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Protein

Protein FAM199X

Gene

FAM199X

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM199X
Gene namesi
Name:FAM199X
Synonyms:CXorf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25195. FAM199X.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165756587.

Polymorphism and mutation databases

BioMutaiFAM199X.
DMDMi74749168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Protein FAM199XPRO_0000251210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei316 – 3161PhosphoserineCombined sources
Modified residuei321 – 3211PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PEV8.
PaxDbiQ6PEV8.
PeptideAtlasiQ6PEV8.
PRIDEiQ6PEV8.

PTM databases

iPTMnetiQ6PEV8.
PhosphoSiteiQ6PEV8.

Expressioni

Gene expression databases

BgeeiQ6PEV8.
CleanExiHS_CXorf39.
ExpressionAtlasiQ6PEV8. baseline and differential.
GenevisibleiQ6PEV8. HS.

Organism-specific databases

HPAiHPA003093.

Interactioni

Protein-protein interaction databases

BioGridi126553. 10 interactions.
IntActiQ6PEV8. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6PEV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi265 – 32359Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM199 family.Curated

Phylogenomic databases

eggNOGiENOG410IDZF. Eukaryota.
ENOG410XU8D. LUCA.
GeneTreeiENSGT00440000033895.
HOGENOMiHOG000038014.
HOVERGENiHBG080534.
InParanoidiQ6PEV8.
OMAiQEFTSFD.
OrthoDBiEOG708W05.
PhylomeDBiQ6PEV8.

Family and domain databases

InterProiIPR029672. FAM199X_fam.
[Graphical view]
PANTHERiPTHR32003:SF1. PTHR32003:SF1. 1 hit.
PfamiPF15814. FAM199X. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PEV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDEASAITS YEKFLTPEEP FPLLGPPRGV GTCPSEEPGC LDISDFGCQL
60 70 80 90 100
SSCHRTDPLH RFHTNRWNLT SCGTSVASSE GSEELFSSVS VGDQDDCYSL
110 120 130 140 150
LDDQDFTSFD LFPEGSVCSD VSSSISTYWD WSDSEFEWQL PGSDIASGSD
160 170 180 190 200
VLSDVIPSIP SSPCLLPKKK NKHRNLDELP WSAMTNDEQV EYIEYLSRKV
210 220 230 240 250
STEMGLREQL DIIKIIDPSA QISPTDSEFI IELNCLTDEK LKQVRNYIKE
260 270 280 290 300
HSPRQRPARE AWKRSNFSCA STSGVSGASA SASSSSASMV SSASSSGSSV
310 320 330 340 350
GNSASNSSAN MSRAHSDSNL SASAAERIRD SKKRSKQRKL QQKAFRKRQL
360 370 380
KEQRQARKER LSGLFLNEEV LSLKVTEEDH EADVDVLM
Length:388
Mass (Da):42,801
Last modified:July 5, 2004 - v1
Checksum:iF08D56A0D5C60B21
GO
Isoform 2 (identifier: Q6PEV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-332: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):38,604
Checksum:i6524335737D348E0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei290 – 33243Missing in isoform 2. 1 PublicationVSP_020747Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135959, AL049631 Genomic DNA. Translation: CAI42479.1.
BC016683 mRNA. Translation: AAH16683.1.
BC017665 mRNA. Translation: AAH17665.2.
BC057847 mRNA. Translation: AAH57847.1.
CCDSiCCDS35364.1. [Q6PEV8-1]
RefSeqiNP_997201.1. NM_207318.3. [Q6PEV8-1]
XP_005262136.1. XM_005262079.1. [Q6PEV8-2]
UniGeneiHs.496535.

Genome annotation databases

EnsembliENST00000493442; ENSP00000417581; ENSG00000123575. [Q6PEV8-1]
GeneIDi139231.
KEGGihsa:139231.
UCSCiuc004elw.4. human. [Q6PEV8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135959, AL049631 Genomic DNA. Translation: CAI42479.1.
BC016683 mRNA. Translation: AAH16683.1.
BC017665 mRNA. Translation: AAH17665.2.
BC057847 mRNA. Translation: AAH57847.1.
CCDSiCCDS35364.1. [Q6PEV8-1]
RefSeqiNP_997201.1. NM_207318.3. [Q6PEV8-1]
XP_005262136.1. XM_005262079.1. [Q6PEV8-2]
UniGeneiHs.496535.

3D structure databases

ProteinModelPortaliQ6PEV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126553. 10 interactions.
IntActiQ6PEV8. 3 interactions.

PTM databases

iPTMnetiQ6PEV8.
PhosphoSiteiQ6PEV8.

Polymorphism and mutation databases

BioMutaiFAM199X.
DMDMi74749168.

Proteomic databases

MaxQBiQ6PEV8.
PaxDbiQ6PEV8.
PeptideAtlasiQ6PEV8.
PRIDEiQ6PEV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493442; ENSP00000417581; ENSG00000123575. [Q6PEV8-1]
GeneIDi139231.
KEGGihsa:139231.
UCSCiuc004elw.4. human. [Q6PEV8-1]

Organism-specific databases

CTDi139231.
GeneCardsiFAM199X.
H-InvDBHIX0016963.
HGNCiHGNC:25195. FAM199X.
HPAiHPA003093.
neXtProtiNX_Q6PEV8.
PharmGKBiPA165756587.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDZF. Eukaryota.
ENOG410XU8D. LUCA.
GeneTreeiENSGT00440000033895.
HOGENOMiHOG000038014.
HOVERGENiHBG080534.
InParanoidiQ6PEV8.
OMAiQEFTSFD.
OrthoDBiEOG708W05.
PhylomeDBiQ6PEV8.

Miscellaneous databases

GenomeRNAii139231.
PROiQ6PEV8.

Gene expression databases

BgeeiQ6PEV8.
CleanExiHS_CXorf39.
ExpressionAtlasiQ6PEV8. baseline and differential.
GenevisibleiQ6PEV8. HS.

Family and domain databases

InterProiIPR029672. FAM199X_fam.
[Graphical view]
PANTHERiPTHR32003:SF1. PTHR32003:SF1. 1 hit.
PfamiPF15814. FAM199X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-388 (ISOFORM 2).
    Tissue: Bone, Pancreas and Placenta.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiF199X_HUMAN
AccessioniPrimary (citable) accession number: Q6PEV8
Secondary accession number(s): Q8WVP6, Q96AV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.