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Protein

Kelch-like protein 35

Gene

KLHL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 35
Gene namesi
Name:KLHL35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149243.15
HGNCiHGNC:26597 KLHL35
neXtProtiNX_Q6PF15

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi283212
OpenTargetsiENSG00000149243
PharmGKBiPA162393595

Polymorphism and mutation databases

DMDMi205831238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444661 – 583Kelch-like protein 35Add BLAST583

Proteomic databases

MaxQBiQ6PF15
PaxDbiQ6PF15
PeptideAtlasiQ6PF15
PRIDEiQ6PF15
ProteomicsDBi67101
67102 [Q6PF15-2]

PTM databases

iPTMnetiQ6PF15
PhosphoSitePlusiQ6PF15

Expressioni

Gene expression databases

BgeeiENSG00000149243
CleanExiHS_KLHL35
ExpressionAtlasiQ6PF15 baseline and differential
GenevisibleiQ6PF15 HS

Organism-specific databases

HPAiHPA039232
HPA039864

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129497, 3 interactors
IntActiQ6PF15, 7 interactors
STRINGi9606.ENSP00000438526

Structurei

3D structure databases

ProteinModelPortaliQ6PF15
SMRiQ6PF15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 119BTBPROSITE-ProRule annotationAdd BLAST79
Domaini146 – 248BACKAdd BLAST103
Repeati301 – 350Kelch 1Add BLAST50
Repeati352 – 394Kelch 2Add BLAST43
Repeati395 – 441Kelch 3Add BLAST47
Repeati443 – 489Kelch 4Add BLAST47
Repeati490 – 531Kelch 5Add BLAST42
Repeati533 – 579Kelch 6Add BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 220Ala-richAdd BLAST164

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000230817
HOVERGENiHBG095887
InParanoidiQ6PF15
KOiK10461
OMAiLDYVYGA
OrthoDBiEOG091G037V
PhylomeDBiQ6PF15
TreeFamiTF351654

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030601 KLHL35
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF187 PTHR24412:SF187, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR
60 70 80 90 100
DFPCHRAALS AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA
110 120 130 140 150
AALAVVLDYV YGAGVRLRAE DEAAAVLALA ERLGVAGLRE ACVRFLEGRL
160 170 180 190 200
RAANSLALRR VAAAFSLAPL AERCGRVLRQ AFAEVARHAD FLELAPDEVV
210 220 230 240 250
ALLADPALGV AREEAVFEAA MRWVRHDAPA RRGQLRRLLE HVRLPLLAPA
260 270 280 290 300
YFLEKVEADE LLQACGECRP LLLEARACFI LGREAGALRT RPRRFMDLAE
310 320 330 340 350
VIVVIGGCDR KGLLKLPFAD AYHPESQRWT PLPSLPGYTR SEFAACALRN
360 370 380 390 400
DVYVSGGHIN SHDVWMFSSH LHTWIKVASL HKGRWRHKMA VVQGQLFAVG
410 420 430 440 450
GFDGLRRLHS VERYDPFSNT WAAAAPLPEA VSSAAVASCA GKLFVIGGAR
460 470 480 490 500
QGGVNTDKVQ CFDPKEDRWS LRSPAPFSQR CLEAVSLEDT IYVMGGLMSK
510 520 530 540 550
IFTYDPGTDV WGEAAVLPSP VESCGVTVCD GKVHILGGRD DRGESTDKVF
560 570 580
TFDPSSGQVE VQPSLQRCTS SHGCVTIIQS LGR
Length:583
Mass (Da):62,892
Last modified:September 3, 2014 - v3
Checksum:i05BA7D11DF77FD30
GO
Isoform 2 (identifier: Q6PF15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-293: R → RRHWAYPHA
     396-419: LFAVGGFDGLRRLHSVERYDPFSN → VGTSCSGCPGTQGTDLWMCWREVL
     420-583: Missing.

Show »
Length:427
Mass (Da):46,467
Checksum:iB546A2EE68943F03
GO

Sequence cautioni

The sequence AAH42952 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH57763 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI32709 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI32711 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03585 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW74965 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW74966 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034783293R → RRHWAYPHA in isoform 2. 1 Publication1
Alternative sequenceiVSP_034784396 – 419LFAVG…DPFSN → VGTSCSGCPGTQGTDLWMCW REVL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_034785420 – 583Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000744 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74965.1 Sequence problems.
CH471076 Genomic DNA Translation: EAW74966.1 Sequence problems.
BC042952 mRNA Translation: AAH42952.3 Different initiation.
BC057763 mRNA Translation: AAH57763.1 Different initiation.
BC132708 mRNA Translation: AAI32709.1 Different initiation.
BC132710 mRNA Translation: AAI32711.1 Different initiation.
AK091109 mRNA Translation: BAC03585.1 Different initiation.
CCDSiCCDS44685.2 [Q6PF15-1]
RefSeqiNP_001034637.2, NM_001039548.2 [Q6PF15-1]
UniGeneiHs.292451

Genome annotation databases

EnsembliENST00000539798; ENSP00000438526; ENSG00000149243 [Q6PF15-1]
GeneIDi283212
KEGGihsa:283212
UCSCiuc001owm.3 human [Q6PF15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKLH35_HUMAN
AccessioniPrimary (citable) accession number: Q6PF15
Secondary accession number(s): A2RU06
, F5H412, Q86XM7, Q8NBB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: September 3, 2014
Last modified: June 20, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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