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Q6PEW0 (PRS54_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive serine protease 54
Alternative name(s):
Cancer/testis antigen 67
Short name=CT67
Plasma kallikrein-like protein 4
Gene names
Name:PRSS54
Synonyms:KLKBL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Contains 1 peptidase S1 domain.

Caution

Although related to peptidase S1 family, lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is therefore predicted to have lost protease activity.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionSerine protease homolog
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 395365Inactive serine protease 54
PRO_0000288801

Regions

Domain37 – 269233Peptidase S1

Amino acid modifications

Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation3271N-linked (GlcNAc...) Potential
Disulfide bond164 ↔ 227 By similarity
Disulfide bond195 ↔ 205 By similarity
Disulfide bond217 ↔ 248 By similarity

Natural variations

Natural variant1821S → G. Ref.1
Corresponds to variant rs3815803 [ dbSNP | Ensembl ].
VAR_032497
Natural variant2401V → I. Ref.1
Corresponds to variant rs1052276 [ dbSNP | Ensembl ].
VAR_032498
Natural variant2951T → A. Ref.1
Corresponds to variant rs2241414 [ dbSNP | Ensembl ].
VAR_032499

Sequences

Sequence LengthMass (Da)Tools
Q6PEW0 [UniParc].

Last modified May 29, 2007. Version 3.
Checksum: 5414B2DB041066EF

FASTA39543,832
        10         20         30         40         50         60 
MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS MEFPWVVSLQ 

        70         80         90        100        110        120 
DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM DPSKIAHTEY PVNTIIIHED 

       130        140        150        160        170        180 
FDNNSMSNNI ALLKTDTAMH FGNLVQSICF LGRMLHTPPV LQNCWVSGWN PTSATGNHMT 

       190        200        210        220        230        240 
MSVLRKIFVK DLDMCPLYKL QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV 

       250        260        270        280        290        300 
LNFGGETCPG LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT 

       310        320        330        340        350        360 
YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS VQPLYYDYYG 

       370        380        390 
GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSI 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-182; ILE-240 AND ALA-295.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-395.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK058068 mRNA. Translation: BAB71649.1.
BC057843 mRNA. Translation: AAH57843.2.
AL137484 mRNA. Translation: CAB70765.1.
PIRT46470.
RefSeqNP_001073961.1. NM_001080492.1.
XP_005255895.1. XM_005255838.1.
UniGeneHs.411239.

3D structure databases

ProteinModelPortalQ6PEW0.
SMRQ6PEW0. Positions 53-264.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.992.

Polymorphism databases

DMDM148876818.

Proteomic databases

PaxDbQ6PEW0.
PRIDEQ6PEW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000219301; ENSP00000219301; ENSG00000103023.
ENST00000567164; ENSP00000455024; ENSG00000103023.
GeneID221191.
KEGGhsa:221191.
UCSCuc002enf.3. human.

Organism-specific databases

CTD221191.
GeneCardsGC16M058313.
H-InvDBHIX0013089.
HGNCHGNC:26336. PRSS54.
HPAHPA040750.
HPA041549.
neXtProtNX_Q6PEW0.
PharmGKBPA165450675.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274039.
HOGENOMHOG000285942.
HOVERGENHBG106642.
InParanoidQ6PEW0.
OMAIHEDFDN.
OrthoDBEOG7QK0BZ.
PhylomeDBQ6PEW0.
TreeFamTF338267.

Gene expression databases

ArrayExpressQ6PEW0.
BgeeQ6PEW0.
GenevestigatorQ6PEW0.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi221191.
NextBio91235.
PROQ6PEW0.

Entry information

Entry namePRS54_HUMAN
AccessionPrimary (citable) accession number: Q6PEW0
Secondary accession number(s): Q96LN9, Q9NT77
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM