SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6PE15

- ABHDA_MOUSE

UniProt

Q6PE15 - ABHDA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene
Abhd10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431Charge relay system By similarity
Active sitei240 – 2401Charge relay system By similarity
Active sitei270 – 2701Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: Ensembl

GO - Biological processi

  1. glucuronoside catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS09.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 10
Short name:
Abhydrolase domain-containing protein 10
Gene namesi
Name:Abhd10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2442422. Abhd10.

Subcellular locationi

Mitochondrion Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Mitochondrion Reviewed predictionAdd
BLAST
Chaini44 – 297254Mycophenolic acid acyl-glucuronide esterase, mitochondrialPRO_0000280734Add
BLAST

Proteomic databases

MaxQBiQ6PE15.
PaxDbiQ6PE15.
PRIDEiQ6PE15.

PTM databases

PhosphoSiteiQ6PE15.

Expressioni

Gene expression databases

BgeeiQ6PE15.
CleanExiMM_ABHD10.
GenevestigatoriQ6PE15.

Interactioni

Protein-protein interaction databases

IntActiQ6PE15. 1 interaction.
MINTiMINT-4114279.

Structurei

3D structure databases

ProteinModelPortaliQ6PE15.
SMRiQ6PE15. Positions 67-290.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000017765.
HOGENOMiHOG000139902.
HOVERGENiHBG080562.
InParanoidiQ6PE15.
KOiK13702.
OMAiIEDGRNH.
OrthoDBiEOG7673B6.
PhylomeDBiQ6PE15.
TreeFamiTF329757.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PE15-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAWAPCRRW GWAAVSFGRH PGLSASLARK PPRAWWLSAC RQKASLSFLN    50
RSELPNLAYK RLKGKTPGII FIPGYLSNMN GIKAVAVEEF CKSLGHAFIR 100
FDYSGIGSSD GNLAECTVGK WRKDVLSILD DVAEGPQILV GSSLGGWLML 150
HAAIARPEKV IALIGIATAA DGLVTQYHAL PVETQKEIEM KGEWTLPSRY 200
NKEGYFRIPY SFIKEAEHHC LLHSPIPVTC PVRLLHGMKD EIVPWQRSLQ 250
VADRIVSPDV DVILRKQGDH RMKEKADIHL LICTIDDLID KLSTVVP 297
Length:297
Mass (Da):33,040
Last modified:July 5, 2004 - v1
Checksum:i7AE4AEBD214ED6CE
GO
Isoform 2 (identifier: Q6PE15-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-269: D → AQSVDICGAATPSEWSSKPLGTDS
     270-297: Missing.

Show »
Length:292
Mass (Da):32,115
Checksum:i03B5FC190A05C96F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei269 – 2691D → AQSVDICGAATPSEWSSKPL GTDS in isoform 2. VSP_023893
Alternative sequencei270 – 29728Missing in isoform 2. VSP_023894Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2671Q → R in BAC35091. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052670 mRNA. Translation: BAC35091.1.
AK084998 mRNA. Translation: BAC39335.1.
AK166025 mRNA. Translation: BAE38528.1.
BC027656 mRNA. Translation: AAH27656.1.
BC058347 mRNA. Translation: AAH58347.1.
CCDSiCCDS28201.1. [Q6PE15-1]
RefSeqiNP_001258999.1. NM_001272070.1. [Q6PE15-2]
NP_766099.3. NM_172511.4. [Q6PE15-1]
UniGeneiMm.247453.

Genome annotation databases

EnsembliENSMUST00000066983; ENSMUSP00000065282; ENSMUSG00000033157. [Q6PE15-1]
GeneIDi213012.
KEGGimmu:213012.
UCSCiuc007zix.2. mouse. [Q6PE15-2]
uc007ziy.2. mouse. [Q6PE15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052670 mRNA. Translation: BAC35091.1 .
AK084998 mRNA. Translation: BAC39335.1 .
AK166025 mRNA. Translation: BAE38528.1 .
BC027656 mRNA. Translation: AAH27656.1 .
BC058347 mRNA. Translation: AAH58347.1 .
CCDSi CCDS28201.1. [Q6PE15-1 ]
RefSeqi NP_001258999.1. NM_001272070.1. [Q6PE15-2 ]
NP_766099.3. NM_172511.4. [Q6PE15-1 ]
UniGenei Mm.247453.

3D structure databases

ProteinModelPortali Q6PE15.
SMRi Q6PE15. Positions 67-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6PE15. 1 interaction.
MINTi MINT-4114279.

Chemistry

ChEMBLi CHEMBL2146294.

Protein family/group databases

MEROPSi S09.023.

PTM databases

PhosphoSitei Q6PE15.

Proteomic databases

MaxQBi Q6PE15.
PaxDbi Q6PE15.
PRIDEi Q6PE15.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066983 ; ENSMUSP00000065282 ; ENSMUSG00000033157 . [Q6PE15-1 ]
GeneIDi 213012.
KEGGi mmu:213012.
UCSCi uc007zix.2. mouse. [Q6PE15-2 ]
uc007ziy.2. mouse. [Q6PE15-1 ]

Organism-specific databases

CTDi 55347.
MGIi MGI:2442422. Abhd10.

Phylogenomic databases

eggNOGi COG0596.
GeneTreei ENSGT00390000017765.
HOGENOMi HOG000139902.
HOVERGENi HBG080562.
InParanoidi Q6PE15.
KOi K13702.
OMAi IEDGRNH.
OrthoDBi EOG7673B6.
PhylomeDBi Q6PE15.
TreeFami TF329757.

Miscellaneous databases

NextBioi 373814.
PROi Q6PE15.
SOURCEi Search...

Gene expression databases

Bgeei Q6PE15.
CleanExi MM_ABHD10.
Genevestigatori Q6PE15.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Kidney and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6 and C57BL/6J.
    Tissue: Brain and Thymus.

Entry informationi

Entry nameiABHDA_MOUSE
AccessioniPrimary (citable) accession number: Q6PE15
Secondary accession number(s): Q3TMB4
, Q8C3S8, Q8C724, Q8K188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi