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Q6PER3

- MARE3_MOUSE

UniProt

Q6PER3 - MARE3_MOUSE

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Protein
Microtubule-associated protein RP/EB family member 3
Gene
Mapre3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration By similarity.

GO - Molecular functioni

  1. microtubule binding Source: BHF-UCL
  2. protein binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
  3. positive regulation of microtubule plus-end binding Source: MGI
  4. positive regulation of transcription, DNA-templated Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein RP/EB family member 3
Alternative name(s):
EB1 protein family member 3
Short name:
EBF3
End-binding protein 3
Short name:
EB3
RP3
Gene namesi
Name:Mapre3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2140967. Mapre3.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
Note: Associated with the microtubule network. Detected at the plus end of microtubules By similarity.

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoplasmic microtubule Source: Ensembl
  3. microtubule cytoskeleton Source: BHF-UCL
  4. midbody Source: BHF-UCL
  5. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Microtubule-associated protein RP/EB family member 3
PRO_0000213429Add
BLAST

Proteomic databases

MaxQBiQ6PER3.
PaxDbiQ6PER3.
PRIDEiQ6PER3.

PTM databases

PhosphoSiteiQ6PER3.

Expressioni

Gene expression databases

ArrayExpressiQ6PER3.
BgeeiQ6PER3.
GenevestigatoriQ6PER3.

Interactioni

Subunit structurei

Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2 By similarity. Interacts with APC2.1 Publication

Protein-protein interaction databases

IntActiQ6PER3. 1 interaction.
MINTiMINT-4101277.

Structurei

3D structure databases

ProteinModelPortaliQ6PER3.
SMRiQ6PER3. Positions 1-147, 204-260.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 116103CH
Add
BLAST
Domaini194 – 26471EB1 C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni217 – 28165DCTN1-binding By similarity
Add
BLAST
Regioni217 – 26044APC-binding By similarity
Add
BLAST

Domaini

Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1 By similarity.

Sequence similaritiesi

Belongs to the MAPRE family.

Phylogenomic databases

eggNOGiCOG5217.
GeneTreeiENSGT00490000043329.
HOGENOMiHOG000198048.
HOVERGENiHBG052410.
InParanoidiQ6PER3.
KOiK10436.
OMAiNYHALER.
OrthoDBiEOG7ZD1W5.
PhylomeDBiQ6PER3.
TreeFamiTF313620.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR004953. EB1_C.
IPR027738. EB3_vertebrate.
IPR027328. MAPRE.
[Graphical view]
PANTHERiPTHR10623. PTHR10623. 1 hit.
PTHR10623:SF10. PTHR10623:SF10. 1 hit.
PfamiPF00307. CH. 1 hit.
PF03271. EB1. 1 hit.
[Graphical view]
SUPFAMiSSF140612. SSF140612. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51230. EB1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PER3-1 [UniParc]FASTAAdd to Basket

« Hide

MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM    50
LFPGCVHLRK VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK 100
FQDNFEFIQW FKKFFDANYD GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK 150
KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP PCILRKNPPS ARNGGHEADA 200
QILELNQQLL DLKLTVDGLE KERDFYFSKL RDIELICQEH ESENSPVISG 250
IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y 281
Length:281
Mass (Da):31,966
Last modified:July 5, 2004 - v1
Checksum:i6713427C480838DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057918 mRNA. Translation: AAH57918.1.
U51204 mRNA. Translation: AAA96321.1.
CCDSiCCDS19163.1.
RefSeqiNP_579928.1. NM_133350.1.
XP_006503686.1. XM_006503623.1.
UniGeneiMm.332295.
Mm.471154.

Genome annotation databases

EnsembliENSMUST00000031058; ENSMUSP00000031058; ENSMUSG00000029166.
GeneIDi100732.
KEGGimmu:100732.
UCSCiuc008wvz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057918 mRNA. Translation: AAH57918.1 .
U51204 mRNA. Translation: AAA96321.1 .
CCDSi CCDS19163.1.
RefSeqi NP_579928.1. NM_133350.1.
XP_006503686.1. XM_006503623.1.
UniGenei Mm.332295.
Mm.471154.

3D structure databases

ProteinModelPortali Q6PER3.
SMRi Q6PER3. Positions 1-147, 204-260.
ModBasei Search...

Protein-protein interaction databases

IntActi Q6PER3. 1 interaction.
MINTi MINT-4101277.

PTM databases

PhosphoSitei Q6PER3.

Proteomic databases

MaxQBi Q6PER3.
PaxDbi Q6PER3.
PRIDEi Q6PER3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031058 ; ENSMUSP00000031058 ; ENSMUSG00000029166 .
GeneIDi 100732.
KEGGi mmu:100732.
UCSCi uc008wvz.1. mouse.

Organism-specific databases

CTDi 22924.
MGIi MGI:2140967. Mapre3.

Phylogenomic databases

eggNOGi COG5217.
GeneTreei ENSGT00490000043329.
HOGENOMi HOG000198048.
HOVERGENi HBG052410.
InParanoidi Q6PER3.
KOi K10436.
OMAi NYHALER.
OrthoDBi EOG7ZD1W5.
PhylomeDBi Q6PER3.
TreeFami TF313620.

Miscellaneous databases

ChiTaRSi MAPRE3. mouse.
NextBioi 354616.
PROi Q6PER3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PER3.
Bgeei Q6PER3.
Genevestigatori Q6PER3.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
InterProi IPR001715. CH-domain.
IPR004953. EB1_C.
IPR027738. EB3_vertebrate.
IPR027328. MAPRE.
[Graphical view ]
PANTHERi PTHR10623. PTHR10623. 1 hit.
PTHR10623:SF10. PTHR10623:SF10. 1 hit.
Pfami PF00307. CH. 1 hit.
PF03271. EB1. 1 hit.
[Graphical view ]
SUPFAMi SSF140612. SSF140612. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEi PS50021. CH. 1 hit.
PS51230. EB1_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  2. Hoffman N.G., Kay B.K.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-281.
  3. "p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway."
    Hsieh P.-C., Chang J.-C., Sun W.-T., Hsieh S.-C., Wang M.-C., Wang F.-F.
    Oncogene 26:4928-4940(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH APC2.

Entry informationi

Entry nameiMARE3_MOUSE
AccessioniPrimary (citable) accession number: Q6PER3
Secondary accession number(s): Q61167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi