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Q6PEW1 (ZCH12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger CCHC domain-containing protein 12
Alternative name(s):
Smad-interacting zinc finger protein 1
Gene names
Name:ZCCHC12
Synonyms:SIZN1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression By similarity.

Subunit structure

Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 By similarity.

Sequence similarities

Belongs to the ZCCHC12 family.

Contains 1 CCHC-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Coding sequence diversityPolymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Zinc finger CCHC domain-containing protein 12
PRO_0000150971

Regions

Zinc finger345 – 36218CCHC-type

Natural variations

Natural variant71R → C.
Corresponds to variant rs35356061 [ dbSNP | Ensembl ].
VAR_045908
Natural variant1791L → I. Ref.3
Corresponds to variant rs17854957 [ dbSNP | Ensembl ].
VAR_045909
Natural variant2141R → G. Ref.3
Corresponds to variant rs17853670 [ dbSNP | Ensembl ].
VAR_045910

Sequences

Sequence LengthMass (Da)Tools
Q6PEW1 [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: D748B77689E38518

FASTA40245,369
        10         20         30         40         50         60 
MASIIARVGN SRRLNAPLPP WAHSMLRSLG RSLGPIMASM ADRNMKLFSG RVVPAQGEET 

        70         80         90        100        110        120 
FENWLTQVNG VLPDWNMSEE EKLKRLMKTL RGPAREVMRV LQATNPNLSV ADFLRAMKLV 

       130        140        150        160        170        180 
FGESESSVTA HGKFFNTLQA QGEKASLYVI RLEVQLQNAI QAGIIAEKDA NRTRLQQLLL 

       190        200        210        220        230        240 
GGELSRDLRL RLKDFLRMYA NEQERLPNFL ELIRMVREEE DWDDAFIKRK RPKRSESMVE 

       250        260        270        280        290        300 
RAVSPVAFQG SPPIVIGSAD CNVIEIDDTL DDSDEDVILV ESQDPPLPSW GAPPLRDRAR 

       310        320        330        340        350        360 
PQDEVLVIDS PHNSRAQFPS TSGGSGYKNN GPGEMRRARK RKHTIRCSYC GEEGHSKETC 

       370        380        390        400 
DNESDKAQVF ENLIITLQEL THTEMERSRV APGEYNDFSE PL

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-179 AND GLY-214.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK122676 mRNA. Translation: BAG53660.1.
CH471161 Genomic DNA. Translation: EAW89892.1.
BC031241 mRNA. Translation: AAH31241.1.
BC036572 mRNA. Translation: AAH36572.1.
BC057841 mRNA. Translation: AAH57841.1.
IPIIPI00166136.
RefSeqNP_776159.1. NM_173798.2.
UniGeneHs.21417.

3D structure databases

ProteinModelPortalQ6PEW1.
SMRQ6PEW1. Positions 340-365.
ModBaseSearch...

Protein-protein interaction databases

IntActQ6PEW1. 1 interaction.
STRINGQ6PEW1.

PTM databases

PhosphoSiteQ6PEW1.

Polymorphism databases

DMDM85718626.

Proteomic databases

PRIDEQ6PEW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310164; ENSP00000308921; ENSG00000174460.
GeneID170261.
KEGGhsa:170261.
UCSCuc004equ.1. human.

Organism-specific databases

CTD170261.
GeneCardsGC0XP117958.
HGNCHGNC:27273. ZCCHC12.
HPAHPA034940.
MIM300701. gene.
neXtProtNX_Q6PEW1.
PharmGKBPA134885304.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG14441.
GeneTreeENSGT00530000062986.
HOGENOMHBG127472.
HOVERGENHBG073535.
InParanoidQ6PEW1.
OMANEQERLP.
OrthoDBEOG4M398X.
PhylomeDBQ6PEW1.

Gene expression databases

ArrayExpressQ6PEW1.
BgeeQ6PEW1.
CleanExHS_ZCCHC12.
GenevestigatorQ6PEW1.
GermOnlineENSG00000174460. Homo sapiens.

Family and domain databases

InterProIPR013084. Znf_CCH_retrovir.
IPR001878. Znf_CCHC.
[Graphical view]
Gene3DG3DSA:4.10.60.10. Znf_CCH_retrovir. 1 hit.
SMARTSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEPS50158. ZF_CCHC. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio88877.
SOURCESearch...

Entry information

Entry nameZCH12_HUMAN
AccessionPrimary (citable) accession number: Q6PEW1
Secondary accession number(s): B3KV48, Q6PID5, Q8N1C1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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