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Protein

Kinesin-like protein KIF18B

Gene

Kif18b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 118ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF18B
Gene namesi
Name:Kif18b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2446979. Kif18b.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton Curated

  • Note: Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189701 – 834Kinesin-like protein KIF18BAdd BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei431PhosphothreonineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei634PhosphoserineBy similarity1
Modified residuei657PhosphoserineBy similarity1
Modified residuei669PhosphothreonineBy similarity1
Modified residuei814PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PFD6.
MaxQBiQ6PFD6.
PaxDbiQ6PFD6.
PeptideAtlasiQ6PFD6.
PRIDEiQ6PFD6.

PTM databases

iPTMnetiQ6PFD6.
PhosphoSitePlusiQ6PFD6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051378.
CleanExiMM_3000004C01RIK.
GenevisibleiQ6PFD6. MM.

Interactioni

Subunit structurei

Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213921. 8 interactors.
IntActiQ6PFD6. 7 interactors.
STRINGi10090.ENSMUSP00000021311.

Structurei

3D structure databases

ProteinModelPortaliQ6PFD6.
SMRiQ6PFD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 353Kinesin motorPROSITE-ProRule annotationAdd BLAST345

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili368 – 404Sequence analysisAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi619 – 627Nuclear localization signalBy similarity9

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000231436.
HOVERGENiHBG108062.
InParanoidiQ6PFD6.
OMAiWENVPQE.
OrthoDBiEOG091G0438.
TreeFamiTF105231.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PFD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMAVEDSVV RVVVRVRPPT PKELESQRRP VIQVVDERML VFDPEECDGG
60 70 80 90 100
FPGLKWSGSH NGPKKKGKDL TFVFDRVFGE MATQEDVFQH TTHNILDSFL
110 120 130 140 150
QGYNCSVFAY GATGAGKTHT MLGREGEPGI MYLTTMELYR RLEARQEEKQ
160 170 180 190 200
FEVLISYLEV YNEQIHDLLE PKGPLTIRED PDKGVVVPGL SFHQPASAEQ
210 220 230 240 250
LLEMLTRGNC SRTQHPTDAN ATSSRSHAIF QIFVKQQDRV PGLTQALRVA
260 270 280 290 300
KMSLIDLAGS ERASSTHAKG ERLREGANIN RSLLALINVL NALADAKGRK
310 320 330 340 350
SHVPYRDSKL TRLLKDSIGG NCRTVMIAAI SPSSLTYEDT YNTLKYADRA
360 370 380 390 400
KEIRLTLKSN VISVDHHISQ YATICQQLQA EVAFLREKLQ MYEAGAQALQ
410 420 430 440 450
QQCSPQPPTL SIPQSLSSSS LQPGPSSQSS TLECHAKNET LQEESLGSDA
460 470 480 490 500
QGQEIVEESA SEQEQCPQDK QCPTQKPEPN LPGSPSPSVQ AKPGTGQHSP
510 520 530 540 550
QKQDADHSKQ LALQVLRLAQ RQYSLLQAAN LLTPDMISEF ETLQQLVLEE
560 570 580 590 600
SVDHRAESPR SPALARGDPL AQALCSESKS SGYCGPVTRT MAKQLNGLTH
610 620 630 640 650
TLGAPLAPDC TSDKTFQKPT KEKKRKLTPE EPGSLPAPNL EMKRQRQSFL
660 670 680 690 700
PCLRRGSLPK AQPCSEPRTP KRERASSPSP SSRVCPATVI KSRVPLGPSA
710 720 730 740 750
LQNCSTPLAL PTRDLNTTFN VSEESPSKPS FQEFVDWEKV SPELNSTDQP
760 770 780 790 800
FLPSAPVFIF TKGRKPSLPA VTASKKRRTM RPSVSRGRSC IARLHSSTLK
810 820 830
KPNRPFTVPE PPLSPHCLDD QRTPKGLTGV TESY
Length:834
Mass (Da):91,936
Last modified:February 26, 2008 - v2
Checksum:i3043F4339E0B82AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211S → I in AAH57614 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156592 mRNA. Translation: BAE33771.1.
AL731670 Genomic DNA. Translation: CAM25116.1.
BC049272 mRNA. Translation: AAH49272.1.
BC057614 mRNA. Translation: AAH57614.1.
CCDSiCCDS25508.1.
RefSeqiNP_932063.2. NM_197959.2.
XP_011247545.1. XM_011249243.1.
UniGeneiMm.32084.

Genome annotation databases

EnsembliENSMUST00000021311; ENSMUSP00000021311; ENSMUSG00000051378.
GeneIDi70218.
KEGGimmu:70218.
UCSCiuc007lsy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156592 mRNA. Translation: BAE33771.1.
AL731670 Genomic DNA. Translation: CAM25116.1.
BC049272 mRNA. Translation: AAH49272.1.
BC057614 mRNA. Translation: AAH57614.1.
CCDSiCCDS25508.1.
RefSeqiNP_932063.2. NM_197959.2.
XP_011247545.1. XM_011249243.1.
UniGeneiMm.32084.

3D structure databases

ProteinModelPortaliQ6PFD6.
SMRiQ6PFD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213921. 8 interactors.
IntActiQ6PFD6. 7 interactors.
STRINGi10090.ENSMUSP00000021311.

PTM databases

iPTMnetiQ6PFD6.
PhosphoSitePlusiQ6PFD6.

Proteomic databases

EPDiQ6PFD6.
MaxQBiQ6PFD6.
PaxDbiQ6PFD6.
PeptideAtlasiQ6PFD6.
PRIDEiQ6PFD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021311; ENSMUSP00000021311; ENSMUSG00000051378.
GeneIDi70218.
KEGGimmu:70218.
UCSCiuc007lsy.2. mouse.

Organism-specific databases

CTDi146909.
MGIiMGI:2446979. Kif18b.

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000231436.
HOVERGENiHBG108062.
InParanoidiQ6PFD6.
OMAiWENVPQE.
OrthoDBiEOG091G0438.
TreeFamiTF105231.

Miscellaneous databases

PROiQ6PFD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051378.
CleanExiMM_3000004C01RIK.
GenevisibleiQ6PFD6. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI18B_MOUSE
AccessioniPrimary (citable) accession number: Q6PFD6
Secondary accession number(s): Q3U0T0, Q80V20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.