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Protein

MOB-like protein phocein

Gene

Mob4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in membrane trafficking, specifically in membrane budding reactions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921ZincBy similarity
Metal bindingi97 – 971ZincBy similarity
Metal bindingi169 – 1691ZincBy similarity
Metal bindingi174 – 1741ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB-like protein phocein
Alternative name(s):
Class II mMOB1
Mob1 homolog 3
Short name:
Mob3
Mps one binder kinase activator-like 3
Preimplantation protein 3
Gene namesi
Name:Mob4
Synonyms:Mob3, Mobkl3, Phocn, Prei3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104899. Mob4.

Subcellular locationi

  • Cytoplasmperinuclear region 1 Publication
  • Membrane 1 Publication; Peripheral membrane protein 1 Publication
  • Golgi apparatusGolgi stack membrane 1 Publication; Peripheral membrane protein 1 Publication

  • Note: In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225MOB-like protein phoceinPRO_0000193577Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PEB6.
MaxQBiQ6PEB6.
PaxDbiQ6PEB6.
PRIDEiQ6PEB6.

PTM databases

PhosphoSiteiQ6PEB6.

Expressioni

Gene expression databases

BgeeiQ6PEB6.
ExpressionAtlasiQ6PEB6. baseline and differential.
GenevisibleiQ6PEB6. MM.

Interactioni

Subunit structurei

Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with CTTNBP2 and CTTNBP2NL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202356. 1 interaction.
IntActiQ6PEB6. 2 interactions.
STRINGi10090.ENSMUSP00000125415.

Structurei

3D structure databases

ProteinModelPortaliQ6PEB6.
SMRiQ6PEB6. Positions 24-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1852. Eukaryota.
ENOG410XNS1. LUCA.
GeneTreeiENSGT00390000012143.
HOGENOMiHOG000253925.
HOVERGENiHBG052490.
InParanoidiQ6PEB6.
OMAiDEPFEEM.
OrthoDBiEOG7VDXQ5.
TreeFamiTF314078.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PEB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD
60 70 80 90 100
CSNIDKILEP PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM
110 120 130 140 150
TATEQWIFLC AAHKTPKECP AIDYTRHTLD GAACLLNSNK YFPSRVSIKE
160 170 180 190 200
SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE YENETFLCHR FTKFVMKYNL
210 220
MSKDNLIVPI LEEEVQNSVS GESEA
Length:225
Mass (Da):26,032
Last modified:July 5, 2004 - v1
Checksum:iD0EF1219711458BA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421F → S in BAB32105 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020446 mRNA. Translation: BAB32105.1.
AK034840 mRNA. Translation: BAC28849.1.
AK162327 mRNA. Translation: BAE36855.1.
BC037499 mRNA. Translation: AAH37499.1.
BC058168 mRNA. Translation: AAH58168.1.
CCDSiCCDS14960.1.
RefSeqiNP_079559.2. NM_025283.3.
UniGeneiMm.291037.

Genome annotation databases

EnsembliENSMUST00000162364; ENSMUSP00000125415; ENSMUSG00000025979.
GeneIDi19070.
KEGGimmu:19070.
UCSCiuc007bad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020446 mRNA. Translation: BAB32105.1.
AK034840 mRNA. Translation: BAC28849.1.
AK162327 mRNA. Translation: BAE36855.1.
BC037499 mRNA. Translation: AAH37499.1.
BC058168 mRNA. Translation: AAH58168.1.
CCDSiCCDS14960.1.
RefSeqiNP_079559.2. NM_025283.3.
UniGeneiMm.291037.

3D structure databases

ProteinModelPortaliQ6PEB6.
SMRiQ6PEB6. Positions 24-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202356. 1 interaction.
IntActiQ6PEB6. 2 interactions.
STRINGi10090.ENSMUSP00000125415.

PTM databases

PhosphoSiteiQ6PEB6.

Proteomic databases

EPDiQ6PEB6.
MaxQBiQ6PEB6.
PaxDbiQ6PEB6.
PRIDEiQ6PEB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162364; ENSMUSP00000125415; ENSMUSG00000025979.
GeneIDi19070.
KEGGimmu:19070.
UCSCiuc007bad.1. mouse.

Organism-specific databases

CTDi25843.
MGIiMGI:104899. Mob4.

Phylogenomic databases

eggNOGiKOG1852. Eukaryota.
ENOG410XNS1. LUCA.
GeneTreeiENSGT00390000012143.
HOGENOMiHOG000253925.
HOVERGENiHBG052490.
InParanoidiQ6PEB6.
OMAiDEPFEEM.
OrthoDBiEOG7VDXQ5.
TreeFamiTF314078.

Miscellaneous databases

NextBioi295590.
PROiQ6PEB6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PEB6.
ExpressionAtlasiQ6PEB6. baseline and differential.
GenevisibleiQ6PEB6. MM.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary gland and Mammary tumor.
  3. "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes."
    Moreno C.S., Lane W.S., Pallas D.C.
    J. Biol. Chem. 276:24253-24260(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STRN; STRN3 AND THE PPA2 COMPLEX, PHOSPHORYLATION, SUBCELLULAR LOCATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPHOCN_MOUSE
AccessioniPrimary (citable) accession number: Q6PEB6
Secondary accession number(s): Q3TS21, Q8BSA3, Q9CX28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.