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Protein

F-box only protein 42

Gene

Fbxo42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity).By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 42
Gene namesi
Name:Fbxo42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924992 Fbxo42

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199431 – 717F-box only protein 42Add BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei378PhosphothreonineBy similarity1
Modified residuei552PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PDJ6
MaxQBiQ6PDJ6
PaxDbiQ6PDJ6
PRIDEiQ6PDJ6

PTM databases

iPTMnetiQ6PDJ6
PhosphoSitePlusiQ6PDJ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000028920
CleanExiMM_FBXO42
GenevisibleiQ6PDJ6 MM

Interactioni

Subunit structurei

Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030757

Structurei

3D structure databases

ProteinModelPortaliQ6PDJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 93F-boxPROSITE-ProRule annotationAdd BLAST50
Repeati132 – 184Kelch 1Add BLAST53
Repeati186 – 242Kelch 2Add BLAST57
Repeati244 – 293Kelch 3Add BLAST50
Repeati295 – 342Kelch 4Add BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 513Poly-Ser6

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00440000039706
HOGENOMiHOG000231102
HOVERGENiHBG051582
InParanoidiQ6PDJ6
KOiK10317
OMAiNCKPMQM
OrthoDBiEOG091G0DN3
PhylomeDBiQ6PDJ6
TreeFamiTF324505

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF07646 Kelch_2, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF117281 SSF117281, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q6PDJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSDSEDD SVMAVDQEET ALEGTMEQDE DPHPVLEVEE TRHNRSMSEL
60 70 80 90 100
PEEVLEYILS FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG
110 120 130 140 150
NIQWESRTYP YPGTPITQRF SHSACYYDAN QSMYVFGGCT QSSCNAAFND
160 170 180 190 200
LWRLDLNSKE WIRPLASGSY PSPKAGATLV VYKDLLVLFG GWTRPSPYPL
210 220 230 240 250
HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI GDKMIVFGGS
260 270 280 290 300
LGSRQMSNEV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDTTLLILG
310 320 330 340 350
GCGGPNALFK DAWLLHMHPG PWAWQPLKVE NEDHGAPELW CHPACRVGQC
360 370 380 390 400
VVVFSQAPSG RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE
410 420 430 440 450
APCVNGRWGT LRPRAQRQTP SGSREGSLSP ARGDGSPILN GGNLSPGTVA
460 470 480 490 500
VGGASLDSPV QVVSPSTPSA SDGYDLKVGL SLAPRRGSLP DQKDLRLSSI
510 520 530 540 550
DLNWDLKSAS SSSHVDSIDN RTVAGSVRHP PEQTNGVHTP PHVASALAGA
560 570 580 590 600
VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPSSPGS QSLSSGETVP
610 620 630 640 650
NSRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD
660 670 680 690 700
IKDTKEKGRV KWKVFTSSSV VGPPETSLHT VVQGRGELIV FGGLMDKKQN
710
VKYYPKTNAL YFVRAKR
Length:717
Mass (Da):77,777
Last modified:July 5, 2004 - v1
Checksum:i0CE982C850704CDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48S → Y in BAC26160 (PubMed:16141072).Curated1
Sequence conflicti518I → T in AAH03960 (PubMed:15489334).Curated1
Sequence conflicti602S → P in AAH03960 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028867 mRNA Translation: BAC26160.1
AL607087 Genomic DNA No translation available.
BC003960 mRNA Translation: AAH03960.1
BC058667 mRNA Translation: AAH58667.1
CCDSiCCDS18866.1
RefSeqiNP_766106.2, NM_172518.3
UniGeneiMm.28865

Genome annotation databases

EnsembliENSMUST00000030757; ENSMUSP00000030757; ENSMUSG00000028920
GeneIDi213499
KEGGimmu:213499
UCSCiuc008vnz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFBX42_MOUSE
AccessioniPrimary (citable) accession number: Q6PDJ6
Secondary accession number(s): A2A824, Q8CE76, Q99KY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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