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Protein

MORN repeat-containing protein 3

Gene

MORN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 3
Gene namesi
Name:MORN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29807. MORN3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139714.
PharmGKBiPA143485546.

Polymorphism and mutation databases

BioMutaiMORN3.
DMDMi296438295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474591 – 240MORN repeat-containing protein 3Add BLAST240

Proteomic databases

PaxDbiQ6PF18.
PeptideAtlasiQ6PF18.
PRIDEiQ6PF18.

PTM databases

iPTMnetiQ6PF18.
PhosphoSitePlusiQ6PF18.

Expressioni

Gene expression databases

BgeeiENSG00000139714.
CleanExiHS_MORN3.
ExpressionAtlasiQ6PF18. baseline and differential.
GenevisibleiQ6PF18. HS.

Organism-specific databases

HPAiHPA038709.
HPA038710.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-9675802,EBI-10173507
CDCA7LQ96GN53EBI-9675802,EBI-5278764
DYNLL2Q96FJ23EBI-9675802,EBI-742371
FAM208BQ5VWN6-23EBI-9675802,EBI-10172380
GOLGA2Q083793EBI-9675802,EBI-618309
IKZF3Q9UKT93EBI-9675802,EBI-747204
KRT15P190123EBI-9675802,EBI-739566
LZTS2Q9BRK43EBI-9675802,EBI-741037
MAGEA6P433605EBI-9675802,EBI-1045155
MEOX2A4D1273EBI-9675802,EBI-10172134
RSPH1Q8WYR45EBI-9675802,EBI-10253582
SOX5P357113EBI-9675802,EBI-3505701
TRAF1Q130777EBI-9675802,EBI-359224
TRAF2Q129335EBI-9675802,EBI-355744
TRIP13Q156453EBI-9675802,EBI-358993

Protein-protein interaction databases

BioGridi129545. 17 interactors.
IntActiQ6PF18. 25 interactors.
STRINGi9606.ENSP00000347486.

Structurei

3D structure databases

ProteinModelPortaliQ6PF18.
SMRiQ6PF18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 60MORN 1Add BLAST23
Repeati62 – 84MORN 2Add BLAST23
Repeati91 – 113MORN 3Add BLAST23
Repeati114 – 136MORN 4Add BLAST23
Repeati137 – 159MORN 5Add BLAST23
Repeati160 – 182MORN 6Add BLAST23
Repeati184 – 205MORN 7Add BLAST22

Sequence similaritiesi

Contains 7 MORN repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000007397.
HOVERGENiHBG067658.
InParanoidiQ6PF18.
OMAiWKKKGAI.
OrthoDBiEOG091G0AU5.
PhylomeDBiQ6PF18.
TreeFamiTF323893.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 5 hits.
[Graphical view]
SMARTiSM00698. MORN. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVSKCPKKS ESLWKGWDRK AQRNGLRSQV YAVNGDYYVG EWKDNVKHGK
60 70 80 90 100
GTQVWKKKGA IYEGDWKFGK RDGYGTLSLP DQQTGKCRRV YSGWWKGDKK
110 120 130 140 150
SGYGIQFFGP KEYYEGDWCG SQRSGWGRMY YSNGDIYEGQ WENDKPNGEG
160 170 180 190 200
MLRLKNGNRY EGCWERGMKN GAGRFFHLDH GQLFEGFWVD NMAKCGTMID
210 220 230 240
FGRDEAPEPT QFPIPEVKIL DPDGVLAEAL AMFRKTEEGD
Length:240
Mass (Da):27,585
Last modified:May 18, 2010 - v2
Checksum:i8B87C00C47203D55
GO
Isoform 2 (identifier: Q6PF18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-160: KNGNRY → SQNPRP
     161-240: Missing.

Show »
Length:160
Mass (Da):18,546
Checksum:iC756381DBD39E318
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43K → E in AAH57760 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019996155 – 160KNGNRY → SQNPRP in isoform 2. 1 Publication6
Alternative sequenceiVSP_019997161 – 240Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177732 mRNA. Translation: AAO18675.1.
AC084018 Genomic DNA. No translation available.
AC140062 Genomic DNA. No translation available.
BC057760 mRNA. Translation: AAH57760.1.
CCDSiCCDS31917.1. [Q6PF18-1]
RefSeqiNP_776254.3. NM_173855.4. [Q6PF18-1]
XP_005253926.1. XM_005253869.4. [Q6PF18-1]
XP_011536515.1. XM_011538213.2. [Q6PF18-1]
UniGeneiHs.434154.

Genome annotation databases

EnsembliENST00000355329; ENSP00000347486; ENSG00000139714. [Q6PF18-1]
ENST00000392462; ENSP00000376255; ENSG00000139714. [Q6PF18-2]
ENST00000542364; ENSP00000445643; ENSG00000139714. [Q6PF18-2]
GeneIDi283385.
KEGGihsa:283385.
UCSCiuc001uax.4. human. [Q6PF18-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177732 mRNA. Translation: AAO18675.1.
AC084018 Genomic DNA. No translation available.
AC140062 Genomic DNA. No translation available.
BC057760 mRNA. Translation: AAH57760.1.
CCDSiCCDS31917.1. [Q6PF18-1]
RefSeqiNP_776254.3. NM_173855.4. [Q6PF18-1]
XP_005253926.1. XM_005253869.4. [Q6PF18-1]
XP_011536515.1. XM_011538213.2. [Q6PF18-1]
UniGeneiHs.434154.

3D structure databases

ProteinModelPortaliQ6PF18.
SMRiQ6PF18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129545. 17 interactors.
IntActiQ6PF18. 25 interactors.
STRINGi9606.ENSP00000347486.

PTM databases

iPTMnetiQ6PF18.
PhosphoSitePlusiQ6PF18.

Polymorphism and mutation databases

BioMutaiMORN3.
DMDMi296438295.

Proteomic databases

PaxDbiQ6PF18.
PeptideAtlasiQ6PF18.
PRIDEiQ6PF18.

Protocols and materials databases

DNASUi283385.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355329; ENSP00000347486; ENSG00000139714. [Q6PF18-1]
ENST00000392462; ENSP00000376255; ENSG00000139714. [Q6PF18-2]
ENST00000542364; ENSP00000445643; ENSG00000139714. [Q6PF18-2]
GeneIDi283385.
KEGGihsa:283385.
UCSCiuc001uax.4. human. [Q6PF18-1]

Organism-specific databases

CTDi283385.
GeneCardsiMORN3.
HGNCiHGNC:29807. MORN3.
HPAiHPA038709.
HPA038710.
neXtProtiNX_Q6PF18.
OpenTargetsiENSG00000139714.
PharmGKBiPA143485546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000007397.
HOVERGENiHBG067658.
InParanoidiQ6PF18.
OMAiWKKKGAI.
OrthoDBiEOG091G0AU5.
PhylomeDBiQ6PF18.
TreeFamiTF323893.

Miscellaneous databases

ChiTaRSiMORN3. human.
GenomeRNAii283385.
PROiQ6PF18.

Gene expression databases

BgeeiENSG00000139714.
CleanExiHS_MORN3.
ExpressionAtlasiQ6PF18. baseline and differential.
GenevisibleiQ6PF18. HS.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 5 hits.
[Graphical view]
SMARTiSM00698. MORN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMORN3_HUMAN
AccessioniPrimary (citable) accession number: Q6PF18
Secondary accession number(s): Q86YQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.