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Protein

F-box only protein 42

Gene

Fbxo42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity).By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 42
Gene namesi
Name:Fbxo42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924992. Fbxo42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199431 – 717F-box only protein 42Add BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei378PhosphothreonineBy similarity1
Modified residuei552PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PDJ6.
MaxQBiQ6PDJ6.
PaxDbiQ6PDJ6.
PRIDEiQ6PDJ6.

PTM databases

iPTMnetiQ6PDJ6.
PhosphoSitePlusiQ6PDJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028920.
CleanExiMM_FBXO42.
GenevisibleiQ6PDJ6. MM.

Interactioni

Subunit structurei

Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030757.

Structurei

3D structure databases

ProteinModelPortaliQ6PDJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 93F-boxPROSITE-ProRule annotationAdd BLAST50
Repeati132 – 184Kelch 1Add BLAST53
Repeati186 – 242Kelch 2Add BLAST57
Repeati244 – 293Kelch 3Add BLAST50
Repeati295 – 342Kelch 4Add BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 513Poly-Ser6

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 4 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00440000039706.
HOGENOMiHOG000231102.
HOVERGENiHBG051582.
InParanoidiQ6PDJ6.
KOiK10317.
OMAiPWAWQPL.
OrthoDBiEOG091G0DN3.
PhylomeDBiQ6PDJ6.
TreeFamiTF324505.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF07646. Kelch_2. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PDJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSDSEDD SVMAVDQEET ALEGTMEQDE DPHPVLEVEE TRHNRSMSEL
60 70 80 90 100
PEEVLEYILS FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG
110 120 130 140 150
NIQWESRTYP YPGTPITQRF SHSACYYDAN QSMYVFGGCT QSSCNAAFND
160 170 180 190 200
LWRLDLNSKE WIRPLASGSY PSPKAGATLV VYKDLLVLFG GWTRPSPYPL
210 220 230 240 250
HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI GDKMIVFGGS
260 270 280 290 300
LGSRQMSNEV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDTTLLILG
310 320 330 340 350
GCGGPNALFK DAWLLHMHPG PWAWQPLKVE NEDHGAPELW CHPACRVGQC
360 370 380 390 400
VVVFSQAPSG RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE
410 420 430 440 450
APCVNGRWGT LRPRAQRQTP SGSREGSLSP ARGDGSPILN GGNLSPGTVA
460 470 480 490 500
VGGASLDSPV QVVSPSTPSA SDGYDLKVGL SLAPRRGSLP DQKDLRLSSI
510 520 530 540 550
DLNWDLKSAS SSSHVDSIDN RTVAGSVRHP PEQTNGVHTP PHVASALAGA
560 570 580 590 600
VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPSSPGS QSLSSGETVP
610 620 630 640 650
NSRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD
660 670 680 690 700
IKDTKEKGRV KWKVFTSSSV VGPPETSLHT VVQGRGELIV FGGLMDKKQN
710
VKYYPKTNAL YFVRAKR
Length:717
Mass (Da):77,777
Last modified:July 5, 2004 - v1
Checksum:i0CE982C850704CDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48S → Y in BAC26160 (PubMed:16141072).Curated1
Sequence conflicti518I → T in AAH03960 (PubMed:15489334).Curated1
Sequence conflicti602S → P in AAH03960 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028867 mRNA. Translation: BAC26160.1.
AL607087 Genomic DNA. Translation: CAM16991.1.
BC003960 mRNA. Translation: AAH03960.1.
BC058667 mRNA. Translation: AAH58667.1.
CCDSiCCDS18866.1.
RefSeqiNP_766106.2. NM_172518.3.
UniGeneiMm.28865.

Genome annotation databases

EnsembliENSMUST00000030757; ENSMUSP00000030757; ENSMUSG00000028920.
GeneIDi213499.
KEGGimmu:213499.
UCSCiuc008vnz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028867 mRNA. Translation: BAC26160.1.
AL607087 Genomic DNA. Translation: CAM16991.1.
BC003960 mRNA. Translation: AAH03960.1.
BC058667 mRNA. Translation: AAH58667.1.
CCDSiCCDS18866.1.
RefSeqiNP_766106.2. NM_172518.3.
UniGeneiMm.28865.

3D structure databases

ProteinModelPortaliQ6PDJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030757.

PTM databases

iPTMnetiQ6PDJ6.
PhosphoSitePlusiQ6PDJ6.

Proteomic databases

EPDiQ6PDJ6.
MaxQBiQ6PDJ6.
PaxDbiQ6PDJ6.
PRIDEiQ6PDJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030757; ENSMUSP00000030757; ENSMUSG00000028920.
GeneIDi213499.
KEGGimmu:213499.
UCSCiuc008vnz.2. mouse.

Organism-specific databases

CTDi54455.
MGIiMGI:1924992. Fbxo42.

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00440000039706.
HOGENOMiHOG000231102.
HOVERGENiHBG051582.
InParanoidiQ6PDJ6.
KOiK10317.
OMAiPWAWQPL.
OrthoDBiEOG091G0DN3.
PhylomeDBiQ6PDJ6.
TreeFamiTF324505.

Miscellaneous databases

PROiQ6PDJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028920.
CleanExiMM_FBXO42.
GenevisibleiQ6PDJ6. MM.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR001810. F-box_dom.
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF07646. Kelch_2. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX42_MOUSE
AccessioniPrimary (citable) accession number: Q6PDJ6
Secondary accession number(s): A2A824, Q8CE76, Q99KY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.