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Protein

Keratin-associated protein 26-1

Gene

KRTAP26-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 26-1
Gene namesi
Name:KRTAP26-1
Synonyms:KAP26.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000197683.4
HGNCiHGNC:33760 KRTAP26-1
neXtProtiNX_Q6PEX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393763

Polymorphism and mutation databases

BioMutaiKRTAP26-1
DMDMi74737618

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239161 – 210Keratin-associated protein 26-1Add BLAST210

Proteomic databases

PaxDbiQ6PEX3
PeptideAtlasiQ6PEX3
PRIDEiQ6PEX3

Expressioni

Tissue specificityi

Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).1 Publication

Gene expression databases

BgeeiENSG00000197683
CleanExiHS_KRTAP26-1

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi132867, 29 interactors
IntActiQ6PEX3, 87 interactors
MINTiQ6PEX3
STRINGi9606.ENSP00000353742

Structurei

3D structure databases

ProteinModelPortaliQ6PEX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J10U Eukaryota
ENOG41113EF LUCA
GeneTreeiENSGT00730000111511
HOGENOMiHOG000090220
HOVERGENiHBG062834
InParanoidiQ6PEX3
OMAiCQPLTHV
OrthoDBiEOG091G0QOP
PhylomeDBiQ6PEX3
TreeFamiTF337331

Family and domain databases

InterProiView protein in InterPro
IPR007951 KRTAP_PMG
PANTHERiPTHR19051 PTHR19051, 1 hit
PfamiView protein in Pfam
PF05287 PMG, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PEX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCPNYCSGN SNSGSLRTSR HIPLTSIDLC PTSVSCGDVL YLPTSSQDHT
60 70 80 90 100
WVTDNCQETC GEPTSCQPVH CETGNLETSC GSSTAYYVPR PCQGSSFLPA
110 120 130 140 150
SFFSSSCLPV SCRPQRYVSS GCRPLRPLLN SYQPIGDCVP NAYRPQFCLS
160 170 180 190 200
KSCQPQNLLT SGCQPSSCLA YRPQSLHVVS SSLRPLGPLF SGCQPLTHVF
210
STCRPSCSGL
Length:210
Mass (Da):22,554
Last modified:July 5, 2004 - v1
Checksum:i7E4610AAF1044D6C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05347726S → Y. Corresponds to variant dbSNP:rs3804007Ensembl.1
Natural variantiVAR_053478188P → T. Corresponds to variant dbSNP:rs12483584Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096936 mRNA Translation: BAE46351.1
AM941740 mRNA Translation: CAQ03502.1
BC057825 mRNA Translation: AAH57825.1
CCDSiCCDS13588.1
RefSeqiNP_981950.1, NM_203405.1
UniGeneiHs.28704

Genome annotation databases

EnsembliENST00000360542; ENSP00000353742; ENSG00000197683
GeneIDi388818
KEGGihsa:388818
UCSCiuc002ynw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKR261_HUMAN
AccessioniPrimary (citable) accession number: Q6PEX3
Secondary accession number(s): B0RZD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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