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Protein

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Gene

Nudt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis (By similarity).By similarity

Catalytic activityi

P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal ions.By similarity

GO - Molecular functioni

  • bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Source: UniProtKB-EC
  • GTP binding Source: UniProtKB-KW
  • hydrolase activity Source: RGD

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC:3.6.1.17)
Alternative name(s):
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name:
Ap4A hydrolase
Short name:
Ap4Aase
Short name:
Diadenosine tetraphosphatase
Nucleoside diphosphate-linked moiety X motif 2
Short name:
Nudix motif 2
Gene namesi
Name:Nudt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1303023 Nudt2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000571052 – 147Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6PEC0
PRIDEiQ6PEC0

Expressioni

Gene expression databases

BgeeiENSRNOG00000013110
GenevisibleiQ6PEC0 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017712

Structurei

3D structure databases

ProteinModelPortaliQ6PEC0
SMRiQ6PEC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 139Nudix hydrolasePROSITE-ProRule annotationAdd BLAST138

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 64Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG2839 Eukaryota
COG0494 LUCA
GeneTreeiENSGT00390000002416
HOGENOMiHOG000261976
HOVERGENiHBG002853
InParanoidiQ6PEC0
KOiK01518
OMAiFERIVME
OrthoDBiEOG091G0S47
PhylomeDBiQ6PEC0
TreeFamiTF105958

Family and domain databases

CDDicd03428 Ap4A_hydrolase_human_like, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR003565 Tetra_PHTase
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
PR01405 TETRPHPHTASE
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRACGLII FRRHLIPKVD NTTIEFLLLQ ASDGIHHWTP PKGHVDPGEN
60 70 80 90 100
DLETALRETQ EETGIEASQL IVLEGFRREL NYVARKKPKT VIYWLAEVKD
110 120 130 140
YDVEIRLSQE HQAYRWLGLD EACQLAQFEE MKATLQEGHQ FLCSTPA
Length:147
Mass (Da):16,929
Last modified:January 23, 2007 - v3
Checksum:iF17F2BB44D2B9C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058156 mRNA Translation: AAH58156.1
RefSeqiNP_997479.1, NM_207596.1
UniGeneiRn.40265

Genome annotation databases

EnsembliENSRNOT00000017712; ENSRNOP00000017712; ENSRNOG00000013110
GeneIDi297998
KEGGirno:297998
UCSCiRGD:1303023 rat

Similar proteinsi

Entry informationi

Entry nameiAP4A_RAT
AccessioniPrimary (citable) accession number: Q6PEC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 96 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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