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Protein

Zinc finger protein 613

Gene

ZNF613

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53524C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 613
Gene namesi
Name:ZNF613
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25827. ZNF613.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937067.

Polymorphism and mutation databases

BioMutaiZNF613.
DMDMi116242862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Zinc finger protein 613PRO_0000234597Add
BLAST

Proteomic databases

EPDiQ6PF04.
PaxDbiQ6PF04.
PRIDEiQ6PF04.

PTM databases

PhosphoSiteiQ6PF04.

Expressioni

Gene expression databases

BgeeiQ6PF04.
CleanExiHS_ZNF613.
ExpressionAtlasiQ6PF04. baseline and differential.
GenevisibleiQ6PF04. HS.

Organism-specific databases

HPAiHPA026833.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000293471.

Structurei

3D structure databases

ProteinModelPortaliQ6PF04.
SMRiQ6PF04. Positions 8-49, 167-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7871KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53524C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PF04.
KOiK09228.
OMAiFPLRQNH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6PF04.
TreeFamiTF350804.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKSQESLTL EDVAVEFTWE EWQLLGPAQK DLYRDVMLEN YSNLVSVGYQ
60 70 80 90 100
ASKPDALFKL EQGEPWTVEN EIHSQICPEI KKVDNHLQMH SQKQRCLKRV
110 120 130 140 150
EQCHKHNAFG NIIHQRKSDF PLRQNHDTFD LHGKILKSNL SLVNQNKRYE
160 170 180 190 200
IKNSVGVNGD GKSFLHAKHE QFHNEMNFPE GGNSVNTNSQ FIKHQRTQNI
210 220 230 240 250
DKPHVCTECG KAFLKKSRLI YHQRVHTGEK PHGCSICGKA FSRKSGLTEH
260 270 280 290 300
QRNHTGEKPY ECTECDKAFR WKSQLNAHQK IHTGEKSYIC SDCGKGFIKK
310 320 330 340 350
SRLINHQRVH TGEKPHGCSL CGKAFSKRSR LTEHQRTHTG EKPYECTECD
360 370 380 390 400
KAFRWKSQLN AHQKAHTGEK SYICRDCGKG FIQKGNLIVH QRIHTGEKPY
410 420 430 440 450
ICNECGKGFI QKGNLLIHRR THTGEKPYVC NECGKGFSQK TCLISHQRFH
460 470 480 490 500
TGKTPFVCTE CGKSCSHKSG LINHQRIHTG EKPYTCSDCG KAFRDKSCLN
510 520 530 540 550
RHRRTHTGER PYGCSDCGKA FSHLSCLVYH KGMLHAREKC VGSVKLENPC
560 570 580 590 600
SESHSLSHTR DLIQDKDSVN MVTLQMPSVA AQTSLTNSAF QAESKVAIVS
610
QPVARSSVSA DSRICTE
Length:617
Mass (Da):70,143
Last modified:October 17, 2006 - v2
Checksum:i44C6B14BB2060322
GO
Isoform 2 (identifier: Q6PF04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):65,893
Checksum:iEAB48B2340469FF7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841D → N.1 Publication
Corresponds to variant rs17854933 [ dbSNP | Ensembl ].
VAR_028096
Natural varianti93 – 931K → E.
Corresponds to variant rs8106409 [ dbSNP | Ensembl ].
VAR_028097
Natural varianti135 – 1351I → R.
Corresponds to variant rs16983243 [ dbSNP | Ensembl ].
VAR_028098
Natural varianti163 – 1631S → F.
Corresponds to variant rs33998555 [ dbSNP | Ensembl ].
VAR_057428
Natural varianti611 – 6111D → V.
Corresponds to variant rs16983253 [ dbSNP | Ensembl ].
VAR_057429

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_018388Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027565 mRNA. Translation: BAB55201.1.
BC057776 mRNA. Translation: AAH57776.1.
CCDSiCCDS12844.1. [Q6PF04-2]
CCDS33089.1. [Q6PF04-1]
RefSeqiNP_001026891.2. NM_001031721.3. [Q6PF04-1]
NP_079116.2. NM_024840.3. [Q6PF04-2]
XP_005259326.1. XM_005259269.2. [Q6PF04-1]
XP_011525635.1. XM_011527333.1. [Q6PF04-1]
UniGeneiHs.183390.

Genome annotation databases

EnsembliENST00000293471; ENSP00000293471; ENSG00000176024. [Q6PF04-1]
ENST00000391794; ENSP00000375671; ENSG00000176024. [Q6PF04-2]
ENST00000613007; ENSP00000478924; ENSG00000176024. [Q6PF04-1]
GeneIDi79898.
KEGGihsa:79898.
UCSCiuc002pxz.3. human. [Q6PF04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027565 mRNA. Translation: BAB55201.1.
BC057776 mRNA. Translation: AAH57776.1.
CCDSiCCDS12844.1. [Q6PF04-2]
CCDS33089.1. [Q6PF04-1]
RefSeqiNP_001026891.2. NM_001031721.3. [Q6PF04-1]
NP_079116.2. NM_024840.3. [Q6PF04-2]
XP_005259326.1. XM_005259269.2. [Q6PF04-1]
XP_011525635.1. XM_011527333.1. [Q6PF04-1]
UniGeneiHs.183390.

3D structure databases

ProteinModelPortaliQ6PF04.
SMRiQ6PF04. Positions 8-49, 167-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000293471.

PTM databases

PhosphoSiteiQ6PF04.

Polymorphism and mutation databases

BioMutaiZNF613.
DMDMi116242862.

Proteomic databases

EPDiQ6PF04.
PaxDbiQ6PF04.
PRIDEiQ6PF04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293471; ENSP00000293471; ENSG00000176024. [Q6PF04-1]
ENST00000391794; ENSP00000375671; ENSG00000176024. [Q6PF04-2]
ENST00000613007; ENSP00000478924; ENSG00000176024. [Q6PF04-1]
GeneIDi79898.
KEGGihsa:79898.
UCSCiuc002pxz.3. human. [Q6PF04-1]

Organism-specific databases

CTDi79898.
GeneCardsiZNF613.
HGNCiHGNC:25827. ZNF613.
HPAiHPA026833.
neXtProtiNX_Q6PF04.
PharmGKBiPA134937067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PF04.
KOiK09228.
OMAiFPLRQNH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6PF04.
TreeFamiTF350804.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79898.
NextBioi69738.
PROiQ6PF04.

Gene expression databases

BgeeiQ6PF04.
CleanExiHS_ZNF613.
ExpressionAtlasiQ6PF04. baseline and differential.
GenevisibleiQ6PF04. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-84.
    Tissue: Placenta.

Entry informationi

Entry nameiZN613_HUMAN
AccessioniPrimary (citable) accession number: Q6PF04
Secondary accession number(s): Q96SS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: May 11, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.