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Protein

Keratin-associated protein 26-1

Gene

KRTAP26-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 26-1
Gene namesi
Name:KRTAP26-1
Synonyms:KAP26.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:33760. KRTAP26-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393763.

Polymorphism and mutation databases

BioMutaiKRTAP26-1.
DMDMi74737618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Keratin-associated protein 26-1PRO_0000223916Add
BLAST

Proteomic databases

PaxDbiQ6PEX3.
PeptideAtlasiQ6PEX3.
PRIDEiQ6PEX3.

Expressioni

Tissue specificityi

Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).1 Publication

Gene expression databases

BgeeiENSG00000197683.
CleanExiHS_KRTAP26-1.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNJLF6RF563EBI-3957672,EBI-10177725
COL8A1P276584EBI-3957672,EBI-747133
DTX2Q86UW93EBI-3957672,EBI-740376
GDPD5Q9HBR33EBI-3957672,EBI-10310206
GRNP287993EBI-3957672,EBI-747754
HOXA1P496393EBI-3957672,EBI-740785
Hoxa1P090224EBI-3957672,EBI-3957603From a different organism.
KRTAP10-5P603703EBI-3957672,EBI-10172150
KRTAP10-9P604113EBI-3957672,EBI-10172052
KRTAP12-2P599913EBI-3957672,EBI-10176379
KRTAP3-2Q9BYR73EBI-3957672,EBI-751260
KRTAP4-12Q9BQ663EBI-3957672,EBI-739863
KRTAP4-2Q9BYR53EBI-3957672,EBI-10172511
KRTAP4-7Q9BYR03EBI-3957672,EBI-10302547
KRTAP5-6Q6L8G93EBI-3957672,EBI-10250562
KRTAP9-2Q9BYQ43EBI-3957672,EBI-1044640
NOTCH2NLQ7Z3S93EBI-3957672,EBI-945833
OTX1P322423EBI-3957672,EBI-740446
PSMA3P257883EBI-3957672,EBI-348380
SF1Q156373EBI-3957672,EBI-744603
STK16O757163EBI-3957672,EBI-749295
taxP034103EBI-3957672,EBI-9676218From a different organism.
TEKT4Q8WW243EBI-3957672,EBI-750487
TRIM42A1L4B63EBI-3957672,EBI-10172216
TRIP13Q156453EBI-3957672,EBI-358993
TRIP6Q156543EBI-3957672,EBI-742327

Protein-protein interaction databases

BioGridi132867. 29 interactions.
IntActiQ6PEX3. 27 interactions.
STRINGi9606.ENSP00000353742.

Structurei

3D structure databases

ProteinModelPortaliQ6PEX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J10U. Eukaryota.
ENOG41113EF. LUCA.
GeneTreeiENSGT00730000111511.
HOGENOMiHOG000090220.
HOVERGENiHBG062834.
InParanoidiQ6PEX3.
OMAiCQPLTHV.
OrthoDBiEOG091G0QOP.
PhylomeDBiQ6PEX3.
TreeFamiTF337331.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PEX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCPNYCSGN SNSGSLRTSR HIPLTSIDLC PTSVSCGDVL YLPTSSQDHT
60 70 80 90 100
WVTDNCQETC GEPTSCQPVH CETGNLETSC GSSTAYYVPR PCQGSSFLPA
110 120 130 140 150
SFFSSSCLPV SCRPQRYVSS GCRPLRPLLN SYQPIGDCVP NAYRPQFCLS
160 170 180 190 200
KSCQPQNLLT SGCQPSSCLA YRPQSLHVVS SSLRPLGPLF SGCQPLTHVF
210
STCRPSCSGL
Length:210
Mass (Da):22,554
Last modified:July 5, 2004 - v1
Checksum:i7E4610AAF1044D6C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261S → Y.
Corresponds to variant rs3804007 [ dbSNP | Ensembl ].
VAR_053477
Natural varianti188 – 1881P → T.
Corresponds to variant rs12483584 [ dbSNP | Ensembl ].
VAR_053478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096936 mRNA. Translation: BAE46351.1.
AM941740 mRNA. Translation: CAQ03502.1.
BC057825 mRNA. Translation: AAH57825.1.
CCDSiCCDS13588.1.
RefSeqiNP_981950.1. NM_203405.1.
UniGeneiHs.28704.

Genome annotation databases

EnsembliENST00000360542; ENSP00000353742; ENSG00000197683.
GeneIDi388818.
KEGGihsa:388818.
UCSCiuc002ynw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096936 mRNA. Translation: BAE46351.1.
AM941740 mRNA. Translation: CAQ03502.1.
BC057825 mRNA. Translation: AAH57825.1.
CCDSiCCDS13588.1.
RefSeqiNP_981950.1. NM_203405.1.
UniGeneiHs.28704.

3D structure databases

ProteinModelPortaliQ6PEX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132867. 29 interactions.
IntActiQ6PEX3. 27 interactions.
STRINGi9606.ENSP00000353742.

Polymorphism and mutation databases

BioMutaiKRTAP26-1.
DMDMi74737618.

Proteomic databases

PaxDbiQ6PEX3.
PeptideAtlasiQ6PEX3.
PRIDEiQ6PEX3.

Protocols and materials databases

DNASUi388818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360542; ENSP00000353742; ENSG00000197683.
GeneIDi388818.
KEGGihsa:388818.
UCSCiuc002ynw.5. human.

Organism-specific databases

CTDi388818.
GeneCardsiKRTAP26-1.
HGNCiHGNC:33760. KRTAP26-1.
neXtProtiNX_Q6PEX3.
PharmGKBiPA162393763.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J10U. Eukaryota.
ENOG41113EF. LUCA.
GeneTreeiENSGT00730000111511.
HOGENOMiHOG000090220.
HOVERGENiHBG062834.
InParanoidiQ6PEX3.
OMAiCQPLTHV.
OrthoDBiEOG091G0QOP.
PhylomeDBiQ6PEX3.
TreeFamiTF337331.

Miscellaneous databases

GenomeRNAii388818.
PROiQ6PEX3.

Gene expression databases

BgeeiENSG00000197683.
CleanExiHS_KRTAP26-1.

Family and domain databases

InterProiIPR007951. KRTAP_PMG.
[Graphical view]
PANTHERiPTHR19051. PTHR19051. 1 hit.
PfamiPF05287. PMG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKR261_HUMAN
AccessioniPrimary (citable) accession number: Q6PEX3
Secondary accession number(s): B0RZD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.