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Protein

Disks large-associated protein 3

Gene

Dlgap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

  • amyloid-beta binding Source: MGI
  • protein domain specific binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 3
Short name:
DAP-3
Alternative name(s):
PSD-95/SAP90-binding protein 3
SAP90/PSD-95-associated protein 3
Short name:
SAPAP3
Gene namesi
Name:Dlgap3
Synonyms:Dap3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3039563 Dlgap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742951 – 977Disks large-associated protein 3Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Modified residuei930PhosphoserineBy similarity1
Modified residuei933PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PFD5
PaxDbiQ6PFD5
PRIDEiQ6PFD5

PTM databases

iPTMnetiQ6PFD5
PhosphoSitePlusiQ6PFD5

Expressioni

Tissue specificityi

Highly expressed in central and peripherical nervous system (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000042388
CleanExiMM_DAP3
ExpressionAtlasiQ6PFD5 baseline and differential
GenevisibleiQ6PFD5 MM

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232440, 8 interactors
IntActiQ6PFD5, 6 interactors
MINTiQ6PFD5
STRINGi10090.ENSMUSP00000039724

Structurei

Secondary structure

1977
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi964 – 977Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IZUX-ray2.49B/D963-977[»]
ProteinModelPortaliQ6PFD5
SMRiQ6PFD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 233Poly-HisAdd BLAST12

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOGENOMiHOG000015346
HOVERGENiHBG018957
InParanoidiQ6PFD5
OMAiQRKWRPS
OrthoDBiEOG091G0J9O
PhylomeDBiQ6PFD5
TreeFamiTF321382

Family and domain databases

InterProiView protein in InterPro
IPR030526 DLGAP3
IPR005026 SAPAP
PANTHERiPTHR12353:SF4 PTHR12353:SF4, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PFD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP
60 70 80 90 100
RAGLGHLSPE GPLSLSEGPS SVGPEGGPGG VGAGGGSSTF PRMYPGQGPF
110 120 130 140 150
DTCEDCVGHP QGKGATRLPP TLLDQFEKQL PVQQDGFHTL PYQRGPAGPG
160 170 180 190 200
PGPGSGAAPE ARSESPSRIR HLVHSVQKLF AKSHSLEAPG KRDYNGPKAD
210 220 230 240 250
GRGSSGGDSY SGPGSGGTPT SHHHHHHHHH HHHQSRHGKR SKSKDRKGDG
260 270 280 290 300
RHQTKATGWW SSDDNLDSDS GFLGGRPPGE PGGPFCLDAP DGSYRDLSFK
310 320 330 340 350
GRSGGSEGRC LACTGMSMSL DGQSVKRSAW HTMMVSQGRD GYPGAGPGKG
360 370 380 390 400
LLGPETKAKA RTYHYLQVPQ DDWGGYPTGG KDGEIPCRRM RSGSYIKAMG
410 420 430 440 450
DEESGDSDGS PKTSPKALAR RFASRRSSSV DTARINCCVP PRIHPRSSIP
460 470 480 490 500
GYSRSLTTGQ LSEEFNQQLE AVCGSVFGEL ESQAVDALDL PGCFRMRSHS
510 520 530 540 550
YLRAIQAGCS QDDDCLPLLA APASVSGRPG SSFNFRKAPP PIPPGSQAPP
560 570 580 590 600
RISITAQSST DSAHESFTAA EGPARRCSSA DGLDGPTMGA RTLELAPVPP
610 620 630 640 650
RASPKPPTLI IKTIPGREEL RSLARQRKWR PSIGVQVETI SDSDTENRSR
660 670 680 690 700
REFHSIGVQV EEDKRRARFK RSNSVTAGVQ ADLELEGLAG LATVATEDKA
710 720 730 740 750
LQFGRSFQRH ASEPQPGPRA PTYSVFRTVH TQGQWAYREG YPLPYEPPAT
760 770 780 790 800
DGSPGPTPVP APGPGSGRRD SWMERGSRSL PDSGRTSPCP RDGEWFIKML
810 820 830 840 850
RAEVEKLEHW CQQMEREAED YELPEEILEK IRSAVGSTQL LLSQKVQQFF
860 870 880 890 900
RLCQQSLDPT AFPVPTFQDL AGFWDLLQLS IEDVTLKFLE LQQLKANSWK
910 920 930 940 950
LLEPKEEKKV PPPIPKKPSR GRGVPVKERS LDSVDRQRQE ARKRLLAAKR
960 970
AASFRHSSAT ESADSIEIYI PEAQTRL
Length:977
Mass (Da):105,873
Last modified:July 5, 2004 - v1
Checksum:i26665D623D49E4C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436N → S in AAO89219 (PubMed:15024750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243848 mRNA Translation: AAO89219.2
BC057615 mRNA Translation: AAH57615.1
BC058433 mRNA Translation: AAH58433.1
CCDSiCCDS18665.1
RefSeqiNP_001289010.1, NM_001302081.1
NP_941020.1, NM_198618.5
XP_011238839.1, XM_011240537.2
UniGeneiMm.331885

Genome annotation databases

EnsembliENSMUST00000046659; ENSMUSP00000039724; ENSMUSG00000042388
ENSMUST00000106094; ENSMUSP00000101700; ENSMUSG00000042388
GeneIDi242667
KEGGimmu:242667
UCSCiuc008uuo.3 mouse

Similar proteinsi

Entry informationi

Entry nameiDLGP3_MOUSE
AccessioniPrimary (citable) accession number: Q6PFD5
Secondary accession number(s): Q6PDX0, Q6XBF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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