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Protein

Stomatin-like protein 3

Gene

Stoml3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.1 Publication

GO - Biological processi

  • signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 3
Short name:
SLP-3
Alternative name(s):
Stomatin-related olfactory protein
Gene namesi
Name:Stoml3
Synonyms:Sro
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2388072. Stoml3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini46 – 287242CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cilium Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

In deficient mice 35% of skin mechanoreceptors do not respond to mechanical stimuli. In addition, mechanosensitive ion channels find in many sensory neurons do not function. Tactile-driven behaviors are also impaired in mutant mice, including touch-evoked pain caused by neuropathic injury.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi40 – 401P → S: Mis-localization predominantly to the cytoplasmic compartment. 1 Publication
Mutagenesisi89 – 902LR → EE: Abolishes the activity of STOML3. 1 Publication
Mutagenesisi90 – 901R → S: Abolishes STOML3 modulation of mechanosensitive currents. 1 Publication
Mutagenesisi190 – 1901V → P: Reduced oligomerization. Does not sensitize mechanically gated currents. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Stomatin-like protein 3PRO_0000094034Add
BLAST

Proteomic databases

PaxDbiQ6PE84.
PRIDEiQ6PE84.

PTM databases

PhosphoSiteiQ6PE84.

Expressioni

Tissue specificityi

Expressed by all dorsal root ganglion neurons and is selectively expressed in neuronal tissues. Detected in olfactory epithelium.2 Publications

Gene expression databases

BgeeiQ6PE84.
CleanExiMM_STOML3.
ExpressionAtlasiQ6PE84. baseline and differential.
GenevisibleiQ6PE84. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with PIEZO1 and PIEZO2.1 Publication

Protein-protein interaction databases

BioGridi230826. 2 interactions.
STRINGi10090.ENSMUSP00000029307.

Structurei

3D structure databases

ProteinModelPortaliQ6PE84.
SMRiQ6PE84. Positions 82-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217040.
HOVERGENiHBG004815.
InParanoidiQ6PE84.
KOiK17286.
OMAiSIWACIK.
OrthoDBiEOG78D7KJ.
PhylomeDBiQ6PE84.
TreeFamiTF105750.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028519. SLP3.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF49. PTHR10264:SF49. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PE84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPEKLEKN NLVGTNKSRL GVCGWILFFL SFLLMLVTFP ISVWMCLKII
60 70 80 90 100
KEYERAVVFR LGRIQADKAK GPGLILVLPC IDVFVKVDLR TVTCNIPPQE
110 120 130 140 150
ILTRDSVTTQ VDGVVYYRIY SAVSAVANVN DVHQATFLLA QTTLRNVLGT
160 170 180 190 200
QTLSQILSGR EEIAHSIQTL LDDATELWGI RVARVEIKDV RIPVQLQRSM
210 220 230 240 250
AAEAEATREA RAKVLAAEGE MNASKSLKSA SMVLAESPVA LQLRYLQTLT
260 270 280
TVATEKNSTI VFPLPMNILE GIGGISYGNN KKVTAKA
Length:287
Mass (Da):31,591
Last modified:February 1, 2005 - v2
Checksum:iBD8FAC8A6E998AD6
GO

Sequence cautioni

The sequence AAH58224.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH80859.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201E → V in AAH80859 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085692 mRNA. Translation: BAC05692.1.
BC058224 mRNA. Translation: AAH58224.1. Different initiation.
BC080859 mRNA. Translation: AAH80859.1. Different initiation.
CCDSiCCDS17347.1.
RefSeqiNP_694796.1. NM_153156.1.
UniGeneiMm.222810.

Genome annotation databases

EnsembliENSMUST00000029307; ENSMUSP00000029307; ENSMUSG00000027744.
GeneIDi229277.
KEGGimmu:229277.
UCSCiuc008pew.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085692 mRNA. Translation: BAC05692.1.
BC058224 mRNA. Translation: AAH58224.1. Different initiation.
BC080859 mRNA. Translation: AAH80859.1. Different initiation.
CCDSiCCDS17347.1.
RefSeqiNP_694796.1. NM_153156.1.
UniGeneiMm.222810.

3D structure databases

ProteinModelPortaliQ6PE84.
SMRiQ6PE84. Positions 82-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230826. 2 interactions.
STRINGi10090.ENSMUSP00000029307.

PTM databases

PhosphoSiteiQ6PE84.

Proteomic databases

PaxDbiQ6PE84.
PRIDEiQ6PE84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029307; ENSMUSP00000029307; ENSMUSG00000027744.
GeneIDi229277.
KEGGimmu:229277.
UCSCiuc008pew.1. mouse.

Organism-specific databases

CTDi161003.
MGIiMGI:2388072. Stoml3.

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOGENOMiHOG000217040.
HOVERGENiHBG004815.
InParanoidiQ6PE84.
KOiK17286.
OMAiSIWACIK.
OrthoDBiEOG78D7KJ.
PhylomeDBiQ6PE84.
TreeFamiTF105750.

Miscellaneous databases

NextBioi379370.
PROiQ6PE84.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PE84.
CleanExiMM_STOML3.
ExpressionAtlasiQ6PE84. baseline and differential.
GenevisibleiQ6PE84. MM.

Family and domain databases

InterProiIPR001107. Band_7.
IPR018080. Band_7/stomatin-like_CS.
IPR028519. SLP3.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF49. PTHR10264:SF49. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
PROSITEiPS01270. BAND_7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons."
    Kobayakawa K., Hayashi R., Morita K., Miyamichi K., Oka Y., Tsuboi A., Sakano H.
    J. Neurosci. 22:5931-5937(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Olfactory epithelium.
  3. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  4. "Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch."
    Poole K., Herget R., Lapatsina L., Ngo H.D., Lewin G.R.
    Nat. Commun. 5:3520-3520(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIEZO1 AND PIEZO2, MUTAGENESIS OF PRO-40; 89-LEU-ARG-90; ARG-90 AND VAL-190, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSTML3_MOUSE
AccessioniPrimary (citable) accession number: Q6PE84
Secondary accession number(s): Q66JM3, Q8K4P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: January 20, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.