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Q6PE01 (SNR40_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U5 small nuclear ribonucleoprotein 40 kDa protein

Short name=U5 snRNP 40 kDa protein
Alternative name(s):
WD repeat-containing protein 57
Gene names
Name:Snrnp40
Synonyms:Wdr57
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs By similarity.

Subunit structure

Identified in the spliceosome C complex. Associated with the spliceosome complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 7 WD repeats.

Sequence caution

The sequence BAB22049.1 differs from that shown. Reason: Frameshift at position 314.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
Spliceosome
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA splicing

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcatalytic step 2 spliceosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358U5 small nuclear ribonucleoprotein 40 kDa protein
PRO_0000051418

Regions

Repeat65 – 10440WD 1
Repeat108 – 14740WD 2
Repeat150 – 19041WD 3
Repeat192 – 23140WD 4
Repeat234 – 27340WD 5
Repeat284 – 32340WD 6
Repeat326 – 35833WD 7

Experimental info

Sequence conflict1851K → R in BAB22049. Ref.1
Sequence conflict2411G → D in BAB22049. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6PE01 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3B3EEA458D8228CA

FASTA35839,276
        10         20         30         40         50         60 
MIEQQKRKGP ELPLVPVKRP RHELLLGAAG AGPGAGPQQA TPGALLQAGP PRCSSLQAPI 

        70         80         90        100        110        120 
MLLSGHEGEV YCCKFHPNGS TLASAGFDRL ILLWNVYGDC DNYATLKGHS GAVMELHYNT 

       130        140        150        160        170        180 
DGSMLFSAST DKTVAVWDSE TGERVKRLKG HTSFVNSCYP ARRGPQLVCT GSDDGTVKLW 

       190        200        210        220        230        240 
DIRKKAAVQT FQNTYQVLAV TFNDTSDQII SGGIDNDIKV WDLRQNKLTY TMRGHADSVT 

       250        260        270        280        290        300 
GLSLSSEGSY LLSNAMDNTV RVWDVRPFAP KERCVKIFQG NVHNFEKNLL RCSWSPDGSK 

       310        320        330        340        350 
IAAGSADRFV YVWDTTSRRV LYKLPGHAGS INEVAFHPDE PIILSASSDK RLYMGEIQ 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Kidney and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002371 mRNA. Translation: BAB22049.1. Frameshift.
AK169605 mRNA. Translation: BAE41255.1.
BC058365 mRNA. Translation: AAH58365.1.
CCDSCCDS38892.1.
RefSeqNP_079921.2. NM_025645.2.
UniGeneMm.423019.

3D structure databases

ProteinModelPortalQ6PE01.
SMRQ6PE01. Positions 63-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6PE01. 2 interactions.
MINTMINT-4128759.

PTM databases

PhosphoSiteQ6PE01.

Proteomic databases

MaxQBQ6PE01.
PaxDbQ6PE01.
PRIDEQ6PE01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105994; ENSMUSP00000101616; ENSMUSG00000074088.
GeneID66585.
KEGGmmu:66585.
UCSCuc008uzf.1. mouse.

Organism-specific databases

CTD9410.
MGIMGI:1913835. Snrnp40.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00740000115355.
HOGENOMHOG000091644.
HOVERGENHBG105197.
InParanoidQ6PE01.
KOK12857.
OMATAVDFHP.
OrthoDBEOG7992QT.
PhylomeDBQ6PE01.
TreeFamTF300039.

Gene expression databases

BgeeQ6PE01.
GenevestigatorQ6PE01.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio322070.
PROQ6PE01.
SOURCESearch...

Entry information

Entry nameSNR40_MOUSE
AccessionPrimary (citable) accession number: Q6PE01
Secondary accession number(s): Q3TEJ3, Q9DCX3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot