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Protein

Disks large-associated protein 3

Gene

Dlgap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

  • beta-amyloid binding Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 3
Short name:
DAP-3
Alternative name(s):
PSD-95/SAP90-binding protein 3
SAP90/PSD-95-associated protein 3
Short name:
SAPAP3
Gene namesi
Name:Dlgap3
Synonyms:Dap3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3039563. Dlgap3.

Subcellular locationi

  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
  • Cell junctionsynapsepostsynaptic cell membranepostsynaptic density 1 Publication
  • Cell junctionsynapse 1 Publication

  • Note: Postsynaptic density of neuronal cells.

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742951 – 977Disks large-associated protein 3Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Modified residuei930PhosphoserineBy similarity1
Modified residuei933PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PFD5.
PaxDbiQ6PFD5.
PRIDEiQ6PFD5.

PTM databases

iPTMnetiQ6PFD5.
PhosphoSitePlusiQ6PFD5.

Expressioni

Tissue specificityi

Highly expressed in central and peripherical nervous system (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000042388.
CleanExiMM_DAP3.
ExpressionAtlasiQ6PFD5. baseline and differential.
GenevisibleiQ6PFD5. MM.

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95.By similarity

Protein-protein interaction databases

BioGridi232440. 2 interactors.
IntActiQ6PFD5. 2 interactors.
MINTiMINT-4789697.
STRINGi10090.ENSMUSP00000039724.

Structurei

Secondary structure

1977
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi964 – 977Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IZUX-ray2.49B/D963-977[»]
ProteinModelPortaliQ6PFD5.
SMRiQ6PFD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 233Poly-HisAdd BLAST12

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ6PFD5.
OMAiGSAQMLM.
OrthoDBiEOG091G0J9O.
PhylomeDBiQ6PFD5.
TreeFamiTF321382.

Family and domain databases

InterProiIPR030526. DLGAP3.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF4. PTHR12353:SF4. 3 hits.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PFD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP
60 70 80 90 100
RAGLGHLSPE GPLSLSEGPS SVGPEGGPGG VGAGGGSSTF PRMYPGQGPF
110 120 130 140 150
DTCEDCVGHP QGKGATRLPP TLLDQFEKQL PVQQDGFHTL PYQRGPAGPG
160 170 180 190 200
PGPGSGAAPE ARSESPSRIR HLVHSVQKLF AKSHSLEAPG KRDYNGPKAD
210 220 230 240 250
GRGSSGGDSY SGPGSGGTPT SHHHHHHHHH HHHQSRHGKR SKSKDRKGDG
260 270 280 290 300
RHQTKATGWW SSDDNLDSDS GFLGGRPPGE PGGPFCLDAP DGSYRDLSFK
310 320 330 340 350
GRSGGSEGRC LACTGMSMSL DGQSVKRSAW HTMMVSQGRD GYPGAGPGKG
360 370 380 390 400
LLGPETKAKA RTYHYLQVPQ DDWGGYPTGG KDGEIPCRRM RSGSYIKAMG
410 420 430 440 450
DEESGDSDGS PKTSPKALAR RFASRRSSSV DTARINCCVP PRIHPRSSIP
460 470 480 490 500
GYSRSLTTGQ LSEEFNQQLE AVCGSVFGEL ESQAVDALDL PGCFRMRSHS
510 520 530 540 550
YLRAIQAGCS QDDDCLPLLA APASVSGRPG SSFNFRKAPP PIPPGSQAPP
560 570 580 590 600
RISITAQSST DSAHESFTAA EGPARRCSSA DGLDGPTMGA RTLELAPVPP
610 620 630 640 650
RASPKPPTLI IKTIPGREEL RSLARQRKWR PSIGVQVETI SDSDTENRSR
660 670 680 690 700
REFHSIGVQV EEDKRRARFK RSNSVTAGVQ ADLELEGLAG LATVATEDKA
710 720 730 740 750
LQFGRSFQRH ASEPQPGPRA PTYSVFRTVH TQGQWAYREG YPLPYEPPAT
760 770 780 790 800
DGSPGPTPVP APGPGSGRRD SWMERGSRSL PDSGRTSPCP RDGEWFIKML
810 820 830 840 850
RAEVEKLEHW CQQMEREAED YELPEEILEK IRSAVGSTQL LLSQKVQQFF
860 870 880 890 900
RLCQQSLDPT AFPVPTFQDL AGFWDLLQLS IEDVTLKFLE LQQLKANSWK
910 920 930 940 950
LLEPKEEKKV PPPIPKKPSR GRGVPVKERS LDSVDRQRQE ARKRLLAAKR
960 970
AASFRHSSAT ESADSIEIYI PEAQTRL
Length:977
Mass (Da):105,873
Last modified:July 5, 2004 - v1
Checksum:i26665D623D49E4C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436N → S in AAO89219 (PubMed:15024750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243848 mRNA. Translation: AAO89219.2.
BC057615 mRNA. Translation: AAH57615.1.
BC058433 mRNA. Translation: AAH58433.1.
CCDSiCCDS18665.1.
RefSeqiNP_001289010.1. NM_001302081.1.
NP_941020.1. NM_198618.5.
XP_011238839.1. XM_011240537.2.
UniGeneiMm.331885.

Genome annotation databases

EnsembliENSMUST00000046659; ENSMUSP00000039724; ENSMUSG00000042388.
ENSMUST00000106094; ENSMUSP00000101700; ENSMUSG00000042388.
GeneIDi242667.
KEGGimmu:242667.
UCSCiuc008uuo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243848 mRNA. Translation: AAO89219.2.
BC057615 mRNA. Translation: AAH57615.1.
BC058433 mRNA. Translation: AAH58433.1.
CCDSiCCDS18665.1.
RefSeqiNP_001289010.1. NM_001302081.1.
NP_941020.1. NM_198618.5.
XP_011238839.1. XM_011240537.2.
UniGeneiMm.331885.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IZUX-ray2.49B/D963-977[»]
ProteinModelPortaliQ6PFD5.
SMRiQ6PFD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232440. 2 interactors.
IntActiQ6PFD5. 2 interactors.
MINTiMINT-4789697.
STRINGi10090.ENSMUSP00000039724.

PTM databases

iPTMnetiQ6PFD5.
PhosphoSitePlusiQ6PFD5.

Proteomic databases

MaxQBiQ6PFD5.
PaxDbiQ6PFD5.
PRIDEiQ6PFD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046659; ENSMUSP00000039724; ENSMUSG00000042388.
ENSMUST00000106094; ENSMUSP00000101700; ENSMUSG00000042388.
GeneIDi242667.
KEGGimmu:242667.
UCSCiuc008uuo.3. mouse.

Organism-specific databases

CTDi58512.
MGIiMGI:3039563. Dlgap3.

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiQ6PFD5.
OMAiGSAQMLM.
OrthoDBiEOG091G0J9O.
PhylomeDBiQ6PFD5.
TreeFamiTF321382.

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

PROiQ6PFD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042388.
CleanExiMM_DAP3.
ExpressionAtlasiQ6PFD5. baseline and differential.
GenevisibleiQ6PFD5. MM.

Family and domain databases

InterProiIPR030526. DLGAP3.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF4. PTHR12353:SF4. 3 hits.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLGP3_MOUSE
AccessioniPrimary (citable) accession number: Q6PFD5
Secondary accession number(s): Q6PDX0, Q6XBF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.