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Q6PE15

- ABHDA_MOUSE

UniProt

Q6PE15 - ABHDA_MOUSE

Protein

Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene

Abhd10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei143 – 1431Charge relay systemBy similarity
    Active sitei240 – 2401Charge relay systemBy similarity
    Active sitei270 – 2701Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: Ensembl

    GO - Biological processi

    1. glucuronoside catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS09.023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
    Alternative name(s):
    Alpha/beta hydrolase domain-containing protein 10
    Short name:
    Abhydrolase domain-containing protein 10
    Gene namesi
    Name:Abhd10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2442422. Abhd10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343MitochondrionSequence AnalysisAdd
    BLAST
    Chaini44 – 297254Mycophenolic acid acyl-glucuronide esterase, mitochondrialPRO_0000280734Add
    BLAST

    Proteomic databases

    MaxQBiQ6PE15.
    PaxDbiQ6PE15.
    PRIDEiQ6PE15.

    PTM databases

    PhosphoSiteiQ6PE15.

    Expressioni

    Gene expression databases

    BgeeiQ6PE15.
    CleanExiMM_ABHD10.
    GenevestigatoriQ6PE15.

    Interactioni

    Protein-protein interaction databases

    IntActiQ6PE15. 1 interaction.
    MINTiMINT-4114279.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PE15.
    SMRiQ6PE15. Positions 67-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0596.
    GeneTreeiENSGT00390000017765.
    HOGENOMiHOG000139902.
    HOVERGENiHBG080562.
    InParanoidiQ6PE15.
    KOiK13702.
    OMAiIEDGRNH.
    OrthoDBiEOG7673B6.
    PhylomeDBiQ6PE15.
    TreeFamiTF329757.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PE15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAWAPCRRW GWAAVSFGRH PGLSASLARK PPRAWWLSAC RQKASLSFLN    50
    RSELPNLAYK RLKGKTPGII FIPGYLSNMN GIKAVAVEEF CKSLGHAFIR 100
    FDYSGIGSSD GNLAECTVGK WRKDVLSILD DVAEGPQILV GSSLGGWLML 150
    HAAIARPEKV IALIGIATAA DGLVTQYHAL PVETQKEIEM KGEWTLPSRY 200
    NKEGYFRIPY SFIKEAEHHC LLHSPIPVTC PVRLLHGMKD EIVPWQRSLQ 250
    VADRIVSPDV DVILRKQGDH RMKEKADIHL LICTIDDLID KLSTVVP 297
    Length:297
    Mass (Da):33,040
    Last modified:July 5, 2004 - v1
    Checksum:i7AE4AEBD214ED6CE
    GO
    Isoform 2 (identifier: Q6PE15-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         269-269: D → AQSVDICGAATPSEWSSKPLGTDS
         270-297: Missing.

    Show »
    Length:292
    Mass (Da):32,115
    Checksum:i03B5FC190A05C96F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti267 – 2671Q → R in BAC35091. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei269 – 2691D → AQSVDICGAATPSEWSSKPL GTDS in isoform 2. 1 PublicationVSP_023893
    Alternative sequencei270 – 29728Missing in isoform 2. 1 PublicationVSP_023894Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052670 mRNA. Translation: BAC35091.1.
    AK084998 mRNA. Translation: BAC39335.1.
    AK166025 mRNA. Translation: BAE38528.1.
    BC027656 mRNA. Translation: AAH27656.1.
    BC058347 mRNA. Translation: AAH58347.1.
    CCDSiCCDS28201.1. [Q6PE15-1]
    RefSeqiNP_001258999.1. NM_001272070.1. [Q6PE15-2]
    NP_766099.3. NM_172511.4. [Q6PE15-1]
    UniGeneiMm.247453.

    Genome annotation databases

    EnsembliENSMUST00000066983; ENSMUSP00000065282; ENSMUSG00000033157. [Q6PE15-1]
    GeneIDi213012.
    KEGGimmu:213012.
    UCSCiuc007zix.2. mouse. [Q6PE15-2]
    uc007ziy.2. mouse. [Q6PE15-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052670 mRNA. Translation: BAC35091.1 .
    AK084998 mRNA. Translation: BAC39335.1 .
    AK166025 mRNA. Translation: BAE38528.1 .
    BC027656 mRNA. Translation: AAH27656.1 .
    BC058347 mRNA. Translation: AAH58347.1 .
    CCDSi CCDS28201.1. [Q6PE15-1 ]
    RefSeqi NP_001258999.1. NM_001272070.1. [Q6PE15-2 ]
    NP_766099.3. NM_172511.4. [Q6PE15-1 ]
    UniGenei Mm.247453.

    3D structure databases

    ProteinModelPortali Q6PE15.
    SMRi Q6PE15. Positions 67-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6PE15. 1 interaction.
    MINTi MINT-4114279.

    Chemistry

    ChEMBLi CHEMBL2146294.

    Protein family/group databases

    MEROPSi S09.023.

    PTM databases

    PhosphoSitei Q6PE15.

    Proteomic databases

    MaxQBi Q6PE15.
    PaxDbi Q6PE15.
    PRIDEi Q6PE15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066983 ; ENSMUSP00000065282 ; ENSMUSG00000033157 . [Q6PE15-1 ]
    GeneIDi 213012.
    KEGGi mmu:213012.
    UCSCi uc007zix.2. mouse. [Q6PE15-2 ]
    uc007ziy.2. mouse. [Q6PE15-1 ]

    Organism-specific databases

    CTDi 55347.
    MGIi MGI:2442422. Abhd10.

    Phylogenomic databases

    eggNOGi COG0596.
    GeneTreei ENSGT00390000017765.
    HOGENOMi HOG000139902.
    HOVERGENi HBG080562.
    InParanoidi Q6PE15.
    KOi K13702.
    OMAi IEDGRNH.
    OrthoDBi EOG7673B6.
    PhylomeDBi Q6PE15.
    TreeFami TF329757.

    Miscellaneous databases

    NextBioi 373814.
    PROi Q6PE15.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PE15.
    CleanExi MM_ABHD10.
    Genevestigatori Q6PE15.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Kidney and Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6 and C57BL/6J.
      Tissue: Brain and Thymus.

    Entry informationi

    Entry nameiABHDA_MOUSE
    AccessioniPrimary (citable) accession number: Q6PE15
    Secondary accession number(s): Q3TMB4
    , Q8C3S8, Q8C724, Q8K188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3