERNLCQG
610 620 630 640 650
LLSVFPAGYN PLQFSEEESG KLQVLVKLLA VIHELRPTEK VILVSNYRQT
660 670 680 690 700
LNVLEEVCKR HGYACARLDG QTPVSQRQHI VDSFNSKYST DFIFLLSSKA
710 720 730 740 750
GGVGLNLIGG SHLILYDIDW NPATDIQAMS RVWRDGQKHP VHIYRLLTTG
760 770 780 790 800
TIEEKIYQRQ ISKQGLSGAV VDLTRSSEHI QFSVEELKNL FTLHESSHCV
810 820 830 840 850
THDLLDCECT GEKGHTEDAS EGPVASRQCQ FGPQKSDALR PLSMSQLKQW
860 870 880
KHFSGDHLNL PDPFLERIRE NVSFFFQNIT NQAPAV
Length:886
Mass (Da):99,338
Last modified:July 5, 2004 - v1
Checksum:iA723501E5D5723A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732538 Genomic DNA No translation available.
BC057604 mRNA Translation: AAH57604.1
CCDSiCCDS17970.1
RefSeqiNP_001034645.1, NM_001039556.3
UniGeneiMm.491200

Genome annotation databases

EnsembliENSMUST00000070755; ENSMUSP00000066977; ENSMUSG00000078773
GeneIDi623474
KEGGimmu:623474
UCSCiuc008rzs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRA54B_MOUSE
AccessioniPrimary (citable) accession number: Q6PFE3
Secondary accession number(s): A2AIV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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