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Q6PER3 (MARE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microtubule-associated protein RP/EB family member 3
Alternative name(s):
EB1 protein family member 3
Short name=EBF3
End-binding protein 3
Short name=EB3
RP3
Gene names
Name:Mapre3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration By similarity.

Subunit structure

Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2 By similarity. Interacts with APC2. Ref.3

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Note: Associated with the microtubule network. Detected at the plus end of microtubules By similarity.

Domain

Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1 By similarity.

Sequence similarities

Belongs to the MAPRE family.

Contains 1 CH (calponin-homology) domain.

Contains 1 EB1 C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Microtubule-associated protein RP/EB family member 3
PRO_0000213429

Regions

Domain14 – 116103CH
Domain194 – 26471EB1 C-terminal
Region217 – 28165DCTN1-binding By similarity
Region217 – 26044APC-binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6PER3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6713427C480838DC

FASTA28131,966
        10         20         30         40         50         60 
MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM LFPGCVHLRK 

        70         80         90        100        110        120 
VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK FQDNFEFIQW FKKFFDANYD 

       130        140        150        160        170        180 
GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP 

       190        200        210        220        230        240 
PCILRKNPPS ARNGGHEADA QILELNQQLL DLKLTVDGLE KERDFYFSKL RDIELICQEH 

       250        260        270        280 
ESENSPVISG IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[2]Hoffman N.G., Kay B.K.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-281.
[3]"p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway."
Hsieh P.-C., Chang J.-C., Sun W.-T., Hsieh S.-C., Wang M.-C., Wang F.-F.
Oncogene 26:4928-4940(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH APC2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC057918 mRNA. Translation: AAH57918.1.
U51204 mRNA. Translation: AAA96321.1.
CCDSCCDS19163.1.
RefSeqNP_579928.1. NM_133350.1.
XP_006503686.1. XM_006503623.1.
UniGeneMm.332295.
Mm.471154.

3D structure databases

ProteinModelPortalQ6PER3.
SMRQ6PER3. Positions 1-147, 204-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6PER3. 1 interaction.
MINTMINT-4101277.

PTM databases

PhosphoSiteQ6PER3.

Proteomic databases

MaxQBQ6PER3.
PaxDbQ6PER3.
PRIDEQ6PER3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031058; ENSMUSP00000031058; ENSMUSG00000029166.
GeneID100732.
KEGGmmu:100732.
UCSCuc008wvz.1. mouse.

Organism-specific databases

CTD22924.
MGIMGI:2140967. Mapre3.

Phylogenomic databases

eggNOGCOG5217.
GeneTreeENSGT00490000043329.
HOGENOMHOG000198048.
HOVERGENHBG052410.
InParanoidQ6PER3.
KOK10436.
OMANYHALER.
OrthoDBEOG7ZD1W5.
PhylomeDBQ6PER3.
TreeFamTF313620.

Gene expression databases

ArrayExpressQ6PER3.
BgeeQ6PER3.
GenevestigatorQ6PER3.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
InterProIPR001715. CH-domain.
IPR004953. EB1_C.
IPR027738. EB3_vertebrate.
IPR027328. MAPRE.
[Graphical view]
PANTHERPTHR10623. PTHR10623. 1 hit.
PTHR10623:SF10. PTHR10623:SF10. 1 hit.
PfamPF00307. CH. 1 hit.
PF03271. EB1. 1 hit.
[Graphical view]
SUPFAMSSF140612. SSF140612. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEPS50021. CH. 1 hit.
PS51230. EB1_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMAPRE3. mouse.
NextBio354616.
PROQ6PER3.
SOURCESearch...

Entry information

Entry nameMARE3_MOUSE
AccessionPrimary (citable) accession number: Q6PER3
Secondary accession number(s): Q61167
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot