ID Q6PE26_DANRE Unreviewed; 418 AA. AC Q6PE26; A0A8M1PB70; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 150. DE RecName: Full=Calreticulin {ECO:0000256|PIRNR:PIRNR002356}; GN Name=calr3a {ECO:0000313|Ensembl:ENSDARP00000130666, GN ECO:0000313|RefSeq:NP_571122.2, ECO:0000313|ZFIN:ZDB-GENE-000208-17}; GN Synonyms=calr {ECO:0000313|RefSeq:NP_571122.2}, zgc:85636 GN {ECO:0000313|RefSeq:NP_571122.2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH58314.1}; RN [1] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=11477699; RA Etheridge L.A., Wu T., Liang J.O., Ekker S.C., Halpern M.E.; RT "Floor plate develops upon depletion of tiggy-winkle and sonic hedgehog."; RL Genesis 30:164-169(2001). RN [2] {ECO:0000313|EMBL:AAH58314.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAH58314.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=21488074; RA Thakur P.C., Stuckenholz C., Rivera M.R., Davison J.M., Yao J.K., RA Amsterdam A., Sadler K.C., Bahary N.; RT "Lack of de novo phosphatidylinositol synthesis leads to endoplasmic RT reticulum stress and hepatic steatosis in cdipt-deficient zebrafish."; RL Hepatology 54:452-462(2011). RN [4] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=22805612; RA Yang D., Liu Q., Yang M., Wu H., Wang Q., Xiao J., Zhang Y.; RT "RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway RT and an inhibited MHC-II pathway at the early stage of vaccine immunization RT in zebrafish."; RL BMC Genomics 13:319-319(2012). RN [5] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=23873374; RA Hung I.C., Cherng B.W., Hsu W.M., Lee S.J.; RT "Calnexin is required for zebrafish posterior lateral line development."; RL Int. J. Dev. Biol. 57:427-438(2013). RN [6] {ECO:0000313|Ensembl:ENSDARP00000130666, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000130666}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [7] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=24874946; RA Howarth D.L., Lindtner C., Vacaru A.M., Sachidanandam R., Tsedensodnom O., RA Vasilkova T., Buettner C., Sadler K.C.; RT "Activating transcription factor 6 is necessary and sufficient for RT alcoholic fatty liver disease in zebrafish."; RL PLoS Genet. 10:e1004335-e1004335(2014). RN [8] {ECO:0000313|Ensembl:ENSDARP00000130666} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000130666}; RG Ensembl; RL Submitted (NOV-2015) to UniProtKB. RN [9] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=27716741; RA Lim K.H., Chang Y.C., Chiang Y.H., Lin H.C., Chang C.Y., Lin C.S., RA Huang L., Wang W.T., Gon-Shen Chen C., Chou W.C., Kuo Y.Y.; RT "Expression of CALR mutants causes mpl-dependent thrombocytosis in RT zebrafish."; RL Blood Cancer J. 6:e481-e481(2016). RN [10] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=27503704; RA Lui E.Y., Li C., Li Z.H., Gong Z., Lam S.H.; RT "Molecular insights of organochlorine biocide-induced toxicity in RT zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression RT and histological analyses."; RL J. Genet. Genomics 43:525-528(2016). RN [11] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=28801532; RA Sun Y., Wang Q., Fang Y., Wu C., Lu G., Chen Z.; RT "Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia RT induces cardiac remodeling and dysfunction in adult zebrafish."; RL Dis. Model. Mech. 10:1217-1227(2017). RN [12] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [13] {ECO:0000313|RefSeq:NP_571122.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RX PubMed=29471808; RA Grimholt U.; RT "Whole genome duplications have provided teleosts with many roads to RT peptide loaded MHC class I molecules."; RL BMC Evol. Biol. 18:25-25(2018). RN [14] {ECO:0000313|RefSeq:NP_571122.2} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571122.2}; RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen CC {ECO:0000256|ARBA:ARBA00004319, ECO:0000256|PIRNR:PIRNR002356}. CC -!- SIMILARITY: Belongs to the calreticulin family. CC {ECO:0000256|ARBA:ARBA00010983, ECO:0000256|PIRNR:PIRNR002356, CC ECO:0000256|RuleBase:RU362126}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR751224; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU570881; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC058314; AAH58314.1; -; mRNA. DR RefSeq; NP_571122.2; NM_131047.2. DR STRING; 7955.ENSDARP00000130666; -. DR PaxDb; 7955-ENSDARP00000063524; -. DR DNASU; 30248; -. DR Ensembl; ENSDART00000165235.2; ENSDARP00000130666.1; ENSDARG00000103979.2. DR GeneID; 30248; -. DR KEGG; dre:30248; -. DR AGR; ZFIN:ZDB-GENE-000208-17; -. DR CTD; 30248; -. DR ZFIN; ZDB-GENE-000208-17; calr3a. DR eggNOG; KOG0674; Eukaryota. DR HOGENOM; CLU_018224_0_2_1; -. DR OMA; YSDWSLL; -. DR OrthoDB; 5489154at2759; -. DR TreeFam; TF338438; -. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000103979; Expressed in intestine and 42 other cell types or tissues. DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central. DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central. DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro. DR GO; GO:0006457; P:protein folding; IBA:GO_Central. DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central. DR Gene3D; 2.60.120.200; -; 1. DR Gene3D; 2.10.250.10; Calreticulin/calnexin, P domain; 1. DR InterPro; IPR001580; Calret/calnex. DR InterPro; IPR018124; Calret/calnex_CS. DR InterPro; IPR009169; Calreticulin. DR InterPro; IPR009033; Calreticulin/calnexin_P_dom_sf. DR InterPro; IPR013320; ConA-like_dom_sf. DR PANTHER; PTHR11073:SF62; CALRETICULIN; 1. DR PANTHER; PTHR11073; CALRETICULIN AND CALNEXIN; 1. DR Pfam; PF00262; Calreticulin; 2. DR PIRSF; PIRSF002356; Calreticulin; 1. DR PRINTS; PR00626; CALRETICULIN. DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1. DR SUPFAM; SSF63887; P-domain of calnexin/calreticulin; 1. DR PROSITE; PS00803; CALRETICULIN_1; 1. DR PROSITE; PS00804; CALRETICULIN_2; 1. DR PROSITE; PS00805; CALRETICULIN_REPEAT; 1. PE 1: Evidence at protein level; KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR002356}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002356-3}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|PIRNR:PIRNR002356}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PE26}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU362126}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|RuleBase:RU362126" FT CHAIN 20..418 FT /note="Calreticulin" FT /evidence="ECO:0000256|RuleBase:RU362126, FT ECO:0000313|RefSeq:NP_571122.2" FT /id="PRO_5035035762" FT REGION 194..256 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 343..418 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 194..254 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 351..376 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 377..418 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 105..137 FT /evidence="ECO:0000256|PIRSR:PIRSR002356-3" SQ SEQUENCE 418 AA; 48540 MW; 10D092CC380C7071 CRC64; MRITAAVCFI SALAFIAHAD VYFKEQFLDG DGWKSRWVES KHKSDYGQWK LTSGKFYGDA ELDKGLQTSQ DARFYALSSR FDSFSNEGKT LVIQFTVKHE QKIDCGGGYV KVFPAEMDQT EMHGESQYYI MFGPDICGYS TKKVHVIFNY KGQNHLIKKD IKCKDDELTH LYTLILRPDQ TYEVKIDNEK VESGSLEEDW DFLPPKKIKD PEAKKPDDWD DRAKIDDPED TKPEDWDKPE NIPDPDAKKP DDWDEDMDGE WEPAMIPNPE YKGEWKPKQI DNPSYKGTWV HPEIDNPEYA ADDAIYKFDS IGVLGLDLWQ VKSGTIFDNF LITDDVEEAE KFGTDTWGAT KGPEKKMKDQ QEEEERKKRE EEEKSKKDDN EEDEEDEDED EPEEDDHTEE PPEEEEEGED DALPKDEL //