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Protein

WAS/WASL-interacting protein family member 2

Gene

Wipf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
WAS/WASL-interacting protein family member 2
Alternative name(s):
WASP-interacting protein-related protein
WIP-related protein
Gene namesi
Name:Wipf2
Synonyms:Wire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924462. Wipf2.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Localized to stress fibers and bundles of actin filaments.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659761 – 440WAS/WASL-interacting protein family member 2Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ6PEV3.
PaxDbiQ6PEV3.
PeptideAtlasiQ6PEV3.
PRIDEiQ6PEV3.

PTM databases

iPTMnetiQ6PEV3.
PhosphoSitePlusiQ6PEV3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038013.
CleanExiMM_WIPF2.
ExpressionAtlasiQ6PEV3. baseline and differential.
GenevisibleiQ6PEV3. MM.

Interactioni

Subunit structurei

Interacts with WASL and WASP, and this interaction results in cytoplasmic relocation of these two proteins along actin filaments. Interacts with NCK2 resulting in the localization to sites of focal adhesions (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046991.

Structurei

3D structure databases

ProteinModelPortaliQ6PEV3.
SMRiQ6PEV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 53WH2PROSITE-ProRule annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 52Binds actinSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 17Poly-ProAdd BLAST16
Compositional biasi177 – 182Poly-Pro6
Compositional biasi250 – 254Poly-Pro5
Compositional biasi296 – 299Poly-Pro4
Compositional biasi311 – 314Poly-Pro4
Compositional biasi325 – 330Poly-Pro6
Compositional biasi340 – 345Poly-Pro6
Compositional biasi359 – 363Poly-Pro5
Compositional biasi370 – 377Poly-Pro8

Sequence similaritiesi

Belongs to the verprolin family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4462. Eukaryota.
ENOG4111FVT. LUCA.
GeneTreeiENSGT00810000125434.
HOGENOMiHOG000231914.
HOVERGENiHBG060210.
InParanoidiQ6PEV3.
KOiK19475.
OMAiYKHFQRV.
OrthoDBiEOG091G16MU.
PhylomeDBiQ6PEV3.
TreeFamiTF332135.

Family and domain databases

InterProiIPR003124. WH2_dom.
IPR028294. WIPF2.
[Graphical view]
PANTHERiPTHR23202:SF3. PTHR23202:SF3. 1 hit.
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PEV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIPPPPPPP PGPPPPPTFN QANTEQPKLS RDEQRNRGAL LQDICKGTKL
60 70 80 90 100
KKVTNVNDRS APVIEKPRGS SGGYGPGAAA LQPKGGLFQG GVPKLRPVGA
110 120 130 140 150
KDASEAPAGK PALQVPSSRA AAPRPPGSAA SGRPHDDTDS NRASLPELPR
160 170 180 190 200
MQRPSLPDLS RPNTASGTGM KHSSSAPPPP PPGRRANAPP TPLPLHSNKA
210 220 230 240 250
QAYNREKPLP PTPGQRLHPG REGHPAPPPV KPPPSPVNIR TGPSGQSLAP
260 270 280 290 300
PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT
310 320 330 340 350
SATPSLLSNR PPPPAREPPS RGAAPPPPPP MIRNGARDAP PPPPPYRMHG
360 370 380 390 400
SEPPSRGKPP PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY
410 420 430 440
SFHPVEDFPA PEEYKHLQRV YPSKTNRAAR GAPPLPPILR
Length:440
Mass (Da):46,297
Last modified:July 5, 2004 - v1
Checksum:i8DBE6864CABD52B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057854 mRNA. Translation: AAH57854.1.
CCDSiCCDS25366.1.
RefSeqiNP_922922.1. NM_197940.2.
XP_006534119.1. XM_006534056.3.
XP_006534120.1. XM_006534057.3.
XP_006534121.1. XM_006534058.2.
XP_006534122.1. XM_006534059.3.
UniGeneiMm.28661.
Mm.473466.

Genome annotation databases

EnsembliENSMUST00000037480; ENSMUSP00000046991; ENSMUSG00000038013.
GeneIDi68524.
KEGGimmu:68524.
UCSCiuc007lht.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057854 mRNA. Translation: AAH57854.1.
CCDSiCCDS25366.1.
RefSeqiNP_922922.1. NM_197940.2.
XP_006534119.1. XM_006534056.3.
XP_006534120.1. XM_006534057.3.
XP_006534121.1. XM_006534058.2.
XP_006534122.1. XM_006534059.3.
UniGeneiMm.28661.
Mm.473466.

3D structure databases

ProteinModelPortaliQ6PEV3.
SMRiQ6PEV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046991.

PTM databases

iPTMnetiQ6PEV3.
PhosphoSitePlusiQ6PEV3.

Proteomic databases

MaxQBiQ6PEV3.
PaxDbiQ6PEV3.
PeptideAtlasiQ6PEV3.
PRIDEiQ6PEV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037480; ENSMUSP00000046991; ENSMUSG00000038013.
GeneIDi68524.
KEGGimmu:68524.
UCSCiuc007lht.2. mouse.

Organism-specific databases

CTDi147179.
MGIiMGI:1924462. Wipf2.

Phylogenomic databases

eggNOGiKOG4462. Eukaryota.
ENOG4111FVT. LUCA.
GeneTreeiENSGT00810000125434.
HOGENOMiHOG000231914.
HOVERGENiHBG060210.
InParanoidiQ6PEV3.
KOiK19475.
OMAiYKHFQRV.
OrthoDBiEOG091G16MU.
PhylomeDBiQ6PEV3.
TreeFamiTF332135.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

PROiQ6PEV3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038013.
CleanExiMM_WIPF2.
ExpressionAtlasiQ6PEV3. baseline and differential.
GenevisibleiQ6PEV3. MM.

Family and domain databases

InterProiIPR003124. WH2_dom.
IPR028294. WIPF2.
[Graphical view]
PANTHERiPTHR23202:SF3. PTHR23202:SF3. 1 hit.
PfamiPF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWIPF2_MOUSE
AccessioniPrimary (citable) accession number: Q6PEV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.