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Q6PEW0

- PRS54_HUMAN

UniProt

Q6PEW0 - PRS54_HUMAN

Protein

Inactive serine protease 54

Gene

PRSS54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (29 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Serine protease homolog

    Protein family/group databases

    MEROPSiS01.992.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive serine protease 54
    Alternative name(s):
    Cancer/testis antigen 67
    Short name:
    CT67
    Plasma kallikrein-like protein 4
    Gene namesi
    Name:PRSS54
    Synonyms:KLKBL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26336. PRSS54.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165450675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 395365Inactive serine protease 54PRO_0000288801Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi164 ↔ 227PROSITE-ProRule annotation
    Disulfide bondi195 ↔ 205PROSITE-ProRule annotation
    Disulfide bondi217 ↔ 248PROSITE-ProRule annotation
    Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6PEW0.
    PRIDEiQ6PEW0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PEW0.
    BgeeiQ6PEW0.
    GenevestigatoriQ6PEW0.

    Organism-specific databases

    HPAiHPA040750.
    HPA041549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PEW0.
    SMRiQ6PEW0. Positions 53-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 269233Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG274039.
    HOGENOMiHOG000285942.
    HOVERGENiHBG106642.
    InParanoidiQ6PEW0.
    OMAiIHEDFDN.
    OrthoDBiEOG7QK0BZ.
    PhylomeDBiQ6PEW0.
    TreeFamiTF338267.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6PEW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS    50
    MEFPWVVSLQ DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM 100
    DPSKIAHTEY PVNTIIIHED FDNNSMSNNI ALLKTDTAMH FGNLVQSICF 150
    LGRMLHTPPV LQNCWVSGWN PTSATGNHMT MSVLRKIFVK DLDMCPLYKL 200
    QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV LNFGGETCPG 250
    LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT 300
    YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS 350
    VQPLYYDYYG GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSI 395
    Length:395
    Mass (Da):43,832
    Last modified:May 29, 2007 - v3
    Checksum:i5414B2DB041066EF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti182 – 1821S → G.1 Publication
    Corresponds to variant rs3815803 [ dbSNP | Ensembl ].
    VAR_032497
    Natural varianti240 – 2401V → I.1 Publication
    Corresponds to variant rs1052276 [ dbSNP | Ensembl ].
    VAR_032498
    Natural varianti295 – 2951T → A.1 Publication
    Corresponds to variant rs2241414 [ dbSNP | Ensembl ].
    VAR_032499

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK058068 mRNA. Translation: BAB71649.1.
    BC057843 mRNA. Translation: AAH57843.2.
    AL137484 mRNA. Translation: CAB70765.1.
    CCDSiCCDS32463.1.
    PIRiT46470.
    RefSeqiNP_001073961.1. NM_001080492.1.
    XP_005255895.1. XM_005255838.1.
    UniGeneiHs.411239.

    Genome annotation databases

    EnsembliENST00000219301; ENSP00000219301; ENSG00000103023.
    ENST00000567164; ENSP00000455024; ENSG00000103023.
    GeneIDi221191.
    KEGGihsa:221191.
    UCSCiuc002enf.3. human.

    Polymorphism databases

    DMDMi148876818.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK058068 mRNA. Translation: BAB71649.1 .
    BC057843 mRNA. Translation: AAH57843.2 .
    AL137484 mRNA. Translation: CAB70765.1 .
    CCDSi CCDS32463.1.
    PIRi T46470.
    RefSeqi NP_001073961.1. NM_001080492.1.
    XP_005255895.1. XM_005255838.1.
    UniGenei Hs.411239.

    3D structure databases

    ProteinModelPortali Q6PEW0.
    SMRi Q6PEW0. Positions 53-264.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.992.

    Polymorphism databases

    DMDMi 148876818.

    Proteomic databases

    PaxDbi Q6PEW0.
    PRIDEi Q6PEW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219301 ; ENSP00000219301 ; ENSG00000103023 .
    ENST00000567164 ; ENSP00000455024 ; ENSG00000103023 .
    GeneIDi 221191.
    KEGGi hsa:221191.
    UCSCi uc002enf.3. human.

    Organism-specific databases

    CTDi 221191.
    GeneCardsi GC16M058313.
    H-InvDB HIX0013089.
    HGNCi HGNC:26336. PRSS54.
    HPAi HPA040750.
    HPA041549.
    neXtProti NX_Q6PEW0.
    PharmGKBi PA165450675.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274039.
    HOGENOMi HOG000285942.
    HOVERGENi HBG106642.
    InParanoidi Q6PEW0.
    OMAi IHEDFDN.
    OrthoDBi EOG7QK0BZ.
    PhylomeDBi Q6PEW0.
    TreeFami TF338267.

    Miscellaneous databases

    GenomeRNAii 221191.
    NextBioi 91235.
    PROi Q6PEW0.

    Gene expression databases

    ArrayExpressi Q6PEW0.
    Bgeei Q6PEW0.
    Genevestigatori Q6PEW0.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-182; ILE-240 AND ALA-295.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-395.
      Tissue: Testis.

    Entry informationi

    Entry nameiPRS54_HUMAN
    AccessioniPrimary (citable) accession number: Q6PEW0
    Secondary accession number(s): Q96LN9, Q9NT77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although related to peptidase S1 family, lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is therefore predicted to have lost protease activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3