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Q6PF18 (MORN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MORN repeat-containing protein 3
Gene names
Name:MORN3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 MORN repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay PubMed 21630459. Source: UniProt

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PF18-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PF18-2)

The sequence of this isoform differs from the canonical sequence as follows:
     155-160: KNGNRY → SQNPRP
     161-240: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240MORN repeat-containing protein 3
PRO_0000247459

Regions

Repeat38 – 6023MORN 1
Repeat62 – 8423MORN 2
Repeat91 – 11323MORN 3
Repeat114 – 13623MORN 4
Repeat137 – 15923MORN 5
Repeat160 – 18223MORN 6
Repeat184 – 20522MORN 7

Natural variations

Alternative sequence155 – 1606KNGNRY → SQNPRP in isoform 2.
VSP_019996
Alternative sequence161 – 24080Missing in isoform 2.
VSP_019997

Experimental info

Sequence conflict431K → E in AAH57760. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 8B87C00C47203D55

FASTA24027,585
        10         20         30         40         50         60 
MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK GTQVWKKKGA 

        70         80         90        100        110        120 
IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK SGYGIQFFGP KEYYEGDWCG 

       130        140        150        160        170        180 
SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG MLRLKNGNRY EGCWERGMKN GAGRFFHLDH 

       190        200        210        220        230        240 
GQLFEGFWVD NMAKCGTMID FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD 

« Hide

Isoform 2 [UniParc].

Checksum: C756381DBD39E318
Show »

FASTA16018,546

References

« Hide 'large scale' references
[1]Mao Y., Xie Y., Wu H.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY177732 mRNA. Translation: AAO18675.1.
AC084018 Genomic DNA. No translation available.
AC140062 Genomic DNA. No translation available.
BC057760 mRNA. Translation: AAH57760.1.
CCDSCCDS31917.1. [Q6PF18-1]
RefSeqNP_776254.3. NM_173855.4. [Q6PF18-1]
XP_005253926.1. XM_005253869.2. [Q6PF18-1]
UniGeneHs.434154.

3D structure databases

ProteinModelPortalQ6PF18.
SMRQ6PF18. Positions 12-99, 136-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000347486.

PTM databases

PhosphoSiteQ6PF18.

Polymorphism databases

DMDM296438295.

Proteomic databases

PaxDbQ6PF18.
PRIDEQ6PF18.

Protocols and materials databases

DNASU283385.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355329; ENSP00000347486; ENSG00000139714. [Q6PF18-1]
ENST00000392462; ENSP00000376255; ENSG00000139714. [Q6PF18-2]
ENST00000542364; ENSP00000445643; ENSG00000139714. [Q6PF18-2]
ENST00000606616; ENSP00000475353; ENSG00000271801. [Q6PF18-2]
ENST00000607636; ENSP00000475831; ENSG00000271801. [Q6PF18-2]
ENST00000607775; ENSP00000475971; ENSG00000271801. [Q6PF18-1]
GeneID283385.
KEGGhsa:283385.
UCSCuc001uax.3. human. [Q6PF18-1]

Organism-specific databases

CTD283385.
GeneCardsGC12M122089.
HGNCHGNC:29807. MORN3.
HPAHPA038709.
HPA038710.
neXtProtNX_Q6PF18.
PharmGKBPA143485546.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4642.
HOGENOMHOG000007397.
HOVERGENHBG067658.
InParanoidQ6PF18.
OMAYEGCWER.
OrthoDBEOG7CCBS3.
PhylomeDBQ6PF18.
TreeFamTF323893.

Gene expression databases

BgeeQ6PF18.
CleanExHS_MORN3.
GenevestigatorQ6PF18.

Family and domain databases

InterProIPR003409. MORN.
[Graphical view]
PfamPF02493. MORN. 5 hits.
[Graphical view]
SMARTSM00698. MORN. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi283385.
NextBio93859.
PROQ6PF18.

Entry information

Entry nameMORN3_HUMAN
AccessionPrimary (citable) accession number: Q6PF18
Secondary accession number(s): Q86YQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM