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Q6PDK2 (KMT2D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase 2D

Short name=Lysine N-methyltransferase 2D
EC=2.1.1.43
Alternative name(s):
ALL1-related protein
Myeloid/lymphoid or mixed-lineage leukemia protein 2
Gene names
Name:Kmt2d
Synonyms:Mll2, Mll4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length5588 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Interacts with ESR1; interaction is direct By similarity. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Ref.5

Subcellular location

Nucleus By similarity.

Domain

LXXLL motifs 5 and 6 are essential for the association with ESR1 nuclear receptor By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

Contains 1 FYR C-terminal domain.

Contains 1 FYR N-terminal domain.

Contains 5 PHD-type zinc fingers.

Contains 1 post-SET domain.

Contains 4 RING-type zinc fingers.

Contains 1 SET domain.

Caution

Human protein KMT2B/MLL4 was first named MLL2 (see AC Q9UMN6). Thus, also mouse Mll4 is often referred to as Mll2 and vice versa in the literature.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
S-adenosyl-L-methionine
Zinc
   Molecular functionChromatin regulator
Methyltransferase
Transferase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin silencing

Inferred from mutant phenotype PubMed 20808952. Source: UniProtKB

histone H3-K4 methylation

Inferred from mutant phenotype PubMed 20808952. Source: UniProtKB

in utero embryonic development

Inferred from mutant phenotype PubMed 16540515. Source: MGI

oocyte growth

Inferred from mutant phenotype PubMed 20808952. Source: UniProtKB

oogenesis

Inferred from mutant phenotype PubMed 20808952. Source: UniProtKB

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of intracellular estrogen receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthistone methyltransferase complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 55885588Histone-lysine N-methyltransferase 2D
PRO_0000401938

Regions

Repeat442 – 44651
Repeat460 – 46452
Repeat469 – 47354
Repeat477 – 48155
Repeat520 – 52457
Repeat529 – 53358
Repeat538 – 54259
Repeat547 – 551510
Repeat574 – 578511
Repeat583 – 587512
Repeat592 – 596513
Repeat610 – 614514
Repeat637 – 641515
Domain5226 – 528661FYR N-terminal
Domain5287 – 537286FYR C-terminal
Domain5448 – 5564117SET
Domain5572 – 558817Post-SET
Zinc finger226 – 27651PHD-type 1; degenerate
Zinc finger229 – 27446RING-type 1; atypical
Zinc finger270 – 32354PHD-type 2
Zinc finger276 – 32146RING-type 2; degenerate
Zinc finger1071 – 112454PHD-type 3
Zinc finger1121 – 117151PHD-type 4
Zinc finger1198 – 125356PHD-type 5
Zinc finger1201 – 125151RING-type 3; atypical
Zinc finger4829 – 487446RING-type 4; degenerate
Region439 – 64220415 X 5 AA repeats of S/P-P-P-E/P-E/A
Region5525 – 55262S-adenosyl-L-methionine binding By similarity
Coiled coil2627 – 266539 Potential
Coiled coil2768 – 281346 Potential
Coiled coil3559 – 361355 Potential
Coiled coil3712 – 374736 Potential
Coiled coil3854 – 388330 Potential
Coiled coil3912 – 4052141 Potential
Motif2644 – 26485LXXLL motif 1
Motif3030 – 30345LXXLL motif 2
Motif4279 – 429315LXXLL motif 3
Motif4310 – 43145LXXLL motif 4
Motif4514 – 45185LXXLL motif 5
Motif5041 – 50455LXXLL motif 6
Compositional bias1307 – 13115Poly-Glu
Compositional bias2064 – 2583520Pro-rich
Compositional bias2610 – 26134Poly-Ser
Compositional bias2769 – 281244Gln-rich
Compositional bias2813 – 28197Poly-Ala
Compositional bias3255 – 43321078Gln-rich
Compositional bias4841 – 48444Poly-Ala
Compositional bias4960 – 502869Pro-rich

Sites

Metal binding55281Zinc By similarity
Metal binding55761Zinc By similarity
Metal binding55781Zinc By similarity
Metal binding55831Zinc By similarity
Binding site55021S-adenosyl-L-methionine By similarity

Amino acid modifications

Modified residue15621Phosphoserine By similarity
Modified residue16271Phosphoserine Ref.4
Modified residue22031N6-acetyllysine By similarity
Modified residue22311Phosphoserine By similarity
Modified residue22661Phosphoserine By similarity
Modified residue22681Phosphoserine By similarity
Modified residue30711N6-acetyllysine Ref.6
Modified residue31221Phosphoserine By similarity
Modified residue31931Phosphoserine By similarity
Modified residue34301N6-acetyllysine By similarity
Modified residue42721Phosphoserine By similarity
Modified residue44101Phosphoserine By similarity
Modified residue45161N6-acetyllysine By similarity
Modified residue47891Phosphoserine Ref.3
Modified residue48271N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6PDK2 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 37A0E5D319A5F1A6

FASTA5,588600,245
        10         20         30         40         50         60 
MDSQKPPAED KDSDPAADGL AAPEKPGATE PDLPILCIGE VSVPGSGGSR PQKPPHDCSR 

        70         80         90        100        110        120 
GPARRCALCN CGEPGLHGQR ELQRFELPSD WPGFPVVPSG GNSGPCEAVL PKEDASQIGF 

       130        140        150        160        170        180 
PEGLTPAHLG EPGGHCWAHH WCAAWSAGVW GQEGPELCGV DKAIFSGISQ RCSHCARFGA 

       190        200        210        220        230        240 
SVPCRSPGCS RLYHFPCATA SGSFLSMKTL QLLCPEHSDG AAHLEEARCA VCEGPGQLCD 

       250        260        270        280        290        300 
LLFCTSCGHH YHGACLDTAL TARKRASWQC PECKVCQSCR KPGNDSKMLV CETCDKGYHT 

       310        320        330        340        350        360 
FCLKPPMEDL PAHSWKCKTC RLCRACGAGS AELNPNSEWF ENYSLCHRCH KAQGSQPVTS 

       370        380        390        400        410        420 
VAEQHPAVCS RLSPPEPGEI PIDAPDALYV ACQGQPKGGH VTSMQPKELA PLQCEAKPLG 

       430        440        450        460        470        480 
RAGTQLEAQL EAPLHEEMPL LPPPEESPLS PPPEESPTSP PPEASRLSPP TEESPLSPPP 

       490        500        510        520        530        540 
ESSPFSPLEG CPPSPALDTP LSPPPEASPL SPPFEESPLS PPPEELPSSP PPEASRLSPP 

       550        560        570        580        590        600 
PEESPMSPPP EESPMSPPPE ASRLFPPFEE SPLSPPPEDS PLSPPPEASR LSPPPEDSPM 

       610        620        630        640        650        660 
SPPPEDSPMS PPPEVSRFLP LPVLSHLSPL PEVSRLSPPP EESPLSPPPE DSPASPPPEA 

       670        680        690        700        710        720 
SRLSPPPEDS PASPPPEASR LSRPREDSPA SPPPEDSLVS LPMEESPLSP LPEELRLCPQ 

       730        740        750        760        770        780 
PEEPYLSPQP EEPRLCPQPE ELPLSPQSEE PCLSPVLVEP GPSSQPEEPH LSPVPQEPHL 

       790        800        810        820        830        840 
SPQPEEPHLS PQPQQLHLSP HSEEPCLSPM PEEPCLSPQP EELNGPPQPA EPPEEPSQSS 

       850        860        870        880        890        900 
APKELSLFSP SGEPPLPPML GEPALSEPGE PPLSPLPEEL PLSLSGEPVL SPQLMPPDPL 

       910        920        930        940        950        960 
PPPLSPIIPA AAPPALSPLG ELEYPFGAKG DSDPESPLAA PILETPISPP PEANCTDPEP 

       970        980        990       1000       1010       1020 
VPPMILPPSP GSPLGPASPI LMERLPPPCS PLLPHSLPPP TPPPSHCSPP ALPLSVPSPL 

      1030       1040       1050       1060       1070       1080 
SPVQKAVDVS DEAELHEMET DKGPEPECPA LEPRATSPLP SPLGDLSCPA PSPAPALDDF 

      1090       1100       1110       1120       1130       1140 
SGLGEDTAPL DGTGQMSGSL AGELKGSPVL LDPEELTPVT PMEVYGPECK QAGQGSPCEE 

      1150       1160       1170       1180       1190       1200 
QEEPGAPMAP MPPTLIKSDI VNEISNLSQG DASASFPGSE PLLGSPDPEG GGSLSMELGV 

      1210       1220       1230       1240       1250       1260 
STDVSPARDE GSLRLCTDSL PETDDSLLCD TGTATSGGKA EGDKGRRRSS PARSRIKQGR 

      1270       1280       1290       1300       1310       1320 
SSSFPGRRRP RGGAAHGGRG RGRARLKSTT SSVETLVADI DSSPSKEEEE EDDDTMQNTV 

      1330       1340       1350       1360       1370       1380 
VLFSNTDKFV LMQDMCVVCG SFGRGAEGHL LACSQCSQCY HPYCVNSKIT KVMLLKGWRC 

      1390       1400       1410       1420       1430       1440 
VECIVCEVCG QASDPSRLLL CDDCDISYHT YCLDPPLLTV PKGGWKCKWC VSCMQCGAAS 

      1450       1460       1470       1480       1490       1500 
PGFHCEWQNS YTHCGPCASL VTCPVCHAPY VEEDLLIQCR HCERWMHAGC ESLFTEDEVE 

      1510       1520       1530       1540       1550       1560 
QAADEGFDCV SCQPYVVKPV VPVAPPELVP VKVKEPEPQF FRFEGVWLTE TGMAVLRNLT 

      1570       1580       1590       1600       1610       1620 
MSPLHKRRQR RGRLGLPGEA GLEGSEPSDA LGPDDKKDGD LDTDDLLKGE GGVEQMECEI 

      1630       1640       1650       1660       1670       1680 
KLEGPASPDV ELGKEETEES KKRKRKPYRP GIGGFMVRQR KSHTRVKRGP AAQAEVLSGD 

      1690       1700       1710       1720       1730       1740 
GQPDEVMPAD LPAEGSVEQS LAEGDEKKKQ QRRARKKSKL EDMFPAYLQA AFFGKDLLDL 

      1750       1760       1770       1780       1790       1800 
SRKALFAVGV GRPGFGLGAS KPRADGGSDR KELMTAMHKG DDGPDVADEE SHGPEGTADL 

      1810       1820       1830       1840       1850       1860 
PGLEDGGVKA SPVPSDPEKP GTPGEGVLSS DLDRIPTEEL PKMESKDLQQ LFKDVLGSER 

      1870       1880       1890       1900       1910       1920 
EQHLGCGTPG LEGGRTSLQR PFLQGGLALG SLPSSSPMDS YPGLCQSPFL DSRERGGFFS 

      1930       1940       1950       1960       1970       1980 
PEPGEPDSPW TGSGGTTPST PTTPTTEGEG DGLSYNQRSL QRWEKDEELG QLSTISPVLY 

      1990       2000       2010       2020       2030       2040 
ANINFPNLKQ DYPDWSSRCK QIMKLWRKVP AADKAPYLQK AKDNRAAHRI SKVQKQAESQ 

      2050       2060       2070       2080       2090       2100 
ISKQAKMGDI ARKTDRPALH LRIPSQPGAL GSPPPAAAPT IFLGSPTTPA GLSTSADGFL 

      2110       2120       2130       2140       2150       2160 
KPPAGTVPGP DSPGELFLKL PPQVPAQVPS QDPFGLAPAY APEPRFSAAP PTYPPYPSPT 

      2170       2180       2190       2200       2210       2220 
GAPAQPPMLG TTTRPGTGQP GEFHTTPPGT PRHQPSTPDP FLKPRCPSLD NLAVPESPGV 

      2230       2240       2250       2260       2270       2280 
AGGKASEPLL SPPPFGESRK SLEVKKEELG ASSPGYGPPN LGCVDSPSAG PHLGGLELKA 

      2290       2300       2310       2320       2330       2340 
PDVFKAPLTP RASQVEPQSP GLGLRAQEPP PAQALAPSPP SHPDVFRSGP YPDPYAQPPL 

      2350       2360       2370       2380       2390       2400 
TPRPQPPPPE SCCAPPPRSL PSDPFSRVPA SPQSQSSSQS PLTPRPLSAE AFCPSPVTPR 

      2410       2420       2430       2440       2450       2460 
FQSPDPYSRP PSRPQSRDPF APLHKPPRPQ PPEVAFKAGP LAHTPLGAGG FPAALPSGPA 

      2470       2480       2490       2500       2510       2520 
GELHAKVPSG QPTNFARSPG TGTFVGTPSP MRFTFPQGVG EPSLKPPVPQ PGLPSPHGIN 

      2530       2540       2550       2560       2570       2580 
SHFGPGPTLG KPQSTNYAVA TGNFHPSGSP LGPNSGPTGE GYGLSPLRPA SVLPPPAPDG 

      2590       2600       2610       2620       2630       2640 
SLPYLTHGAS QRVGITSPVE KREDPGATMS SSSLATPELS SAQDAGISSL SQTELEKQRQ 

      2650       2660       2670       2680       2690       2700 
RQRLRELLIR QQIQRNTLRQ EKETAAAAAG AVGPPGNWGA EPSSPAFEQL SRGQTPFTGS 

      2710       2720       2730       2740       2750       2760 
QDRSSIVGLP ASKLGGPTLG PGAFSSDDRL ARPLPPATPS SMDMNSRQLV GGSQAFYQRT 

      2770       2780       2790       2800       2810       2820 
PYPGSLPLQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQLWQ QQQQQQQQQQ QQAAAAAAAT 

      2830       2840       2850       2860       2870       2880 
SMRLAMSARF PSTPGPELGR QALGSPLAGI PTRLPGPAEP VPGPAGPAQF IELRHNVQKG 

      2890       2900       2910       2920       2930       2940 
LGPGVSPFPG QGPPQRPRFY PVSEELHRLA PEGLRGLAVP GLPSQKPSAL PAPELNNSLH 

      2950       2960       2970       2980       2990       3000 
QTPHAKGPAL ASGLELVSRP PSNTELSRPP LALEAGKLPC EDPELDDDFD AHKALEDDEE 

      3010       3020       3030       3040       3050       3060 
LAHLGLGVDV AKGDDELGTL ENLETNDPHL DDLLNGDEFD LLAYTDPELD TGDKKDIFNE 

      3070       3080       3090       3100       3110       3120 
HLRLVESANE KAEREALLRG VEPVSLGPEE RPPPAPDNSE PRLTSVLPEV KPKVEEGGRH 

      3130       3140       3150       3160       3170       3180 
PSPCQFTINT PKVEPAPPAT SLSLGLKPGQ TVMGTRDTRG GVGTGSFPSS GHTAEKGPFG 

      3190       3200       3210       3220       3230       3240 
ATGGTPAHLL NPSSLSGPAA SSLLEKFELE SGALTLPSGH AAAGDELDKM ESSLVASELP 

      3250       3260       3270       3280       3290       3300 
LLIEDLLEHE KKELQKKQQL SAQTVLPAQQ QQQQQQQQQQ QQQQHTLLPT PGPAQALPLP 

      3310       3320       3330       3340       3350       3360 
HEPGPPQQLA LGIGSTRQPG LGQSMVPIQP PAHALQQRLA PSVAMVSNQG HMLSGQQAGQ 

      3370       3380       3390       3400       3410       3420 
TGLVPQQSSQ PVLAQKPMSA MPASMCMKPQ QLAMQQQQLA NSFFPDTDLD KFAAEDIIDP 

      3430       3440       3450       3460       3470       3480 
IAKAKMVALK GIKKVMAQGS IGVAPGMNRQ QVSLLAQRLS GGSGSDLQNH VAPGSGQERN 

      3490       3500       3510       3520       3530       3540 
AGDPAQPRPN PPTFAQGVIN EADQRQYEEW LFHTQQLLQM QLKVLEEQIG VHRKSRKALC 

      3550       3560       3570       3580       3590       3600 
AKQRTAKKAG REFPEADAEK LKLVTEQQSK IQKQLDQVRK QQKEHTNLMA EYRNKQQQQQ 

      3610       3620       3630       3640       3650       3660 
QQQQQQQQQQ HSAVLAVSPS QNPRVLTKLP GQLLPAHGLQ PPQAPPGGQA GGLRLPPGGM 

      3670       3680       3690       3700       3710       3720 
VLPGQSGGPF LNTTLAQQQQ QQHSGVAGSL TGPPGSFFPG NLALRSLGPD SRLLQERQLQ 

      3730       3740       3750       3760       3770       3780 
LQQQRMQLAQ KLQQQQQQQQ QQQQQQHLLG QVAIQQQQGP GVQNQALGPK PQGLLPPSNH 

      3790       3800       3810       3820       3830       3840 
QGLLVQQLSP QQSQGSQGLL GPAQVTVLQQ QQQQQQHSGA LGPQGPHRQV LMTQSRVLSS 

      3850       3860       3870       3880       3890       3900 
PQLAQQGHSL MGHRLLTAQQ QQQQQQQQQQ QQQQQQQQQQ QQQGSMTGLS QLQQGMMSHG 

      3910       3920       3930       3940       3950       3960 
GQPKMSAQAL GSLQQQQQQL QQQQMLQQQQ LQQQQQQLQQ QQQQQQLQQQ QQQQLQLQQQ 

      3970       3980       3990       4000       4010       4020 
QQQQQQHLQH QQQQQQQLQQ QQQLQQQQQQ QLHLQQQLHQ QQQLQLQQQQ MGLLNQNRTL 

      4030       4040       4050       4060       4070       4080 
LSPQQQQQQQ QQQQQQQQQQ QQQQQQQQQV TLGPGLPVKP LQHFSSSGAL GPTLLLTGKE 

      4090       4100       4110       4120       4130       4140 
QNNAETALPS EVTEGPSTHQ GGPPAVGTAP EPMSVEPGEV KPSISGDSQL LLVQSQAQSQ 

      4150       4160       4170       4180       4190       4200 
ATSVQLQPPL RLPGQPQPQV NLLHTAGGGS HGQQLGSGSS SESPAVPHLL AQPSVSLGEQ 

      4210       4220       4230       4240       4250       4260 
PGPMAQNLLG SQQPLGLDRP IQNNTGSQPP KSGPAPQSGQ GPPGAGVMPT VGQLRAQLQG 

      4270       4280       4290       4300       4310       4320 
VLAKNPQLRH LSPQQQQQLQ ALLMQRQLQQ SQAVRQTPPF QEPGTQPSPL QGLLGCQPQP 

      4330       4340       4350       4360       4370       4380 
GGFSVSQTGP LQELGAGSRP QGPPRLPVPQ GALSTGPVLG PAHPTPPPSS PQEPKRPSQL 

      4390       4400       4410       4420       4430       4440 
PSPSAQLTPT HPGTPKPQGP ALELPPGRVS PAAAQLADTF FGKGLGPWDP SDNLTEAQKP 

      4450       4460       4470       4480       4490       4500 
EQSSLVPGHL DQVNGQVVHE PSQLSIKQEP REEPCALGAQ TVKREANGEP AGAPGTSNHL 

      4510       4520       4530       4540       4550       4560 
LLAGSRSEAG HLLLQKLLRA KNVQLGAGRG PEGLRAEING HIDSKLSGLE QKLQGTSSNK 

      4570       4580       4590       4600       4610       4620 
EDAATRKPLP AKPKRVQKTS DRLPSSRKKL RKEDGVRANE ALLKQLKQEL SQLPLTEPTI 

      4630       4640       4650       4660       4670       4680 
TANFSLFAPF GSGCLVSGQS QLRGAFGSGA LHTGPDYYSQ LLTKNNLSNP PTPPSSLPPT 

      4690       4700       4710       4720       4730       4740 
PPPSVQQKMV NGVTPSDELG ERPKDTASAQ DSEGALRDAA EVKSLDLLAA LPTPPHNQTE 

      4750       4760       4770       4780       4790       4800 
DVRMESDEDS DSPDSIVPAS SPESILGEEA PRFPQLGSGR WEQDNRALSP VIPIIPRTGI 

      4810       4820       4830       4840       4850       4860 
PVFPDTKPYG VLDLEVPGKL PATAWEKGKG SEVSVMLTVS AAAAKNLNGV MVAVAELLSM 

      4870       4880       4890       4900       4910       4920 
KIPNSYEVLF PDGPARAGLE PKKGEAEGPG GKEKGLSGKG PDTGPDWLKQ FDAVLPGYTL 

      4930       4940       4950       4960       4970       4980 
KSQLDILSLL KQESPAPEPS IQHSYTYNVS NLDVRQLSAP PPEEPSPPPS PLAPSPASPP 

      4990       5000       5010       5020       5030       5040 
AEPMVELQAE RPAEPPIPSP LPLASSPESA RPKPRARPPE ESEDSRPPRL KKWKGVRWKR 

      5050       5060       5070       5080       5090       5100 
LRLLLTIQKG SGHQEDEREV AEFMEQFGTA LRPSKVPRDN RRCCFCHEEG DGATDGPARL 

      5110       5120       5130       5140       5150       5160 
LNLDLDLWVH LNCALWSTEV YETQGGALMN VEVALHRGLL TKCSLCQRTG ATSSCNRMRC 

      5170       5180       5190       5200       5210       5220 
PNVYHFACAI RAKCMFFKDK TMLCPVHKIK GPCEQELSSF AVFRRVYIER DEVKQIASII 

      5230       5240       5250       5260       5270       5280 
QRGERLHMFR VGGLVFHAIG QLLPHQMADF HSATALYPVG YEATRIYWSL RTNNRRCCYR 

      5290       5300       5310       5320       5330       5340 
CSISENNGRP EFVIKVIEQG LEDLVFTDAS PQAVWNRIIE PVAAMRKEAD MLRLFPEYLK 

      5350       5360       5370       5380       5390       5400 
GEELFGLTVH AVLRIAESLP GVESCQNYLF RYGRHPLMEL PLMINPTGCA RSEPKILTHY 

      5410       5420       5430       5440       5450       5460 
KRPHTLNSTS MSKAYQSTFT GETNTPYSKQ FVHSKSSQYR RLRTEWKNNV YLARSRIQGL 

      5470       5480       5490       5500       5510       5520 
GLYAAKDLEK HTMVIEYIGT IIRNEVANRR EKIYEEQNRG IYMFRINNEH VIDATLTGGP 

      5530       5540       5550       5560       5570       5580 
ARYINHSCAP NCVAEVVTFD KEDKIIIISS RRIPKGEELT YDYQFDFEDD QHKIPCHCGA 


WNCRKWMN 

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References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4339-5588.
Strain: C57BL/6.
Tissue: Brain.
[3]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4789, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1627, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains."
Jiang H., Shukla A., Wang X., Chen W.Y., Bernstein B.E., Roeder R.G.
Cell 144:513-525(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE MLL COMPLEX, INTERACTION WITH ASH2L; DPY30; KMT2A; RRBP5 AND WDR5.
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3071, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC161165 Genomic DNA. No translation available.
BC058659 mRNA. Translation: AAH58659.1.
CCDSCCDS49725.2.
UniGeneMm.264889.

3D structure databases

ProteinModelPortalQ6PDK2.
SMRQ6PDK2. Positions 220-323, 1957-2034.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid237747. 9 interactions.
IntActQ6PDK2. 2 interactions.
STRING10090.ENSMUSP00000023741.

PTM databases

PhosphoSiteQ6PDK2.

Proteomic databases

MaxQBQ6PDK2.
PaxDbQ6PDK2.
PRIDEQ6PDK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000178486; ENSMUSP00000135941; ENSMUSG00000048154.
UCSCuc029suy.1. mouse.

Organism-specific databases

MGIMGI:2682319. Kmt2d.

Phylogenomic databases

eggNOGCOG2940.
GeneTreeENSGT00740000115009.
HOGENOMHOG000168503.
InParanoidQ6PDK2.
PhylomeDBQ6PDK2.

Gene expression databases

ArrayExpressQ6PDK2.
BgeeQ6PDK2.
GenevestigatorQ6PDK2.

Family and domain databases

Gene3D3.30.40.10. 5 hits.
InterProIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR009071. HMG_box_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 3 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 7 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 6 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
SSF57903. SSF57903. 5 hits.
PROSITEPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 5 hits.
PS50016. ZF_PHD_2. 4 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMLL2. mouse.
PROQ6PDK2.
SOURCESearch...

Entry information

Entry nameKMT2D_MOUSE
AccessionPrimary (citable) accession number: Q6PDK2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot