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Q6PDG8

- MON1A_MOUSE

UniProt

Q6PDG8 - MON1A_MOUSE

Protein

Vacuolar fusion protein MON1 homolog A

Gene

Mon1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 3 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes.1 Publication

    GO - Biological processi

    1. cellular iron ion homeostasis Source: MGI
    2. protein secretion Source: MGI
    3. protein transport Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar fusion protein MON1 homolog A
    Gene namesi
    Name:Mon1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1920075. Mon1a.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Vacuolar fusion protein MON1 homolog APRO_0000285763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine2 Publications
    Modified residuei56 – 561Phosphoserine1 Publication
    Modified residuei79 – 791Phosphoserine1 Publication
    Modified residuei91 – 911Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6PDG8.
    PRIDEiQ6PDG8.

    PTM databases

    PhosphoSiteiQ6PDG8.

    Expressioni

    Tissue specificityi

    Widely expressed (at protein level).1 Publication

    Gene expression databases

    BgeeiQ6PDG8.
    CleanExiMM_MON1A.
    GenevestigatoriQ6PDG8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PDG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MON1/SAND family.Curated

    Phylogenomic databases

    eggNOGiNOG256927.
    GeneTreeiENSGT00390000006665.
    HOGENOMiHOG000031337.
    HOVERGENiHBG064381.
    InParanoidiQ6PDG8.
    OrthoDBiEOG79GT63.
    PhylomeDBiQ6PDG8.
    TreeFamiTF314665.

    Family and domain databases

    InterProiIPR004353. Vacuolar_fusion_protein_MON1.
    [Graphical view]
    PANTHERiPTHR13027. PTHR13027. 1 hit.
    PfamiPF03164. Mon1. 1 hit.
    [Graphical view]
    PRINTSiPR01546. YEAST73DUF.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PDG8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADMQRKRS SECPEGTLAP SNGQSVERAE SPTPGLTQGT EPGAGQEGAM    50
    FVHTRSYEDL TELEDREASG DSPKECVGSP PPLATDMRQI SQDFSELSTQ 100
    LTGVARDLQE EMLPGSSEDW PEPQGAAGRG AATEPSQEGS TEGEEEDATE 150
    AWRLHQKHVF VLSEAGKPVY SRYGSEEALS STMGVMVALV SFLEADKNAI 200
    RSIHADGYKV VFVRRSPLVL VAVARTRQSA QELAQELLYI YYQILSLLTG 250
    AQLSHIFQQK QNYDLRRLLS GSERITDNLL QLMARDPSFL MGAARCLPLA 300
    AAVRDTVSAS LQQARARSLV FSILLAHNQL VALVRRKDQF LHPIDLHLLF 350
    NLISSSSSFR EGEAWTPVCL PKFNAAGFFH AHISYLEPDT DLCLLLISTD 400
    REDFFAVSDC RRRFQERLRK RGTHLALREA LRTPYYSVAQ VGIPDLRHFL 450
    YKSKSSGLFT SPEIEAPYSS EEEQERLLGL YQYLHSRAHN ASRPLKTIYY 500
    TGPNENLLAW VTGAFELYMC YSPLGTKASA VSAIHKLMRW IRKEEDRLFI 550
    LTPLTY 556
    Length:556
    Mass (Da):62,131
    Last modified:January 15, 2008 - v3
    Checksum:i78E1EA166530540F
    GO
    Isoform 2 (identifier: Q6PDG8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         461-461: S → R
         462-556: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:461
    Mass (Da):51,166
    Checksum:iCBC21E21542CC3B8
    GO

    Polymorphismi

    The variant Ser-374 is unique to C57BL strains. It may confer the low iron phenotype observed in these strains.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti374 – 3741N → S in strain: C57BL. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei461 – 4611S → R in isoform 2. 1 PublicationVSP_024913
    Alternative sequencei462 – 55695Missing in isoform 2. 1 PublicationVSP_024914Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013387 mRNA. Translation: BAB28823.1.
    AK172624 mRNA. Translation: BAE43102.1.
    BC048852 mRNA. Translation: AAH48852.1.
    BC058717 mRNA. Translation: AAH58717.1.
    CCDSiCCDS23508.1. [Q6PDG8-1]
    RefSeqiNP_082645.1. NM_028369.3.
    UniGeneiMm.38037.

    Genome annotation databases

    EnsembliENSMUST00000035202; ENSMUSP00000035202; ENSMUSG00000032583.
    GeneIDi72825.
    KEGGimmu:72825.
    UCSCiuc009rng.2. mouse. [Q6PDG8-1]
    uc009rnh.2. mouse. [Q6PDG8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013387 mRNA. Translation: BAB28823.1 .
    AK172624 mRNA. Translation: BAE43102.1 .
    BC048852 mRNA. Translation: AAH48852.1 .
    BC058717 mRNA. Translation: AAH58717.1 .
    CCDSi CCDS23508.1. [Q6PDG8-1 ]
    RefSeqi NP_082645.1. NM_028369.3.
    UniGenei Mm.38037.

    3D structure databases

    ProteinModelPortali Q6PDG8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PDG8.

    Proteomic databases

    PaxDbi Q6PDG8.
    PRIDEi Q6PDG8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035202 ; ENSMUSP00000035202 ; ENSMUSG00000032583 .
    GeneIDi 72825.
    KEGGi mmu:72825.
    UCSCi uc009rng.2. mouse. [Q6PDG8-1 ]
    uc009rnh.2. mouse. [Q6PDG8-2 ]

    Organism-specific databases

    CTDi 84315.
    MGIi MGI:1920075. Mon1a.

    Phylogenomic databases

    eggNOGi NOG256927.
    GeneTreei ENSGT00390000006665.
    HOGENOMi HOG000031337.
    HOVERGENi HBG064381.
    InParanoidi Q6PDG8.
    OrthoDBi EOG79GT63.
    PhylomeDBi Q6PDG8.
    TreeFami TF314665.

    Miscellaneous databases

    NextBioi 336995.
    PROi Q6PDG8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PDG8.
    CleanExi MM_MON1A.
    Genevestigatori Q6PDG8.

    Family and domain databases

    InterProi IPR004353. Vacuolar_fusion_protein_MON1.
    [Graphical view ]
    PANTHERi PTHR13027. PTHR13027. 1 hit.
    Pfami PF03164. Mon1. 1 hit.
    [Graphical view ]
    PRINTSi PR01546. YEAST73DUF.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Embryo and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6 and FVB/N.
      Tissue: Embryonic brain and Mammary tumor.
    3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    4. "Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice."
      Wang F., Paradkar P.N., Custodio A.O., McVey Ward D., Fleming M.D., Campagna D., Roberts K.A., Boyartchuk V., Dietrich W.F., Kaplan J., Andrews N.C.
      Nat. Genet. 39:1025-1032(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, VARIANT SER-374, TISSUE SPECIFICITY.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-56; SER-79 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMON1A_MOUSE
    AccessioniPrimary (citable) accession number: Q6PDG8
    Secondary accession number(s): Q80UP6, Q9CYS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 63 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3