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Protein

Kelch-like protein 35

Gene

KLHL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 35
Gene namesi
Name:KLHL35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26597. KLHL35.

Pathology & Biotechi

Organism-specific databases

DisGeNETi283212.
OpenTargetsiENSG00000149243.
PharmGKBiPA162393595.

Polymorphism and mutation databases

DMDMi205831238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444661 – 583Kelch-like protein 35Add BLAST583

Proteomic databases

MaxQBiQ6PF15.
PaxDbiQ6PF15.
PeptideAtlasiQ6PF15.
PRIDEiQ6PF15.

PTM databases

iPTMnetiQ6PF15.
PhosphoSitePlusiQ6PF15.

Expressioni

Gene expression databases

BgeeiENSG00000149243.
CleanExiHS_KLHL35.
ExpressionAtlasiQ6PF15. baseline and differential.
GenevisibleiQ6PF15. HS.

Organism-specific databases

HPAiHPA039232.
HPA039864.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-9477654,EBI-3905054
APPBP2Q926245EBI-9477654,EBI-743771

Protein-protein interaction databases

BioGridi129497. 3 interactors.
IntActiQ6PF15. 5 interactors.
STRINGi9606.ENSP00000438526.

Structurei

3D structure databases

ProteinModelPortaliQ6PF15.
SMRiQ6PF15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 119BTBPROSITE-ProRule annotationAdd BLAST79
Domaini146 – 248BACKAdd BLAST103
Repeati301 – 350Kelch 1Add BLAST50
Repeati352 – 394Kelch 2Add BLAST43
Repeati395 – 441Kelch 3Add BLAST47
Repeati443 – 489Kelch 4Add BLAST47
Repeati490 – 531Kelch 5Add BLAST42
Repeati533 – 579Kelch 6Add BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 220Ala-richAdd BLAST164

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000230817.
HOVERGENiHBG095887.
InParanoidiQ6PF15.
KOiK10461.
OMAiDYVYGAG.
OrthoDBiEOG091G037V.
PhylomeDBiQ6PF15.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030601. KLHL35.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF187. PTHR24412:SF187. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR
60 70 80 90 100
DFPCHRAALS AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA
110 120 130 140 150
AALAVVLDYV YGAGVRLRAE DEAAAVLALA ERLGVAGLRE ACVRFLEGRL
160 170 180 190 200
RAANSLALRR VAAAFSLAPL AERCGRVLRQ AFAEVARHAD FLELAPDEVV
210 220 230 240 250
ALLADPALGV AREEAVFEAA MRWVRHDAPA RRGQLRRLLE HVRLPLLAPA
260 270 280 290 300
YFLEKVEADE LLQACGECRP LLLEARACFI LGREAGALRT RPRRFMDLAE
310 320 330 340 350
VIVVIGGCDR KGLLKLPFAD AYHPESQRWT PLPSLPGYTR SEFAACALRN
360 370 380 390 400
DVYVSGGHIN SHDVWMFSSH LHTWIKVASL HKGRWRHKMA VVQGQLFAVG
410 420 430 440 450
GFDGLRRLHS VERYDPFSNT WAAAAPLPEA VSSAAVASCA GKLFVIGGAR
460 470 480 490 500
QGGVNTDKVQ CFDPKEDRWS LRSPAPFSQR CLEAVSLEDT IYVMGGLMSK
510 520 530 540 550
IFTYDPGTDV WGEAAVLPSP VESCGVTVCD GKVHILGGRD DRGESTDKVF
560 570 580
TFDPSSGQVE VQPSLQRCTS SHGCVTIIQS LGR
Length:583
Mass (Da):62,892
Last modified:September 3, 2014 - v3
Checksum:i05BA7D11DF77FD30
GO
Isoform 2 (identifier: Q6PF15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-293: R → RRHWAYPHA
     396-419: LFAVGGFDGLRRLHSVERYDPFSN → VGTSCSGCPGTQGTDLWMCWREVL
     420-583: Missing.

Show »
Length:427
Mass (Da):46,467
Checksum:iB546A2EE68943F03
GO

Sequence cautioni

The sequence AAH42952 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH57763 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI32709 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI32711 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03585 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW74965 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW74966 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034783293R → RRHWAYPHA in isoform 2. 1 Publication1
Alternative sequenceiVSP_034784396 – 419LFAVG…DPFSN → VGTSCSGCPGTQGTDLWMCW REVL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_034785420 – 583Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000744 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74965.1. Sequence problems.
CH471076 Genomic DNA. Translation: EAW74966.1. Sequence problems.
BC042952 mRNA. Translation: AAH42952.3. Different initiation.
BC057763 mRNA. Translation: AAH57763.1. Different initiation.
BC132708 mRNA. Translation: AAI32709.1. Different initiation.
BC132710 mRNA. Translation: AAI32711.1. Different initiation.
AK091109 mRNA. Translation: BAC03585.1. Different initiation.
CCDSiCCDS44685.2. [Q6PF15-1]
RefSeqiNP_001034637.2. NM_001039548.2. [Q6PF15-1]
UniGeneiHs.292451.

Genome annotation databases

EnsembliENST00000539798; ENSP00000438526; ENSG00000149243. [Q6PF15-1]
GeneIDi283212.
KEGGihsa:283212.
UCSCiuc001owm.3. human. [Q6PF15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000744 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74965.1. Sequence problems.
CH471076 Genomic DNA. Translation: EAW74966.1. Sequence problems.
BC042952 mRNA. Translation: AAH42952.3. Different initiation.
BC057763 mRNA. Translation: AAH57763.1. Different initiation.
BC132708 mRNA. Translation: AAI32709.1. Different initiation.
BC132710 mRNA. Translation: AAI32711.1. Different initiation.
AK091109 mRNA. Translation: BAC03585.1. Different initiation.
CCDSiCCDS44685.2. [Q6PF15-1]
RefSeqiNP_001034637.2. NM_001039548.2. [Q6PF15-1]
UniGeneiHs.292451.

3D structure databases

ProteinModelPortaliQ6PF15.
SMRiQ6PF15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129497. 3 interactors.
IntActiQ6PF15. 5 interactors.
STRINGi9606.ENSP00000438526.

PTM databases

iPTMnetiQ6PF15.
PhosphoSitePlusiQ6PF15.

Polymorphism and mutation databases

DMDMi205831238.

Proteomic databases

MaxQBiQ6PF15.
PaxDbiQ6PF15.
PeptideAtlasiQ6PF15.
PRIDEiQ6PF15.

Protocols and materials databases

DNASUi283212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539798; ENSP00000438526; ENSG00000149243. [Q6PF15-1]
GeneIDi283212.
KEGGihsa:283212.
UCSCiuc001owm.3. human. [Q6PF15-1]

Organism-specific databases

CTDi283212.
DisGeNETi283212.
GeneCardsiKLHL35.
HGNCiHGNC:26597. KLHL35.
HPAiHPA039232.
HPA039864.
neXtProtiNX_Q6PF15.
OpenTargetsiENSG00000149243.
PharmGKBiPA162393595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000230817.
HOVERGENiHBG095887.
InParanoidiQ6PF15.
KOiK10461.
OMAiDYVYGAG.
OrthoDBiEOG091G037V.
PhylomeDBiQ6PF15.
TreeFamiTF351654.

Miscellaneous databases

GenomeRNAii283212.
PROiQ6PF15.

Gene expression databases

BgeeiENSG00000149243.
CleanExiHS_KLHL35.
ExpressionAtlasiQ6PF15. baseline and differential.
GenevisibleiQ6PF15. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR030601. KLHL35.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF187. PTHR24412:SF187. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 4 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH35_HUMAN
AccessioniPrimary (citable) accession number: Q6PF15
Secondary accession number(s): A2RU06
, F5H412, Q86XM7, Q8NBB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: September 3, 2014
Last modified: November 30, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.