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Protein

2-aminoethanethiol dioxygenase

Gene

Ado

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-aminoethanethiol + O2 = hypotaurine.1 Publication

Cofactori

Fe cation1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.19 3474
ReactomeiR-MMU-1614558 Degradation of cysteine and homocysteine

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethanethiol dioxygenase (EC:1.13.11.19)
Alternative name(s):
Cysteamine dioxygenase
Gene namesi
Name:Ado
Synonyms:Gm237
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685083 Ado

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897851 – 2562-aminoethanethiol dioxygenaseAdd BLAST256

Proteomic databases

EPDiQ6PDY2
MaxQBiQ6PDY2
PaxDbiQ6PDY2
PeptideAtlasiQ6PDY2
PRIDEiQ6PDY2

PTM databases

iPTMnetiQ6PDY2
PhosphoSitePlusiQ6PDY2

Expressioni

Tissue specificityi

Ubiquitous, with highest expression in brain, heart and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000057134
CleanExiMM_ADO
GenevisibleiQ6PDY2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075107

Structurei

3D structure databases

ProteinModelPortaliQ6PDY2
SMRiQ6PDY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4281 Eukaryota
ENOG4111Y3H LUCA
GeneTreeiENSGT00390000014082
HOGENOMiHOG000037604
HOVERGENiHBG050966
InParanoidiQ6PDY2
KOiK10712
OMAiSCMDKLE
OrthoDBiEOG091G0QE1
PhylomeDBiQ6PDY2
TreeFamiTF314673

Family and domain databases

InterProiView protein in InterPro
IPR012864 PCO/ADO
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF07847 PCO_ADO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PDY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRDNMASLI QRIARQACLT FRGSSTGSEG PAPGFPENLS LLKSLLTQVR
60 70 80 90 100
AEDLNIAPRK ALPQPLPRNL PPVTYMHIYE TEGFSLGVFL LKSGTCIPLH
110 120 130 140 150
DHPGMHGMLK VLYGTVRISC MDKLDTGAGH RRPPPEQQFE PPLQPLEREA
160 170 180 190 200
VRPGVLRSRA EYTEASGPCV LTPHRDNLHQ IDAVDGPAAF LDILAPPYDP
210 220 230 240 250
EDGRDCHYYR VVEPIRPKEA SGSACDLPRE VWLLETPQAD DFWCEGEPYP

GPKVLP
Length:256
Mass (Da):28,372
Last modified:February 21, 2006 - v2
Checksum:iC5E23C4A72A79678
GO

Sequence cautioni

The sequence AAH57106 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH58407 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155334 mRNA Translation: BAE33200.1
BC057106 mRNA Translation: AAH57106.1 Different initiation.
BC058407 mRNA Translation: AAH58407.1 Different initiation.
CCDSiCCDS48588.1
RefSeqiNP_001005419.2, NM_001005419.2
UniGeneiMm.297250
Mm.491461

Genome annotation databases

EnsembliENSMUST00000075686; ENSMUSP00000075107; ENSMUSG00000057134
GeneIDi211488
KEGGimmu:211488
UCSCiuc007flz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAEDO_MOUSE
AccessioniPrimary (citable) accession number: Q6PDY2
Secondary accession number(s): Q3U2E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 21, 2006
Last modified: April 25, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health