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Q6PE01

- SNR40_MOUSE

UniProt

Q6PE01 - SNR40_MOUSE

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Protein

U5 small nuclear ribonucleoprotein 40 kDa protein

Gene

Snrnp40

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs (By similarity).By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiREACT_235610. mRNA Splicing - Minor Pathway.
REACT_260226. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U5 small nuclear ribonucleoprotein 40 kDa protein
Short name:
U5 snRNP 40 kDa protein
Alternative name(s):
WD repeat-containing protein 57
Gene namesi
Name:Snrnp40
Synonyms:Wdr57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1913835. Snrnp40.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: Ensembl
  2. cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358U5 small nuclear ribonucleoprotein 40 kDa proteinPRO_0000051418Add
BLAST

Proteomic databases

MaxQBiQ6PE01.
PaxDbiQ6PE01.
PRIDEiQ6PE01.

PTM databases

PhosphoSiteiQ6PE01.

Expressioni

Gene expression databases

BgeeiQ6PE01.
GenevestigatoriQ6PE01.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Associated with the spliceosome complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6PE01. 2 interactions.
MINTiMINT-4128759.

Structurei

3D structure databases

ProteinModelPortaliQ6PE01.
SMRiQ6PE01. Positions 63-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati65 – 10440WD 1Add
BLAST
Repeati108 – 14740WD 2Add
BLAST
Repeati150 – 19041WD 3Add
BLAST
Repeati192 – 23140WD 4Add
BLAST
Repeati234 – 27340WD 5Add
BLAST
Repeati284 – 32340WD 6Add
BLAST
Repeati326 – 35833WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000118869.
HOGENOMiHOG000091644.
HOVERGENiHBG105197.
InParanoidiQ6PE01.
KOiK12857.
OMAiTAVDFHP.
OrthoDBiEOG7992QT.
PhylomeDBiQ6PE01.
TreeFamiTF300039.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PE01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEQQKRKGP ELPLVPVKRP RHELLLGAAG AGPGAGPQQA TPGALLQAGP
60 70 80 90 100
PRCSSLQAPI MLLSGHEGEV YCCKFHPNGS TLASAGFDRL ILLWNVYGDC
110 120 130 140 150
DNYATLKGHS GAVMELHYNT DGSMLFSAST DKTVAVWDSE TGERVKRLKG
160 170 180 190 200
HTSFVNSCYP ARRGPQLVCT GSDDGTVKLW DIRKKAAVQT FQNTYQVLAV
210 220 230 240 250
TFNDTSDQII SGGIDNDIKV WDLRQNKLTY TMRGHADSVT GLSLSSEGSY
260 270 280 290 300
LLSNAMDNTV RVWDVRPFAP KERCVKIFQG NVHNFEKNLL RCSWSPDGSK
310 320 330 340 350
IAAGSADRFV YVWDTTSRRV LYKLPGHAGS INEVAFHPDE PIILSASSDK

RLYMGEIQ
Length:358
Mass (Da):39,276
Last modified:July 5, 2004 - v1
Checksum:i3B3EEA458D8228CA
GO

Sequence cautioni

The sequence BAB22049.1 differs from that shown. Reason: Frameshift at position 314. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851K → R in BAB22049. (PubMed:16141072)Curated
Sequence conflicti241 – 2411G → D in BAB22049. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002371 mRNA. Translation: BAB22049.1. Frameshift.
AK169605 mRNA. Translation: BAE41255.1.
BC058365 mRNA. Translation: AAH58365.1.
CCDSiCCDS38892.1.
RefSeqiNP_079921.2. NM_025645.2.
UniGeneiMm.423019.

Genome annotation databases

EnsembliENSMUST00000105994; ENSMUSP00000101616; ENSMUSG00000074088.
GeneIDi66585.
KEGGimmu:66585.
UCSCiuc008uzf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002371 mRNA. Translation: BAB22049.1 . Frameshift.
AK169605 mRNA. Translation: BAE41255.1 .
BC058365 mRNA. Translation: AAH58365.1 .
CCDSi CCDS38892.1.
RefSeqi NP_079921.2. NM_025645.2.
UniGenei Mm.423019.

3D structure databases

ProteinModelPortali Q6PE01.
SMRi Q6PE01. Positions 63-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6PE01. 2 interactions.
MINTi MINT-4128759.

PTM databases

PhosphoSitei Q6PE01.

Proteomic databases

MaxQBi Q6PE01.
PaxDbi Q6PE01.
PRIDEi Q6PE01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105994 ; ENSMUSP00000101616 ; ENSMUSG00000074088 .
GeneIDi 66585.
KEGGi mmu:66585.
UCSCi uc008uzf.1. mouse.

Organism-specific databases

CTDi 9410.
MGIi MGI:1913835. Snrnp40.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000118869.
HOGENOMi HOG000091644.
HOVERGENi HBG105197.
InParanoidi Q6PE01.
KOi K12857.
OMAi TAVDFHP.
OrthoDBi EOG7992QT.
PhylomeDBi Q6PE01.
TreeFami TF300039.

Enzyme and pathway databases

Reactomei REACT_235610. mRNA Splicing - Minor Pathway.
REACT_260226. mRNA Splicing - Major Pathway.

Miscellaneous databases

NextBioi 322070.
PROi Q6PE01.
SOURCEi Search...

Gene expression databases

Bgeei Q6PE01.
Genevestigatori Q6PE01.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Kidney and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiSNR40_MOUSE
AccessioniPrimary (citable) accession number: Q6PE01
Secondary accession number(s): Q3TEJ3, Q9DCX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3