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Q6PEB4 (OSGP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1
Gene names
Name:Osgepl1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity.

Sequence similarities

Belongs to the KAE1 / YgjD family.

Ontologies

Keywords
   Biological processtRNA processing
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrion

Inferred from direct assay. Source: MGI

   Molecular functionmetalloendopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PEB4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PEB4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     366-371: NGIERL → HGGARL
     372-414: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1
PRO_0000307779

Amino acid modifications

Modified residue71Phosphothreonine Ref.3

Natural variations

Alternative sequence366 – 3716NGIERL → HGGARL in isoform 2.
VSP_028831
Alternative sequence372 – 41443Missing in isoform 2.
VSP_028832

Experimental info

Sequence conflict1021C → S in AAH58172. Ref.2
Sequence conflict1371Q → R in AAH58172. Ref.2
Sequence conflict2271Q → H in AAH58172. Ref.2
Sequence conflict2761G → E in BAB27506. Ref.1
Sequence conflict3941V → I in AAH58172. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 9A2D27B576C7DB24

FASTA41444,928
        10         20         30         40         50         60 
MLMLRRTAGA IPKPPKSKVY GFLRRFSVHP RTLSCHKLVL GIETSCDDTG AAVVDETGNV 

        70         80         90        100        110        120 
LGEALHSQTQ VHLKTGGIVP PVAQQLHREN IQRIVEETLS ACRITPSDLS AIATTIKPGL 

       130        140        150        160        170        180 
ALSLGVGLSF SLQLVNQFKK PFIPIHHMEA HALTIRLTNK VEFPFLVLLI SGGHCLLALV 

       190        200        210        220        230        240 
QGVSDFLLLG KSLDIAPGDM LDKVARRLSL IKHPECSTMS GGKAIEQLAK DGNRFHFTIN 

       250        260        270        280        290        300 
PPMQNAKNCD FSFTGLQHIT DKLITHKEKE EGIEKGQILS SAADIAAAVQ HATACHLAKR 

       310        320        330        340        350        360 
THRAILFCKQ KNLLSPANAV LVVSGGVASN LYIRKALEIV ANATQCTLLC PPPRLCTDNG 

       370        380        390        400        410 
IMIAWNGIER LRAGLGVLHD VEDIRYEPKC PLGVDISREV AEAAIKVPRL KMAL

« Hide

Isoform 2 [UniParc].

Checksum: E7195AF96B5AFC8C
Show »

FASTA37140,125

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Cerebellum, Corpora quadrigemina and Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Mammary tumor.
[3]"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry."
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.
J. Proteome Res. 6:250-262(2007) [PubMed: 17203969] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK011265 mRNA. Translation: BAB27506.1.
AK045669 mRNA. Translation: BAC32450.1.
AK137332 mRNA. Translation: BAE23308.1.
BC058172 mRNA. Translation: AAH58172.1.
IPIIPI00387219.
IPI00869458.
RefSeqNP_082367.2. NM_028091.3.
UniGeneMm.482256.

3D structure databases

ProteinModelPortalQ6PEB4.
SMRQ6PEB4. Positions 37-394.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6PEB4.

PTM databases

PhosphoSiteQ6PEB4.

Proteomic databases

PRIDEQ6PEB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027265; ENSMUSP00000027265; ENSMUSG00000026096.
ENSMUST00000114484; ENSMUSP00000110128; ENSMUSG00000026096.
ENSMUST00000164503; ENSMUSP00000129717; ENSMUSG00000026096.
GeneID72085.
KEGGmmu:72085.
UCSCuc007aza.1. mouse.

Organism-specific databases

CTD64172.
MGIMGI:1919335. Osgepl1.

Phylogenomic databases

eggNOGroNOG07935.
GeneTreeENSGT00550000075001.
HOGENOMHBG304663.
HOVERGENHBG108218.
InParanoidQ6PEB4.
OMAPAVGVHH.
OrthoDBEOG4T4CVS.
PhylomeDBQ6PEB4.

Gene expression databases

ArrayExpressQ6PEB4.
BgeeQ6PEB4.
GenevestigatorQ6PEB4.

Family and domain databases

InterProIPR000905. Peptidase_M22.
IPR017861. Peptidase_M22_subgr.
[Graphical view]
KOK01409.
PfamPF00814. Peptidase_M22. 1 hit.
[Graphical view]
PRINTSPR00789. OSIALOPTASE.
TIGRFAMsTIGR00329. Gcp_kae1. 1 hit.
ProtoNetSearch...

Other

NextBio335400.
SOURCESearch...

Entry information

Entry nameOSGP2_MOUSE
AccessionPrimary (citable) accession number: Q6PEB4
Secondary accession number(s): Q3UVG1, Q8BLB6, Q9D0N0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 16, 2011
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents