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Protein

Inactive serine protease 54

Gene

PRSS54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Serine protease homolog

Protein family/group databases

MEROPSiS01.992.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease 54
Alternative name(s):
Cancer/testis antigen 67
Short name:
CT67
Plasma kallikrein-like protein 4
Gene namesi
Name:PRSS54
Synonyms:KLKBL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26336. PRSS54.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165450675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 395365Inactive serine protease 54PRO_0000288801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi164 ↔ 227PROSITE-ProRule annotation
Disulfide bondi195 ↔ 205PROSITE-ProRule annotation
Disulfide bondi217 ↔ 248PROSITE-ProRule annotation
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6PEW0.
PRIDEiQ6PEW0.

Expressioni

Gene expression databases

BgeeiQ6PEW0.
ExpressionAtlasiQ6PEW0. baseline and differential.
GenevestigatoriQ6PEW0.

Organism-specific databases

HPAiHPA040750.
HPA041549.

Structurei

3D structure databases

ProteinModelPortaliQ6PEW0.
SMRiQ6PEW0. Positions 53-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 269233Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG274039.
GeneTreeiENSGT00770000120569.
HOGENOMiHOG000285942.
HOVERGENiHBG106642.
InParanoidiQ6PEW0.
OMAiCWVAGWN.
OrthoDBiEOG7QK0BZ.
PhylomeDBiQ6PEW0.
TreeFamiTF338267.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PEW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS
60 70 80 90 100
MEFPWVVSLQ DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM
110 120 130 140 150
DPSKIAHTEY PVNTIIIHED FDNNSMSNNI ALLKTDTAMH FGNLVQSICF
160 170 180 190 200
LGRMLHTPPV LQNCWVSGWN PTSATGNHMT MSVLRKIFVK DLDMCPLYKL
210 220 230 240 250
QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV LNFGGETCPG
260 270 280 290 300
LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT
310 320 330 340 350
YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS
360 370 380 390
VQPLYYDYYG GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSI
Length:395
Mass (Da):43,832
Last modified:May 29, 2007 - v3
Checksum:i5414B2DB041066EF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821S → G.1 Publication
Corresponds to variant rs3815803 [ dbSNP | Ensembl ].
VAR_032497
Natural varianti240 – 2401V → I.1 Publication
Corresponds to variant rs1052276 [ dbSNP | Ensembl ].
VAR_032498
Natural varianti295 – 2951T → A.1 Publication
Corresponds to variant rs2241414 [ dbSNP | Ensembl ].
VAR_032499

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058068 mRNA. Translation: BAB71649.1.
BC057843 mRNA. Translation: AAH57843.2.
AL137484 mRNA. Translation: CAB70765.1.
CCDSiCCDS32463.1.
PIRiT46470.
RefSeqiNP_001073961.1. NM_001080492.1.
XP_005255895.1. XM_005255838.1.
UniGeneiHs.411239.

Genome annotation databases

EnsembliENST00000219301; ENSP00000219301; ENSG00000103023.
ENST00000567164; ENSP00000455024; ENSG00000103023.
GeneIDi221191.
KEGGihsa:221191.
UCSCiuc002enf.3. human.

Polymorphism databases

DMDMi148876818.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058068 mRNA. Translation: BAB71649.1.
BC057843 mRNA. Translation: AAH57843.2.
AL137484 mRNA. Translation: CAB70765.1.
CCDSiCCDS32463.1.
PIRiT46470.
RefSeqiNP_001073961.1. NM_001080492.1.
XP_005255895.1. XM_005255838.1.
UniGeneiHs.411239.

3D structure databases

ProteinModelPortaliQ6PEW0.
SMRiQ6PEW0. Positions 53-264.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.992.

Polymorphism databases

DMDMi148876818.

Proteomic databases

PaxDbiQ6PEW0.
PRIDEiQ6PEW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219301; ENSP00000219301; ENSG00000103023.
ENST00000567164; ENSP00000455024; ENSG00000103023.
GeneIDi221191.
KEGGihsa:221191.
UCSCiuc002enf.3. human.

Organism-specific databases

CTDi221191.
GeneCardsiGC16M058313.
H-InvDBHIX0013089.
HGNCiHGNC:26336. PRSS54.
HPAiHPA040750.
HPA041549.
neXtProtiNX_Q6PEW0.
PharmGKBiPA165450675.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274039.
GeneTreeiENSGT00770000120569.
HOGENOMiHOG000285942.
HOVERGENiHBG106642.
InParanoidiQ6PEW0.
OMAiCWVAGWN.
OrthoDBiEOG7QK0BZ.
PhylomeDBiQ6PEW0.
TreeFamiTF338267.

Miscellaneous databases

GenomeRNAii221191.
NextBioi91235.
PROiQ6PEW0.

Gene expression databases

BgeeiQ6PEW0.
ExpressionAtlasiQ6PEW0. baseline and differential.
GenevestigatoriQ6PEW0.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-182; ILE-240 AND ALA-295.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-395.
    Tissue: Testis.

Entry informationi

Entry nameiPRS54_HUMAN
AccessioniPrimary (citable) accession number: Q6PEW0
Secondary accession number(s): Q96LN9, Q9NT77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: January 7, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although related to peptidase S1 family, lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is therefore predicted to have lost protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.