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Q6PE80

- Q6PE80_MOUSE

UniProt

Q6PE80 - Q6PE80_MOUSE

Protein
Submitted name:

Axl protein

Gene

Axl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein heterodimerization activity Source: MGI
    3. protein tyrosine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic cell clearance Source: MGI
    2. blood vessel remodeling Source: MGI
    3. cellular response to extracellular stimulus Source: MGI
    4. enzyme linked receptor protein signaling pathway Source: MGI
    5. erythrocyte homeostasis Source: MGI
    6. forebrain cell migration Source: MGI
    7. inflammatory response Source: MGI
    8. natural killer cell differentiation Source: MGI
    9. negative regulation of apoptotic process Source: MGI
    10. negative regulation of lymphocyte activation Source: MGI
    11. negative regulation of neuron apoptotic process Source: MGI
    12. negative regulation of tumor necrosis factor production Source: MGI
    13. neuron migration Source: MGI
    14. ovulation cycle Source: MGI
    15. phagocytosis Source: MGI
    16. platelet activation Source: MGI
    17. protein kinase B signaling Source: MGI
    18. secretion by cell Source: MGI
    19. spermatogenesis Source: MGI
    20. substrate adhesion-dependent cell spreading Source: MGI
    21. vagina development Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Axl proteinImported
    Submitted name:
    Tyrosine-protein kinase receptor UFOImported
    Gene namesi
    Name:AxlImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1347244. Axl.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ6PE80.

    Family & Domainsi

    Sequence similaritiesi

    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108377.
    HOGENOMiHOG000231685.
    HOVERGENiHBG006346.
    KOiK05115.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00060. FN3. 2 hits.
    SM00409. IG. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PE80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRVPLAWWL ALCCWGCAAH KDTQTEAGSP FVGNPGNITG ARGLTGTLRC    50
    ELQVQGEPPE VVWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA 100
    LQLSDAGEYQ CMVHLEGRTF VSQPGFVGLE GLPYFLEEPE DKAVPANTPF 150
    NLSCQAQGPP EPVTLLWLQD AVPLAPVTGH SSQHSLQTPG LNKTSSFSCE 200
    AHNAKGVTTS RTATITVLPQ RPHHLHVVSR QPTELEVAWT PGLSGIYPLT 250
    HCNLQAVLSD DGVGIWLGKS DPPEDPLTLQ VSVPPHQLRL EKLLPHTPYH 300
    IRISCSSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQVLVRWQEP 350
    RVPLQGTLLG YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV 400
    TAYTSAGDGP WSLPVPLEPW RPVSEPPPRA FSWPWWYVLL GALVAAACVL 450
    ILALFLVHRR KKETRYGEVF EPTVERGELV VRYRVRKSYS RRTTEATLNS 500
    LGISEELKEK LRDVMVDRHK VALGKTLGEG EFGAVMEGQL NQDDSILKVA 550
    VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF QGSDREGFPE 600
    PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST 650
    KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 700
    IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG 750
    NRLKQPVDCL DGLYALMSRC WELNPRDRPS FAELREDLEN TLKALPPAQE 800
    PDEILYVNMD EGGSHLEPRG AAGGADPPTQ PDPKDSCSCL TAADVHSAGR 850
    YVLCPSTAPG PTLSADRGCP APPGQEDGA 879
    Length:879
    Mass (Da):97,223
    Last modified:July 5, 2004 - v1
    Checksum:iCEE76A976A8E88EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC119211 Genomic DNA. No translation available.
    AC162614 Genomic DNA. No translation available.
    BC058230 mRNA. Translation: AAH58230.1.
    RefSeqiNP_001177903.1. NM_001190974.1.
    XP_006540054.1. XM_006539991.1.
    UniGeneiMm.4128.

    Genome annotation databases

    EnsembliENSMUST00000085948; ENSMUSP00000083110; ENSMUSG00000002602.
    GeneIDi26362.
    KEGGimmu:26362.
    UCSCiuc009fty.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC119211 Genomic DNA. No translation available.
    AC162614 Genomic DNA. No translation available.
    BC058230 mRNA. Translation: AAH58230.1 .
    RefSeqi NP_001177903.1. NM_001190974.1.
    XP_006540054.1. XM_006539991.1.
    UniGenei Mm.4128.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085948 ; ENSMUSP00000083110 ; ENSMUSG00000002602 .
    GeneIDi 26362.
    KEGGi mmu:26362.
    UCSCi uc009fty.2. mouse.

    Organism-specific databases

    CTDi 558.
    MGIi MGI:1347244. Axl.

    Phylogenomic databases

    GeneTreei ENSGT00720000108377.
    HOGENOMi HOG000231685.
    HOVERGENi HBG006346.
    KOi K05115.

    Miscellaneous databases

    ChiTaRSi AXL. mouse.
    NextBioi 304223.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6PE80.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00060. FN3. 2 hits.
    SM00409. IG. 2 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epitheliumImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6PE80_MOUSE
    AccessioniPrimary (citable) accession number: Q6PE80
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3