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Protein

Vacuolar fusion protein MON1 homolog A

Gene

Mon1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes.1 Publication

GO - Biological processi

  • cellular iron ion homeostasis Source: MGI
  • protein secretion Source: MGI
  • protein transport Source: MGI
  • vesicle-mediated transport Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein MON1 homolog A
Gene namesi
Name:Mon1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1920075. Mon1a.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Vacuolar fusion protein MON1 homolog APRO_0000285763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine2 Publications
Modified residuei56 – 561Phosphoserine1 Publication
Modified residuei79 – 791Phosphoserine1 Publication
Modified residuei91 – 911Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PDG8.
PaxDbiQ6PDG8.
PRIDEiQ6PDG8.

PTM databases

PhosphoSiteiQ6PDG8.

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiQ6PDG8.
CleanExiMM_MON1A.
GenevisibleiQ6PDG8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035202.

Structurei

3D structure databases

ProteinModelPortaliQ6PDG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON1/SAND family.Curated

Phylogenomic databases

eggNOGiNOG256927.
HOGENOMiHOG000031337.
HOVERGENiHBG064381.
InParanoidiQ6PDG8.
OrthoDBiEOG79GT63.
PhylomeDBiQ6PDG8.
TreeFamiTF314665.

Family and domain databases

InterProiIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERiPTHR13027. PTHR13027. 1 hit.
PfamiPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSiPR01546. YEAST73DUF.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PDG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADMQRKRS SECPEGTLAP SNGQSVERAE SPTPGLTQGT EPGAGQEGAM
60 70 80 90 100
FVHTRSYEDL TELEDREASG DSPKECVGSP PPLATDMRQI SQDFSELSTQ
110 120 130 140 150
LTGVARDLQE EMLPGSSEDW PEPQGAAGRG AATEPSQEGS TEGEEEDATE
160 170 180 190 200
AWRLHQKHVF VLSEAGKPVY SRYGSEEALS STMGVMVALV SFLEADKNAI
210 220 230 240 250
RSIHADGYKV VFVRRSPLVL VAVARTRQSA QELAQELLYI YYQILSLLTG
260 270 280 290 300
AQLSHIFQQK QNYDLRRLLS GSERITDNLL QLMARDPSFL MGAARCLPLA
310 320 330 340 350
AAVRDTVSAS LQQARARSLV FSILLAHNQL VALVRRKDQF LHPIDLHLLF
360 370 380 390 400
NLISSSSSFR EGEAWTPVCL PKFNAAGFFH AHISYLEPDT DLCLLLISTD
410 420 430 440 450
REDFFAVSDC RRRFQERLRK RGTHLALREA LRTPYYSVAQ VGIPDLRHFL
460 470 480 490 500
YKSKSSGLFT SPEIEAPYSS EEEQERLLGL YQYLHSRAHN ASRPLKTIYY
510 520 530 540 550
TGPNENLLAW VTGAFELYMC YSPLGTKASA VSAIHKLMRW IRKEEDRLFI

LTPLTY
Length:556
Mass (Da):62,131
Last modified:January 15, 2008 - v3
Checksum:i78E1EA166530540F
GO
Isoform 2 (identifier: Q6PDG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-461: S → R
     462-556: Missing.

Note: No experimental confirmation available.
Show »
Length:461
Mass (Da):51,166
Checksum:iCBC21E21542CC3B8
GO

Polymorphismi

The variant Ser-374 is unique to C57BL strains. It may confer the low iron phenotype observed in these strains.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti374 – 3741N → S in strain: C57BL. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei461 – 4611S → R in isoform 2. 1 PublicationVSP_024913
Alternative sequencei462 – 55695Missing in isoform 2. 1 PublicationVSP_024914Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013387 mRNA. Translation: BAB28823.1.
AK172624 mRNA. Translation: BAE43102.1.
BC048852 mRNA. Translation: AAH48852.1.
BC058717 mRNA. Translation: AAH58717.1.
CCDSiCCDS23508.1. [Q6PDG8-1]
RefSeqiNP_082645.1. NM_028369.3.
UniGeneiMm.38037.

Genome annotation databases

GeneIDi72825.
KEGGimmu:72825.
UCSCiuc009rng.2. mouse. [Q6PDG8-1]
uc009rnh.2. mouse. [Q6PDG8-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013387 mRNA. Translation: BAB28823.1.
AK172624 mRNA. Translation: BAE43102.1.
BC048852 mRNA. Translation: AAH48852.1.
BC058717 mRNA. Translation: AAH58717.1.
CCDSiCCDS23508.1. [Q6PDG8-1]
RefSeqiNP_082645.1. NM_028369.3.
UniGeneiMm.38037.

3D structure databases

ProteinModelPortaliQ6PDG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035202.

PTM databases

PhosphoSiteiQ6PDG8.

Proteomic databases

MaxQBiQ6PDG8.
PaxDbiQ6PDG8.
PRIDEiQ6PDG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi72825.
KEGGimmu:72825.
UCSCiuc009rng.2. mouse. [Q6PDG8-1]
uc009rnh.2. mouse. [Q6PDG8-2]

Organism-specific databases

CTDi84315.
MGIiMGI:1920075. Mon1a.

Phylogenomic databases

eggNOGiNOG256927.
HOGENOMiHOG000031337.
HOVERGENiHBG064381.
InParanoidiQ6PDG8.
OrthoDBiEOG79GT63.
PhylomeDBiQ6PDG8.
TreeFamiTF314665.

Miscellaneous databases

NextBioi336995.
PROiQ6PDG8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PDG8.
CleanExiMM_MON1A.
GenevisibleiQ6PDG8. MM.

Family and domain databases

InterProiIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERiPTHR13027. PTHR13027. 1 hit.
PfamiPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSiPR01546. YEAST73DUF.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and FVB/N.
    Tissue: Embryonic brain and Mammary tumor.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  4. "Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice."
    Wang F., Paradkar P.N., Custodio A.O., McVey Ward D., Fleming M.D., Campagna D., Roberts K.A., Boyartchuk V., Dietrich W.F., Kaplan J., Andrews N.C.
    Nat. Genet. 39:1025-1032(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, VARIANT SER-374, TISSUE SPECIFICITY.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-56; SER-79 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMON1A_MOUSE
AccessioniPrimary (citable) accession number: Q6PDG8
Secondary accession number(s): Q80UP6, Q9CYS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 15, 2008
Last modified: June 24, 2015
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.