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Protein

MOB-like protein phocein

Gene

Mob4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in membrane trafficking, specifically in membrane budding reactions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92ZincBy similarity1
Metal bindingi97ZincBy similarity1
Metal bindingi169ZincBy similarity1
Metal bindingi174ZincBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB-like protein phocein
Alternative name(s):
Class II mMOB1
Mob1 homolog 3
Short name:
Mob3
Mps one binder kinase activator-like 3
Preimplantation protein 3
Gene namesi
Name:Mob4
Synonyms:Mob3, Mobkl3, Phocn, Prei3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104899 Mob4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935771 – 225MOB-like protein phoceinAdd BLAST225

Post-translational modificationi

Phosphorylated on serine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PEB6
MaxQBiQ6PEB6
PaxDbiQ6PEB6
PRIDEiQ6PEB6

PTM databases

iPTMnetiQ6PEB6
PhosphoSitePlusiQ6PEB6

Expressioni

Gene expression databases

BgeeiENSMUSG00000025979
ExpressionAtlasiQ6PEB6 baseline and differential
GenevisibleiQ6PEB6 MM

Interactioni

Subunit structurei

Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with CTTNBP2 and CTTNBP2NL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202356, 3 interactors
IntActiQ6PEB6, 3 interactors
STRINGi10090.ENSMUSP00000125415

Structurei

3D structure databases

ProteinModelPortaliQ6PEB6
SMRiQ6PEB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1852 Eukaryota
ENOG410XNS1 LUCA
GeneTreeiENSGT00390000012143
HOGENOMiHOG000253925
HOVERGENiHBG052490
InParanoidiQ6PEB6
OMAiNECPAID
OrthoDBiEOG091G0IDP
TreeFamiTF314078

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PEB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD
60 70 80 90 100
CSNIDKILEP PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM
110 120 130 140 150
TATEQWIFLC AAHKTPKECP AIDYTRHTLD GAACLLNSNK YFPSRVSIKE
160 170 180 190 200
SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE YENETFLCHR FTKFVMKYNL
210 220
MSKDNLIVPI LEEEVQNSVS GESEA
Length:225
Mass (Da):26,032
Last modified:July 5, 2004 - v1
Checksum:iD0EF1219711458BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142F → S in BAB32105 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020446 mRNA Translation: BAB32105.1
AK034840 mRNA Translation: BAC28849.1
AK162327 mRNA Translation: BAE36855.1
BC037499 mRNA Translation: AAH37499.1
BC058168 mRNA Translation: AAH58168.1
CCDSiCCDS14960.1
RefSeqiNP_079559.2, NM_025283.3
UniGeneiMm.291037

Genome annotation databases

EnsembliENSMUST00000162364; ENSMUSP00000125415; ENSMUSG00000025979
GeneIDi19070
KEGGimmu:19070
UCSCiuc007bad.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPHOCN_MOUSE
AccessioniPrimary (citable) accession number: Q6PEB6
Secondary accession number(s): Q3TS21, Q8BSA3, Q9CX28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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