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Protein
Submitted name:

NK2 homeobox 1

Gene

Nkx2-1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi161 – 220HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
NK2 homeobox 1Imported
Gene namesi
Name:Nkx2-1Imported
Synonyms:Titf1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108067 Nkx2-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevisibleiQ6PFE0 MM

Structurei

3D structure databases

ProteinModelPortaliQ6PFE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 219HomeoboxInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
HOVERGENiHBG006689
KOiK09342

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PFE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPA
60 70 80 90 100
AAMQQHAVGH HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY
110 120 130 140 150
QDTMRNSASG PGWYGANPDP RFPAISRFMG PASGMNMSGM GGLGSLGDVS
160 170 180 190 200
KNMAPLPSAP RRKRRVLFSQ AQVYELERRF KQQKYLSAPE REHLASMIHL
210 220 230 240 250
TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG GGAGCPQQQQ
260 270 280 290 300
AQQQSPRRVA VPVLVKDGKP CQAGAPAPGA ASLQSHAQQQ AQQQAQAAQA
310 320 330 340 350
AAAAISVGSG GAVLGAHPGH QPGSAGQSPD LAHHAASPAG LQGQVSSLSH
360 370
LNSSGSDYGA MSCSTLLYGR TW
Length:372
Mass (Da):38,612
Last modified:July 5, 2004 - v1
Checksum:i377B5CF8A609503E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057607 mRNA Translation: AAH57607.1
RefSeqiNP_033411.3, NM_009385.3
UniGeneiMm.89972

Genome annotation databases

GeneIDi21869
KEGGimmu:21869

Similar proteinsi

Entry informationi

Entry nameiQ6PFE0_MOUSE
AccessioniPrimary (citable) accession number: Q6PFE0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health