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Protein

U5 small nuclear ribonucleoprotein 40 kDa protein

Gene

Snrnp40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U5 small nuclear ribonucleoprotein 40 kDa protein
Short name:
U5 snRNP 40 kDa protein
Alternative name(s):
WD repeat-containing protein 57
Gene namesi
Name:Snrnp40
Synonyms:Wdr57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913835. Snrnp40.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514181 – 358U5 small nuclear ribonucleoprotein 40 kDa proteinAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki18Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei21Asymmetric dimethylarginineCombined sources1
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiQ6PE01.
MaxQBiQ6PE01.
PaxDbiQ6PE01.
PeptideAtlasiQ6PE01.
PRIDEiQ6PE01.

PTM databases

iPTMnetiQ6PE01.
PhosphoSitePlusiQ6PE01.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074088.
GenevisibleiQ6PE01. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Associated with the spliceosome complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211571. 1 interactor.
IntActiQ6PE01. 2 interactors.
MINTiMINT-4128759.
STRINGi10090.ENSMUSP00000101616.

Structurei

3D structure databases

ProteinModelPortaliQ6PE01.
SMRiQ6PE01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati65 – 104WD 1Add BLAST40
Repeati108 – 147WD 2Add BLAST40
Repeati150 – 190WD 3Add BLAST41
Repeati192 – 231WD 4Add BLAST40
Repeati234 – 273WD 5Add BLAST40
Repeati284 – 323WD 6Add BLAST40
Repeati326 – 358WD 7Add BLAST33

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0265. Eukaryota.
ENOG410XSEW. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000091644.
HOVERGENiHBG105197.
InParanoidiQ6PE01.
KOiK12857.
OMAiGDCENYG.
OrthoDBiEOG091G0DR4.
PhylomeDBiQ6PE01.
TreeFamiTF300039.

Family and domain databases

InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PE01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEQQKRKGP ELPLVPVKRP RHELLLGAAG AGPGAGPQQA TPGALLQAGP
60 70 80 90 100
PRCSSLQAPI MLLSGHEGEV YCCKFHPNGS TLASAGFDRL ILLWNVYGDC
110 120 130 140 150
DNYATLKGHS GAVMELHYNT DGSMLFSAST DKTVAVWDSE TGERVKRLKG
160 170 180 190 200
HTSFVNSCYP ARRGPQLVCT GSDDGTVKLW DIRKKAAVQT FQNTYQVLAV
210 220 230 240 250
TFNDTSDQII SGGIDNDIKV WDLRQNKLTY TMRGHADSVT GLSLSSEGSY
260 270 280 290 300
LLSNAMDNTV RVWDVRPFAP KERCVKIFQG NVHNFEKNLL RCSWSPDGSK
310 320 330 340 350
IAAGSADRFV YVWDTTSRRV LYKLPGHAGS INEVAFHPDE PIILSASSDK

RLYMGEIQ
Length:358
Mass (Da):39,276
Last modified:July 5, 2004 - v1
Checksum:i3B3EEA458D8228CA
GO

Sequence cautioni

The sequence BAB22049 differs from that shown. Reason: Frameshift at position 314.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185K → R in BAB22049 (PubMed:16141072).Curated1
Sequence conflicti241G → D in BAB22049 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002371 mRNA. Translation: BAB22049.1. Frameshift.
AK169605 mRNA. Translation: BAE41255.1.
BC058365 mRNA. Translation: AAH58365.1.
CCDSiCCDS38892.1.
RefSeqiNP_079921.2. NM_025645.2.
UniGeneiMm.423019.

Genome annotation databases

EnsembliENSMUST00000105994; ENSMUSP00000101616; ENSMUSG00000074088.
ENSMUST00000201498; ENSMUSP00000144537; ENSMUSG00000106911.
GeneIDi66585.
KEGGimmu:66585.
UCSCiuc008uzf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSNR40_MOUSE
AccessioniPrimary (citable) accession number: Q6PE01
Secondary accession number(s): Q3TEJ3, Q9DCX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot