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Q6PFE3

- RA54B_MOUSE

UniProt

Q6PFE3 - RA54B_MOUSE

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Protein
DNA repair and recombination protein RAD54B
Gene
Rad54b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi304 – 3118ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA translocase activity Source: Ensembl
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. double-strand break repair via homologous recombination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RAD54B (EC:3.6.4.-)
Alternative name(s):
RAD54 homolog B
Gene namesi
Name:Rad54b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:3605986. Rad54b.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886DNA repair and recombination protein RAD54B
PRO_0000074341Add
BLAST

Proteomic databases

PRIDEiQ6PFE3.

PTM databases

PhosphoSiteiQ6PFE3.

Expressioni

Gene expression databases

ArrayExpressiQ6PFE3.
BgeeiQ6PFE3.
GenevestigatoriQ6PFE3.

Interactioni

Subunit structurei

Interacts with RAD51 through the NH2-terminal domain By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6PFE3.
SMRiQ6PFE3. Positions 300-813.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini291 – 458168Helicase ATP-binding
Add
BLAST
Domaini627 – 788162Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi409 – 4124DEGH box

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00550000074619.
HOGENOMiHOG000204521.
HOVERGENiHBG058654.
InParanoidiA2AIV0.
KOiK10877.
OMAiVYHLRPH.
OrthoDBiEOG7DJSKN.
PhylomeDBiQ6PFE3.
TreeFamiTF101223.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PFE3-1 [UniParc]FASTAAdd to Basket

« Hide

MRRSAAPSQV QGKSFKKTRF IPPGRSNADV SKEITKMSPD PKLFQGAEQS    50
QNDPGVCSSN PCPSEGIPRE VGDGTRVDPL PPVHSASKEI TESKAQEEEA 100
SSLLKYFSVV WCKASKKKHK KWEGDAILIV RGRSFTLKDL EGKDIGRGIG 150
YKFKDLENVE EGQTLIIGGK EIEILGTISS DDFNSGKCFQ HGSGSPAVPS 200
SQAARKCFSN PFKSVCQSTQ AQGKRWNDCR PRHNPCTPNA LVMPRPDENH 250
QRMFNRHCSP IVDVVIDPHL VHHLRPHQKD GIIFLYECVM GMRAVGKCGA 300
ILADEMGLGK TLQCISLIWT LQCQGPYGGK PVIKKTLIVT PGSLVNNWRK 350
EFQKWLGSER IKIFTVDQDH KVEEFINSTF HSVLIISYEM LLRSLDQIKT 400
IPFGLLICDE GHRLKNSSIK TTTALSSLSC EKTVILTGTP VQNDLQEFFA 450
LVDFVNPGIL GSLSSYRKIY EEPIIISREP SSSKEERELG ERRATELTRL 500
TGRFILRRTQ EVINKYLPPK IENVVFCRPG ALQIELYRKL LRSQSVRFCL 550
QGLLENSAHL ICIGALKKLC NHPCLLFSSV KGKEFSSSCE ENEERNLCQG 600
LLSVFPAGYN PLQFSEEESG KLQVLVKLLA VIHELRPTEK VILVSNYRQT 650
LNVLEEVCKR HGYACARLDG QTPVSQRQHI VDSFNSKYST DFIFLLSSKA 700
GGVGLNLIGG SHLILYDIDW NPATDIQAMS RVWRDGQKHP VHIYRLLTTG 750
TIEEKIYQRQ ISKQGLSGAV VDLTRSSEHI QFSVEELKNL FTLHESSHCV 800
THDLLDCECT GEKGHTEDAS EGPVASRQCQ FGPQKSDALR PLSMSQLKQW 850
KHFSGDHLNL PDPFLERIRE NVSFFFQNIT NQAPAV 886
Length:886
Mass (Da):99,338
Last modified:July 5, 2004 - v1
Checksum:iA723501E5D5723A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732538 Genomic DNA. Translation: CAM18403.1.
BC057604 mRNA. Translation: AAH57604.1.
CCDSiCCDS17970.1.
RefSeqiNP_001034645.1. NM_001039556.3.
UniGeneiMm.491200.

Genome annotation databases

EnsembliENSMUST00000070755; ENSMUSP00000066977; ENSMUSG00000078773.
GeneIDi623474.
KEGGimmu:623474.
UCSCiuc008rzs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL732538 Genomic DNA. Translation: CAM18403.1 .
BC057604 mRNA. Translation: AAH57604.1 .
CCDSi CCDS17970.1.
RefSeqi NP_001034645.1. NM_001039556.3.
UniGenei Mm.491200.

3D structure databases

ProteinModelPortali Q6PFE3.
SMRi Q6PFE3. Positions 300-813.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6PFE3.

Proteomic databases

PRIDEi Q6PFE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070755 ; ENSMUSP00000066977 ; ENSMUSG00000078773 .
GeneIDi 623474.
KEGGi mmu:623474.
UCSCi uc008rzs.2. mouse.

Organism-specific databases

CTDi 25788.
MGIi MGI:3605986. Rad54b.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00550000074619.
HOGENOMi HOG000204521.
HOVERGENi HBG058654.
InParanoidi A2AIV0.
KOi K10877.
OMAi VYHLRPH.
OrthoDBi EOG7DJSKN.
PhylomeDBi Q6PFE3.
TreeFami TF101223.

Miscellaneous databases

NextBioi 417142.
PROi Q6PFE3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PFE3.
Bgeei Q6PFE3.
Genevestigatori Q6PFE3.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryonic brain.
  3. "Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination."
    Bross L., Wesoly J., Buerstedde J.-M., Kanaar R., Jacobs H.
    Eur. J. Immunol. 33:352-357(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRA54B_MOUSE
AccessioniPrimary (citable) accession number: Q6PFE3
Secondary accession number(s): A2AIV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi