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Q6PE80

- Q6PE80_MOUSE

UniProt

Q6PE80 - Q6PE80_MOUSE

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Protein
Submitted name:

Axl protein

Gene

Axl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: MGI
  3. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic cell clearance Source: MGI
  2. blood vessel remodeling Source: MGI
  3. cellular response to extracellular stimulus Source: MGI
  4. enzyme linked receptor protein signaling pathway Source: MGI
  5. erythrocyte homeostasis Source: MGI
  6. forebrain cell migration Source: MGI
  7. inflammatory response Source: MGI
  8. natural killer cell differentiation Source: MGI
  9. negative regulation of apoptotic process Source: MGI
  10. negative regulation of lymphocyte activation Source: MGI
  11. negative regulation of neuron apoptotic process Source: MGI
  12. negative regulation of tumor necrosis factor production Source: MGI
  13. neuron migration Source: MGI
  14. ovulation cycle Source: MGI
  15. phagocytosis Source: MGI
  16. platelet activation Source: MGI
  17. protein kinase B signaling Source: MGI
  18. secretion by cell Source: MGI
  19. spermatogenesis Source: MGI
  20. substrate adhesion-dependent cell spreading Source: MGI
  21. vagina development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Axl proteinImported
Submitted name:
Tyrosine-protein kinase receptor UFOImported
Gene namesi
Name:AxlImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1347244. Axl.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ6PE80.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120499.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
KOiK05115.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PE80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRVPLAWWL ALCCWGCAAH KDTQTEAGSP FVGNPGNITG ARGLTGTLRC
60 70 80 90 100
ELQVQGEPPE VVWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA
110 120 130 140 150
LQLSDAGEYQ CMVHLEGRTF VSQPGFVGLE GLPYFLEEPE DKAVPANTPF
160 170 180 190 200
NLSCQAQGPP EPVTLLWLQD AVPLAPVTGH SSQHSLQTPG LNKTSSFSCE
210 220 230 240 250
AHNAKGVTTS RTATITVLPQ RPHHLHVVSR QPTELEVAWT PGLSGIYPLT
260 270 280 290 300
HCNLQAVLSD DGVGIWLGKS DPPEDPLTLQ VSVPPHQLRL EKLLPHTPYH
310 320 330 340 350
IRISCSSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQVLVRWQEP
360 370 380 390 400
RVPLQGTLLG YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV
410 420 430 440 450
TAYTSAGDGP WSLPVPLEPW RPVSEPPPRA FSWPWWYVLL GALVAAACVL
460 470 480 490 500
ILALFLVHRR KKETRYGEVF EPTVERGELV VRYRVRKSYS RRTTEATLNS
510 520 530 540 550
LGISEELKEK LRDVMVDRHK VALGKTLGEG EFGAVMEGQL NQDDSILKVA
560 570 580 590 600
VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF QGSDREGFPE
610 620 630 640 650
PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST
660 670 680 690 700
KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW
710 720 730 740 750
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG
760 770 780 790 800
NRLKQPVDCL DGLYALMSRC WELNPRDRPS FAELREDLEN TLKALPPAQE
810 820 830 840 850
PDEILYVNMD EGGSHLEPRG AAGGADPPTQ PDPKDSCSCL TAADVHSAGR
860 870
YVLCPSTAPG PTLSADRGCP APPGQEDGA
Length:879
Mass (Da):97,223
Last modified:July 5, 2004 - v1
Checksum:iCEE76A976A8E88EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1.
RefSeqiNP_001177903.1. NM_001190974.1.
XP_006540054.1. XM_006539991.1.
UniGeneiMm.4128.

Genome annotation databases

EnsembliENSMUST00000085948; ENSMUSP00000083110; ENSMUSG00000002602.
GeneIDi26362.
KEGGimmu:26362.
UCSCiuc009fty.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1 .
RefSeqi NP_001177903.1. NM_001190974.1.
XP_006540054.1. XM_006539991.1.
UniGenei Mm.4128.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I43.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085948 ; ENSMUSP00000083110 ; ENSMUSG00000002602 .
GeneIDi 26362.
KEGGi mmu:26362.
UCSCi uc009fty.2. mouse.

Organism-specific databases

CTDi 558.
MGIi MGI:1347244. Axl.

Phylogenomic databases

GeneTreei ENSGT00770000120499.
HOGENOMi HOG000231685.
HOVERGENi HBG006346.
KOi K05115.

Miscellaneous databases

ChiTaRSi Axl. mouse.
NextBioi 304223.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6PE80.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epitheliumImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6PE80_MOUSE
AccessioniPrimary (citable) accession number: Q6PE80
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3