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Q6PDG8 (MON1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar fusion protein MON1 homolog A
Gene names
Name:Mon1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Ref.4

Tissue specificity

Widely expressed (at protein level). Ref.4

Polymorphism

The variant Ser-374 is unique to C57BL strains. It may confer the low iron phenotype observed in these strains.

Sequence similarities

Belongs to the MON1/SAND family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PDG8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PDG8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     461-461: S → R
     462-556: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Vacuolar fusion protein MON1 homolog A
PRO_0000285763

Amino acid modifications

Modified residue311Phosphoserine Ref.5 Ref.6
Modified residue561Phosphoserine Ref.6
Modified residue791Phosphoserine Ref.6
Modified residue911Phosphoserine Ref.6

Natural variations

Alternative sequence4611S → R in isoform 2.
VSP_024913
Alternative sequence462 – 55695Missing in isoform 2.
VSP_024914
Natural variant3741N → S in strain: C57BL. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 3.
Checksum: 78E1EA166530540F

FASTA55662,131
        10         20         30         40         50         60 
MAADMQRKRS SECPEGTLAP SNGQSVERAE SPTPGLTQGT EPGAGQEGAM FVHTRSYEDL 

        70         80         90        100        110        120 
TELEDREASG DSPKECVGSP PPLATDMRQI SQDFSELSTQ LTGVARDLQE EMLPGSSEDW 

       130        140        150        160        170        180 
PEPQGAAGRG AATEPSQEGS TEGEEEDATE AWRLHQKHVF VLSEAGKPVY SRYGSEEALS 

       190        200        210        220        230        240 
STMGVMVALV SFLEADKNAI RSIHADGYKV VFVRRSPLVL VAVARTRQSA QELAQELLYI 

       250        260        270        280        290        300 
YYQILSLLTG AQLSHIFQQK QNYDLRRLLS GSERITDNLL QLMARDPSFL MGAARCLPLA 

       310        320        330        340        350        360 
AAVRDTVSAS LQQARARSLV FSILLAHNQL VALVRRKDQF LHPIDLHLLF NLISSSSSFR 

       370        380        390        400        410        420 
EGEAWTPVCL PKFNAAGFFH AHISYLEPDT DLCLLLISTD REDFFAVSDC RRRFQERLRK 

       430        440        450        460        470        480 
RGTHLALREA LRTPYYSVAQ VGIPDLRHFL YKSKSSGLFT SPEIEAPYSS EEEQERLLGL 

       490        500        510        520        530        540 
YQYLHSRAHN ASRPLKTIYY TGPNENLLAW VTGAFELYMC YSPLGTKASA VSAIHKLMRW 

       550 
IRKEEDRLFI LTPLTY 

« Hide

Isoform 2 [UniParc].

Checksum: CBC21E21542CC3B8
Show »

FASTA46151,166

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Embryo and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6 and FVB/N.
Tissue: Embryonic brain and Mammary tumor.
[3]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
[4]"Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice."
Wang F., Paradkar P.N., Custodio A.O., McVey Ward D., Fleming M.D., Campagna D., Roberts K.A., Boyartchuk V., Dietrich W.F., Kaplan J., Andrews N.C.
Nat. Genet. 39:1025-1032(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, VARIANT SER-374, TISSUE SPECIFICITY.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-56; SER-79 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK013387 mRNA. Translation: BAB28823.1.
AK172624 mRNA. Translation: BAE43102.1.
BC048852 mRNA. Translation: AAH48852.1.
BC058717 mRNA. Translation: AAH58717.1.
RefSeqNP_082645.1. NM_028369.3.
UniGeneMm.38037.

3D structure databases

ProteinModelPortalQ6PDG8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6PDG8.

Proteomic databases

PaxDbQ6PDG8.
PRIDEQ6PDG8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035202; ENSMUSP00000035202; ENSMUSG00000032583.
GeneID72825.
KEGGmmu:72825.
UCSCuc009rng.2. mouse. [Q6PDG8-1]
uc009rnh.2. mouse. [Q6PDG8-2]

Organism-specific databases

CTD84315.
MGIMGI:1920075. Mon1a.

Phylogenomic databases

eggNOGNOG256927.
GeneTreeENSGT00390000006665.
HOGENOMHOG000031337.
HOVERGENHBG064381.
InParanoidQ6PDG8.
OrthoDBEOG79GT63.
PhylomeDBQ6PDG8.
TreeFamTF314665.

Gene expression databases

BgeeQ6PDG8.
CleanExMM_MON1A.
GenevestigatorQ6PDG8.

Family and domain databases

InterProIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERPTHR13027. PTHR13027. 1 hit.
PfamPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSPR01546. YEAST73DUF.
ProtoNetSearch...

Other

NextBio336995.
PROQ6PDG8.
SOURCESearch...

Entry information

Entry nameMON1A_MOUSE
AccessionPrimary (citable) accession number: Q6PDG8
Secondary accession number(s): Q80UP6, Q9CYS2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 61 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot