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Protein

Zinc finger protein 613

Gene

ZNF613

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 613
Gene namesi
Name:ZNF613
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25827. ZNF613.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176024.
PharmGKBiPA134937067.

Polymorphism and mutation databases

BioMutaiZNF613.
DMDMi116242862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345971 – 617Zinc finger protein 613Add BLAST617

Proteomic databases

EPDiQ6PF04.
MaxQBiQ6PF04.
PaxDbiQ6PF04.
PeptideAtlasiQ6PF04.
PRIDEiQ6PF04.

PTM databases

iPTMnetiQ6PF04.
PhosphoSitePlusiQ6PF04.

Expressioni

Gene expression databases

BgeeiENSG00000176024.
CleanExiHS_ZNF613.
ExpressionAtlasiQ6PF04. baseline and differential.
GenevisibleiQ6PF04. HS.

Organism-specific databases

HPAiHPA026833.

Interactioni

Protein-protein interaction databases

IntActiQ6PF04. 2 interactors.
STRINGi9606.ENSP00000293471.

Structurei

3D structure databases

ProteinModelPortaliQ6PF04.
SMRiQ6PF04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133760.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PF04.
KOiK09228.
OMAiFPLRQNH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6PF04.
TreeFamiTF350804.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKSQESLTL EDVAVEFTWE EWQLLGPAQK DLYRDVMLEN YSNLVSVGYQ
60 70 80 90 100
ASKPDALFKL EQGEPWTVEN EIHSQICPEI KKVDNHLQMH SQKQRCLKRV
110 120 130 140 150
EQCHKHNAFG NIIHQRKSDF PLRQNHDTFD LHGKILKSNL SLVNQNKRYE
160 170 180 190 200
IKNSVGVNGD GKSFLHAKHE QFHNEMNFPE GGNSVNTNSQ FIKHQRTQNI
210 220 230 240 250
DKPHVCTECG KAFLKKSRLI YHQRVHTGEK PHGCSICGKA FSRKSGLTEH
260 270 280 290 300
QRNHTGEKPY ECTECDKAFR WKSQLNAHQK IHTGEKSYIC SDCGKGFIKK
310 320 330 340 350
SRLINHQRVH TGEKPHGCSL CGKAFSKRSR LTEHQRTHTG EKPYECTECD
360 370 380 390 400
KAFRWKSQLN AHQKAHTGEK SYICRDCGKG FIQKGNLIVH QRIHTGEKPY
410 420 430 440 450
ICNECGKGFI QKGNLLIHRR THTGEKPYVC NECGKGFSQK TCLISHQRFH
460 470 480 490 500
TGKTPFVCTE CGKSCSHKSG LINHQRIHTG EKPYTCSDCG KAFRDKSCLN
510 520 530 540 550
RHRRTHTGER PYGCSDCGKA FSHLSCLVYH KGMLHAREKC VGSVKLENPC
560 570 580 590 600
SESHSLSHTR DLIQDKDSVN MVTLQMPSVA AQTSLTNSAF QAESKVAIVS
610
QPVARSSVSA DSRICTE
Length:617
Mass (Da):70,143
Last modified:October 17, 2006 - v2
Checksum:i44C6B14BB2060322
GO
Isoform 2 (identifier: Q6PF04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):65,893
Checksum:iEAB48B2340469FF7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02809684D → N.1 PublicationCorresponds to variant rs17854933dbSNPEnsembl.1
Natural variantiVAR_02809793K → E.Corresponds to variant rs8106409dbSNPEnsembl.1
Natural variantiVAR_028098135I → R.Corresponds to variant rs16983243dbSNPEnsembl.1
Natural variantiVAR_057428163S → F.Corresponds to variant rs33998555dbSNPEnsembl.1
Natural variantiVAR_057429611D → V.Corresponds to variant rs16983253dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183881 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027565 mRNA. Translation: BAB55201.1.
BC057776 mRNA. Translation: AAH57776.1.
CCDSiCCDS12844.1. [Q6PF04-2]
CCDS33089.1. [Q6PF04-1]
RefSeqiNP_001026891.2. NM_001031721.3. [Q6PF04-1]
NP_079116.2. NM_024840.3. [Q6PF04-2]
XP_005259326.1. XM_005259269.3. [Q6PF04-1]
XP_011525635.1. XM_011527333.2. [Q6PF04-1]
XP_016882804.1. XM_017027315.1. [Q6PF04-2]
UniGeneiHs.183390.

Genome annotation databases

EnsembliENST00000293471; ENSP00000293471; ENSG00000176024. [Q6PF04-1]
ENST00000391794; ENSP00000375671; ENSG00000176024. [Q6PF04-2]
GeneIDi79898.
KEGGihsa:79898.
UCSCiuc002pxz.3. human. [Q6PF04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027565 mRNA. Translation: BAB55201.1.
BC057776 mRNA. Translation: AAH57776.1.
CCDSiCCDS12844.1. [Q6PF04-2]
CCDS33089.1. [Q6PF04-1]
RefSeqiNP_001026891.2. NM_001031721.3. [Q6PF04-1]
NP_079116.2. NM_024840.3. [Q6PF04-2]
XP_005259326.1. XM_005259269.3. [Q6PF04-1]
XP_011525635.1. XM_011527333.2. [Q6PF04-1]
XP_016882804.1. XM_017027315.1. [Q6PF04-2]
UniGeneiHs.183390.

3D structure databases

ProteinModelPortaliQ6PF04.
SMRiQ6PF04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6PF04. 2 interactors.
STRINGi9606.ENSP00000293471.

PTM databases

iPTMnetiQ6PF04.
PhosphoSitePlusiQ6PF04.

Polymorphism and mutation databases

BioMutaiZNF613.
DMDMi116242862.

Proteomic databases

EPDiQ6PF04.
MaxQBiQ6PF04.
PaxDbiQ6PF04.
PeptideAtlasiQ6PF04.
PRIDEiQ6PF04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293471; ENSP00000293471; ENSG00000176024. [Q6PF04-1]
ENST00000391794; ENSP00000375671; ENSG00000176024. [Q6PF04-2]
GeneIDi79898.
KEGGihsa:79898.
UCSCiuc002pxz.3. human. [Q6PF04-1]

Organism-specific databases

CTDi79898.
GeneCardsiZNF613.
HGNCiHGNC:25827. ZNF613.
HPAiHPA026833.
neXtProtiNX_Q6PF04.
OpenTargetsiENSG00000176024.
PharmGKBiPA134937067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133760.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PF04.
KOiK09228.
OMAiFPLRQNH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6PF04.
TreeFamiTF350804.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79898.
PROiQ6PF04.

Gene expression databases

BgeeiENSG00000176024.
CleanExiHS_ZNF613.
ExpressionAtlasiQ6PF04. baseline and differential.
GenevisibleiQ6PF04. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN613_HUMAN
AccessioniPrimary (citable) accession number: Q6PF04
Secondary accession number(s): Q96SS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.