Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

Taf1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-427359. SIRT1 negatively regulates rRNA Expression.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 95 kDa
Short name:
TAFI95
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:Taf1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:109576. Taf1c.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836TATA box-binding protein-associated factor RNA polymerase I subunit CPRO_0000118864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei802 – 8021PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PDZ2.
MaxQBiQ6PDZ2.
PaxDbiQ6PDZ2.
PeptideAtlasiQ6PDZ2.
PRIDEiQ6PDZ2.

PTM databases

iPTMnetiQ6PDZ2.
PhosphoSiteiQ6PDZ2.

Expressioni

Gene expression databases

BgeeiQ6PDZ2.
ExpressionAtlasiQ6PDZ2. baseline and differential.
GenevisibleiQ6PDZ2. MM.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription (By similarity).By similarity

Protein-protein interaction databases

BioGridi203958. 6 interactions.
STRINGi10090.ENSMUSP00000090789.

Structurei

3D structure databases

ProteinModelPortaliQ6PDZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOGENOMiHOG000154497.
HOVERGENiHBG079499.
InParanoidiQ6PDZ2.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG7SBNPC.
PhylomeDBiQ6PDZ2.
TreeFamiTF351959.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PDZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPGTLRPS LFKAGPLGMT DGPDLSFMCS WRDALTLPGS QPQNCKDPTL
60 70 80 90 100
SFAKNLLWEP STPGPLPLLM PPDPDPWDPG VTAQDFLFRG GHCYQYQSQA
110 120 130 140 150
VLDVTEQLSR FLWDHGDIAF APLGRLMLEN FRLEGNRGYS KKMTIVSAKK
160 170 180 190 200
LLQDLGGHQP WGCPWASLSR RLRRFSIVGG PVLSRSVSLL MGKLLHEELA
210 220 230 240 250
MRWEQLLMDE AFTGGALAWL PGRTARAGQL VYPSGGALDK LYFQEVSVTS
260 270 280 290 300
GGNPRILENP GHVQLRGPVR QVVTSTVQGE TLLAVRSDYH CATWKIDKQG
310 320 330 340 350
PPALLQVMQV EKGATGISLS PHLSGELAIC SRSGAVCLWT PQAGLQTIYK
360 370 380 390 400
DTETLAFRDP SPWRWADFTA HPRVLTVGDR TGVKMVDIQG PPGCGLLLFR
410 420 430 440 450
AGAEAACQKG ERVLLAQYLG QPGQTPPSLH LICTQFSIYL MDERLPLVPM
460 470 480 490 500
LKWDHGLPSA PLLARLLPPA SPGHPRPLLL GGQGGQLQLL HITGEGTSMP
510 520 530 540 550
QLAGPPQSLP SITESLSAFP LLEPKKQQLL QERLEAPVIG LAAVPLCASA
560 570 580 590 600
PGLLLFQLSA AGDVFYQHLR LLQASSPRKV PEQATAPSVD QVSTPSWTPQ
610 620 630 640 650
ASARCSRWLE DLMELSPTRP LWVAPTFSHR RFLGHMERQK SQETMPQKLR
660 670 680 690 700
AAMAKGQLLR PGDLSTLPRA EPPPAPQCSQ QDELTERLTE AWEGRVTAWW
710 720 730 740 750
RRHRGETSET QTQSKRPKRR TQLSSTFSSF TSYLDSPDAS SAPRSQDLST
760 770 780 790 800
SEARLQSPRV PPSQELTQEV WGQGVKRERR QTLRDHTDKL PLKRDTPGPV
810 820 830
ATPPSQASSL QTMSFRQQTP VHSGSQPPQK KPRMGF
Length:836
Mass (Da):92,023
Last modified:July 5, 2004 - v1
Checksum:iBAB6A50F5369368D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891R → Q in BAC39916 (PubMed:16141072).Curated
Sequence conflicti694 – 6941G → A in CAA71093 (PubMed:9050847).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09974 mRNA. Translation: CAA71093.1.
AK087534 mRNA. Translation: BAC39916.1.
AK154846 mRNA. Translation: BAE32872.1.
BC058383 mRNA. Translation: AAH58383.1.
CCDSiCCDS40493.1.
RefSeqiNP_067416.2. NM_021441.2.
UniGeneiMm.41977.

Genome annotation databases

EnsembliENSMUST00000093099; ENSMUSP00000090789; ENSMUSG00000031832.
GeneIDi21341.
KEGGimmu:21341.
UCSCiuc009npy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09974 mRNA. Translation: CAA71093.1.
AK087534 mRNA. Translation: BAC39916.1.
AK154846 mRNA. Translation: BAE32872.1.
BC058383 mRNA. Translation: AAH58383.1.
CCDSiCCDS40493.1.
RefSeqiNP_067416.2. NM_021441.2.
UniGeneiMm.41977.

3D structure databases

ProteinModelPortaliQ6PDZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203958. 6 interactions.
STRINGi10090.ENSMUSP00000090789.

PTM databases

iPTMnetiQ6PDZ2.
PhosphoSiteiQ6PDZ2.

Proteomic databases

EPDiQ6PDZ2.
MaxQBiQ6PDZ2.
PaxDbiQ6PDZ2.
PeptideAtlasiQ6PDZ2.
PRIDEiQ6PDZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093099; ENSMUSP00000090789; ENSMUSG00000031832.
GeneIDi21341.
KEGGimmu:21341.
UCSCiuc009npy.1. mouse.

Organism-specific databases

CTDi9013.
MGIiMGI:109576. Taf1c.

Phylogenomic databases

eggNOGiENOG410IH3X. Eukaryota.
ENOG41101B7. LUCA.
GeneTreeiENSGT00390000010767.
HOGENOMiHOG000154497.
HOVERGENiHBG079499.
InParanoidiQ6PDZ2.
KOiK15214.
OMAiLKWNHGL.
OrthoDBiEOG7SBNPC.
PhylomeDBiQ6PDZ2.
TreeFamiTF351959.

Enzyme and pathway databases

ReactomeiR-MMU-427359. SIRT1 negatively regulates rRNA Expression.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73863. RNA Polymerase I Transcription Termination.

Miscellaneous databases

PROiQ6PDZ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PDZ2.
ExpressionAtlasiQ6PDZ2. baseline and differential.
GenevisibleiQ6PDZ2. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1."
    Heix J., Zomerdijk J.C.B.M., Ravanpay A., Tjian R., Grummt I.
    Proc. Natl. Acad. Sci. U.S.A. 94:1733-1738(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TBP; TAF1A AND TAF1B.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Eye.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Mammalian RNA polymerase I exists as a holoenzyme with associated basal transcription factors."
    Seither P., Iben S., Grummt I.
    J. Mol. Biol. 275:43-53(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE RNA POLYMERASE I HOLOCOMPLEX.
  5. "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter."
    Yuan X., Zhao J., Zentgraf H., Hoffmann-Rohrer U., Grummt I.
    EMBO Rep. 3:1082-1087(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RRN3.

Entry informationi

Entry nameiTAF1C_MOUSE
AccessioniPrimary (citable) accession number: Q6PDZ2
Secondary accession number(s): P97359, Q3U3B6, Q8BN54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.