Q6PEW0 (PRS54_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inactive serine protease 54

Alternative name(s):
Cancer/testis antigen 67
Short name=CT67
Plasma kallikrein-like protein 4

Gene names

Name:	PRSS54
Synonyms:	KLKBL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the peptidase S1 family. Plasma kallikrein subfamily. Contains 1 peptidase S1 domain.
Caution	Although related to peptidase S1 family, lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is therefore predicted to have lost protease activity.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Serine protease homolog
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 395	365	Inactive serine protease 54		PRO_0000288801
Regions
	Domain	37 – 269	233	Peptidase S1
Amino acid modifications
	Glycosylation	123	1	N-linked (GlcNAc...) Potential
	Glycosylation	327	1	N-linked (GlcNAc...) Potential
	Disulfide bond	164 ↔ 227		By similarity
	Disulfide bond	195 ↔ 205		By similarity
	Disulfide bond	217 ↔ 248		By similarity
Natural variations
	Natural variant	182	1	S → G. Ref.1 Corresponds to variant rs3815803 [ dbSNP | Ensembl ].		VAR_032497
	Natural variant	240	1	V → I. Ref.1 Corresponds to variant rs1052276 [ dbSNP | Ensembl ].		VAR_032498
	Natural variant	295	1	T → A. Ref.1 Corresponds to variant rs2241414 [ dbSNP | Ensembl ].		VAR_032499

Sequences

	Sequence		Length	Mass (Da)
	Q6PEW0 [UniParc]. Last modified May 29, 2007. Version 3. Checksum: 5414B2DB041066EF	FASTA	395	43,832
	10 20 30 40 50 60 MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS MEFPWVVSLQ 70 80 90 100 110 120 DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM DPSKIAHTEY PVNTIIIHED 130 140 150 160 170 180 FDNNSMSNNI ALLKTDTAMH FGNLVQSICF LGRMLHTPPV LQNCWVSGWN PTSATGNHMT 190 200 210 220 230 240 MSVLRKIFVK DLDMCPLYKL QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV 250 260 270 280 290 300 LNFGGETCPG LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT 310 320 330 340 350 360 YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS VQPLYYDYYG 370 380 390 GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSI

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-182; ILE-240 AND ALA-295. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-395. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK058068 mRNA. Translation: BAB71649.1. BC057843 mRNA. Translation: AAH57843.2. AL137484 mRNA. Translation: CAB70765.1.
IPI	IPI00307320.
PIR	T46470.
RefSeq	NP_001073961.1. NM_001080492.1.
UniGene	Hs.411239.
3D structure databases
ProteinModelPortal	Q6PEW0.
ModBase	Search...
Protein family/group databases
MEROPS	S01.992.
Polymorphism databases
DMDM	148876818.
Proteomic databases
PaxDb	Q6PEW0.
PRIDE	Q6PEW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000219301; ENSP00000219301; ENSG00000103023. ENST00000567164; ENSP00000455024; ENSG00000103023.
GeneID	221191.
KEGG	hsa:221191.
UCSC	uc002enf.3. human.
Organism-specific databases
CTD	221191.
GeneCards	GC16M058313.
H-InvDB	HIX0013089.
HGNC	HGNC:26336. PRSS54.
HPA	HPA040750. HPA041549.
neXtProt	NX_Q6PEW0.
PharmGKB	PA165450675.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274039.
HOGENOM	HOG000285942.
HOVERGEN	HBG106642.
InParanoid	Q6PEW0.
OMA	IHEDFDN.
OrthoDB	EOG4H9XMP.
Gene expression databases
ArrayExpress	Q6PEW0.
Bgee	Q6PEW0.
Genevestigator	Q6PEW0.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	221191.
NextBio	91235.

Entry information

Entry name

PRS54_HUMAN

Accession

Primary (citable) accession number: Q6PEW0
Secondary accession number(s): Q96LN9, Q9NT77

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.