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Protein

Zinc finger protein 613

Gene

ZNF613

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 613
Gene namesi
Name:ZNF613
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000176024.16
HGNCiHGNC:25827 ZNF613
neXtProtiNX_Q6PF04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176024
PharmGKBiPA134937067

Polymorphism and mutation databases

BioMutaiZNF613
DMDMi116242862

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345971 – 617Zinc finger protein 613Add BLAST617

Proteomic databases

EPDiQ6PF04
MaxQBiQ6PF04
PaxDbiQ6PF04
PeptideAtlasiQ6PF04
PRIDEiQ6PF04

PTM databases

iPTMnetiQ6PF04
PhosphoSitePlusiQ6PF04

Expressioni

Gene expression databases

BgeeiENSG00000176024
CleanExiHS_ZNF613
ExpressionAtlasiQ6PF04 baseline and differential
GenevisibleiQ6PF04 HS

Organism-specific databases

HPAiHPA026833

Interactioni

Protein-protein interaction databases

IntActiQ6PF04, 4 interactors
STRINGi9606.ENSP00000293471

Structurei

3D structure databases

ProteinModelPortaliQ6PF04
SMRiQ6PF04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00860000133760
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6PF04
KOiK09228
OMAiFPLRQNH
OrthoDBiEOG091G02KC
PhylomeDBiQ6PF04
TreeFamiTF350804

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PF04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKSQESLTL EDVAVEFTWE EWQLLGPAQK DLYRDVMLEN YSNLVSVGYQ
60 70 80 90 100
ASKPDALFKL EQGEPWTVEN EIHSQICPEI KKVDNHLQMH SQKQRCLKRV
110 120 130 140 150
EQCHKHNAFG NIIHQRKSDF PLRQNHDTFD LHGKILKSNL SLVNQNKRYE
160 170 180 190 200
IKNSVGVNGD GKSFLHAKHE QFHNEMNFPE GGNSVNTNSQ FIKHQRTQNI
210 220 230 240 250
DKPHVCTECG KAFLKKSRLI YHQRVHTGEK PHGCSICGKA FSRKSGLTEH
260 270 280 290 300
QRNHTGEKPY ECTECDKAFR WKSQLNAHQK IHTGEKSYIC SDCGKGFIKK
310 320 330 340 350
SRLINHQRVH TGEKPHGCSL CGKAFSKRSR LTEHQRTHTG EKPYECTECD
360 370 380 390 400
KAFRWKSQLN AHQKAHTGEK SYICRDCGKG FIQKGNLIVH QRIHTGEKPY
410 420 430 440 450
ICNECGKGFI QKGNLLIHRR THTGEKPYVC NECGKGFSQK TCLISHQRFH
460 470 480 490 500
TGKTPFVCTE CGKSCSHKSG LINHQRIHTG EKPYTCSDCG KAFRDKSCLN
510 520 530 540 550
RHRRTHTGER PYGCSDCGKA FSHLSCLVYH KGMLHAREKC VGSVKLENPC
560 570 580 590 600
SESHSLSHTR DLIQDKDSVN MVTLQMPSVA AQTSLTNSAF QAESKVAIVS
610
QPVARSSVSA DSRICTE
Length:617
Mass (Da):70,143
Last modified:October 17, 2006 - v2
Checksum:i44C6B14BB2060322
GO
Isoform 2 (identifier: Q6PF04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):65,893
Checksum:iEAB48B2340469FF7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02809684D → N1 PublicationCorresponds to variant dbSNP:rs17854933Ensembl.1
Natural variantiVAR_02809793K → E. Corresponds to variant dbSNP:rs8106409Ensembl.1
Natural variantiVAR_028098135I → R. Corresponds to variant dbSNP:rs16983243Ensembl.1
Natural variantiVAR_057428163S → F. Corresponds to variant dbSNP:rs33998555Ensembl.1
Natural variantiVAR_057429611D → V. Corresponds to variant dbSNP:rs16983253Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183881 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027565 mRNA Translation: BAB55201.1
BC057776 mRNA Translation: AAH57776.1
CCDSiCCDS12844.1 [Q6PF04-2]
CCDS33089.1 [Q6PF04-1]
RefSeqiNP_001026891.2, NM_001031721.3 [Q6PF04-1]
NP_079116.2, NM_024840.3 [Q6PF04-2]
XP_005259326.1, XM_005259269.3 [Q6PF04-1]
XP_011525635.1, XM_011527333.2 [Q6PF04-1]
XP_016882804.1, XM_017027315.1 [Q6PF04-2]
UniGeneiHs.183390

Genome annotation databases

EnsembliENST00000293471; ENSP00000293471; ENSG00000176024 [Q6PF04-1]
ENST00000391794; ENSP00000375671; ENSG00000176024 [Q6PF04-2]
GeneIDi79898
KEGGihsa:79898
UCSCiuc002pxz.3 human [Q6PF04-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN613_HUMAN
AccessioniPrimary (citable) accession number: Q6PF04
Secondary accession number(s): Q96SS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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