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Protein

VWFA and cache domain-containing protein 1

Gene

Cachd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate voltage-dependent calcium channels.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
VWFA and cache domain-containing protein 1
Short name:
Cache domain-containing protein 1
Gene namesi
Name:Cachd1
Synonyms:Kiaa1573, Vwcd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2444177. Cachd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 1109ExtracellularSequence analysisAdd BLAST1060
Transmembranei1110 – 1130HelicalSequence analysisAdd BLAST21
Topological domaini1131 – 1288CytoplasmicSequence analysisAdd BLAST158

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 49Sequence analysisAdd BLAST49
ChainiPRO_000030466250 – 1288VWFA and cache domain-containing protein 1Add BLAST1239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PDJ1.
PeptideAtlasiQ6PDJ1.
PRIDEiQ6PDJ1.

PTM databases

iPTMnetiQ6PDJ1.
PhosphoSitePlusiQ6PDJ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028532.
CleanExiMM_CACHD1.
ExpressionAtlasiQ6PDJ1. baseline and differential.
GenevisibleiQ6PDJ1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030257.

Structurei

3D structure databases

ProteinModelPortaliQ6PDJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 457VWFAPROSITE-ProRule annotationAdd BLAST216
Domaini467 – 546Cache 1Add BLAST80
Domaini786 – 867Cache 2Add BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi957 – 996Cys-richAdd BLAST40
Compositional biasi1257 – 1274His-richAdd BLAST18

Sequence similaritiesi

Contains 2 cache domains.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2353. Eukaryota.
ENOG410XPDX. LUCA.
GeneTreeiENSGT00530000062904.
HOGENOMiHOG000111294.
HOVERGENiHBG059120.
InParanoidiQ6PDJ1.
OMAiCPCECPM.
OrthoDBiEOG091G013E.
PhylomeDBiQ6PDJ1.
TreeFamiTF315824.

Family and domain databases

Gene3Di3.40.50.410. 2 hits.
InterProiIPR029151. Sensor-like.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PDJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAREPEEEET VRPAAVVRRC PRCPGWPGAP RPPLWLLCLV ACWILGAVAD
60 70 80 90 100
ADFSILDEAQ VLASQMRRLA AEELGVVTMQ RIFNSLVYTE KISNGESEVQ
110 120 130 140 150
QLAKKIREKF NRYLDVVNRN KQVVEASYTA HLTSPLTAIQ DCCTIPPSMM
160 170 180 190 200
EFDGNFNTNV SRTVSCDRLS TTVNSRAFNP GRDLNSVLAD NLKSNPGIKW
210 220 230 240 250
QYFSSEEGIF TVFPAHKFRC KGSYEHRSRP IYVSTVRPQS KHIVVILDHG
260 270 280 290 300
ASVTDTQLQI AKDAAQVILS AIDEHDKISV LTVADAVRTC SLDQCYKTYL
310 320 330 340 350
SPATSETKRK MSTFVSSVKP SDSPTQHAVG FHRAFQLIRS TSNSTRFQAN
360 370 380 390 400
TDMVIIYLSA GITSKDSSEE DKKATLRVIN EENGFLNNSV MILTYALMND
410 420 430 440 450
GVTGLKELAF LRDLAEQNSG KYGIPDRTAL PVIKGSMMVL NQLSNLETTV
460 470 480 490 500
GRFYTNLPNR MIDEAVFSLP FSDEMGDGLI MTVSKPCYFG NLLLGIVGVD
510 520 530 540 550
VNLAYILEDV TYYQDSLASY TFLIDDKGYT LMHPSLTRPY LLSEPPLHTD
560 570 580 590 600
IIHYENIPKF ELVRQNILSL PLGSQIITVP VNSSLSWHIN KLRETGKEAY
610 620 630 640 650
NVSYAWKMVQ DTSFILCIVV IQPEIPVKQL KNLNTVPSSK LLYHRLDLLG
660 670 680 690 700
QPSACLHFKQ LATLESPTVM LSAGSFSSPY EHLSQPETKR MVEHYTAYLS
710 720 730 740 750
DNTRLIANPG LKFSVRNEVM ATSHVTDEWM TQMEMSSLNT YIVRRYIATP
760 770 780 790 800
NGVLRIYPGS LMDKAFDPTR RQWYLHAVAN PGLISLTGPY LDVGGAGYVV
810 820 830 840 850
TISHTIHSSS TQLSSGHTVA VMGIDFTLRY FYKVLMDLLP VCNQDGGNKI
860 870 880 890 900
RCFIMEDRGY LVAHPTLVDP KGHAPLEQQH ITHKEPLVAN DILNHPNFVK
910 920 930 940 950
KNLCNSFSDR TVQRSYKFNT SLVGDLTNLV HGSHCSKYRL TRIPGTNAFV
960 970 980 990 1000
GIVNETCDSL AFCACSMVDR LCLNCHRMEQ NECECPCECP LEVNECTGNL
1010 1020 1030 1040 1050
TNAENRNPSC EVHQEPVTYT AIDPGLQDAL QQCVNSRCNQ RMESGDCFGV
1060 1070 1080 1090 1100
LDCEWCVVDS DGKTHLDKSY CAPQKECFGG IVGAKSPYVD DMGAIGDEVI
1110 1120 1130 1140 1150
TLNMIKSAPV GPVAGGIMGC IMVLVLAVYA YRHQIHRRSH QHMSPLAAQE
1160 1170 1180 1190 1200
MSVRMSNLEN DRDERDDDSH EDRGIISNTR FIAAVMERHV HSPERRRRYW
1210 1220 1230 1240 1250
GRSGTESDHG YSTMSPQEDS ENPPCNNDPL SAGVDVGNHD DDLDLDTPPQ
1260 1270 1280
TAALLSHKFH HYRPHHPTLH HSHHLQAAVT VHTVDAEC
Length:1,288
Mass (Da):143,812
Last modified:July 5, 2004 - v1
Checksum:iCF4ABE98727BABF5
GO
Isoform 2 (identifier: Q6PDJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-828: Missing.

Note: No experimental confirmation available.
Show »
Length:1,282
Mass (Da):143,166
Checksum:iF31FDC1445747565
GO

Sequence cautioni

The sequence CAM20140 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM22543 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028073823 – 828Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670223, AL627083 Genomic DNA. Translation: CAM20139.1.
AL670223, AL627083 Genomic DNA. Translation: CAM20140.1. Sequence problems.
AL627083, AL670223 Genomic DNA. Translation: CAM22542.1.
AL627083, AL670223 Genomic DNA. Translation: CAM22543.1. Sequence problems.
BC058676 mRNA. Translation: AAH58676.1.
BC057356 mRNA. Translation: AAH57356.1.
BC080313 mRNA. Translation: AAH80313.1.
AK080923 mRNA. Translation: BAC38080.1.
AK129397 Transcribed RNA. Translation: BAC98207.1.
CCDSiCCDS18391.1. [Q6PDJ1-1]
RefSeqiNP_932154.1. NM_198037.1. [Q6PDJ1-1]
UniGeneiMm.151962.

Genome annotation databases

EnsembliENSMUST00000030257; ENSMUSP00000030257; ENSMUSG00000028532. [Q6PDJ1-1]
GeneIDi320508.
KEGGimmu:320508.
UCSCiuc008tvg.1. mouse. [Q6PDJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670223, AL627083 Genomic DNA. Translation: CAM20139.1.
AL670223, AL627083 Genomic DNA. Translation: CAM20140.1. Sequence problems.
AL627083, AL670223 Genomic DNA. Translation: CAM22542.1.
AL627083, AL670223 Genomic DNA. Translation: CAM22543.1. Sequence problems.
BC058676 mRNA. Translation: AAH58676.1.
BC057356 mRNA. Translation: AAH57356.1.
BC080313 mRNA. Translation: AAH80313.1.
AK080923 mRNA. Translation: BAC38080.1.
AK129397 Transcribed RNA. Translation: BAC98207.1.
CCDSiCCDS18391.1. [Q6PDJ1-1]
RefSeqiNP_932154.1. NM_198037.1. [Q6PDJ1-1]
UniGeneiMm.151962.

3D structure databases

ProteinModelPortaliQ6PDJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030257.

PTM databases

iPTMnetiQ6PDJ1.
PhosphoSitePlusiQ6PDJ1.

Proteomic databases

PaxDbiQ6PDJ1.
PeptideAtlasiQ6PDJ1.
PRIDEiQ6PDJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030257; ENSMUSP00000030257; ENSMUSG00000028532. [Q6PDJ1-1]
GeneIDi320508.
KEGGimmu:320508.
UCSCiuc008tvg.1. mouse. [Q6PDJ1-1]

Organism-specific databases

CTDi57685.
MGIiMGI:2444177. Cachd1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2353. Eukaryota.
ENOG410XPDX. LUCA.
GeneTreeiENSGT00530000062904.
HOGENOMiHOG000111294.
HOVERGENiHBG059120.
InParanoidiQ6PDJ1.
OMAiCPCECPM.
OrthoDBiEOG091G013E.
PhylomeDBiQ6PDJ1.
TreeFamiTF315824.

Miscellaneous databases

PROiQ6PDJ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028532.
CleanExiMM_CACHD1.
ExpressionAtlasiQ6PDJ1. baseline and differential.
GenevisibleiQ6PDJ1. MM.

Family and domain databases

Gene3Di3.40.50.410. 2 hits.
InterProiIPR029151. Sensor-like.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SUPFAMiSSF103190. SSF103190. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAHD1_MOUSE
AccessioniPrimary (citable) accession number: Q6PDJ1
Secondary accession number(s): A2A8W3
, Q6PFZ0, Q6ZPM4, Q8BNP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.