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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit C

Gene

Taf1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription by RNA polymerase I Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 95 kDa
Short name:
TAFI95
TATA box-binding protein-associated factor 1C
Short name:
TBP-associated factor 1C
Transcription initiation factor SL1/TIF-IB subunit C
Gene namesi
Name:Taf1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:109576 Taf1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188641 – 836TATA box-binding protein-associated factor RNA polymerase I subunit CAdd BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei802PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PDZ2
MaxQBiQ6PDZ2
PaxDbiQ6PDZ2
PeptideAtlasiQ6PDZ2
PRIDEiQ6PDZ2

PTM databases

iPTMnetiQ6PDZ2
PhosphoSitePlusiQ6PDZ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000031832
ExpressionAtlasiQ6PDZ2 baseline and differential
GenevisibleiQ6PDZ2 MM

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription (By similarity).By similarity

Protein-protein interaction databases

BioGridi203958, 6 interactors
CORUMiQ6PDZ2
STRINGi10090.ENSMUSP00000090789

Structurei

3D structure databases

ProteinModelPortaliQ6PDZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IH3X Eukaryota
ENOG41101B7 LUCA
GeneTreeiENSGT00390000010767
HOGENOMiHOG000154497
HOVERGENiHBG079499
InParanoidiQ6PDZ2
KOiK15214
OMAiLKWNHGL
OrthoDBiEOG091G09D1
PhylomeDBiQ6PDZ2
TreeFamiTF351959

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR038801 TAF1C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15319 PTHR15319, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PDZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFPGTLRPS LFKAGPLGMT DGPDLSFMCS WRDALTLPGS QPQNCKDPTL
60 70 80 90 100
SFAKNLLWEP STPGPLPLLM PPDPDPWDPG VTAQDFLFRG GHCYQYQSQA
110 120 130 140 150
VLDVTEQLSR FLWDHGDIAF APLGRLMLEN FRLEGNRGYS KKMTIVSAKK
160 170 180 190 200
LLQDLGGHQP WGCPWASLSR RLRRFSIVGG PVLSRSVSLL MGKLLHEELA
210 220 230 240 250
MRWEQLLMDE AFTGGALAWL PGRTARAGQL VYPSGGALDK LYFQEVSVTS
260 270 280 290 300
GGNPRILENP GHVQLRGPVR QVVTSTVQGE TLLAVRSDYH CATWKIDKQG
310 320 330 340 350
PPALLQVMQV EKGATGISLS PHLSGELAIC SRSGAVCLWT PQAGLQTIYK
360 370 380 390 400
DTETLAFRDP SPWRWADFTA HPRVLTVGDR TGVKMVDIQG PPGCGLLLFR
410 420 430 440 450
AGAEAACQKG ERVLLAQYLG QPGQTPPSLH LICTQFSIYL MDERLPLVPM
460 470 480 490 500
LKWDHGLPSA PLLARLLPPA SPGHPRPLLL GGQGGQLQLL HITGEGTSMP
510 520 530 540 550
QLAGPPQSLP SITESLSAFP LLEPKKQQLL QERLEAPVIG LAAVPLCASA
560 570 580 590 600
PGLLLFQLSA AGDVFYQHLR LLQASSPRKV PEQATAPSVD QVSTPSWTPQ
610 620 630 640 650
ASARCSRWLE DLMELSPTRP LWVAPTFSHR RFLGHMERQK SQETMPQKLR
660 670 680 690 700
AAMAKGQLLR PGDLSTLPRA EPPPAPQCSQ QDELTERLTE AWEGRVTAWW
710 720 730 740 750
RRHRGETSET QTQSKRPKRR TQLSSTFSSF TSYLDSPDAS SAPRSQDLST
760 770 780 790 800
SEARLQSPRV PPSQELTQEV WGQGVKRERR QTLRDHTDKL PLKRDTPGPV
810 820 830
ATPPSQASSL QTMSFRQQTP VHSGSQPPQK KPRMGF
Length:836
Mass (Da):92,023
Last modified:July 5, 2004 - v1
Checksum:iBAB6A50F5369368D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89R → Q in BAC39916 (PubMed:16141072).Curated1
Sequence conflicti694G → A in CAA71093 (PubMed:9050847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09974 mRNA Translation: CAA71093.1
AK087534 mRNA Translation: BAC39916.1
AK154846 mRNA Translation: BAE32872.1
BC058383 mRNA Translation: AAH58383.1
CCDSiCCDS40493.1
RefSeqiNP_067416.2, NM_021441.2
UniGeneiMm.41977

Genome annotation databases

EnsembliENSMUST00000093099; ENSMUSP00000090789; ENSMUSG00000031832
GeneIDi21341
KEGGimmu:21341
UCSCiuc009npy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTAF1C_MOUSE
AccessioniPrimary (citable) accession number: Q6PDZ2
Secondary accession number(s): P97359, Q3U3B6, Q8BN54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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