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Q6PER3

- MARE3_MOUSE

UniProt

Q6PER3 - MARE3_MOUSE

Protein

Microtubule-associated protein RP/EB family member 3

Gene

Mapre3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration By similarity.By similarity

    GO - Molecular functioni

    1. microtubule binding Source: BHF-UCL
    2. protein binding Source: BHF-UCL

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    3. positive regulation of microtubule plus-end binding Source: MGI
    4. positive regulation of transcription, DNA-templated Source: BHF-UCL

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-associated protein RP/EB family member 3
    Alternative name(s):
    EB1 protein family member 3
    Short name:
    EBF3
    End-binding protein 3
    Short name:
    EB3
    RP3
    Gene namesi
    Name:Mapre3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2140967. Mapre3.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: Associated with the microtubule network. Detected at the plus end of microtubules By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytoplasmic microtubule Source: Ensembl
    3. microtubule cytoskeleton Source: BHF-UCL
    4. midbody Source: BHF-UCL
    5. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Microtubule-associated protein RP/EB family member 3PRO_0000213429Add
    BLAST

    Proteomic databases

    MaxQBiQ6PER3.
    PaxDbiQ6PER3.
    PRIDEiQ6PER3.

    PTM databases

    PhosphoSiteiQ6PER3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PER3.
    BgeeiQ6PER3.
    GenevestigatoriQ6PER3.

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer with MAPRE1. Interacts with DCTN1 and SRCIN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin. Interacts (via C-terminus) with CLIP1. Interacts with SLAIN2 By similarity. Interacts with APC2.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ6PER3. 1 interaction.
    MINTiMINT-4101277.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PER3.
    SMRiQ6PER3. Positions 1-147, 204-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 116103CHPROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 26471EB1 C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni217 – 28165DCTN1-bindingBy similarityAdd
    BLAST
    Regioni217 – 26044APC-bindingBy similarityAdd
    BLAST

    Domaini

    Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the MAPRE family.Curated
    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
    Contains 1 EB1 C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5217.
    GeneTreeiENSGT00490000043329.
    HOGENOMiHOG000198048.
    HOVERGENiHBG052410.
    InParanoidiQ6PER3.
    KOiK10436.
    OMAiNYHALER.
    OrthoDBiEOG7ZD1W5.
    PhylomeDBiQ6PER3.
    TreeFamiTF313620.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    InterProiIPR001715. CH-domain.
    IPR004953. EB1_C.
    IPR027738. EB3_vertebrate.
    IPR027328. MAPRE.
    [Graphical view]
    PANTHERiPTHR10623. PTHR10623. 1 hit.
    PTHR10623:SF10. PTHR10623:SF10. 1 hit.
    PfamiPF00307. CH. 1 hit.
    PF03271. EB1. 1 hit.
    [Graphical view]
    SUPFAMiSSF140612. SSF140612. 1 hit.
    SSF47576. SSF47576. 1 hit.
    PROSITEiPS50021. CH. 1 hit.
    PS51230. EB1_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PER3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM    50
    LFPGCVHLRK VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK 100
    FQDNFEFIQW FKKFFDANYD GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK 150
    KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP PCILRKNPPS ARNGGHEADA 200
    QILELNQQLL DLKLTVDGLE KERDFYFSKL RDIELICQEH ESENSPVISG 250
    IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y 281
    Length:281
    Mass (Da):31,966
    Last modified:July 5, 2004 - v1
    Checksum:i6713427C480838DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057918 mRNA. Translation: AAH57918.1.
    U51204 mRNA. Translation: AAA96321.1.
    CCDSiCCDS19163.1.
    RefSeqiNP_579928.1. NM_133350.1.
    XP_006503686.1. XM_006503623.1.
    UniGeneiMm.332295.
    Mm.471154.

    Genome annotation databases

    EnsembliENSMUST00000031058; ENSMUSP00000031058; ENSMUSG00000029166.
    GeneIDi100732.
    KEGGimmu:100732.
    UCSCiuc008wvz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057918 mRNA. Translation: AAH57918.1 .
    U51204 mRNA. Translation: AAA96321.1 .
    CCDSi CCDS19163.1.
    RefSeqi NP_579928.1. NM_133350.1.
    XP_006503686.1. XM_006503623.1.
    UniGenei Mm.332295.
    Mm.471154.

    3D structure databases

    ProteinModelPortali Q6PER3.
    SMRi Q6PER3. Positions 1-147, 204-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6PER3. 1 interaction.
    MINTi MINT-4101277.

    PTM databases

    PhosphoSitei Q6PER3.

    Proteomic databases

    MaxQBi Q6PER3.
    PaxDbi Q6PER3.
    PRIDEi Q6PER3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031058 ; ENSMUSP00000031058 ; ENSMUSG00000029166 .
    GeneIDi 100732.
    KEGGi mmu:100732.
    UCSCi uc008wvz.1. mouse.

    Organism-specific databases

    CTDi 22924.
    MGIi MGI:2140967. Mapre3.

    Phylogenomic databases

    eggNOGi COG5217.
    GeneTreei ENSGT00490000043329.
    HOGENOMi HOG000198048.
    HOVERGENi HBG052410.
    InParanoidi Q6PER3.
    KOi K10436.
    OMAi NYHALER.
    OrthoDBi EOG7ZD1W5.
    PhylomeDBi Q6PER3.
    TreeFami TF313620.

    Miscellaneous databases

    ChiTaRSi MAPRE3. mouse.
    NextBioi 354616.
    PROi Q6PER3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PER3.
    Bgeei Q6PER3.
    Genevestigatori Q6PER3.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    InterProi IPR001715. CH-domain.
    IPR004953. EB1_C.
    IPR027738. EB3_vertebrate.
    IPR027328. MAPRE.
    [Graphical view ]
    PANTHERi PTHR10623. PTHR10623. 1 hit.
    PTHR10623:SF10. PTHR10623:SF10. 1 hit.
    Pfami PF00307. CH. 1 hit.
    PF03271. EB1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF140612. SSF140612. 1 hit.
    SSF47576. SSF47576. 1 hit.
    PROSITEi PS50021. CH. 1 hit.
    PS51230. EB1_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    2. Hoffman N.G., Kay B.K.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-281.
    3. "p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway."
      Hsieh P.-C., Chang J.-C., Sun W.-T., Hsieh S.-C., Wang M.-C., Wang F.-F.
      Oncogene 26:4928-4940(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH APC2.

    Entry informationi

    Entry nameiMARE3_MOUSE
    AccessioniPrimary (citable) accession number: Q6PER3
    Secondary accession number(s): Q61167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3