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Q6PE80

- Q6PE80_MOUSE

UniProt

Q6PE80 - Q6PE80_MOUSE

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Protein
Submitted name:

Axl protein

Gene
Axl
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: MGI
  3. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic cell clearance Source: MGI
  2. blood vessel remodeling Source: MGI
  3. cellular response to extracellular stimulus Source: MGI
  4. enzyme linked receptor protein signaling pathway Source: MGI
  5. erythrocyte homeostasis Source: MGI
  6. forebrain cell migration Source: MGI
  7. inflammatory response Source: MGI
  8. natural killer cell differentiation Source: MGI
  9. negative regulation of apoptotic process Source: MGI
  10. negative regulation of lymphocyte activation Source: MGI
  11. negative regulation of neuron apoptotic process Source: MGI
  12. negative regulation of tumor necrosis factor production Source: MGI
  13. neuron migration Source: MGI
  14. ovulation cycle Source: MGI
  15. phagocytosis Source: MGI
  16. platelet activation Source: MGI
  17. protein kinase B signaling Source: MGI
  18. secretion by cell Source: MGI
  19. spermatogenesis Source: MGI
  20. substrate adhesion-dependent cell spreading Source: MGI
  21. vagina development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotations, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Axl proteinImported
Submitted name:
Tyrosine-protein kinase receptor UFOImported
Gene namesi
Name:AxlImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1347244. Axl.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ6PE80.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Immunoglobulin domainSAAS annotations, RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00720000108377.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
KOiK05115.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PE80-1 [UniParc]FASTAAdd to Basket

« Hide

MGRVPLAWWL ALCCWGCAAH KDTQTEAGSP FVGNPGNITG ARGLTGTLRC    50
ELQVQGEPPE VVWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA 100
LQLSDAGEYQ CMVHLEGRTF VSQPGFVGLE GLPYFLEEPE DKAVPANTPF 150
NLSCQAQGPP EPVTLLWLQD AVPLAPVTGH SSQHSLQTPG LNKTSSFSCE 200
AHNAKGVTTS RTATITVLPQ RPHHLHVVSR QPTELEVAWT PGLSGIYPLT 250
HCNLQAVLSD DGVGIWLGKS DPPEDPLTLQ VSVPPHQLRL EKLLPHTPYH 300
IRISCSSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQVLVRWQEP 350
RVPLQGTLLG YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV 400
TAYTSAGDGP WSLPVPLEPW RPVSEPPPRA FSWPWWYVLL GALVAAACVL 450
ILALFLVHRR KKETRYGEVF EPTVERGELV VRYRVRKSYS RRTTEATLNS 500
LGISEELKEK LRDVMVDRHK VALGKTLGEG EFGAVMEGQL NQDDSILKVA 550
VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF QGSDREGFPE 600
PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST 650
KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 700
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG 750
NRLKQPVDCL DGLYALMSRC WELNPRDRPS FAELREDLEN TLKALPPAQE 800
PDEILYVNMD EGGSHLEPRG AAGGADPPTQ PDPKDSCSCL TAADVHSAGR 850
YVLCPSTAPG PTLSADRGCP APPGQEDGA 879
Length:879
Mass (Da):97,223
Last modified:July 5, 2004 - v1
Checksum:iCEE76A976A8E88EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1.
RefSeqiNP_001177903.1. NM_001190974.1.
XP_006540054.1. XM_006539991.1.
UniGeneiMm.4128.

Genome annotation databases

EnsembliENSMUST00000085948; ENSMUSP00000083110; ENSMUSG00000002602.
GeneIDi26362.
KEGGimmu:26362.
UCSCiuc009fty.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1 .
RefSeqi NP_001177903.1. NM_001190974.1.
XP_006540054.1. XM_006539991.1.
UniGenei Mm.4128.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I43.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085948 ; ENSMUSP00000083110 ; ENSMUSG00000002602 .
GeneIDi 26362.
KEGGi mmu:26362.
UCSCi uc009fty.2. mouse.

Organism-specific databases

CTDi 558.
MGIi MGI:1347244. Axl.

Phylogenomic databases

GeneTreei ENSGT00720000108377.
HOGENOMi HOG000231685.
HOVERGENi HBG006346.
KOi K05115.

Miscellaneous databases

ChiTaRSi AXL. mouse.
NextBioi 304223.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6PE80.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epitheliumImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6PE80_MOUSE
AccessioniPrimary (citable) accession number: Q6PE80
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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