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Protein

Coiled-coil domain-containing protein 85B

Gene

Ccdc85b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85B
Alternative name(s):
Hepatitis delta antigen-interacting protein A homolog
Short name:
Delta-interacting protein A homolog
Gene namesi
Name:Ccdc85b
Synonyms:Dipa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147607. Ccdc85b.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Coiled-coil domain-containing protein 85BPRO_0000079909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6PDY0.
PaxDbiQ6PDY0.
PRIDEiQ6PDY0.

Expressioni

Tissue specificityi

Expressed in white and brown adipose tissue.1 Publication

Gene expression databases

BgeeiQ6PDY0.
CleanExiMM_CCDC85B.
GenevisibleiQ6PDY0. MM.

Interactioni

Subunit structurei

Interacts with MCRS1. Interacts with TCF7L2; competes with CTNNB1 (By similarity). Interacts with CEBPB. May interact with CEBPD.By similarity1 Publication

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili44 – 8239Sequence analysisAdd
BLAST
Coiled coili118 – 14124Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3819. Eukaryota.
ENOG410YXPD. LUCA.
GeneTreeiENSGT00390000003531.
HOVERGENiHBG107255.
InParanoidiQ6PDY0.
OMAiGHHAAKV.
OrthoDBiEOG7V49ZJ.
PhylomeDBiQ6PDY0.
TreeFamiTF320243.

Family and domain databases

InterProiIPR019359. CCDC85.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PDY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN
60 70 80 90 100
RQLQGHLGEI RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL
110 120 130 140 150
FGTQASRAVR EDLGGCWQKL AELEGRQEEL LRENLALKEL CLALGEEWGP
160 170 180 190 200
RGGPGGAVGS GAGPTPELAL PPCGPRDLGD GSSSTGSVGS PDQLPLACSP

DD
Length:202
Mass (Da):22,133
Last modified:July 5, 2004 - v1
Checksum:iDD49A77706FDE2C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058411 mRNA. Translation: AAH58411.1.
CCDSiCCDS50357.1.
RefSeqiNP_941018.1. NM_198616.4.
UniGeneiMm.329657.
Mm.486877.

Genome annotation databases

EnsembliENSMUST00000179549; ENSMUSP00000137537; ENSMUSG00000095098.
GeneIDi240514.
KEGGimmu:240514.
UCSCiuc012bgx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058411 mRNA. Translation: AAH58411.1.
CCDSiCCDS50357.1.
RefSeqiNP_941018.1. NM_198616.4.
UniGeneiMm.329657.
Mm.486877.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ6PDY0.
PaxDbiQ6PDY0.
PRIDEiQ6PDY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179549; ENSMUSP00000137537; ENSMUSG00000095098.
GeneIDi240514.
KEGGimmu:240514.
UCSCiuc012bgx.2. mouse.

Organism-specific databases

CTDi11007.
MGIiMGI:2147607. Ccdc85b.

Phylogenomic databases

eggNOGiKOG3819. Eukaryota.
ENOG410YXPD. LUCA.
GeneTreeiENSGT00390000003531.
HOVERGENiHBG107255.
InParanoidiQ6PDY0.
OMAiGHHAAKV.
OrthoDBiEOG7V49ZJ.
PhylomeDBiQ6PDY0.
TreeFamiTF320243.

Miscellaneous databases

ChiTaRSiCcdc85b. mouse.
NextBioi384611.
PROiQ6PDY0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PDY0.
CleanExiMM_CCDC85B.
GenevisibleiQ6PDY0. MM.

Family and domain databases

InterProiIPR019359. CCDC85.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation."
    Bezy O., Elabd C., Cochet O., Petersen R.K., Kristiansen K., Dani C., Ailhaud G., Amri E.-Z.
    J. Biol. Chem. 280:11432-11438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CEBPB AND CEBPD, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCC85B_MOUSE
AccessioniPrimary (citable) accession number: Q6PDY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.