Reviewed, UniProtKB/Swiss-Prot Q6PDY2 (AEDO_MOUSE)

Names and origin

Protein names

Recommended name:
    2-aminoethanethiol dioxygenase
    EC=1.13.11.19
Alternative name(s):
    Cysteamine dioxygenase

Gene names

Name:	Ado
Synonyms:	Gm237

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2-aminoethanethiol + O(2) = hypotaurine. Ref.3
Cofactor	Iron. Ref.3
Tissue specificity	Ubiquitous, with highest expression in brain, heart and skeletal muscle (at protein level). Ref.3

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteamine dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	2-aminoethanethiol dioxygenase		PRO_0000089785

Sequences

	Sequence		Length	Mass (Da)
	Q6PDY2-1 [UniParc]. Last modified February 21, 2006. Version 2. Checksum: C5E23C4A72A79678	FASTA	256	28,372
	10 20 30 40 50 60 MPRDNMASLI QRIARQACLT FRGSSTGSEG PAPGFPENLS LLKSLLTQVR AEDLNIAPRK 70 80 90 100 110 120 ALPQPLPRNL PPVTYMHIYE TEGFSLGVFL LKSGTCIPLH DHPGMHGMLK VLYGTVRISC 130 140 150 160 170 180 MDKLDTGAGH RRPPPEQQFE PPLQPLEREA VRPGVLRSRA EYTEASGPCV LTPHRDNLHQ 190 200 210 220 230 240 IDAVDGPAAF LDILAPPYDP EDGRDCHYYR VVEPIRPKEA SGSACDLPRE VWLLETPQAD 250 DFWCEGEPYP GPKVLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NOD. Tissue: Dendritic cell.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase." Dominy J.E. Jr., Simmons C.R., Hirschberger L.L., Hwang J., Coloso R.M., Stipanuk M.H. J. Biol. Chem. 282:25189-25198(2007) [PubMed: 17581819] [Abstract] Cited for: CATALYTIC ACTIVITY, COFACTOR, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK155334 mRNA. Translation: BAE33200.1. BC057106 mRNA. Translation: AAH57106.1. Different initiation. BC058407 mRNA. Translation: AAH58407.1. Different initiation.
RefSeq	NP_001005419.1.
UniGene	Mm.297250 Mm.456890
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6PDY2.
Proteomic databases
PRIDE	Q6PDY2.
Genome annotation databases
Ensembl	ENSMUSG00000057134. Mus musculus. [Contig view]
GeneID	211488.
KEGG	mmu:211488.
Organism-specific databases
MGI	MGI:2685083. Ado.
Phylogenomic databases
HOGENOM	Q6PDY2.
HOVERGEN	Q6PDY2.
Gene expression databases
ArrayExpress	Q6PDY2.
CleanEx	MM_ADO.
GermOnline	ENSMUSG00000057134. Mus musculus.
Family and domain databases
InterPro	IPR012864. DUF1637. [Graphical view]
PANTHER	PTHR22966. DUF1637. 1 hit.
Pfam	PF07847. DUF1637. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	373260.
SOURCE	Search...

Entry information

Entry name

AEDO_MOUSE

Accession

Primary (citable) accession number: Q6PDY2
Secondary accession number(s): Q3U2E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	February 21, 2006
Last modified:	December 16, 2008
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)