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Q6PE80 (Q6PE80_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Axl protein EMBL AAH58230.1
Submitted name:
Tyrosine-protein kinase receptor UFO Ensembl ENSMUSP00000083110
Gene names
Name:Axl Ensembl ENSMUSP00000083110 MGI 1347244
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length879 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266

Sequence similarities

Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain SAAS SAAS008266
Transmembrane
Transmembrane helix SAAS SAAS008266
   LigandATP-binding SAAS SAAS008266
Nucleotide-binding
   Molecular functionKinase
Receptor SAAS SAAS008266
Transferase
Tyrosine-protein kinase SAAS SAAS008266
   PTMPhosphoprotein SAAS SAAS008266
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic cell clearance

Inferred from mutant phenotype PubMed 18804096. Source: MGI

blood vessel remodeling

Inferred from mutant phenotype PubMed 16627783. Source: MGI

cellular response to extracellular stimulus

Inferred from direct assay PubMed 10322635. Source: MGI

enzyme linked receptor protein signaling pathway

Inferred from genetic interaction PubMed 9395235. Source: MGI

erythrocyte homeostasis

Inferred from mutant phenotype PubMed 18188450. Source: MGI

forebrain cell migration

Inferred from genetic interaction PubMed 18787040. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 16627783. Source: MGI

natural killer cell differentiation

Inferred from genetic interaction PubMed 16751775. Source: MGI

negative regulation of lymphocyte activation

Inferred from genetic interaction PubMed 11452127. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 18787040. Source: MGI

negative regulation of tumor necrosis factor production

Inferred from genetic interaction PubMed 16831897. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 19463168. Source: MGI

ovulation cycle

Inferred from genetic interaction PubMed 18787040. Source: MGI

platelet activation

Inferred from mutant phenotype PubMed 15650770. Source: MGI

protein kinase B signaling cascade

Inferred from mutant phenotype PubMed 16627783. Source: MGI

secretion by cell

Inferred from mutant phenotype PubMed 15650770. Source: MGI

spermatogenesis

Inferred from genetic interaction PubMed 10227296PubMed 19602523. Source: MGI

substrate adhesion-dependent cell spreading

Inferred from mutant phenotype PubMed 15650770. Source: MGI

vagina development

Inferred from genetic interaction PubMed 18393392. Source: MGI

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6PE80 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CEE76A976A8E88EC

FASTA87997,223
        10         20         30         40         50         60 
MGRVPLAWWL ALCCWGCAAH KDTQTEAGSP FVGNPGNITG ARGLTGTLRC ELQVQGEPPE 

        70         80         90        100        110        120 
VVWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA LQLSDAGEYQ CMVHLEGRTF 

       130        140        150        160        170        180 
VSQPGFVGLE GLPYFLEEPE DKAVPANTPF NLSCQAQGPP EPVTLLWLQD AVPLAPVTGH 

       190        200        210        220        230        240 
SSQHSLQTPG LNKTSSFSCE AHNAKGVTTS RTATITVLPQ RPHHLHVVSR QPTELEVAWT 

       250        260        270        280        290        300 
PGLSGIYPLT HCNLQAVLSD DGVGIWLGKS DPPEDPLTLQ VSVPPHQLRL EKLLPHTPYH 

       310        320        330        340        350        360 
IRISCSSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQVLVRWQEP RVPLQGTLLG 

       370        380        390        400        410        420 
YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV TAYTSAGDGP WSLPVPLEPW 

       430        440        450        460        470        480 
RPVSEPPPRA FSWPWWYVLL GALVAAACVL ILALFLVHRR KKETRYGEVF EPTVERGELV 

       490        500        510        520        530        540 
VRYRVRKSYS RRTTEATLNS LGISEELKEK LRDVMVDRHK VALGKTLGEG EFGAVMEGQL 

       550        560        570        580        590        600 
NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF QGSDREGFPE 

       610        620        630        640        650        660 
PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST KRFIHRDLAA 

       670        680        690        700        710        720 
RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW IAIESLADRV YTSKSDVWSF 

       730        740        750        760        770        780 
GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPVDCL DGLYALMSRC WELNPRDRPS 

       790        800        810        820        830        840 
FAELREDLEN TLKALPPAQE PDEILYVNMD EGGSHLEPRG AAGGADPPTQ PDPKDSCSCL 

       850        860        870 
TAADVHSAGR YVLCPSTAPG PTLSADRGCP APPGQEDGA

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium EMBL AAH58230.1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000083110.
[3]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000083110.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1.
IPIIPI00830433.
RefSeqNP_001177903.1. NM_001190974.1.
UniGeneMm.4128.

3D structure databases

HSSPHSSP built from PDB template 1AGW based on UniProtKB P11362.
SMRQ6PE80. Positions 29-417, 476-827.
ModBaseSearch...

Protein family/group databases

MEROPSI43.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000085948; ENSMUSP00000083110; ENSMUSG00000002602.
GeneID26362.
KEGGmmu:26362.
UCSCuc009fty.2. mouse.

Organism-specific databases

CTD558.
MGIMGI:1347244. Axl.

Phylogenomic databases

GeneTreeENSGT00550000074361.
HOGENOMHOG000231685.
HOVERGENHBG006346.
KOK05115.

Gene expression databases

GenevestigatorQ6PE80.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 2 hits.
SSF56112. Kinase_like. 1 hit.
PROSITEPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAXL. mouse.
NextBio304223.
SOURCESearch...

Entry information

Entry nameQ6PE80_MOUSE
AccessionPrimary (citable) accession number: Q6PE80
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info