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Protein

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Gene

Nudt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis (By similarity).By similarity

Catalytic activityi

P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal ions.By similarity

GO - Molecular functioni

  • bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Source: UniProtKB-EC
  • GTP binding Source: UniProtKB-KW
  • hydrolase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC:3.6.1.17)
Alternative name(s):
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name:
Ap4A hydrolase
Short name:
Ap4Aase
Short name:
Diadenosine tetraphosphatase
Nucleoside diphosphate-linked moiety X motif 2
Short name:
Nudix motif 2
Gene namesi
Name:Nudt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1303023. Nudt2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 147146Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]PRO_0000057105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6PEC0.
PRIDEiQ6PEC0.

Expressioni

Gene expression databases

GenevisibleiQ6PEC0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017712.

Structurei

3D structure databases

ProteinModelPortaliQ6PEC0.
SMRiQ6PEC0. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 139138Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 6422Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2839. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00390000002416.
HOGENOMiHOG000261976.
HOVERGENiHBG002853.
InParanoidiQ6PEC0.
KOiK01518.
OMAiYRWAPLE.
OrthoDBiEOG7GBFZN.
PhylomeDBiQ6PEC0.
TreeFamiTF105958.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR003565. Tetra_PHTase.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
PR01405. TETRPHPHTASE.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRACGLII FRRHLIPKVD NTTIEFLLLQ ASDGIHHWTP PKGHVDPGEN
60 70 80 90 100
DLETALRETQ EETGIEASQL IVLEGFRREL NYVARKKPKT VIYWLAEVKD
110 120 130 140
YDVEIRLSQE HQAYRWLGLD EACQLAQFEE MKATLQEGHQ FLCSTPA
Length:147
Mass (Da):16,929
Last modified:January 23, 2007 - v3
Checksum:iF17F2BB44D2B9C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058156 mRNA. Translation: AAH58156.1.
RefSeqiNP_997479.1. NM_207596.1.
UniGeneiRn.40265.

Genome annotation databases

EnsembliENSRNOT00000017712; ENSRNOP00000017712; ENSRNOG00000013110.
GeneIDi297998.
KEGGirno:297998.
UCSCiRGD:1303023. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058156 mRNA. Translation: AAH58156.1.
RefSeqiNP_997479.1. NM_207596.1.
UniGeneiRn.40265.

3D structure databases

ProteinModelPortaliQ6PEC0.
SMRiQ6PEC0. Positions 1-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017712.

Proteomic databases

PaxDbiQ6PEC0.
PRIDEiQ6PEC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017712; ENSRNOP00000017712; ENSRNOG00000013110.
GeneIDi297998.
KEGGirno:297998.
UCSCiRGD:1303023. rat.

Organism-specific databases

CTDi318.
RGDi1303023. Nudt2.

Phylogenomic databases

eggNOGiKOG2839. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00390000002416.
HOGENOMiHOG000261976.
HOVERGENiHBG002853.
InParanoidiQ6PEC0.
KOiK01518.
OMAiYRWAPLE.
OrthoDBiEOG7GBFZN.
PhylomeDBiQ6PEC0.
TreeFamiTF105958.

Enzyme and pathway databases

ReactomeiR-RNO-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiQ6PEC0.

Gene expression databases

GenevisibleiQ6PEC0. RN.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR003565. Tetra_PHTase.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
PR01405. TETRPHPHTASE.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiAP4A_RAT
AccessioniPrimary (citable) accession number: Q6PEC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.