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Q6PF18

- MORN3_HUMAN

UniProt

Q6PF18 - MORN3_HUMAN

Protein

MORN repeat-containing protein 3

Gene

MORN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MORN repeat-containing protein 3
    Gene namesi
    Name:MORN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29807. MORN3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485546.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240MORN repeat-containing protein 3PRO_0000247459Add
    BLAST

    Proteomic databases

    PaxDbiQ6PF18.
    PRIDEiQ6PF18.

    PTM databases

    PhosphoSiteiQ6PF18.

    Expressioni

    Gene expression databases

    BgeeiQ6PF18.
    CleanExiHS_MORN3.
    GenevestigatoriQ6PF18.

    Organism-specific databases

    HPAiHPA038709.
    HPA038710.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000347486.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PF18.
    SMRiQ6PF18. Positions 12-99, 136-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati38 – 6023MORN 1Add
    BLAST
    Repeati62 – 8423MORN 2Add
    BLAST
    Repeati91 – 11323MORN 3Add
    BLAST
    Repeati114 – 13623MORN 4Add
    BLAST
    Repeati137 – 15923MORN 5Add
    BLAST
    Repeati160 – 18223MORN 6Add
    BLAST
    Repeati184 – 20522MORN 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 MORN repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG4642.
    HOGENOMiHOG000007397.
    HOVERGENiHBG067658.
    InParanoidiQ6PF18.
    OMAiYEGCWER.
    OrthoDBiEOG7CCBS3.
    PhylomeDBiQ6PF18.
    TreeFamiTF323893.

    Family and domain databases

    InterProiIPR003409. MORN.
    [Graphical view]
    PfamiPF02493. MORN. 5 hits.
    [Graphical view]
    SMARTiSM00698. MORN. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PF18-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK    50
    GTQVWKKKGA IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK 100
    SGYGIQFFGP KEYYEGDWCG SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG 150
    MLRLKNGNRY EGCWERGMKN GAGRFFHLDH GQLFEGFWVD NMAKCGTMID 200
    FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD 240
    Length:240
    Mass (Da):27,585
    Last modified:May 18, 2010 - v2
    Checksum:i8B87C00C47203D55
    GO
    Isoform 2 (identifier: Q6PF18-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-160: KNGNRY → SQNPRP
         161-240: Missing.

    Show »
    Length:160
    Mass (Da):18,546
    Checksum:iC756381DBD39E318
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431K → E in AAH57760. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei155 – 1606KNGNRY → SQNPRP in isoform 2. 1 PublicationVSP_019996
    Alternative sequencei161 – 24080Missing in isoform 2. 1 PublicationVSP_019997Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY177732 mRNA. Translation: AAO18675.1.
    AC084018 Genomic DNA. No translation available.
    AC140062 Genomic DNA. No translation available.
    BC057760 mRNA. Translation: AAH57760.1.
    CCDSiCCDS31917.1. [Q6PF18-1]
    RefSeqiNP_776254.3. NM_173855.4. [Q6PF18-1]
    XP_005253926.1. XM_005253869.2. [Q6PF18-1]
    UniGeneiHs.434154.

    Genome annotation databases

    EnsembliENST00000355329; ENSP00000347486; ENSG00000139714. [Q6PF18-1]
    ENST00000392462; ENSP00000376255; ENSG00000139714. [Q6PF18-2]
    ENST00000542364; ENSP00000445643; ENSG00000139714. [Q6PF18-2]
    GeneIDi283385.
    KEGGihsa:283385.
    UCSCiuc001uax.3. human. [Q6PF18-1]

    Polymorphism databases

    DMDMi296438295.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY177732 mRNA. Translation: AAO18675.1 .
    AC084018 Genomic DNA. No translation available.
    AC140062 Genomic DNA. No translation available.
    BC057760 mRNA. Translation: AAH57760.1 .
    CCDSi CCDS31917.1. [Q6PF18-1 ]
    RefSeqi NP_776254.3. NM_173855.4. [Q6PF18-1 ]
    XP_005253926.1. XM_005253869.2. [Q6PF18-1 ]
    UniGenei Hs.434154.

    3D structure databases

    ProteinModelPortali Q6PF18.
    SMRi Q6PF18. Positions 12-99, 136-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000347486.

    PTM databases

    PhosphoSitei Q6PF18.

    Polymorphism databases

    DMDMi 296438295.

    Proteomic databases

    PaxDbi Q6PF18.
    PRIDEi Q6PF18.

    Protocols and materials databases

    DNASUi 283385.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355329 ; ENSP00000347486 ; ENSG00000139714 . [Q6PF18-1 ]
    ENST00000392462 ; ENSP00000376255 ; ENSG00000139714 . [Q6PF18-2 ]
    ENST00000542364 ; ENSP00000445643 ; ENSG00000139714 . [Q6PF18-2 ]
    GeneIDi 283385.
    KEGGi hsa:283385.
    UCSCi uc001uax.3. human. [Q6PF18-1 ]

    Organism-specific databases

    CTDi 283385.
    GeneCardsi GC12M122089.
    HGNCi HGNC:29807. MORN3.
    HPAi HPA038709.
    HPA038710.
    neXtProti NX_Q6PF18.
    PharmGKBi PA143485546.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4642.
    HOGENOMi HOG000007397.
    HOVERGENi HBG067658.
    InParanoidi Q6PF18.
    OMAi YEGCWER.
    OrthoDBi EOG7CCBS3.
    PhylomeDBi Q6PF18.
    TreeFami TF323893.

    Miscellaneous databases

    GenomeRNAii 283385.
    NextBioi 93859.
    PROi Q6PF18.

    Gene expression databases

    Bgeei Q6PF18.
    CleanExi HS_MORN3.
    Genevestigatori Q6PF18.

    Family and domain databases

    InterProi IPR003409. MORN.
    [Graphical view ]
    Pfami PF02493. MORN. 5 hits.
    [Graphical view ]
    SMARTi SM00698. MORN. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mao Y., Xie Y., Wu H.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.

    Entry informationi

    Entry nameiMORN3_HUMAN
    AccessioniPrimary (citable) accession number: Q6PF18
    Secondary accession number(s): Q86YQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3