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Protein

Receptor protein-tyrosine kinase

Gene

Axl

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • apoptotic cell clearance Source: MGI
  • blood vessel remodeling Source: MGI
  • cellular response to extracellular stimulus Source: MGI
  • cellular response to interferon-alpha Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • enzyme linked receptor protein signaling pathway Source: MGI
  • erythrocyte homeostasis Source: MGI
  • forebrain cell migration Source: MGI
  • inflammatory response Source: MGI
  • natural killer cell differentiation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of dendritic cell apoptotic process Source: MGI
  • negative regulation of interferon-gamma production Source: MGI
  • negative regulation of lymphocyte activation Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of tumor necrosis factor production Source: MGI
  • neuron migration Source: MGI
  • ovulation cycle Source: MGI
  • peptidyl-tyrosine phosphorylation Source: MGI
  • phagocytosis Source: MGI
  • platelet activation Source: MGI
  • positive regulation of cytokine-mediated signaling pathway Source: MGI
  • positive regulation of natural killer cell differentiation Source: MGI
  • positive regulation of pinocytosis Source: MGI
  • protein kinase B signaling Source: MGI
  • secretion by cell Source: MGI
  • spermatogenesis Source: MGI
  • substrate adhesion-dependent cell spreading Source: MGI
  • vagina development Source: MGI
  • viral entry into host cell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:AxlImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347244. Axl.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • host cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002677.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120499.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
KOiK05115.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PE80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVPLAWWL ALCCWGCAAH KDTQTEAGSP FVGNPGNITG ARGLTGTLRC
60 70 80 90 100
ELQVQGEPPE VVWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA
110 120 130 140 150
LQLSDAGEYQ CMVHLEGRTF VSQPGFVGLE GLPYFLEEPE DKAVPANTPF
160 170 180 190 200
NLSCQAQGPP EPVTLLWLQD AVPLAPVTGH SSQHSLQTPG LNKTSSFSCE
210 220 230 240 250
AHNAKGVTTS RTATITVLPQ RPHHLHVVSR QPTELEVAWT PGLSGIYPLT
260 270 280 290 300
HCNLQAVLSD DGVGIWLGKS DPPEDPLTLQ VSVPPHQLRL EKLLPHTPYH
310 320 330 340 350
IRISCSSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQVLVRWQEP
360 370 380 390 400
RVPLQGTLLG YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV
410 420 430 440 450
TAYTSAGDGP WSLPVPLEPW RPVSEPPPRA FSWPWWYVLL GALVAAACVL
460 470 480 490 500
ILALFLVHRR KKETRYGEVF EPTVERGELV VRYRVRKSYS RRTTEATLNS
510 520 530 540 550
LGISEELKEK LRDVMVDRHK VALGKTLGEG EFGAVMEGQL NQDDSILKVA
560 570 580 590 600
VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF QGSDREGFPE
610 620 630 640 650
PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST
660 670 680 690 700
KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW
710 720 730 740 750
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG
760 770 780 790 800
NRLKQPVDCL DGLYALMSRC WELNPRDRPS FAELREDLEN TLKALPPAQE
810 820 830 840 850
PDEILYVNMD EGGSHLEPRG AAGGADPPTQ PDPKDSCSCL TAADVHSAGR
860 870
YVLCPSTAPG PTLSADRGCP APPGQEDGA
Length:879
Mass (Da):97,223
Last modified:July 5, 2004 - v1
Checksum:iCEE76A976A8E88EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1.
RefSeqiNP_001177903.1. NM_001190974.1.
XP_006540054.1. XM_006539991.2.
UniGeneiMm.4128.

Genome annotation databases

EnsembliENSMUST00000085948; ENSMUSP00000083110; ENSMUSG00000002602.
GeneIDi26362.
KEGGimmu:26362.
UCSCiuc009fty.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119211 Genomic DNA. No translation available.
AC162614 Genomic DNA. No translation available.
BC058230 mRNA. Translation: AAH58230.1.
RefSeqiNP_001177903.1. NM_001190974.1.
XP_006540054.1. XM_006539991.2.
UniGeneiMm.4128.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002677.

Protein family/group databases

MEROPSiI43.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085948; ENSMUSP00000083110; ENSMUSG00000002602.
GeneIDi26362.
KEGGimmu:26362.
UCSCiuc009fty.2. mouse.

Organism-specific databases

CTDi558.
MGIiMGI:1347244. Axl.

Phylogenomic databases

GeneTreeiENSGT00770000120499.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
KOiK05115.

Miscellaneous databases

ChiTaRSiAxl. mouse.
NextBioi304223.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epitheliumImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6PE80_MOUSE
AccessioniPrimary (citable) accession number: Q6PE80
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.