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Protein

Zinc finger CCHC domain-containing protein 12

Gene

ZCCHC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri345 – 36218CCHC-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 12
Alternative name(s):
Smad-interacting zinc finger protein 1
Gene namesi
Name:ZCCHC12
Synonyms:SIZN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27273. ZCCHC12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885304.

Polymorphism and mutation databases

BioMutaiZCCHC12.
DMDMi85718626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Zinc finger CCHC domain-containing protein 12PRO_0000150971Add
BLAST

Proteomic databases

PaxDbiQ6PEW1.
PRIDEiQ6PEW1.

PTM databases

iPTMnetiQ6PEW1.
PhosphoSiteiQ6PEW1.

Expressioni

Gene expression databases

BgeeiENSG00000174460.
CleanExiHS_ZCCHC12.
GenevisibleiQ6PEW1. HS.

Organism-specific databases

HPAiHPA031016.
HPA034940.

Interactioni

Subunit structurei

Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P43364-23EBI-748373,EBI-10178634
PNMA1Q8ND903EBI-748373,EBI-302345
SUMO1P631653EBI-748373,EBI-80140
TFCP2Q128003EBI-748373,EBI-717422

Protein-protein interaction databases

BioGridi127997. 11 interactions.
IntActiQ6PEW1. 5 interactions.
STRINGi9606.ENSP00000308921.

Structurei

3D structure databases

ProteinModelPortaliQ6PEW1.
SMRiQ6PEW1. Positions 330-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZCCHC12 family.Curated
Contains 1 CCHC-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri345 – 36218CCHC-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J95G. Eukaryota.
ENOG4111945. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000230940.
HOVERGENiHBG073535.
InParanoidiQ6PEW1.
OMAiAFQGSPP.
OrthoDBiEOG091G0AM8.
PhylomeDBiQ6PEW1.
TreeFamiTF335054.

Family and domain databases

InterProiIPR026523. PNMA.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 2 hits.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PEW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIIARVGN SRRLNAPLPP WAHSMLRSLG RSLGPIMASM ADRNMKLFSG
60 70 80 90 100
RVVPAQGEET FENWLTQVNG VLPDWNMSEE EKLKRLMKTL RGPAREVMRV
110 120 130 140 150
LQATNPNLSV ADFLRAMKLV FGESESSVTA HGKFFNTLQA QGEKASLYVI
160 170 180 190 200
RLEVQLQNAI QAGIIAEKDA NRTRLQQLLL GGELSRDLRL RLKDFLRMYA
210 220 230 240 250
NEQERLPNFL ELIRMVREEE DWDDAFIKRK RPKRSESMVE RAVSPVAFQG
260 270 280 290 300
SPPIVIGSAD CNVIEIDDTL DDSDEDVILV ESQDPPLPSW GAPPLRDRAR
310 320 330 340 350
PQDEVLVIDS PHNSRAQFPS TSGGSGYKNN GPGEMRRARK RKHTIRCSYC
360 370 380 390 400
GEEGHSKETC DNESDKAQVF ENLIITLQEL THTEMERSRV APGEYNDFSE

PL
Length:402
Mass (Da):45,369
Last modified:May 10, 2005 - v2
Checksum:iD748B77689E38518
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → C.
Corresponds to variant rs35356061 [ dbSNP | Ensembl ].
VAR_045908
Natural varianti179 – 1791L → I.1 Publication
Corresponds to variant rs17854957 [ dbSNP | Ensembl ].
VAR_045909
Natural varianti214 – 2141R → G.1 Publication
Corresponds to variant rs17853670 [ dbSNP | Ensembl ].
VAR_045910
Natural varianti241 – 2411R → T.1 Publication
Corresponds to variant rs140976011 [ dbSNP | Ensembl ].
VAR_075208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122676 mRNA. Translation: BAG53660.1.
CH471161 Genomic DNA. Translation: EAW89892.1.
BC031241 mRNA. Translation: AAH31241.1.
BC036572 mRNA. Translation: AAH36572.1.
BC057841 mRNA. Translation: AAH57841.1.
CCDSiCCDS14574.1.
RefSeqiNP_001299820.1. NM_001312891.1.
NP_776159.1. NM_173798.3.
UniGeneiHs.21417.

Genome annotation databases

EnsembliENST00000310164; ENSP00000308921; ENSG00000174460.
GeneIDi170261.
KEGGihsa:170261.
UCSCiuc004equ.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122676 mRNA. Translation: BAG53660.1.
CH471161 Genomic DNA. Translation: EAW89892.1.
BC031241 mRNA. Translation: AAH31241.1.
BC036572 mRNA. Translation: AAH36572.1.
BC057841 mRNA. Translation: AAH57841.1.
CCDSiCCDS14574.1.
RefSeqiNP_001299820.1. NM_001312891.1.
NP_776159.1. NM_173798.3.
UniGeneiHs.21417.

3D structure databases

ProteinModelPortaliQ6PEW1.
SMRiQ6PEW1. Positions 330-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127997. 11 interactions.
IntActiQ6PEW1. 5 interactions.
STRINGi9606.ENSP00000308921.

PTM databases

iPTMnetiQ6PEW1.
PhosphoSiteiQ6PEW1.

Polymorphism and mutation databases

BioMutaiZCCHC12.
DMDMi85718626.

Proteomic databases

PaxDbiQ6PEW1.
PRIDEiQ6PEW1.

Protocols and materials databases

DNASUi170261.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310164; ENSP00000308921; ENSG00000174460.
GeneIDi170261.
KEGGihsa:170261.
UCSCiuc004equ.4. human.

Organism-specific databases

CTDi170261.
GeneCardsiZCCHC12.
HGNCiHGNC:27273. ZCCHC12.
HPAiHPA031016.
HPA034940.
MIMi300701. gene.
neXtProtiNX_Q6PEW1.
PharmGKBiPA134885304.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J95G. Eukaryota.
ENOG4111945. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000230940.
HOVERGENiHBG073535.
InParanoidiQ6PEW1.
OMAiAFQGSPP.
OrthoDBiEOG091G0AM8.
PhylomeDBiQ6PEW1.
TreeFamiTF335054.

Miscellaneous databases

GenomeRNAii170261.
PROiQ6PEW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174460.
CleanExiHS_ZCCHC12.
GenevisibleiQ6PEW1. HS.

Family and domain databases

InterProiIPR026523. PNMA.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 2 hits.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZCH12_HUMAN
AccessioniPrimary (citable) accession number: Q6PEW1
Secondary accession number(s): B3KV48, Q6PID5, Q8N1C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.