Q6PEX3 (KR261_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 26-1

Gene names

Name:	KRTAP26-1
Synonyms:	KAP26.1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla). Ref.2
Sequence similarities	Belongs to the PMG family.

Ontologies

Keywords
Cellular component	Keratin
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Keratin-associated protein 26-1		PRO_0000223916
Natural variations
	Natural variant	26	1	S → Y. Corresponds to variant rs3804007 [ dbSNP | Ensembl ].		VAR_053477
	Natural variant	188	1	P → T. Corresponds to variant rs12483584 [ dbSNP | Ensembl ].		VAR_053478

Sequences

	Sequence		Length	Mass (Da)
	Q6PEX3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7E4610AAF1044D6C	FASTA	210	22,554
	10 20 30 40 50 60 MSCPNYCSGN SNSGSLRTSR HIPLTSIDLC PTSVSCGDVL YLPTSSQDHT WVTDNCQETC 70 80 90 100 110 120 GEPTSCQPVH CETGNLETSC GSSTAYYVPR PCQGSSFLPA SFFSSSCLPV SCRPQRYVSS 130 140 150 160 170 180 GCRPLRPLLN SYQPIGDCVP NAYRPQFCLS KSCQPQNLLT SGCQPSSCLA YRPQSLHVVS 190 200 210 SSLRPLGPLF SGCQPLTHVF STCRPSCSGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of complete keratin-associated protein (KAP) gene cluster spanning 800 kb region on human chromosome 21q22.11." Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hair root.
[2]	"Characterization and expression analysis of the hair keratin associated protein KAP26.1." Rogers M.A., Langbein L., Praetzel-Wunder S., Giehl K. Br. J. Dermatol. 159:725-729(2008) [PubMed: 18647308] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Scalp.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB096936 mRNA. Translation: BAE46351.1. AM941740 mRNA. Translation: CAQ03502.1. BC057825 mRNA. Translation: AAH57825.1.
IPI	IPI00397845.
RefSeq	NP_981950.1. NM_203405.1.
UniGene	Hs.28704.
3D structure databases
ProteinModelPortal	Q6PEX3.
ModBase	Search...
Polymorphism databases
DMDM	74737618.
Proteomic databases
PeptideAtlas	Q6PEX3.
PRIDE	Q6PEX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360542; ENSP00000353742; ENSG00000197683.
GeneID	388818.
KEGG	hsa:388818.
UCSC	uc002ynw.1. human.
Organism-specific databases
CTD	388818.
GeneCards	GC21M031691.
H-InvDB	HIX0040916.
HGNC	HGNC:33760. KRTAP26-1.
neXtProt	NX_Q6PEX3.
PharmGKB	PA162393763.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG20229.
GeneTree	ENSGT00530000063824.
HOGENOM	HBG125527.
HOVERGEN	HBG062834.
InParanoid	Q6PEX3.
OMA	VPRPCQG.
OrthoDB	EOG45TCP5.
PhylomeDB	Q6PEX3.
Gene expression databases
ArrayExpress	Q6PEX3.
Bgee	Q6PEX3.
CleanEx	HS_KRTAP26-1.
Genevestigator	Q6PEX3.
Family and domain databases
InterPro	IPR007951. PMG. [Graphical view]
PANTHER	PTHR19051. PMG. 1 hit.
Pfam	PF05287. PMG. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	102389.

Entry information

Entry name

KR261_HUMAN

Accession

Primary (citable) accession number: Q6PEX3
Secondary accession number(s): B0RZD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.