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Protein

Ubiquitin-conjugating enzyme E2 variant 2

Gene

ube2v2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • postreplication repair Source: GO_Central
  • protein K63-linked ubiquitination Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-DRE-5693571. Nonhomologous End-Joining (NHEJ).
R-DRE-5693607. Processing of DNA double-strand break ends.
R-DRE-5696395. Formation of Incision Complex in GG-NER.
R-DRE-69473. G2/M DNA damage checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 2
Gene namesi
Name:ube2v2
ORF Names:zgc:63717
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-040426-2919. ube2v2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Ubiquitin-conjugating enzyme E2 variant 2PRO_0000292587Add
BLAST

Proteomic databases

PaxDbiQ6PEH5.
PRIDEiQ6PEH5.

Expressioni

Gene expression databases

BgeeiQ6PEH5.

Interactioni

Subunit structurei

Heterodimer with ube2n.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi91380. 3 interactions.
STRINGi7955.ENSDARP00000004795.

Structurei

3D structure databases

ProteinModelPortaliQ6PEH5.
SMRiQ6PEH5. Positions 6-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0896. Eukaryota.
ENOG4111MDW. LUCA.
GeneTreeiENSGT00740000115534.
HOGENOMiHOG000036561.
HOVERGENiHBG054552.
InParanoidiQ6PEH5.
KOiK10704.
OMAiNYPREPP.
OrthoDBiEOG77M8R5.
PhylomeDBiQ6PEH5.
TreeFamiTF316971.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PEH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASSGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI
60 70 80 90 100
IGPARTNYEN RIYSLKVECG PKYPEVPPTV RFVTKISMNG INNSNGMVDA
110 120 130 140
RSIPILAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYSN
Length:145
Mass (Da):16,324
Last modified:July 5, 2004 - v1
Checksum:iE7C003AD2FC38138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058061 mRNA. Translation: AAH58061.1.
RefSeqiNP_998680.1. NM_213515.1.
UniGeneiDr.9101.

Genome annotation databases

EnsembliENSDART00000026578; ENSDARP00000004795; ENSDARG00000028198.
GeneIDi406836.
KEGGidre:406836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058061 mRNA. Translation: AAH58061.1.
RefSeqiNP_998680.1. NM_213515.1.
UniGeneiDr.9101.

3D structure databases

ProteinModelPortaliQ6PEH5.
SMRiQ6PEH5. Positions 6-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi91380. 3 interactions.
STRINGi7955.ENSDARP00000004795.

Proteomic databases

PaxDbiQ6PEH5.
PRIDEiQ6PEH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000026578; ENSDARP00000004795; ENSDARG00000028198.
GeneIDi406836.
KEGGidre:406836.

Organism-specific databases

CTDi7336.
ZFINiZDB-GENE-040426-2919. ube2v2.

Phylogenomic databases

eggNOGiKOG0896. Eukaryota.
ENOG4111MDW. LUCA.
GeneTreeiENSGT00740000115534.
HOGENOMiHOG000036561.
HOVERGENiHBG054552.
InParanoidiQ6PEH5.
KOiK10704.
OMAiNYPREPP.
OrthoDBiEOG77M8R5.
PhylomeDBiQ6PEH5.
TreeFamiTF316971.

Enzyme and pathway databases

ReactomeiR-DRE-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-DRE-5693571. Nonhomologous End-Joining (NHEJ).
R-DRE-5693607. Processing of DNA double-strand break ends.
R-DRE-5696395. Formation of Incision Complex in GG-NER.
R-DRE-69473. G2/M DNA damage checkpoint.

Miscellaneous databases

PROiQ6PEH5.

Gene expression databases

BgeeiQ6PEH5.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiUB2V2_DANRE
AccessioniPrimary (citable) accession number: Q6PEH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.