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Protein

MORN repeat-containing protein 3

Gene

MORN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 3
Gene namesi
Name:MORN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139714.12
HGNCiHGNC:29807 MORN3
neXtProtiNX_Q6PF18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139714
PharmGKBiPA143485546

Polymorphism and mutation databases

BioMutaiMORN3
DMDMi296438295

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474591 – 240MORN repeat-containing protein 3Add BLAST240

Proteomic databases

PaxDbiQ6PF18
PeptideAtlasiQ6PF18
PRIDEiQ6PF18
ProteomicsDBi67103
67104 [Q6PF18-2]

PTM databases

iPTMnetiQ6PF18
PhosphoSitePlusiQ6PF18

Expressioni

Gene expression databases

BgeeiENSG00000139714
CleanExiHS_MORN3
ExpressionAtlasiQ6PF18 baseline and differential
GenevisibleiQ6PF18 HS

Organism-specific databases

HPAiHPA038709
HPA038710

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129545, 17 interactors
IntActiQ6PF18, 59 interactors
MINTiQ6PF18
STRINGi9606.ENSP00000347486

Structurei

3D structure databases

ProteinModelPortaliQ6PF18
SMRiQ6PF18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 60MORN 1Add BLAST23
Repeati62 – 84MORN 2Add BLAST23
Repeati91 – 113MORN 3Add BLAST23
Repeati114 – 136MORN 4Add BLAST23
Repeati137 – 159MORN 5Add BLAST23
Repeati160 – 182MORN 6Add BLAST23
Repeati184 – 205MORN 7Add BLAST22

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297
HOGENOMiHOG000007397
HOVERGENiHBG067658
InParanoidiQ6PF18
OMAiSGYGIQF
OrthoDBiEOG091G0AU5
PhylomeDBiQ6PF18
TreeFamiTF323893

Family and domain databases

InterProiView protein in InterPro
IPR003409 MORN
PfamiView protein in Pfam
PF02493 MORN, 5 hits
SMARTiView protein in SMART
SM00698 MORN, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK
60 70 80 90 100
GTQVWKKKGA IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK
110 120 130 140 150
SGYGIQFFGP KEYYEGDWCG SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG
160 170 180 190 200
MLRLKNGNRY EGCWERGMKN GAGRFFHLDH GQLFEGFWVD NMAKCGTMID
210 220 230 240
FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD
Length:240
Mass (Da):27,585
Last modified:May 18, 2010 - v2
Checksum:i8B87C00C47203D55
GO
Isoform 2 (identifier: Q6PF18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-160: KNGNRY → SQNPRP
     161-240: Missing.

Show »
Length:160
Mass (Da):18,546
Checksum:iC756381DBD39E318
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43K → E in AAH57760 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019996155 – 160KNGNRY → SQNPRP in isoform 2. 1 Publication6
Alternative sequenceiVSP_019997161 – 240Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177732 mRNA Translation: AAO18675.1
AC084018 Genomic DNA No translation available.
AC140062 Genomic DNA No translation available.
BC057760 mRNA Translation: AAH57760.1
CCDSiCCDS31917.1 [Q6PF18-1]
RefSeqiNP_776254.3, NM_173855.4 [Q6PF18-1]
XP_005253926.1, XM_005253869.4 [Q6PF18-1]
XP_011536515.1, XM_011538213.2 [Q6PF18-1]
UniGeneiHs.434154

Genome annotation databases

EnsembliENST00000355329; ENSP00000347486; ENSG00000139714 [Q6PF18-1]
ENST00000392462; ENSP00000376255; ENSG00000139714 [Q6PF18-2]
ENST00000542364; ENSP00000445643; ENSG00000139714 [Q6PF18-2]
ENST00000642335; ENSP00000493930; ENSG00000285371 [Q6PF18-1]
ENST00000643015; ENSP00000493884; ENSG00000285371 [Q6PF18-2]
ENST00000643645; ENSP00000495716; ENSG00000285371 [Q6PF18-2]
GeneIDi283385
KEGGihsa:283385
UCSCiuc001uax.4 human [Q6PF18-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMORN3_HUMAN
AccessioniPrimary (citable) accession number: Q6PF18
Secondary accession number(s): Q86YQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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